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The map label for this gene is uxaC

Identifier: 30064435

GI number: 30064435

Start: 3222417

End: 3223829

Strand: Reverse

Name: uxaC

Synonym: S3339

Alternate gene names: 30064435

Gene position: 3223829-3222417 (Counterclockwise)

Preceding gene: 30064437

Following gene: 30064434

Centisome position: 70.09

GC content: 54.0

Gene sequence:

>1413_bases
ATGACTCCGTTTATGACTGAAGATTTCCTGTTAGATACCGAATTTGCCCGCCGTCTGTATCACGACTACGCAAAAGACCA
GCCGATTTTCGATTACCATTGCCATTTGCCGCCGCAGCAGATTGCGGAAGACTATCGTTTTAAAAACCTGTATGACATCT
GGTTGAAGGGCGATCACTACAAATGGCGCGCTATGCGTACCAACGGTGTGGCTGAGCGTCTGTGTACTGGTGATGCGTCT
GACCGTGAAAAATTTGACGCCTGGGCGGCGACTGTTCCGCACACTATCGGCAACCCGTTATACCACTGGACGCACCTCGA
ACTGCGTCGTCCGTTCGGTATCACTGGCAAATTGCTTTCTCCGTCAACTGCCGATGAAATCTGGAACGAATGTAACGAAC
TGCTGGCGCAGGATAACTTCTCCGCGCGCGGCATCATGCAGCAGATGAACGTGAAAATGGTCGGCACCACCGATGACCCG
ATCGATTCTCTGGAGCATCACGCAGAGATCGCCAAAGACGGCTCTTTCACCATCAAAGTGCTGCCGAGCTGGCGTCCGGA
CAAAGCCTTCAATATCGAACAGGCGACCTTTAACGACTACATGGCGAAGCTGGGCGAAGTTTCCGATACCGACATTCGCC
GCTTTGCTGACCTGCAAACTGCCTTGACCAAACGTCTGGATCACTTCGCCGCTCACGGCTGTAAAGTGTCTGACCATGCG
CTGGACGTGGTGATGTTTGCTGAAGCGAACGAAGCGGAACTGGACAGCATTCTGGCGCGCCGTCTGGCTGGCGAAACCCT
GAGCGAGCACGAAGTGGCACAGTTCAAAACTGCGGTACTGGTGTTCCTTGGTGCCGAATATGCACGTCGCGGCTGGGTAC
AGCAGTACCACATTGGCGCGCTGCGTAATAACAACCTGCGTCAGTTCAAACTGCTGGGGCCGGATGTAGGCTTTGACTCC
ATCAACGACCGTCCGATGGCGGAAGAGTTGTCTAAGCTGCTGAGCAAGCAGAACGAAGAAAACCTGCTGCCGAAAACCAT
TCTCTACTGCCTGAACCCGCGCGATAACGAAGTGCTGGGCACCATGATCGGTAACTTCCAGGGCGAAGGTATGCCGGGCA
AAATGCAGTTCGGTTCCGGCTGGTGGTTTAACGATCAGAAAGACGGTATGGAACGTCAGATGACCCAACTGGCGCAGCTC
GGTCTGCTGAGCCGCTTTGTCGGTATGCTGACTGACAGCCGTAGCTTCCTGTCATACACCCGTCACGAATACTTCCGCCG
CATTCTGTGCCAGATGATCGGTCGCTGGGTGGAAGCGGGCGAAGCACCGGCGGACATCAACCTGCTGGGCGAGATGGTGA
AAAATATTTGCTTTAACAATGCGCGTGACTACTTCGCCATTGAACTGAACTAA

Upstream 100 bases:

>100_bases
TAACTCACGAAAATATCTTCGGACTCTGGAAATTGGTGTGATAACTTTGTCAGCATCGCACCATAAGCAAGCTAGCTCAC
TCGTTGAGAGGAAGACGAAA

Downstream 100 bases:

