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The map label for this gene is oxyR

Identifier: 30064748

GI number: 30064748

Start: 3593790

End: 3594707

Strand: Reverse

Name: oxyR

Synonym: S3701

Alternate gene names: 30064748

Gene position: 3594707-3593790 (Counterclockwise)

Preceding gene: 30064749

Following gene: 30064746

Centisome position: 78.16

GC content: 54.9

Gene sequence:

>918_bases
ATGAATATTCGTGATCTTGAGTACCTGGTGGCATTGGCTGAACACCGCCATTTTCGGCGTGCGGCAGATTCCTGCCACGT
TAGCCAGCCGACGCTTAGCGGCCAAATTCGTAAGCTGGAAGATGAGCTGGGCGTGATGTTGCTGGAGCGGACCAGCCGTA
AAGTGTTGTTCACCCAGGCGGGAATGCTGCTGGTGGATCAGGCGCGTACCGTGCTGCGTGAGGTGAAAGTCCTTAAAGAG
ATGGCAAGCCAGCAGGGTGAGACGATGTCCGGACCGCTGCATATTGGTTTGATTCCTACGGTTGGACCATACCTGCTACC
GCATATTATCCCGATGCTGCACCAGACATTTCCAAAGCTGGAAATGTATCTGCATGAAGCACAGACCCACCAGTTACTGG
CGCAACTGGACAGCGGCAAACTCGATTGCGTGATCCTCGCGCTGGTGAAAGAGAGCGAAGCATTCATTGAAGTGCCGTTG
TTTGATGAGCCAATGTTGCTGGCTATCTATGAAGATCACCCGTGGGCGAACCGCGAATGCGTACTGATGGCCGATCTGGC
AGGGGAAAAACTGCTGATGCTGGAAGATGGTCACTGTTTGCGCGATCAGGCAATGGGTTTCTGCTTTGAAGCCGGGGCGG
ATGAAGATACACACTTCCGCGCGACCAGCCTGGAAACTCTGCGCAACATGGTGGCGGCAGGTAGCGGGATCACTTTATTG
CCAGCGCTGGCTGTGCCGCCGGAGCGCAAACGCGATGGGGTTGTTTATCTGCCATGCATTAAGCCGGAACCATGCCGCAC
TATTGGCCTGGTTTATCGTCCTGGCTCACCGCTGCGCAGCCGCTATGAGCAGCTGGCAGAGGCCATCCGCGCAAGAATGG
ATGGCCATTTCGATAAAGTGTTAAAACAGGCGGTTTAA

Upstream 100 bases:

>100_bases
GTTTCTGTGAGCAATTATCAGTCAGAATGCTTGATAGGGATAATCGTTCATTGCTATTCTACCTATCGCCATGAACTATC
GTGGCGATGGAGGATGGATA

Downstream 100 bases:

>100_bases
ACCGTTTAACGCAGCTACCCGATAGGCTTCCGCCATCGTCGGGTAGTTAAAGGTGGTGTTGACGAAGTACTCAATAGTGT
TGCCGCCACCTTTCTGTTCC

Product: DNA-binding transcriptional regulator OxyR

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MNIRDLEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQAGMLLVDQARTVLREVKVLKE
MASQQGETMSGPLHIGLIPTVGPYLLPHIIPMLHQTFPKLEMYLHEAQTHQLLAQLDSGKLDCVILALVKESEAFIEVPL
FDEPMLLAIYEDHPWANRECVLMADLAGEKLLMLEDGHCLRDQAMGFCFEAGADEDTHFRATSLETLRNMVAAGSGITLL
PALAVPPERKRDGVVYLPCIKPEPCRTIGLVYRPGSPLRSRYEQLAEAIRARMDGHFDKVLKQAV

Sequences:

>Translated_305_residues
MNIRDLEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQAGMLLVDQARTVLREVKVLKE
MASQQGETMSGPLHIGLIPTVGPYLLPHIIPMLHQTFPKLEMYLHEAQTHQLLAQLDSGKLDCVILALVKESEAFIEVPL
FDEPMLLAIYEDHPWANRECVLMADLAGEKLLMLEDGHCLRDQAMGFCFEAGADEDTHFRATSLETLRNMVAAGSGITLL
PALAVPPERKRDGVVYLPCIKPEPCRTIGLVYRPGSPLRSRYEQLAEAIRARMDGHFDKVLKQAV
>Mature_305_residues
MNIRDLEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQAGMLLVDQARTVLREVKVLKE
MASQQGETMSGPLHIGLIPTVGPYLLPHIIPMLHQTFPKLEMYLHEAQTHQLLAQLDSGKLDCVILALVKESEAFIEVPL
FDEPMLLAIYEDHPWANRECVLMADLAGEKLLMLEDGHCLRDQAMGFCFEAGADEDTHFRATSLETLRNMVAAGSGITLL
PALAVPPERKRDGVVYLPCIKPEPCRTIGLVYRPGSPLRSRYEQLAEAIRARMDGHFDKVLKQAV

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=305, Percent_Identity=99.344262295082, Blast_Score=615, Evalue=1e-178,
Organism=Escherichia coli, GI157672245, Length=273, Percent_Identity=30.7692307692308, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI145693105, Length=283, Percent_Identity=27.5618374558304, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787879, Length=248, Percent_Identity=31.8548387096774, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1788887, Length=277, Percent_Identity=29.2418772563177, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1787530, Length=253, Percent_Identity=26.0869565217391, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1788748, Length=290, Percent_Identity=26.8965517241379, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790208, Length=261, Percent_Identity=29.8850574712644, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1788297, Length=251, Percent_Identity=27.4900398406374, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI2367136, Length=240, Percent_Identity=26.6666666666667, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787601, Length=145, Percent_Identity=28.9655172413793, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790262, Length=255, Percent_Identity=27.843137254902, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1788296, Length=243, Percent_Identity=24.6913580246914, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI145693193, Length=160, Percent_Identity=30.625, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789506, Length=234, Percent_Identity=23.9316239316239, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI48994962, Length=264, Percent_Identity=26.8939393939394, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788626, Length=296, Percent_Identity=26.0135135135135, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1787806, Length=289, Percent_Identity=21.7993079584775, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87081904, Length=301, Percent_Identity=22.5913621262458, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34239; Mature: 34239

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIRDLEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECC
GMLLVDQARTVLREVKVLKEMASQQGETMSGPLHIGLIPTVGPYLLPHIIPMLHQTFPKL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
EMYLHEAQTHQLLAQLDSGKLDCVILALVKESEAFIEVPLFDEPMLLAIYEDHPWANREC
HHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEECCCCCCCEEEEEECCCCCCCCCE
VLMADLAGEKLLMLEDGHCLRDQAMGFCFEAGADEDTHFRATSLETLRNMVAAGSGITLL
EEEEECCCCEEEEEECCCHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
PALAVPPERKRDGVVYLPCIKPEPCRTIGLVYRPGSPLRSRYEQLAEAIRARMDGHFDKV
EEECCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHH
LKQAV
HHHCC
>Mature Secondary Structure
MNIRDLEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECC
GMLLVDQARTVLREVKVLKEMASQQGETMSGPLHIGLIPTVGPYLLPHIIPMLHQTFPKL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
EMYLHEAQTHQLLAQLDSGKLDCVILALVKESEAFIEVPLFDEPMLLAIYEDHPWANREC
HHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEECCCCCCCEEEEEECCCCCCCCCE
VLMADLAGEKLLMLEDGHCLRDQAMGFCFEAGADEDTHFRATSLETLRNMVAAGSGITLL
EEEEECCCCEEEEEECCCHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
PALAVPPERKRDGVVYLPCIKPEPCRTIGLVYRPGSPLRSRYEQLAEAIRARMDGHFDKV
EEECCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHH
LKQAV
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]