BacMap

Definition	Shigella flexneri 2a str. 2457T, complete genome.
Accession	NC_004741
Length	4,599,354

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The map label for this gene is hflB

Identifier: 30064516

GI number: 30064516

Start: 3308301

End: 3310235

Strand: Reverse

Name: hflB

Synonym: S3436

Alternate gene names: 30064516

Gene position: 3310235-3308301 (Counterclockwise)

Preceding gene: 30064517

Following gene: 161486427

Centisome position: 71.97

GC content: 53.44

Gene sequence:

>1935_bases
ATGGCGAAAAACCTAATACTCTGGCTGGTCATTGCCGTTGTGCTGATGTCAGTATTCCAGAGCTTTGGGCCCAGCGAGTC
TAATGGCCGTAAGGTGGATTACTCTACCTTCCTACAAGAGGTCAATAACGACCAGGTTCGTGAAGCGCGTATCAACGGAC
GTGAAATCAACGTTACCAAGAAAGATAGTAACCGTTATACCACTTACATTCCGGTTCAGGATCCGAAATTACTGGATAAC
CTGTTGACCAAGAACGTCAAGGTTGTCGGTGAACCGCCTGAAGAACCAAGCCTGCTGGCTTCTATCTTCATCTCCTGGTT
CCCGATGCTGTTGCTGATTGGTGTCTGGATCTTCTTCATGCGTCAAATGCAGGGCGGCGGTGGCAAAGGTGCCATGTCGT
TTGGTAAGAGCAAAGCGCGCATGCTGACGGAAGATCAGATCAAAACGACCTTTGCTGACGTTGCGGGCTGCGACGAAGCA
AAAGAAGAAGTTGCTGAACTGGTAGAGTATCTGCGCGAGCCGAGCCGCTTCCAGAAACTCGGCGGTAAGATCCCGAAAGG
CGTCCTGATGGTCGGTCCTCCGGGTACCGGTAAAACGTTGCTGGCGAAAGCGATTGCAGGCGAAGCGAAAGTTCCGTTCT
TTACTATCTCCGGTTCTGACTTCGTAGAAATGTTCGTCGGTGTGGGTGCATCCCGTGTTCGTGACATGTTCGAACAGGCG
AAGAAAGCGGCACCGTGCATCATCTTTATCGATGAAATCGACGCCGTAGGCCGCCAGCGTGGCGCTGGTCTGGGCGGTGG
TCACGATGAACGTGAACAGACTCTGAACCAGATGCTGGTTGAGATGGATGGCTTCGAAGGTAACGAAGGTATCATCGTTA
TCGCCGCGACTAACCGTCCGGACGTTCTCGACCCGGCCCTGCTGCGTCCTGGCCGTTTCGACCGCCAGGTTGTGGTCGGC
TTGCCAGATGTTCGCGGTCGTGAGCAGATCCTGAAAGTTCACATGCGTCGCGTACCATTGGCACCCGATATCGACGCGGC
AATCATTGCTCGTGGTACTCCTGGTTTCTCCGGTGCTGACCTGGCGAACCTGGTGAACGAAGCGGCACTGTTCGCTGCTC
GTGGCAACAAACGCGTTGTGTCGATGGTTGAGTTCGAGAAAGCGAAAGACAAAATCATGATGGGTGCGGAACGTCGCTCC
ATGGTGATGACGGAAGCGCAGAAAGAATCAACGGCTTACCACGAAGCGGGTCATGCGATTATCGGTCGCCTGGTGCCGGA
ACACGATCCGGTGCATAAAGTGACGATTATCCCACGCGGTCGTGCGCTGGGTGTGACTTTCTTCTTGCCTGAGGGCGACG
CAATCAGCGCCAGCCGTCAGAAACTGGAAAGCCAGATTTCTACGCTGTACGGTGGTCGTCTGGCAGAAGAGATCATCTAC
GGGCCGGAACATGTTTCTACCGGTGCGTCCAACGATATTAAAGTTGCGACCAACCTGGCACGTAACATGGTGACTCAGTG
GGGCTTCTCTGAGAAATTGGGTCCACTGCTGTACGCGGAAGAAGAAGGTGAAGTATTCCTCGGCCGTAGCGTAGCGAAAG
CGAAACATATGTCCGATGAAACTGCACGTATCATCGACCAGGAAGTGAAAGCACTGATTGAGCGTAACTATAATCGTGCG
CGTCAGCTTCTGACCGACAATATGGATATTCTGCATGCGATGAAAGATGCTCTCATGAAATATGAGACTATCGACGCACC
GCAGATTGATGACCTGATGGCACGTCGCGATGTACGTCCGCCAGCGGGCTGGGAAGAACCAGGCGCTTCTAACAATTCTG
GCGACAATGGTAGTCCAAAGGCTCCTCGTCCGGTTGATGAACCGCGTACGCCGAACCCGGGTAACACCATGTCAGAGCAG
TTAGGCGACAAGTAA

