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The map label for this gene is yjjG

Identifier: 30065612

GI number: 30065612

Start: 4567668

End: 4568345

Strand: Direct

Name: yjjG

Synonym: S4677

Alternate gene names: 30065612

Gene position: 4567668-4568345 (Clockwise)

Preceding gene: 30065611

Following gene: 30065613

Centisome position: 99.31

GC content: 52.65

Gene sequence:

>678_bases
ATGAAGTGGGACTGGATTTTCTTTGATGCCGATGAAACGCTGTTTACCTTTGACTCATTCACCGGCCTGCAGCGGATGTT
TCTTGATTACAGCGTCACCTTTACCGCTGAAGATTTTCAGGACTATCAGGCCGTTAACAAGCCACTGTGGGTGGATTATC
AAAACGGCGCGATCACTTCATTACAGCTTCAGCACGGGCGTTTCGAGAGCTGGGCCGAACGGCTGAAAGTTGAAGCAGGC
TTGCTTAACGATGCCTTTATTAATGCGATGGCGGAAATCTGTACGCCGTTGCCGGGCGCGGTTTCTCTGCTTAACGCCAT
TCGTAGCAACGCTAAAATCGGCATCATCACCAACGGTTTTAGCGCCTTGCAGCAAGTGCGTCTGGAACGGACGGGCCTGC
GTGATTACTTCGATTTGCTGGTGATTTCCGAAGAAGTTGGCGTTGCCAAACCGAATAAGAAAATTTTCGATTATGCGCTG
GAACAGGCGGGCAATCCTGACCGTTCACGCGTGCTGATGGTTGGCGACACTGCCGAGTCCGATATTCTCGGTGGCATCAA
CGCCGGGCTTGCGACCTGCTGGCTGAATGCGCACAATCGCGAGCAACCAGAAGGCATCGCGCCCACCTGGACCGTTTCTT
CGTTGCACGAACTGGAGCAGCTCCTGTGTAAACACTGA

Upstream 100 bases:

>100_bases
ACGAGGCGACGATTCGCCGCAATTACTACCCCACCACGGACGGTCGCGAAGACGCCATCATCATGGCGTTGCCAATCAGT
ATGTAAGACAAGGTGGAATA

Downstream 100 bases:

>100_bases
TTGCCTCCCCCCCGTTGATGGGTAAAATAGCCGCAATTTTTCGTTTTCAACAAGCGCGGCGCGATGCCGCTTACTCAAGA
AGAAAGAATTATGACGTTGT

Product: nucleotidase

Products: NA

Alternate protein names: House-cleaning nucleotidase; Non-canonical pyrimidine nucleotide phosphatase; Nucleoside 5'-monophosphate phosphohydrolase; dUMP phosphatase [H]

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKWDWIFFDADETLFTFDSFTGLQRMFLDYSVTFTAEDFQDYQAVNKPLWVDYQNGAITSLQLQHGRFESWAERLKVEAG
LLNDAFINAMAEICTPLPGAVSLLNAIRSNAKIGIITNGFSALQQVRLERTGLRDYFDLLVISEEVGVAKPNKKIFDYAL
EQAGNPDRSRVLMVGDTAESDILGGINAGLATCWLNAHNREQPEGIAPTWTVSSLHELEQLLCKH

Sequences:

>Translated_225_residues
MKWDWIFFDADETLFTFDSFTGLQRMFLDYSVTFTAEDFQDYQAVNKPLWVDYQNGAITSLQLQHGRFESWAERLKVEAG
LLNDAFINAMAEICTPLPGAVSLLNAIRSNAKIGIITNGFSALQQVRLERTGLRDYFDLLVISEEVGVAKPNKKIFDYAL
EQAGNPDRSRVLMVGDTAESDILGGINAGLATCWLNAHNREQPEGIAPTWTVSSLHELEQLLCKH
>Mature_225_residues
MKWDWIFFDADETLFTFDSFTGLQRMFLDYSVTFTAEDFQDYQAVNKPLWVDYQNGAITSLQLQHGRFESWAERLKVEAG
LLNDAFINAMAEICTPLPGAVSLLNAIRSNAKIGIITNGFSALQQVRLERTGLRDYFDLLVISEEVGVAKPNKKIFDYAL
EQAGNPDRSRVLMVGDTAESDILGGINAGLATCWLNAHNREQPEGIAPTWTVSSLHELEQLLCKH

Specific function: Nucleotidase that shows high phosphatase activity toward non-canonical pyrimidine nucleotides and three canonical nucleoside 5'-monophosphates (UMP, dUMP, and dTMP), and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6- phosphogluconat

COG id: COG1011

COG function: function code R; Predicted hydrolase (HAD superfamily)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. YjjG family [H]

Homologues:

Organism=Homo sapiens, GI23308749, Length=245, Percent_Identity=30.6122448979592, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1790833, Length=225, Percent_Identity=97.3333333333333, Blast_Score=456, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR011951 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.1.3.5 [H]

Molecular weight: Translated: 25267; Mature: 25267

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWDWIFFDADETLFTFDSFTGLQRMFLDYSVTFTAEDFQDYQAVNKPLWVDYQNGAITS
CCCEEEEEECCCCEEEEHHHHHHHHHHHHEEEEEEHHHHHHHHHHCCCEEEEECCCCEEE
LQLQHGRFESWAERLKVEAGLLNDAFINAMAEICTPLPGAVSLLNAIRSNAKIGIITNGF
EEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECCH
SALQQVRLERTGLRDYFDLLVISEEVGVAKPNKKIFDYALEQAGNPDRSRVLMVGDTAES
HHHHHHHHHHCCHHHHHHHHHEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCC
DILGGINAGLATCWLNAHNREQPEGIAPTWTVSSLHELEQLLCKH
HHHCCCHHHHHHEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKWDWIFFDADETLFTFDSFTGLQRMFLDYSVTFTAEDFQDYQAVNKPLWVDYQNGAITS
CCCEEEEEECCCCEEEEHHHHHHHHHHHHEEEEEEHHHHHHHHHHCCCEEEEECCCCEEE
LQLQHGRFESWAERLKVEAGLLNDAFINAMAEICTPLPGAVSLLNAIRSNAKIGIITNGF
EEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECCH
SALQQVRLERTGLRDYFDLLVISEEVGVAKPNKKIFDYALEQAGNPDRSRVLMVGDTAES
HHHHHHHHHHCCHHHHHHHHHEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCC
DILGGINAGLATCWLNAHNREQPEGIAPTWTVSSLHELEQLLCKH
HHHCCCHHHHHHEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]