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The map label for this gene is accB

Identifier: 30064586

GI number: 30064586

Start: 3383090

End: 3383560

Strand: Direct

Name: accB

Synonym: S3510

Alternate gene names: 30064586

Gene position: 3383090-3383560 (Clockwise)

Preceding gene: 30064584

Following gene: 30064587

Centisome position: 73.56

GC content: 51.8

Gene sequence:

>471_bases
ATGGATATTCGTAAGATTAAAAAACTGATCGAGCTGGTTGAAGAATCAGGCATCTCCGAACTGGAAATTTCTGAAGGCGA
AGAGTCAGTACGCATTAGCCGTGCAGCTCCTGCCGCAAGTTTCCCTGTGATGCAACAAGCTTACGCTGCACCAATGATGC
AGCAGCCAGCTCAATCTAACGCAGCCGCTCCGGCGACCGTTCCTTCCATGGAAGCGCCAGCAGCAGCGGAAATCAGTGGT
CACATCGTACGTTCCCCGATGGTTGGTACTTTCTACCGCACCCCAAGCCCGGACGCAAAAGCGTTCATCGAAGTGGGTCA
GAAAGTCAACGTGGGCGATACCCTGTGCATCGTTGAAGCCATGAAAATGATGAACCAGATCGAAGCGGACAAATCCGGTA
CCGTGAAAGCAATTCTGGTCGAAAGTGGACAACCGGTAGAATTTGACGAGCCGCTGGTCGTCATCGAGTAA

Upstream 100 bases:

>100_bases
GAATTTATCGCTATGCATACAGCTGTCGGGGCATACGCTTTACAGACGGCGGTGAAACGCCTGTCACAATCACACTAAAC
AAAGAGTACGGAACCCACTC

Downstream 100 bases:

>100_bases
CGAGGCGAACATGCTGGATAAAATTGTTATTGCCAACCGCGGCGAGATTGCATTGCGTATTCTTCGTGCCTGTAAAGAAC
TGGGCATCAAGACTGTCGCT

Product: acetyl-CoA carboxylase biotin carboxyl carrier protein subunit

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MDIRKIKKLIELVEESGISELEISEGEESVRISRAAPAASFPVMQQAYAAPMMQQPAQSNAAAPATVPSMEAPAAAEISG
HIVRSPMVGTFYRTPSPDAKAFIEVGQKVNVGDTLCIVEAMKMMNQIEADKSGTVKAILVESGQPVEFDEPLVVIE

Sequences:

>Translated_156_residues
MDIRKIKKLIELVEESGISELEISEGEESVRISRAAPAASFPVMQQAYAAPMMQQPAQSNAAAPATVPSMEAPAAAEISG
HIVRSPMVGTFYRTPSPDAKAFIEVGQKVNVGDTLCIVEAMKMMNQIEADKSGTVKAILVESGQPVEFDEPLVVIE
>Mature_156_residues
MDIRKIKKLIELVEESGISELEISEGEESVRISRAAPAASFPVMQQAYAAPMMQQPAQSNAAAPATVPSMEAPAAAEISG
HIVRSPMVGTFYRTPSPDAKAFIEVGQKVNVGDTLCIVEAMKMMNQIEADKSGTVKAILVESGQPVEFDEPLVVIE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain

Homologues:

Organism=Escherichia coli, GI1789653, Length=156, Percent_Identity=100, Blast_Score=311, Evalue=1e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BCCP_ECO57 (P0ABE0)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   C85990
- PIR:   G91144
- RefSeq:   NP_289823.1
- RefSeq:   NP_312154.1
- ProteinModelPortal:   P0ABE0
- SMR:   P0ABE0
- PRIDE:   P0ABE0
- EnsemblBacteria:   EBESCT00000027340
- EnsemblBacteria:   EBESCT00000058969
- GeneID:   916025
- GeneID:   958692
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4615
- KEGG:   ecs:ECs4127
- GeneTree:   EBGT00050000010164
- HOGENOM:   HBG745267
- OMA:   KMMNRIE
- ProtClustDB:   PRK06302
- BioCyc:   ECOL83334:ECS4127-MONOMER
- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053
- PRINTS:   PR01071
- TIGRFAMs:   TIGR00531

Pfam domain/function: PF00364 Biotin_lipoyl; SSF51230 Hybrid_motif

EC number: NA

Molecular weight: Translated: 16687; Mature: 16687

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: PS00188 BIOTIN; PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRKIKKLIELVEESGISELEISEGEESVRISRAAPAASFPVMQQAYAAPMMQQPAQSN
CCHHHHHHHHHHHHHCCCCEEEECCCCCCEEEECCCCCCCCHHHHHHHHCHHHHCCCCCC
AAAPATVPSMEAPAAAEISGHIVRSPMVGTFYRTPSPDAKAFIEVGQKVNVGDTLCIVEA
CCCCCCCCCCCCCCCHHCCCEEECCCCCCEEECCCCCCHHHHHHCCCCCCCCCHHHHHHH
MKMMNQIEADKSGTVKAILVESGQPVEFDEPLVVIE
HHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEEC
>Mature Secondary Structure
MDIRKIKKLIELVEESGISELEISEGEESVRISRAAPAASFPVMQQAYAAPMMQQPAQSN
CCHHHHHHHHHHHHHCCCCEEEECCCCCCEEEECCCCCCCCHHHHHHHHCHHHHCCCCCC
AAAPATVPSMEAPAAAEISGHIVRSPMVGTFYRTPSPDAKAFIEVGQKVNVGDTLCIVEA
CCCCCCCCCCCCCCCHHCCCEEECCCCCCEEECCCCCCHHHHHHCCCCCCCCCHHHHHHH
MKMMNQIEADKSGTVKAILVESGQPVEFDEPLVVIE
HHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796