Upstream 100 bases:

>100_bases
ACCGGGAGATTTCAGACGAAAGTTTGAAAGATGCTGGATATAGAGTATCCTGACGCTGTTTTTAACACAGTTGTAATAAG
AGGTTAATCCCTTGAGTGAC

Downstream 100 bases:

>100_bases
GTTCCCGCATCAGATGACTGTATTTGTACCGAAAACCCCGGGGCGTGCTCCGGGGTTTTTTCTTATCAATTCATACCAGG
GATAACATAATGAAACTCTT

Product: ATP-dependent metalloprotease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 644; Mature: 643

Protein sequence:

>644_residues
MAKNLILWLVIAVVLMSVFQSFGPSESNGRKVDYSTFLQEVNNDQVREARINGREINVTKKDSNRYTTYIPVQDPKLLDN
LLTKNVKVVGEPPEEPSLLASIFISWFPMLLLIGVWIFFMRQMQGGGGKGAMSFGKSKARMLTEDQIKTTFADVAGCDEA
KEEVAELVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQA
KKAAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPALLRPGRFDRQVVVG
LPDVRGREQILKVHMRRVPLAPDIDAAIIARGTPGFSGADLANLVNEAALFAARGNKRVVSMVEFEKAKDKIMMGAERRS
MVMTEAQKESTAYHEAGHAIIGRLVPEHDPVHKVTIIPRGRALGVTFFLPEGDAISASRQKLESQISTLYGGRLAEEIIY
GPEHVSTGASNDIKVATNLARNMVTQWGFSEKLGPLLYAEEEGEVFLGRSVAKAKHMSDETARIIDQEVKALIERNYNRA
RQLLTDNMDILHAMKDALMKYETIDAPQIDDLMARRDVRPPAGWEEPGASNNSGDNGSPKAPRPVDEPRTPNPGNTMSEQ
LGDK

Sequences:

>Translated_644_residues
MAKNLILWLVIAVVLMSVFQSFGPSESNGRKVDYSTFLQEVNNDQVREARINGREINVTKKDSNRYTTYIPVQDPKLLDN
LLTKNVKVVGEPPEEPSLLASIFISWFPMLLLIGVWIFFMRQMQGGGGKGAMSFGKSKARMLTEDQIKTTFADVAGCDEA
KEEVAELVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQA
KKAAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPALLRPGRFDRQVVVG
LPDVRGREQILKVHMRRVPLAPDIDAAIIARGTPGFSGADLANLVNEAALFAARGNKRVVSMVEFEKAKDKIMMGAERRS
MVMTEAQKESTAYHEAGHAIIGRLVPEHDPVHKVTIIPRGRALGVTFFLPEGDAISASRQKLESQISTLYGGRLAEEIIY
GPEHVSTGASNDIKVATNLARNMVTQWGFSEKLGPLLYAEEEGEVFLGRSVAKAKHMSDETARIIDQEVKALIERNYNRA
RQLLTDNMDILHAMKDALMKYETIDAPQIDDLMARRDVRPPAGWEEPGASNNSGDNGSPKAPRPVDEPRTPNPGNTMSEQ
LGDK
>Mature_643_residues
AKNLILWLVIAVVLMSVFQSFGPSESNGRKVDYSTFLQEVNNDQVREARINGREINVTKKDSNRYTTYIPVQDPKLLDNL
LTKNVKVVGEPPEEPSLLASIFISWFPMLLLIGVWIFFMRQMQGGGGKGAMSFGKSKARMLTEDQIKTTFADVAGCDEAK
EEVAELVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAK
KAAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPALLRPGRFDRQVVVGL
PDVRGREQILKVHMRRVPLAPDIDAAIIARGTPGFSGADLANLVNEAALFAARGNKRVVSMVEFEKAKDKIMMGAERRSM
VMTEAQKESTAYHEAGHAIIGRLVPEHDPVHKVTIIPRGRALGVTFFLPEGDAISASRQKLESQISTLYGGRLAEEIIYG
PEHVSTGASNDIKVATNLARNMVTQWGFSEKLGPLLYAEEEGEVFLGRSVAKAKHMSDETARIIDQEVKALIERNYNRAR
QLLTDNMDILHAMKDALMKYETIDAPQIDDLMARRDVRPPAGWEEPGASNNSGDNGSPKAPRPVDEPRTPNPGNTMSEQL
GDK