>100_bases
GGTCTGGGGTTGATATGCAATACATCAAGATCCATGCGCTGGATAACGTCGCGGTCGCTTTAGCAGATTTGGCTGAAGGC
ACAGAAGTCAGTGTCGATAA

Product: glucuronate isomerase

Products: NA

Alternate protein names: Glucuronate isomerase; Uronic isomerase

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MTPFMTEDFLLDTEFARRLYHDYAKDQPIFDYHCHLPPQQIAEDYRFKNLYDIWLKGDHYKWRAMRTNGVAERLCTGDAS
DREKFDAWAATVPHTIGNPLYHWTHLELRRPFGITGKLLSPSTADEIWNECNELLAQDNFSARGIMQQMNVKMVGTTDDP
IDSLEHHAEIAKDGSFTIKVLPSWRPDKAFNIEQATFNDYMAKLGEVSDTDIRRFADLQTALTKRLDHFAAHGCKVSDHA
LDVVMFAEANEAELDSILARRLAGETLSEHEVAQFKTAVLVFLGAEYARRGWVQQYHIGALRNNNLRQFKLLGPDVGFDS
INDRPMAEELSKLLSKQNEENLLPKTILYCLNPRDNEVLGTMIGNFQGEGMPGKMQFGSGWWFNDQKDGMERQMTQLAQL
GLLSRFVGMLTDSRSFLSYTRHEYFRRILCQMIGRWVEAGEAPADINLLGEMVKNICFNNARDYFAIELN

Sequences:

>Translated_470_residues
MTPFMTEDFLLDTEFARRLYHDYAKDQPIFDYHCHLPPQQIAEDYRFKNLYDIWLKGDHYKWRAMRTNGVAERLCTGDAS
DREKFDAWAATVPHTIGNPLYHWTHLELRRPFGITGKLLSPSTADEIWNECNELLAQDNFSARGIMQQMNVKMVGTTDDP
IDSLEHHAEIAKDGSFTIKVLPSWRPDKAFNIEQATFNDYMAKLGEVSDTDIRRFADLQTALTKRLDHFAAHGCKVSDHA
LDVVMFAEANEAELDSILARRLAGETLSEHEVAQFKTAVLVFLGAEYARRGWVQQYHIGALRNNNLRQFKLLGPDVGFDS
INDRPMAEELSKLLSKQNEENLLPKTILYCLNPRDNEVLGTMIGNFQGEGMPGKMQFGSGWWFNDQKDGMERQMTQLAQL
GLLSRFVGMLTDSRSFLSYTRHEYFRRILCQMIGRWVEAGEAPADINLLGEMVKNICFNNARDYFAIELN
>Mature_469_residues
TPFMTEDFLLDTEFARRLYHDYAKDQPIFDYHCHLPPQQIAEDYRFKNLYDIWLKGDHYKWRAMRTNGVAERLCTGDASD
REKFDAWAATVPHTIGNPLYHWTHLELRRPFGITGKLLSPSTADEIWNECNELLAQDNFSARGIMQQMNVKMVGTTDDPI
DSLEHHAEIAKDGSFTIKVLPSWRPDKAFNIEQATFNDYMAKLGEVSDTDIRRFADLQTALTKRLDHFAAHGCKVSDHAL
DVVMFAEANEAELDSILARRLAGETLSEHEVAQFKTAVLVFLGAEYARRGWVQQYHIGALRNNNLRQFKLLGPDVGFDSI
NDRPMAEELSKLLSKQNEENLLPKTILYCLNPRDNEVLGTMIGNFQGEGMPGKMQFGSGWWFNDQKDGMERQMTQLAQLG
LLSRFVGMLTDSRSFLSYTRHEYFRRILCQMIGRWVEAGEAPADINLLGEMVKNICFNNARDYFAIELN

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG1904

COG function: function code G; Glucuronate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uronate isomerase family

Homologues:

