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The map label for this gene is sqhC [H]

Identifier: 30263505

GI number: 30263505

Start: 3320906

End: 3322759

Strand: Reverse

Name: sqhC [H]

Synonym: BA_3612

Alternate gene names: 30263505

Gene position: 3322759-3320906 (Counterclockwise)

Preceding gene: 30263506

Following gene: 30263503

Centisome position: 63.57

GC content: 37.38

Gene sequence:

>1854_bases
TTGTTATTATACGAAAAAGCGCATGAAGAAATAGTGAGAAGAGCAACAGCACTTCAAACAATGCAATGGCAAGATGGTAC
GTGGCGATTTTGTTTTGAAGGAGCTCCATTAACAGATTGCCATATGATTTTTTTATTAAAATTATTAGGTAGAGATAAAG
AGATAGAACCGTTCGTAGAAAGAGTAGCATCACTCCAAACAAATGAAGGAACATGGAAATTGCACGAAGATGAAGTAGGA
GGTAATTTATCAGCTACAATTCAATCTTATGCCGCCTTACTTGCATCGAAAAAATATACAAAAGAAGATGCGAATATGAA
ACGAGCAGAAAATTTTATTCAGGAACGCGGTGGTGTGGCGCGTGCTCATTTTATGACGAAGTTTTTATTAGCAATTCATG
GAGAATATGAATATCCTTCACTCTTTCATTTACCAACACCAATCATGTTTTTACAGAATGATTCCCCCTTTAGTATATTT
GAATTAAGTAGCTCAGCACGTATTCATTTAATTCCGATGATGCTATGTTTAAATAAAAGATTTCGAGTAGGGAAAAAGTT
ATTACCAAATTTAAATCACATTGCGGGCGGAGGCGGAGAATGGTTTCGGGAGGATCGGTCTCCAGTTTTTCAAACGTTAT
TAAGTGATGTAAAACAAATTATATCGTATCCACTTTCGTTACATCATAAAGGATATGAGGAAATAGAACGTTTTATGAAA
GAGCGTATTGATGAAAATGGAACGTTATATAGTTACGCAACTGCCTCGTTTTATATGATTTATGCTTTACTTGCGTTAGG
GCATTCTCTTCAATCATCAATGATTCAAAAGGCTATAGCTGGGATAACATCTTATATATGGAAGATGGAAAGAGGGAATC
ATTTGCAAAACTCTCCTTCAACCGTGTGGGATACAGCTTTATTAAGCTATGCGTTACAAGAGGCTCAAGTTTCAAAGGAT
AATAAGATGATTCAAAATGCAACAGCGTATTTATTAAAAAAACAGCATACAAAAAAAGCTGATTGGAGCGTACATGCTCC
GGCGCTTACTCCTGGCGGTTGGGGTTTTTCGGATGTGAATACGACAATTCCAGATATAGATGATACAACAGCTGTGCTAA
GGGCATTGGCACGAAGTAGAGGAAACAAAAATATAGATAATGCTTGGAAGAAAGGGGGCAATTGGATTAAAGGATTACAA
AATAATGATGGTGGCTGGGGAGCATTTGAAAAAGGTGTGACGAGCAAATTATTAGCAAAATTACCAATCGAAAACGCAAG
TGATATGATTACAGATCCTTCTACGCCAGATATTACGGGGAGAGTGTTAGAGTTTTTCGGGACGTATGCACAAAACGAAT
TGCCTGAGAAACAGATACAAAGGGCAATAAATTGGTTAATGAATGTACAAGAGGAAAATGGATCATGGTATGGGAAATGG
GGGATTTGTTATCTATATGGTACGTGGGCTGTTATGACTGGTTTACGGTCACTCGGAATTCCGTCTAGCAATCCTTCATT
GACACGAGCAGCTTCATGGCTTGAACATATACAGCATGAAGATGGTGGTTGGGGAGAATCATGCCACAGTAGTGTGGAGA
AAAGGTTCGTTACTTTACCATTTAGTACACCATCCCAAACTGCATGGGCGTTAGATGCTCTCATTTCTTACTATGATACA
GAAACGCCAGCTATTCGAAAAGGTGTTTCATATTTGCTTTCGAATCCTTATGTGAATGAAAGATATCCTACTGGAACAGG
TTTACCAGGTGCGTTTTATATTAGGTATCATAGCTATGCCCATATATATCCACTACTTACTTTGGCACATTATATAAAAA
AATATAGAAAATAA

Upstream 100 bases:

>100_bases
AGCAGAACATTTTATATGTTCTGCTTTTCTTTGTATTCATACATATTCAGCTACCTTCTTGAATATCGTTATACGGATTT
CGAAAGGGTGGGTGAGTAAC

Downstream 100 bases:

>100_bases
ACCGAGAGATATCTCTCGGTTTATTTTGTTGGGTAGTAGGTCCCTGTTGAAAAGAATAAGGTTGTGCTTCCTTATTTTTC
TGTTGACTGGCGTTTTTGAC

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MLLYEKAHEEIVRRATALQTMQWQDGTWRFCFEGAPLTDCHMIFLLKLLGRDKEIEPFVERVASLQTNEGTWKLHEDEVG
GNLSATIQSYAALLASKKYTKEDANMKRAENFIQERGGVARAHFMTKFLLAIHGEYEYPSLFHLPTPIMFLQNDSPFSIF
ELSSSARIHLIPMMLCLNKRFRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLLSDVKQIISYPLSLHHKGYEEIERFMK
ERIDENGTLYSYATASFYMIYALLALGHSLQSSMIQKAIAGITSYIWKMERGNHLQNSPSTVWDTALLSYALQEAQVSKD
NKMIQNATAYLLKKQHTKKADWSVHAPALTPGGWGFSDVNTTIPDIDDTTAVLRALARSRGNKNIDNAWKKGGNWIKGLQ
NNDGGWGAFEKGVTSKLLAKLPIENASDMITDPSTPDITGRVLEFFGTYAQNELPEKQIQRAINWLMNVQEENGSWYGKW
GICYLYGTWAVMTGLRSLGIPSSNPSLTRAASWLEHIQHEDGGWGESCHSSVEKRFVTLPFSTPSQTAWALDALISYYDT
ETPAIRKGVSYLLSNPYVNERYPTGTGLPGAFYIRYHSYAHIYPLLTLAHYIKKYRK

Sequences:

>Translated_617_residues
MLLYEKAHEEIVRRATALQTMQWQDGTWRFCFEGAPLTDCHMIFLLKLLGRDKEIEPFVERVASLQTNEGTWKLHEDEVG
GNLSATIQSYAALLASKKYTKEDANMKRAENFIQERGGVARAHFMTKFLLAIHGEYEYPSLFHLPTPIMFLQNDSPFSIF
ELSSSARIHLIPMMLCLNKRFRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLLSDVKQIISYPLSLHHKGYEEIERFMK
ERIDENGTLYSYATASFYMIYALLALGHSLQSSMIQKAIAGITSYIWKMERGNHLQNSPSTVWDTALLSYALQEAQVSKD
NKMIQNATAYLLKKQHTKKADWSVHAPALTPGGWGFSDVNTTIPDIDDTTAVLRALARSRGNKNIDNAWKKGGNWIKGLQ
NNDGGWGAFEKGVTSKLLAKLPIENASDMITDPSTPDITGRVLEFFGTYAQNELPEKQIQRAINWLMNVQEENGSWYGKW
GICYLYGTWAVMTGLRSLGIPSSNPSLTRAASWLEHIQHEDGGWGESCHSSVEKRFVTLPFSTPSQTAWALDALISYYDT
ETPAIRKGVSYLLSNPYVNERYPTGTGLPGAFYIRYHSYAHIYPLLTLAHYIKKYRK
>Mature_617_residues
MLLYEKAHEEIVRRATALQTMQWQDGTWRFCFEGAPLTDCHMIFLLKLLGRDKEIEPFVERVASLQTNEGTWKLHEDEVG
GNLSATIQSYAALLASKKYTKEDANMKRAENFIQERGGVARAHFMTKFLLAIHGEYEYPSLFHLPTPIMFLQNDSPFSIF
ELSSSARIHLIPMMLCLNKRFRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLLSDVKQIISYPLSLHHKGYEEIERFMK
ERIDENGTLYSYATASFYMIYALLALGHSLQSSMIQKAIAGITSYIWKMERGNHLQNSPSTVWDTALLSYALQEAQVSKD
NKMIQNATAYLLKKQHTKKADWSVHAPALTPGGWGFSDVNTTIPDIDDTTAVLRALARSRGNKNIDNAWKKGGNWIKGLQ
NNDGGWGAFEKGVTSKLLAKLPIENASDMITDPSTPDITGRVLEFFGTYAQNELPEKQIQRAINWLMNVQEENGSWYGKW
GICYLYGTWAVMTGLRSLGIPSSNPSLTRAASWLEHIQHEDGGWGESCHSSVEKRFVTLPFSTPSQTAWALDALISYYDT
ETPAIRKGVSYLLSNPYVNERYPTGTGLPGAFYIRYHSYAHIYPLLTLAHYIKKYRK

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=626, Percent_Identity=23.1629392971246, Blast_Score=123, Evalue=7e-28,
Organism=Homo sapiens, GI47933397, Length=626, Percent_Identity=23.1629392971246, Blast_Score=123, Evalue=7e-28,
Organism=Homo sapiens, GI224177558, Length=626, Percent_Identity=23.1629392971246, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI224177556, Length=563, Percent_Identity=22.7353463587922, Blast_Score=115, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321863, Length=292, Percent_Identity=28.0821917808219, Blast_Score=80, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 69929; Mature: 69929

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLYEKAHEEIVRRATALQTMQWQDGTWRFCFEGAPLTDCHMIFLLKLLGRDKEIEPFVE
CCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHH
RVASLQTNEGTWKLHEDEVGGNLSATIQSYAALLASKKYTKEDANMKRAENFIQERGGVA
HHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHH
RAHFMTKFLLAIHGEYEYPSLFHLPTPIMFLQNDSPFSIFELSSSARIHLIPMMLCLNKR
HHHHHHHHHHHHCCCCCCCCEEECCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHH
FRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLLSDVKQIISYPLSLHHKGYEEIERFMK
HHHHHHHCCCCHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHH
ERIDENGTLYSYATASFYMIYALLALGHSLQSSMIQKAIAGITSYIWKMERGNHLQNSPS
HHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TVWDTALLSYALQEAQVSKDNKMIQNATAYLLKKQHTKKADWSVHAPALTPGGWGFSDVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCC
TTIPDIDDTTAVLRALARSRGNKNIDNAWKKGGNWIKGLQNNDGGWGAFEKGVTSKLLAK
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHH
LPIENASDMITDPSTPDITGRVLEFFGTYAQNELPEKQIQRAINWLMNVQEENGSWYGKW
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHCCCCEEECC
GICYLYGTWAVMTGLRSLGIPSSNPSLTRAASWLEHIQHEDGGWGESCHSSVEKRFVTLP
EEEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCEEECC
FSTPSQTAWALDALISYYDTETPAIRKGVSYLLSNPYVNERYPTGTGLPGAFYIRYHSYA
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCHH
HIYPLLTLAHYIKKYRK
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLYEKAHEEIVRRATALQTMQWQDGTWRFCFEGAPLTDCHMIFLLKLLGRDKEIEPFVE
CCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHH
RVASLQTNEGTWKLHEDEVGGNLSATIQSYAALLASKKYTKEDANMKRAENFIQERGGVA
HHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHH
RAHFMTKFLLAIHGEYEYPSLFHLPTPIMFLQNDSPFSIFELSSSARIHLIPMMLCLNKR
HHHHHHHHHHHHCCCCCCCCEEECCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHH
FRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLLSDVKQIISYPLSLHHKGYEEIERFMK
HHHHHHHCCCCHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHH
ERIDENGTLYSYATASFYMIYALLALGHSLQSSMIQKAIAGITSYIWKMERGNHLQNSPS
HHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TVWDTALLSYALQEAQVSKDNKMIQNATAYLLKKQHTKKADWSVHAPALTPGGWGFSDVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCC
TTIPDIDDTTAVLRALARSRGNKNIDNAWKKGGNWIKGLQNNDGGWGAFEKGVTSKLLAK
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHH
LPIENASDMITDPSTPDITGRVLEFFGTYAQNELPEKQIQRAINWLMNVQEENGSWYGKW
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHCCCCEEECC
GICYLYGTWAVMTGLRSLGIPSSNPSLTRAASWLEHIQHEDGGWGESCHSSVEKRFVTLP
EEEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCEEECC
FSTPSQTAWALDALISYYDTETPAIRKGVSYLLSNPYVNERYPTGTGLPGAFYIRYHSYA
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCHH
HIYPLLTLAHYIKKYRK
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]