Specific function: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins [H]

COG id: COG0465

COG function: function code O; ATP-dependent Zn proteases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase M41 family [H]

Homologues:

Organism=Homo sapiens, GI300192933, Length=518, Percent_Identity=45.3667953667954, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI7657689, Length=440, Percent_Identity=50.6818181818182, Blast_Score=444, Evalue=1e-124,
Organism=Homo sapiens, GI21327685, Length=440, Percent_Identity=50.6818181818182, Blast_Score=444, Evalue=1e-124,
Organism=Homo sapiens, GI4507173, Length=460, Percent_Identity=41.7391304347826, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI4506209, Length=254, Percent_Identity=42.5196850393701, Blast_Score=219, Evalue=6e-57,
Organism=Homo sapiens, GI24497435, Length=269, Percent_Identity=41.2639405204461, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI6005942, Length=226, Percent_Identity=43.8053097345133, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI24430151, Length=254, Percent_Identity=39.7637795275591, Blast_Score=202, Evalue=9e-52,
Organism=Homo sapiens, GI195539395, Length=253, Percent_Identity=41.501976284585, Blast_Score=202, Evalue=9e-52,
Organism=Homo sapiens, GI21361144, Length=225, Percent_Identity=44, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI89064750, Length=264, Percent_Identity=41.2878787878788, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI5729991, Length=264, Percent_Identity=41.2878787878788, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI24430155, Length=264, Percent_Identity=41.2878787878788, Blast_Score=196, Evalue=7e-50,
Organism=Homo sapiens, GI45643123, Length=280, Percent_Identity=38.5714285714286, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI45643125, Length=280, Percent_Identity=38.5714285714286, Blast_Score=191, Evalue=3e-48,
Organism=Homo sapiens, GI157671927, Length=237, Percent_Identity=39.2405063291139, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI4505725, Length=213, Percent_Identity=41.3145539906103, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI40806173, Length=137, Percent_Identity=59.1240875912409, Blast_Score=173, Evalue=5e-43,
Organism=Homo sapiens, GI229577436, Length=256, Percent_Identity=38.28125, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI5901990, Length=233, Percent_Identity=40.7725321888412, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI194018488, Length=255, Percent_Identity=38.4313725490196, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI153792536, Length=231, Percent_Identity=39.3939393939394, Blast_Score=157, Evalue=4e-38,
Organism=Homo sapiens, GI24497618, Length=231, Percent_Identity=39.3939393939394, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI14149767, Length=273, Percent_Identity=36.996336996337, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI62177112, Length=273, Percent_Identity=36.996336996337, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI226371754, Length=234, Percent_Identity=38.034188034188, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI156564401, Length=235, Percent_Identity=39.1489361702128, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI310125282, Length=235, Percent_Identity=38.7234042553192, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI310125280, Length=235, Percent_Identity=38.7234042553192, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI7019569, Length=248, Percent_Identity=36.6935483870968, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI11875211, Length=227, Percent_Identity=40.9691629955947, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI40806170, Length=227, Percent_Identity=40.9691629955947, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI31742536, Length=254, Percent_Identity=34.6456692913386, Blast_Score=136, Evalue=8e-32,
Organism=Homo sapiens, GI112789543, Length=254, Percent_Identity=34.6456692913386, Blast_Score=136, Evalue=8e-32,
Organism=Homo sapiens, GI17865802, Length=250, Percent_Identity=37.2, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI31377644, Length=238, Percent_Identity=34.8739495798319, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI64084766, Length=318, Percent_Identity=27.9874213836478, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI116292174, Length=248, Percent_Identity=30.6451612903226, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI75677353, Length=196, Percent_Identity=30.6122448979592, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI283436222, Length=207, Percent_Identity=28.9855072463768, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI283436220, Length=207, Percent_Identity=28.9855072463768, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI283436224, Length=206, Percent_Identity=29.126213592233, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1789568, Length=644, Percent_Identity=100, Blast_Score=1316, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71994521, Length=478, Percent_Identity=47.6987447698745, Blast_Score=423, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17554264, Length=485, Percent_Identity=44.1237113402062, Blast_Score=408, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI115534323, Length=459, Percent_Identity=43.7908496732026, Blast_Score=364, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17554786, Length=262, Percent_Identity=43.8931297709924, Blast_Score=223, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17563248, Length=261, Percent_Identity=42.5287356321839, Blast_Score=219, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17532375, Length=337, Percent_Identity=37.0919881305638, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI25144278, Length=262, Percent_Identity=43.5114503816794, Blast_Score=216, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI25144281, Length=262, Percent_Identity=43.5114503816794, Blast_Score=215, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI17531535, Length=245, Percent_Identity=43.6734693877551, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71987364, Length=254, Percent_Identity=41.7322834645669, Blast_Score=205, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI71987372, Length=254, Percent_Identity=41.7322834645669, Blast_Score=204, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17508701, Length=225, Percent_Identity=44.4444444444444, Blast_Score=198, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17563250, Length=254, Percent_Identity=39.3700787401575, Blast_Score=198, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI17505546, Length=248, Percent_Identity=40.3225806451613, Blast_Score=192, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17554784, Length=259, Percent_Identity=40.9266409266409, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17508053, Length=243, Percent_Identity=39.5061728395062, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17537217, Length=257, Percent_Identity=37.7431906614786, Blast_Score=165, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI25153574, Length=249, Percent_Identity=36.9477911646586, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI193206114, Length=243, Percent_Identity=39.5061728395062, Blast_Score=160, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI133931034, Length=243, Percent_Identity=39.5061728395062, Blast_Score=160, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI193206116, Length=243, Percent_Identity=39.5061728395062, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI193209502, Length=225, Percent_Identity=38.6666666666667, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17570397, Length=165, Percent_Identity=46.0606060606061, Blast_Score=152, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI32566590, Length=165, Percent_Identity=46.0606060606061, Blast_Score=152, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI25146157, Length=259, Percent_Identity=38.2239382239382, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI133901658, Length=212, Percent_Identity=40.5660377358491, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI133901662, Length=212, Percent_Identity=40.5660377358491, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17562804, Length=230, Percent_Identity=36.9565217391304, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI86561515, Length=242, Percent_Identity=34.7107438016529, Blast_Score=132, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17508421, Length=241, Percent_Identity=37.7593360995851, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI32563584, Length=241, Percent_Identity=37.7593360995851, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17541224, Length=261, Percent_Identity=34.4827586206897, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17541226, Length=263, Percent_Identity=34.6007604562738, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17560432, Length=226, Percent_Identity=36.7256637168142, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71990294, Length=198, Percent_Identity=29.7979797979798, Blast_Score=76, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6325281, Length=495, Percent_Identity=46.8686868686869, Blast_Score=463, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6323736, Length=505, Percent_Identity=46.1386138613861, Blast_Score=442, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6320854, Length=516, Percent_Identity=45.3488372093023, Blast_Score=440, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6322704, Length=261, Percent_Identity=42.911877394636, Blast_Score=221, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6320077, Length=260, Percent_Identity=42.6923076923077, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6321390, Length=254, Percent_Identity=41.3385826771654, Blast_Score=207, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6324691, Length=237, Percent_Identity=43.0379746835443, Blast_Score=199, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6324833, Length=253, Percent_Identity=41.897233201581, Blast_Score=196, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6320197, Length=245, Percent_Identity=37.9591836734694, Blast_Score=191, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6320602, Length=243, Percent_Identity=42.798353909465, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6322994, Length=230, Percent_Identity=38.695652173913, Blast_Score=173, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6324000, Length=240, Percent_Identity=40.8333333333333, Blast_Score=173, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6323429, Length=252, Percent_Identity=40.0793650793651, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6321709, Length=257, Percent_Identity=38.9105058365759, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6322651, Length=245, Percent_Identity=35.1020408163265, Blast_Score=163, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6321465, Length=239, Percent_Identity=38.0753138075314, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6319554, Length=213, Percent_Identity=38.9671361502347, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6325431, Length=226, Percent_Identity=37.6106194690265, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6325183, Length=237, Percent_Identity=34.1772151898734, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320887, Length=249, Percent_Identity=32.5301204819277, Blast_Score=118, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320583, Length=182, Percent_Identity=27.4725274725275, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24658770, Length=449, Percent_Identity=47.6614699331849, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI28574878, Length=519, Percent_Identity=43.1599229287091, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24665814, Length=517, Percent_Identity=43.1334622823985, Blast_Score=427, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24639391, Length=450, Percent_Identity=44, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI161076486, Length=310, Percent_Identity=37.741935483871, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI17137560, Length=310, Percent_Identity=37.741935483871, Blast_Score=223, Evalue=4e-58,
Organism=Drosophila melanogaster, GI161076488, Length=310, Percent_Identity=37.741935483871, Blast_Score=222, Evalue=6e-58,
Organism=Drosophila melanogaster, GI17137738, Length=254, Percent_Identity=43.7007874015748, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI19920408, Length=262, Percent_Identity=41.9847328244275, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24651451, Length=262, Percent_Identity=42.7480916030534, Blast_Score=208, Evalue=9e-54,
Organism=Drosophila melanogaster, GI45554047, Length=163, Percent_Identity=58.2822085889571, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24649446, Length=254, Percent_Identity=40.1574803149606, Blast_Score=203, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24660075, Length=230, Percent_Identity=43.4782608695652, Blast_Score=199, Evalue=6e-51,
Organism=Drosophila melanogaster, GI281365776, Length=230, Percent_Identity=43.4782608695652, Blast_Score=199, Evalue=7e-51,
Organism=Drosophila melanogaster, GI45552965, Length=230, Percent_Identity=43.4782608695652, Blast_Score=199, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24652279, Length=272, Percent_Identity=37.8676470588235, Blast_Score=198, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24640100, Length=253, Percent_Identity=41.1067193675889, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI19921202, Length=243, Percent_Identity=41.1522633744856, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24663015, Length=253, Percent_Identity=41.501976284585, Blast_Score=193, Evalue=4e-49,
Organism=Drosophila melanogaster, GI17738151, Length=239, Percent_Identity=41.4225941422594, Blast_Score=192, Evalue=7e-49,
Organism=Drosophila melanogaster, GI18860063, Length=240, Percent_Identity=41.6666666666667, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI281361487, Length=253, Percent_Identity=40.3162055335968, Blast_Score=189, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24656820, Length=227, Percent_Identity=41.4096916299559, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24656825, Length=227, Percent_Identity=41.4096916299559, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI281363136, Length=235, Percent_Identity=39.1489361702128, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI78707192, Length=235, Percent_Identity=39.1489361702128, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24644145, Length=233, Percent_Identity=38.6266094420601, Blast_Score=151, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21355121, Length=235, Percent_Identity=36.1702127659575, Blast_Score=151, Evalue=2e-36,
Organism=Drosophila melanogaster, GI281360144, Length=228, Percent_Identity=38.1578947368421, Blast_Score=149, Evalue=7e-36,
Organism=Drosophila melanogaster, GI281360140, Length=228, Percent_Identity=38.1578947368421, Blast_Score=149, Evalue=7e-36,
Organism=Drosophila melanogaster, GI281360136, Length=228, Percent_Identity=38.1578947368421, Blast_Score=149, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24644411, Length=228, Percent_Identity=38.1578947368421, Blast_Score=149, Evalue=8e-36,
Organism=Drosophila melanogaster, GI281360146, Length=230, Percent_Identity=38.695652173913, Blast_Score=149, Evalue=8e-36,
Organism=Drosophila melanogaster, GI281360138, Length=230, Percent_Identity=38.695652173913, Blast_Score=149, Evalue=8e-36,
Organism=Drosophila melanogaster, GI281360142, Length=230, Percent_Identity=38.695652173913, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI21357333, Length=230, Percent_Identity=38.695652173913, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI20129529, Length=274, Percent_Identity=35.036496350365, Blast_Score=145, Evalue=1e-34,
Organism=Drosophila melanogaster, GI18859657, Length=251, Percent_Identity=38.2470119521912, Blast_Score=142, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24581396, Length=232, Percent_Identity=39.2241379310345, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI17864540, Length=214, Percent_Identity=41.1214953271028, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI28573010, Length=214, Percent_Identity=41.1214953271028, Blast_Score=139, Evalue=8e-33,
Organism=Drosophila melanogaster, GI28571849, Length=236, Percent_Identity=39.4067796610169, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28571847, Length=236, Percent_Identity=39.4067796610169, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI20129423, Length=233, Percent_Identity=35.1931330472103, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24639486, Length=196, Percent_Identity=35.2040816326531, Blast_Score=106, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR003960
- InterPro:   IPR005936
- InterPro:   IPR011546
- InterPro:   IPR000642 [H]

Pfam domain/function: PF00004 AAA; PF06480 FtsH_ext; PF01434 Peptidase_M41 [H]

EC number: 3.4.24.-

Molecular weight: Translated: 70709; Mature: 70578

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00674 AAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKNLILWLVIAVVLMSVFQSFGPSESNGRKVDYSTFLQEVNNDQVREARINGREINVTK
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEECHHHHHHHHCCCHHHHHHCCCCEEEEEE
KDSNRYTTYIPVQDPKLLDNLLTKNVKVVGEPPEEPSLLASIFISWFPMLLLIGVWIFFM
CCCCCEEEEEECCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RQMQGGGGKGAMSFGKSKARMLTEDQIKTTFADVAGCDEAKEEVAELVEYLREPSRFQKL
HHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHH
GGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQA
CCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCEEEECCHHHHHHHHHCCHHHHHHHHHHH
KKAAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQMLVEMDGFEGNEGIIVIAATNRP
HHCCCEEEEEECHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCC
DVLDPALLRPGRFDRQVVVGLPDVRGREQILKVHMRRVPLAPDIDAAIIARGTPGFSGAD
CCCCHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCHH
LANLVNEAALFAARGNKRVVSMVEFEKAKDKIMMGAERRSMVMTEAQKESTAYHEAGHAI
HHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
IGRLVPEHDPVHKVTIIPRGRALGVTFFLPEGDAISASRQKLESQISTLYGGRLAEEIIY
HHHHCCCCCCCEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GPEHVSTGASNDIKVATNLARNMVTQWGFSEKLGPLLYAEEEGEVFLGRSVAKAKHMSDE
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEECHHHHHHHHCCHH
TARIIDQEVKALIERNYNRARQLLTDNMDILHAMKDALMKYETIDAPQIDDLMARRDVRP
HHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCC
PAGWEEPGASNNSGDNGSPKAPRPVDEPRTPNPGNTMSEQLGDK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCC
>Mature Secondary Structure 
AKNLILWLVIAVVLMSVFQSFGPSESNGRKVDYSTFLQEVNNDQVREARINGREINVTK
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCEECHHHHHHHHCCCHHHHHHCCCCEEEEEE
KDSNRYTTYIPVQDPKLLDNLLTKNVKVVGEPPEEPSLLASIFISWFPMLLLIGVWIFFM
CCCCCEEEEEECCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RQMQGGGGKGAMSFGKSKARMLTEDQIKTTFADVAGCDEAKEEVAELVEYLREPSRFQKL
HHHCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHH
GGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQA
CCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCEEEECCHHHHHHHHHCCHHHHHHHHHHH
KKAAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQMLVEMDGFEGNEGIIVIAATNRP
HHCCCEEEEEECHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCC
DVLDPALLRPGRFDRQVVVGLPDVRGREQILKVHMRRVPLAPDIDAAIIARGTPGFSGAD
CCCCHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCHH
LANLVNEAALFAARGNKRVVSMVEFEKAKDKIMMGAERRSMVMTEAQKESTAYHEAGHAI
HHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
IGRLVPEHDPVHKVTIIPRGRALGVTFFLPEGDAISASRQKLESQISTLYGGRLAEEIIY
HHHHCCCCCCCEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GPEHVSTGASNDIKVATNLARNMVTQWGFSEKLGPLLYAEEEGEVFLGRSVAKAKHMSDE
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEECHHHHHHHHCCHH
TARIIDQEVKALIERNYNRARQLLTDNMDILHAMKDALMKYETIDAPQIDDLMARRDVRP
HHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCC
PAGWEEPGASNNSGDNGSPKAPRPVDEPRTPNPGNTMSEQLGDK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Metalloendopeptidases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]