Organism=Escherichia coli, GI2367192, Length=470, Percent_Identity=100, Blast_Score=987, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXAC_ECO24 (A7ZRX6)

Other databases:

- EMBL:   CP000800
- RefSeq:   YP_001464555.1
- ProteinModelPortal:   A7ZRX6
- SMR:   A7ZRX6
- STRING:   A7ZRX6
- EnsemblBacteria:   EBESCT00000020131
- GeneID:   5589846
- GenomeReviews:   CP000800_GR
- KEGG:   ecw:EcE24377A_3560
- eggNOG:   COG1904
- GeneTree:   EBGT00050000011224
- HOGENOM:   HBG297087
- OMA:   AWAKTVP
- ProtClustDB:   PRK02925
- BioCyc:   ECOL331111:ECE24377A_3560-MONOMER
- HAMAP:   MF_00675
- InterPro:   IPR003766
- InterPro:   IPR023177
- Gene3D:   G3DSA:1.10.2020.10

Pfam domain/function: PF02614 UxaC

EC number: =5.3.1.12

Molecular weight: Translated: 53988; Mature: 53857

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPFMTEDFLLDTEFARRLYHDYAKDQPIFDYHCHLPPQQIAEDYRFKNLYDIWLKGDHY
CCCCCCHHHHCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCEEEEEECCCCE
KWRAMRTNGVAERLCTGDASDREKFDAWAATVPHTIGNPLYHWTHLELRRPFGITGKLLS
EEEEECCCHHHHHHHCCCCCCHHHHHHHHHHCCHHHCCCCEEEEEEEEECCCCCCCCCCC
PSTADEIWNECNELLAQDNFSARGIMQQMNVKMVGTTDDPIDSLEHHAEIAKDGSFTIKV
CCHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEE
LPSWRPDKAFNIEQATFNDYMAKLGEVSDTDIRRFADLQTALTKRLDHFAAHGCKVSDHA
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LDVVMFAEANEAELDSILARRLAGETLSEHEVAQFKTAVLVFLGAEYARRGWVQQYHIGA
EEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LRNNNLRQFKLLGPDVGFDSINDRPMAEELSKLLSKQNEENLLPKTILYCLNPRDNEVLG
HCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHEEECCCCCHHHH
TMIGNFQGEGMPGKMQFGSGWWFNDQKDGMERQMTQLAQLGLLSRFVGMLTDSRSFLSYT
HHHCCCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
RHEYFRRILCQMIGRWVEAGEAPADINLLGEMVKNICFNNARDYFAIELN
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure 
TPFMTEDFLLDTEFARRLYHDYAKDQPIFDYHCHLPPQQIAEDYRFKNLYDIWLKGDHY
CCCCCHHHHCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCEEEEEECCCCE
KWRAMRTNGVAERLCTGDASDREKFDAWAATVPHTIGNPLYHWTHLELRRPFGITGKLLS
EEEEECCCHHHHHHHCCCCCCHHHHHHHHHHCCHHHCCCCEEEEEEEEECCCCCCCCCCC
PSTADEIWNECNELLAQDNFSARGIMQQMNVKMVGTTDDPIDSLEHHAEIAKDGSFTIKV
CCHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEE
LPSWRPDKAFNIEQATFNDYMAKLGEVSDTDIRRFADLQTALTKRLDHFAAHGCKVSDHA
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LDVVMFAEANEAELDSILARRLAGETLSEHEVAQFKTAVLVFLGAEYARRGWVQQYHIGA
EEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LRNNNLRQFKLLGPDVGFDSINDRPMAEELSKLLSKQNEENLLPKTILYCLNPRDNEVLG
HCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHEEECCCCCHHHH
TMIGNFQGEGMPGKMQFGSGWWFNDQKDGMERQMTQLAQLGLLSRFVGMLTDSRSFLSYT
HHHCCCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
RHEYFRRILCQMIGRWVEAGEAPADINLLGEMVKNICFNNARDYFAIELN
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA