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The map label for this gene is hutU

Identifier: 30263597

GI number: 30263597

Start: 3412759

End: 3414417

Strand: Reverse

Name: hutU

Synonym: BA_3711

Alternate gene names: 30263597

Gene position: 3414417-3412759 (Counterclockwise)

Preceding gene: 30263598

Following gene: 30263596

Centisome position: 65.32

GC content: 41.71

Gene sequence:

>1659_bases
ATGGAAAAAGTTAAACAAACAATTCGCGCGCCAAGAGGTACTGAGTTACAAACGAAAGGGTGGGTGCAAGAAGCTGCACT
TCGTATGTTAATGAACAATTTAGATCCTGAAGTTGCTGAAAAACCAGAAGAATTAGTTGTATATGGCGGAATTGGCCGTG
CAGCTCGTAACTGGGAAAGCTATCAGGCGATTGTAGATTCATTAAAAACGTTAGAAAGCGATGAAACTTTACTTGTTCAA
TCAGGAAAACCAGTTGCTATTTTTAAATCACATGAAGATGCGCCTCGCGTTCTTTTAGCGAACTCAAACTTAGTACCGAA
GTGGGCGAACTGGGATCACTTCCGTGAACTAGAGAAAAAAGGTCTTATGATGTACGGACAAATGACGGCAGGTAGCTGGA
TTTACATCGGAACACAAGGTATTTTACAAGGAACTTATGAAACGTTTGGTGAAGCGGCGCGTCAACATTTCGGTGGTTCA
TTAAAAGGCACATTAACACTTACTGCTGGTTTAGGTGGTATGGGTGGTGCACAACCTCTTGCTGTAACGATGAACGGCGG
TGTTGTTATTGCTATTGATGTTGATAAGCGCAGCATCGATCGTCGTATTGAAAAGAGATACTGTGATATGTATACAGAAT
CATTAGAAGAAGCGTTAGCGGTTGCGAACGAGTATAAAGAGAAGAAAGAACCGATTTCTATTGGTTTATTAGGAAATGCG
GCAGAAATTTTACCAGAACTAGTGAAGCGCAATATTACGCCAGACTTGGTTACAGATCAAACATCTGCTCATGATCCATT
AAACGGTTATATTCCAGTAGGCTACACGTTAGAAGAAGCAGCAAAACTTCGTGAAGAAGATCCAGAACGCTACGTACAAT
TATCAAAAGAAAGCATGACAAAACATGTGGAAGCAATGCTTGCTATGCAAGAAAAAGGCGCAATTACATTTGATTACGGA
AATAACATTCGCCAAGTTGCTTTTGATGAAGGTTTGAAAAATGCATTCGATTTCCCAGGATTCGTTCCAGCATTTATCCG
TCCATTATTCTGCGAAGGAAAAGGACCATTCCGCTGGGTAGCACTTTCTGGTGACCCAGAAGATATTTATAAAACAGACG
AAGTAATTTTACGTGAGTTCGCGGATAATGAGCATTTATGTAACTGGATTCGTATGGCTCGTCAGCAAGTTGAATTCCAA
GGCCTTCCATCACGTATTTGTTGGCTTGGTTACGGTGAGCGTGCGAAATTTGGCCGCATCATTAATGAAATGGTTGCAAA
TGGTGAATTATCAGCACCAATCGTTATCGGTCGTGACCATTTAGATTGCGGATCAGTAGCATCTCCAAACCGTGAAACAG
AAGCGATGAAAGACGGTAGTGATTCAGTAGCTGACTGGCCAATCTTAAATGCATTAATTAATAGTGTAAACGGTGCAAGC
TGGGTATCTGTTCACCACGGTGGTGGCGTTGGTATGGGTTATTCACTTCATGCAGGAATGGTTATCGTTGCAGATGGAAC
AGAAGCAGCAGCAAAACGTATTGAGCGCGTATTAACTTCTGACCCTGGTATGGGTGTTGTTCGTCACGTTGATGCAGGAT
ATGACTTAGCTGTGGAAACTGCGAAAGAAAAAGGCGTTAACATTCCAATGATGAAATAA

Upstream 100 bases:

>100_bases
ATATTGAAAATATTACGCATTGGTTAAAAACGAATTATTCGATAAAAGAAAGATTAGATGTAAACGCAGCATTATAAAAT
GAGAAAAGGGAGAGATTGAA

Downstream 100 bases:

>100_bases
GGAGGAGAAAACATGCTGGACACTTTACTAATCAATATCGGTCAATTACTAACAATGGATCAAGAAGATGGCTTGTTAAG
ACGGGAAGCGATGAACACGC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MEKVKQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWESYQAIVDSLKTLESDETLLVQ
SGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKKGLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFGGS
LKGTLTLTAGLGGMGGAQPLAVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALAVANEYKEKKEPISIGLLGNA
AEILPELVKRNITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREEDPERYVQLSKESMTKHVEAMLAMQEKGAITFDYG
NNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWVALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQ
GLPSRICWLGYGERAKFGRIINEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDSVADWPILNALINSVNGAS
WVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVETAKEKGVNIPMMK

Sequences:

>Translated_552_residues
MEKVKQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWESYQAIVDSLKTLESDETLLVQ
SGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKKGLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFGGS
LKGTLTLTAGLGGMGGAQPLAVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALAVANEYKEKKEPISIGLLGNA
AEILPELVKRNITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREEDPERYVQLSKESMTKHVEAMLAMQEKGAITFDYG
NNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWVALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQ
GLPSRICWLGYGERAKFGRIINEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDSVADWPILNALINSVNGAS
WVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVETAKEKGVNIPMMK
>Mature_552_residues
MEKVKQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWESYQAIVDSLKTLESDETLLVQ
SGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKKGLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFGGS
LKGTLTLTAGLGGMGGAQPLAVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALAVANEYKEKKEPISIGLLGNA
AEILPELVKRNITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREEDPERYVQLSKESMTKHVEAMLAMQEKGAITFDYG
NNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWVALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQ
GLPSRICWLGYGERAKFGRIINEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDSVADWPILNALINSVNGAS
WVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVETAKEKGVNIPMMK

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family

Homologues:

Organism=Homo sapiens, GI21389467, Length=563, Percent_Identity=35.5239786856128, Blast_Score=329, Evalue=5e-90,
Organism=Homo sapiens, GI260306182, Length=623, Percent_Identity=32.7447833065811, Blast_Score=300, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI71997891, Length=551, Percent_Identity=35.5716878402904, Blast_Score=338, Evalue=3e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTU_BACAA (C3P4M1)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002867840.1
- ProteinModelPortal:   C3P4M1
- SMR:   C3P4M1
- EnsemblBacteria:   EBBACT00000128156
- GeneID:   7849701
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_3738
- GeneTree:   EBGT00050000001977
- ProtClustDB:   PRK05414
- GO:   GO:0005737
- HAMAP:   MF_00577
- InterPro:   IPR000193
- PIRSF:   PIRSF001423
- TIGRFAMs:   TIGR01228

Pfam domain/function: PF01175 Urocanase; SSF111326 Urocanase

EC number: =4.2.1.49

Molecular weight: Translated: 60779; Mature: 60779

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS01233 UROCANASE

Important sites: ACT_SITE 407-407

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVKQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWES
CHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEECCCCHHHHCHHH
YQAIVDSLKTLESDETLLVQSGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKK
HHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHC
GLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFGGSLKGTLTLTAGLGGMGGAQPL
CCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCE
AVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALAVANEYKEKKEPISIGLLGNA
EEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCH
AEILPELVKRNITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREEDPERYVQLSKESMT
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCEEHHHHHHHHHCCHHHHHHHHHHHHH
KHVEAMLAMQEKGAITFDYGNNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWV
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHEECCCCCEEEE
ALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQGLPSRICWLGYGERAKFGRI
EECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHH
INEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDSVADWPILNALINSVNGAS
HHHHHCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCE
WVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVET
EEEEECCCCCCCCEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEH
AKEKGVNIPMMK
HHHCCCCCCCCC
>Mature Secondary Structure
MEKVKQTIRAPRGTELQTKGWVQEAALRMLMNNLDPEVAEKPEELVVYGGIGRAARNWES
CHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEECCCCHHHHCHHH
YQAIVDSLKTLESDETLLVQSGKPVAIFKSHEDAPRVLLANSNLVPKWANWDHFRELEKK
HHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHC
GLMMYGQMTAGSWIYIGTQGILQGTYETFGEAARQHFGGSLKGTLTLTAGLGGMGGAQPL
CCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCE
AVTMNGGVVIAIDVDKRSIDRRIEKRYCDMYTESLEEALAVANEYKEKKEPISIGLLGNA
EEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCH
AEILPELVKRNITPDLVTDQTSAHDPLNGYIPVGYTLEEAAKLREEDPERYVQLSKESMT
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCEEHHHHHHHHHCCHHHHHHHHHHHHH
KHVEAMLAMQEKGAITFDYGNNIRQVAFDEGLKNAFDFPGFVPAFIRPLFCEGKGPFRWV
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHEECCCCCEEEE
ALSGDPEDIYKTDEVILREFADNEHLCNWIRMARQQVEFQGLPSRICWLGYGERAKFGRI
EECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHH
INEMVANGELSAPIVIGRDHLDCGSVASPNRETEAMKDGSDSVADWPILNALINSVNGAS
HHHHHCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCE
WVSVHHGGGVGMGYSLHAGMVIVADGTEAAAKRIERVLTSDPGMGVVRHVDAGYDLAVET
EEEEECCCCCCCCEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEH
AKEKGVNIPMMK
HHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA