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The map label for this gene is yhfS [H]

Identifier: 30263573

GI number: 30263573

Start: 3388375

End: 3389466

Strand: Reverse

Name: yhfS [H]

Synonym: BA_3687

Alternate gene names: 30263573

Gene position: 3389466-3388375 (Counterclockwise)

Preceding gene: 30263574

Following gene: 30263571

Centisome position: 64.84

GC content: 42.12

Gene sequence:

>1092_bases
ATGAATAGAGCAGTTATTGTAGAAGCGAAAAGGACACCTATTGGTAAGAAGAATGGGATGTTAAAAGACTATGAAGTTCA
GCAATTAGCAGCACCGCTTCTTACATTTTTAAGTAAAGGAATGGAGAGAGCGATAGACGATGTCATATTAGGGAATGTTG
TTGGGCCAGGAGGGAATGTTGCGAGATTATCTGCTTTAGAAGCAGGGCTTGGTCATCATATTCCGGGTGTAACGATTGAC
CGACAATGTGGTGCCGGATTGGAAGCGATTCGCACCGCATGTCATTTCATTCAAGGCGGGGGCGGTAAGTGTTATATCGC
CGGAGGAGTAGAGAGTACAAGTACGTCACCTTTTCAAAATAGGGCGCGATTTTCACCAGAAACAATTGGCGATCCTAATA
TGGGAGTAGCGGCTGAGTATGTTGCAGAAAGTTATAACATCACGAGAGAAATGCAAGACGAGTATGCATGCCTCAGTTAT
AAACGAACACTGCAAGCATTAGCAAAAGGATATATACATGAGGAAATATTGTCTTTTAATGGATTGCTAGATGAATCCAT
TAAGCCAGAAATGAATTATGAACGAATCATTAAAAGAACAAAACCTGCATTTTTACACAATGGTACAGTAACGGCAGGTA
ATTCGTGCGGTGTAAATGATGGAGCATGTGCCGTTCTTGTAATGGAAGAGGGACAAGCCCGAAAATTAGGATACAAGCCT
GTACTTCGTTTCGTTCGTAGTGCTGTAGTTGGAGTGGATCCTAACCTTCCGGGGACTGGTCCGATATTTGCGGTGAACAA
ATTATTAAACGAAAGGAATATGAAAGTAGAGGACATCGATTATTTTGAAATAAATGAAGCATTTGCCTCAAAAGTTGTAG
CTTGTGCAAAGGAGTTACAAATTCCTTTCGGAAAATTAAATGTAAATGGTGGGGCAATTGCGCTTGGTCATCCGTACGGT
GCATCTGGGGCTATGCTTGTAACGCGCTTGTTTTATCAGGCGAAACGAGAGCGTATGAAATATGGAATCGCAACGTTAGG
AATAGGGGGCGGGGTAGGTCTTGCACTATTATTTGAGAAAGTAGAAGACTAG

Upstream 100 bases:

>100_bases
CCGAAAGAATGGTATTTTGTAGATGAAATACCGTATACAAATAGCGGGAAAATCGCTCGTATGGAAGCAAAGAGTATCAT
TGAAAATCAGGAGAAAATAT

Downstream 100 bases:

>100_bases
AAAGGAACTAGTTTTCTACTTTCTGAGGAACATAAGCATTGCTACCAGGTTTTGCTTTTATTTCATTCCAAGCAGCGATA
GCATCAGCTTTTGATTTTCC

Product: acetyl-CoA acetyltransferase

Products: CoA; acetoacetyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MNRAVIVEAKRTPIGKKNGMLKDYEVQQLAAPLLTFLSKGMERAIDDVILGNVVGPGGNVARLSALEAGLGHHIPGVTID
RQCGAGLEAIRTACHFIQGGGGKCYIAGGVESTSTSPFQNRARFSPETIGDPNMGVAAEYVAESYNITREMQDEYACLSY
KRTLQALAKGYIHEEILSFNGLLDESIKPEMNYERIIKRTKPAFLHNGTVTAGNSCGVNDGACAVLVMEEGQARKLGYKP
VLRFVRSAVVGVDPNLPGTGPIFAVNKLLNERNMKVEDIDYFEINEAFASKVVACAKELQIPFGKLNVNGGAIALGHPYG
ASGAMLVTRLFYQAKRERMKYGIATLGIGGGVGLALLFEKVED

Sequences:

>Translated_363_residues
MNRAVIVEAKRTPIGKKNGMLKDYEVQQLAAPLLTFLSKGMERAIDDVILGNVVGPGGNVARLSALEAGLGHHIPGVTID
RQCGAGLEAIRTACHFIQGGGGKCYIAGGVESTSTSPFQNRARFSPETIGDPNMGVAAEYVAESYNITREMQDEYACLSY
KRTLQALAKGYIHEEILSFNGLLDESIKPEMNYERIIKRTKPAFLHNGTVTAGNSCGVNDGACAVLVMEEGQARKLGYKP
VLRFVRSAVVGVDPNLPGTGPIFAVNKLLNERNMKVEDIDYFEINEAFASKVVACAKELQIPFGKLNVNGGAIALGHPYG
ASGAMLVTRLFYQAKRERMKYGIATLGIGGGVGLALLFEKVED
>Mature_363_residues
MNRAVIVEAKRTPIGKKNGMLKDYEVQQLAAPLLTFLSKGMERAIDDVILGNVVGPGGNVARLSALEAGLGHHIPGVTID
RQCGAGLEAIRTACHFIQGGGGKCYIAGGVESTSTSPFQNRARFSPETIGDPNMGVAAEYVAESYNITREMQDEYACLSY
KRTLQALAKGYIHEEILSFNGLLDESIKPEMNYERIIKRTKPAFLHNGTVTAGNSCGVNDGACAVLVMEEGQARKLGYKP
VLRFVRSAVVGVDPNLPGTGPIFAVNKLLNERNMKVEDIDYFEINEAFASKVVACAKELQIPFGKLNVNGGAIALGHPYG
ASGAMLVTRLFYQAKRERMKYGIATLGIGGGVGLALLFEKVED

Specific function: May be involved in fatty acid metabolism [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=392, Percent_Identity=35.969387755102, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI167614485, Length=387, Percent_Identity=33.5917312661499, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI4501853, Length=384, Percent_Identity=35.4166666666667, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=32.994923857868, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4504327, Length=419, Percent_Identity=29.5942720763723, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI194353979, Length=364, Percent_Identity=28.2967032967033, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI48994986, Length=388, Percent_Identity=37.6288659793814, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=38.5572139303483, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1788554, Length=398, Percent_Identity=38.9447236180905, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI87082165, Length=397, Percent_Identity=37.0277078085642, Blast_Score=221, Evalue=8e-59,
Organism=Escherichia coli, GI1788683, Length=410, Percent_Identity=27.5609756097561, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI133906874, Length=392, Percent_Identity=36.9897959183673, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17535921, Length=390, Percent_Identity=32.8205128205128, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17551802, Length=424, Percent_Identity=29.9528301886792, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25147385, Length=388, Percent_Identity=30.4123711340206, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17535917, Length=387, Percent_Identity=26.6149870801034, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6322031, Length=387, Percent_Identity=34.8837209302326, Blast_Score=186, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6325229, Length=401, Percent_Identity=32.4189526184539, Blast_Score=166, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24655093, Length=397, Percent_Identity=38.2871536523929, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=37.4358974358974, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24640423, Length=392, Percent_Identity=32.6530612244898, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI17137578, Length=420, Percent_Identity=28.5714285714286, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.9

Molecular weight: Translated: 39032; Mature: 39032

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS00737 THIOLASE_2 ; PS00139 THIOL_PROTEASE_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRAVIVEAKRTPIGKKNGMLKDYEVQQLAAPLLTFLSKGMERAIDDVILGNVVGPGGNV
CCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ARLSALEAGLGHHIPGVTIDRQCGAGLEAIRTACHFIQGGGGKCYIAGGVESTSTSPFQN
HHHHHHHHCCCCCCCCCEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHH
RARFSPETIGDPNMGVAAEYVAESYNITREMQDEYACLSYKRTLQALAKGYIHEEILSFN
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLLDESIKPEMNYERIIKRTKPAFLHNGTVTAGNSCGVNDGACAVLVMEEGQARKLGYKP
CCCCCCCCCCCCHHHHHHHCCCCEEECCEEECCCCCCCCCCCEEEEEECCCCCCCCCHHH
VLRFVRSAVVGVDPNLPGTGPIFAVNKLLNERNMKVEDIDYFEINEAFASKVVACAKELQ
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHC
IPFGKLNVNGGAIALGHPYGASGAMLVTRLFYQAKRERMKYGIATLGIGGGVGLALLFEK
CCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCHHEEECCCHHHHHHHHHH
VED
HCC
>Mature Secondary Structure
MNRAVIVEAKRTPIGKKNGMLKDYEVQQLAAPLLTFLSKGMERAIDDVILGNVVGPGGNV
CCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ARLSALEAGLGHHIPGVTIDRQCGAGLEAIRTACHFIQGGGGKCYIAGGVESTSTSPFQN
HHHHHHHHCCCCCCCCCEECCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHH
RARFSPETIGDPNMGVAAEYVAESYNITREMQDEYACLSYKRTLQALAKGYIHEEILSFN
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLLDESIKPEMNYERIIKRTKPAFLHNGTVTAGNSCGVNDGACAVLVMEEGQARKLGYKP
CCCCCCCCCCCCHHHHHHHCCCCEEECCEEECCCCCCCCCCCEEEEEECCCCCCCCCHHH
VLRFVRSAVVGVDPNLPGTGPIFAVNKLLNERNMKVEDIDYFEINEAFASKVVACAKELQ
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHC
IPFGKLNVNGGAIALGHPYGASGAMLVTRLFYQAKRERMKYGIATLGIGGGVGLALLFEK
CCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCHHEEECCCHHHHHHHHHH
VED
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acetyl-CoA

Specific reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]