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The map label for this gene is argH-1 [H]

Identifier: 30263497

GI number: 30263497

Start: 3312397

End: 3313905

Strand: Reverse

Name: argH-1 [H]

Synonym: BA_3604

Alternate gene names: 30263497

Gene position: 3313905-3312397 (Counterclockwise)

Preceding gene: 30263498

Following gene: 30263496

Centisome position: 63.4

GC content: 34.72

Gene sequence:

>1509_bases
ATGAAACAAAGCAAAGAAGAGTTTATCAAGAGTGAAGGCGCTGATTTCCCTGGGAAAACATATGTGGATTGTGTATTACA
ACATGTATTTGATTTTCAACGAAATTACTTATTGAAAGATATGTTTCAAGTGCATAAAGCACATATTGTGATGTTGACGG
AAGAAAATTTAATGAAAAAGGAAGAAGCTAAATTTATATTACACGCATTAAAAAAGGTTGAGGAAATTCCAGAAGAGCAA
TTGCTCTATACAGAGCAGCATGAAGATCTCTTTTTTTTAGTGGAACATTTAATTTCTCAAGAAGCGAAAAGCGATTTTGT
AAGTAATATGCATATTGGTAGAAGTAGAAATGATATGGGTGTTACGATGTATCGCATGAGTTTAAGGCGATATGTGCTAC
GATTAATGGAACATCATTTGTTATTGCAAGAAAGTATATTGCAACTTGCTGCTGATCATAAGGAAACGATTATGCCAGCT
TATACACATACACAACCAGCTCAGCCAACAACATTTGGTCATTATACGTTAGCGATTTATGATACGATGCAGAGAGATTT
AGAACGCATGAAAAAAACGTACAAACTTTTAAATCAGTCCCCAATGGGAGCCGCTGCGCTTTCTACAACAAGTTTCCCAA
TTAAACGAGAGCGAGTTGCCGATTTACTTGGATTTACTAATGTAATTGAGAACTCATATGATGCTGTCGCTGGAGCGGAT
TATTTATTAGAGGTTAGCTCGTTACTTATGATAATGATGACGAATACGAGTAGATGGATTCATGATTTTTTACTATTAGC
GACGAAAGAATATGATGGTATTGCAGTTGCAAGGCCGTATGTACAAATTAGTAGTATTATGCCACAAAAGCGAAATCCAG
TTTCGATTGAACACGCCCGTGCAATTACGAGTAGTGCTCCAGGGGAAGCATTTACAGTATTTCAAATGATTCATAATACA
CCATTTGGTGAGATTGTCGATACGGAAGATGACTTGCAGCCGTATTTATATAAAGGAATTGAAAAGGCTATTCGTGTATT
TTGCATTTTGAATGCAGTCATTCGAACGATGAAAGTAGAAGAGGATACCTTAAAAAGACGTTCATATAAACATGCAATTA
CGATTACAGATTTCGCAGATGTTTTAACGAAAAACTATGGCATCCCATTTCGGCATGCTCATCATGCGGCAAGTGTTATT
GCGAATATGTCGTTGGAACAGAAAAAGGAGCTACATGAATTATGTTTCAAAGATGTAAATATATACTTACAAGAAAAATT
TAAAATACAATTATTAGAAAAAGAGTGGGAAGAAATTATATCGCCAGAAGCTTTTATACAAAAAAGAAATGTATATGGTG
GACCGAGTAAAAAAGAAATGGAGCGCATGATTAACAATCGAAAAGAGTTATTTCGAAAAGAAGAAGAGGTATTTGAAGAG
GAAAAACAGAGGATTTTACAAGCTGAAAATGATTTGAATATGTTAGCTTCGAATATTATTGAATCGTAA

Upstream 100 bases:

>100_bases
CTCGGTGCAGAGAGCACCGAGTTTATTTTTGTGTACAAGCACTTTTTTCCTATCTCTGGGTATGATGGGTAGTAATACTG
AGGTGAGAGGGGAAAAAGTG

Downstream 100 bases:

>100_bases
AAGAGGGATTTAATGAATTAATCGCCAATACTTAATAAAACTATAAATAGAGAGAAGAGATTGTCGATGATTCAATTACA
TGTATATGAAGAGGTTGTTA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL 2; Arginosuccinase [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MKQSKEEFIKSEGADFPGKTYVDCVLQHVFDFQRNYLLKDMFQVHKAHIVMLTEENLMKKEEAKFILHALKKVEEIPEEQ
LLYTEQHEDLFFLVEHLISQEAKSDFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLMEHHLLLQESILQLAADHKETIMPA
YTHTQPAQPTTFGHYTLAIYDTMQRDLERMKKTYKLLNQSPMGAAALSTTSFPIKRERVADLLGFTNVIENSYDAVAGAD
YLLEVSSLLMIMMTNTSRWIHDFLLLATKEYDGIAVARPYVQISSIMPQKRNPVSIEHARAITSSAPGEAFTVFQMIHNT
PFGEIVDTEDDLQPYLYKGIEKAIRVFCILNAVIRTMKVEEDTLKRRSYKHAITITDFADVLTKNYGIPFRHAHHAASVI
ANMSLEQKKELHELCFKDVNIYLQEKFKIQLLEKEWEEIISPEAFIQKRNVYGGPSKKEMERMINNRKELFRKEEEVFEE
EKQRILQAENDLNMLASNIIES

Sequences:

>Translated_502_residues
MKQSKEEFIKSEGADFPGKTYVDCVLQHVFDFQRNYLLKDMFQVHKAHIVMLTEENLMKKEEAKFILHALKKVEEIPEEQ
LLYTEQHEDLFFLVEHLISQEAKSDFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLMEHHLLLQESILQLAADHKETIMPA
YTHTQPAQPTTFGHYTLAIYDTMQRDLERMKKTYKLLNQSPMGAAALSTTSFPIKRERVADLLGFTNVIENSYDAVAGAD
YLLEVSSLLMIMMTNTSRWIHDFLLLATKEYDGIAVARPYVQISSIMPQKRNPVSIEHARAITSSAPGEAFTVFQMIHNT
PFGEIVDTEDDLQPYLYKGIEKAIRVFCILNAVIRTMKVEEDTLKRRSYKHAITITDFADVLTKNYGIPFRHAHHAASVI
ANMSLEQKKELHELCFKDVNIYLQEKFKIQLLEKEWEEIISPEAFIQKRNVYGGPSKKEMERMINNRKELFRKEEEVFEE
EKQRILQAENDLNMLASNIIES
>Mature_502_residues
MKQSKEEFIKSEGADFPGKTYVDCVLQHVFDFQRNYLLKDMFQVHKAHIVMLTEENLMKKEEAKFILHALKKVEEIPEEQ
LLYTEQHEDLFFLVEHLISQEAKSDFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLMEHHLLLQESILQLAADHKETIMPA
YTHTQPAQPTTFGHYTLAIYDTMQRDLERMKKTYKLLNQSPMGAAALSTTSFPIKRERVADLLGFTNVIENSYDAVAGAD
YLLEVSSLLMIMMTNTSRWIHDFLLLATKEYDGIAVARPYVQISSIMPQKRNPVSIEHARAITSSAPGEAFTVFQMIHNT
PFGEIVDTEDDLQPYLYKGIEKAIRVFCILNAVIRTMKVEEDTLKRRSYKHAITITDFADVLTKNYGIPFRHAHHAASVI
ANMSLEQKKELHELCFKDVNIYLQEKFKIQLLEKEWEEIISPEAFIQKRNVYGGPSKKEMERMINNRKELFRKEEEVFEE
EKQRILQAENDLNMLASNIIES

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=378, Percent_Identity=27.7777777777778, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI68303542, Length=378, Percent_Identity=27.7777777777778, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI68303547, Length=378, Percent_Identity=28.3068783068783, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI68303549, Length=378, Percent_Identity=25.6613756613757, Blast_Score=119, Evalue=1e-26,
Organism=Escherichia coli, GI1790398, Length=417, Percent_Identity=29.0167865707434, Blast_Score=180, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6321806, Length=431, Percent_Identity=28.0742459396752, Blast_Score=153, Evalue=5e-38,
Organism=Drosophila melanogaster, GI221473854, Length=425, Percent_Identity=26.3529411764706, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI78706858, Length=425, Percent_Identity=26.3529411764706, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 58459; Mature: 58459

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQSKEEFIKSEGADFPGKTYVDCVLQHVFDFQRNYLLKDMFQVHKAHIVMLTEENLMKK
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHH
EEAKFILHALKKVEEIPEEQLLYTEQHEDLFFLVEHLISQEAKSDFVSNMHIGRSRNDMG
HHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
VTMYRMSLRRYVLRLMEHHLLLQESILQLAADHKETIMPAYTHTQPAQPTTFGHYTLAIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCHHHHH
DTMQRDLERMKKTYKLLNQSPMGAAALSTTSFPIKRERVADLLGFTNVIENSYDAVAGAD
HHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHH
YLLEVSSLLMIMMTNTSRWIHDFLLLATKEYDGIAVARPYVQISSIMPQKRNPVSIEHAR
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECHHHHHHHHCCCCCCCCCHHHHH
AITSSAPGEAFTVFQMIHNTPFGEIVDTEDDLQPYLYKGIEKAIRVFCILNAVIRTMKVE
HHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EDTLKRRSYKHAITITDFADVLTKNYGIPFRHAHHAASVIANMSLEQKKELHELCFKDVN
HHHHHHHHHCCEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
IYLQEKFKIQLLEKEWEEIISPEAFIQKRNVYGGPSKKEMERMINNRKELFRKEEEVFEE
HHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKQRILQAENDLNMLASNIIES
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQSKEEFIKSEGADFPGKTYVDCVLQHVFDFQRNYLLKDMFQVHKAHIVMLTEENLMKK
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHH
EEAKFILHALKKVEEIPEEQLLYTEQHEDLFFLVEHLISQEAKSDFVSNMHIGRSRNDMG
HHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
VTMYRMSLRRYVLRLMEHHLLLQESILQLAADHKETIMPAYTHTQPAQPTTFGHYTLAIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCHHHHH
DTMQRDLERMKKTYKLLNQSPMGAAALSTTSFPIKRERVADLLGFTNVIENSYDAVAGAD
HHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHH
YLLEVSSLLMIMMTNTSRWIHDFLLLATKEYDGIAVARPYVQISSIMPQKRNPVSIEHAR
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECHHHHHHHHCCCCCCCCCHHHHH
AITSSAPGEAFTVFQMIHNTPFGEIVDTEDDLQPYLYKGIEKAIRVFCILNAVIRTMKVE
HHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EDTLKRRSYKHAITITDFADVLTKNYGIPFRHAHHAASVIANMSLEQKKELHELCFKDVN
HHHHHHHHHCCEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
IYLQEKFKIQLLEKEWEEIISPEAFIQKRNVYGGPSKKEMERMINNRKELFRKEEEVFEE
HHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKQRILQAENDLNMLASNIIES
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]