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The map label for this gene is xdhA [H]

Identifier: 30064195

GI number: 30064195

Start: 2952399

End: 2954696

Strand: Direct

Name: xdhA [H]

Synonym: S3068

Alternate gene names: 30064195

Gene position: 2952399-2954696 (Clockwise)

Preceding gene: 30064188

Following gene: 30064196

Centisome position: 64.19

GC content: 53.13

Gene sequence:

>2298_bases
ATGGAAGCGCGGGAAGCAACCGCTACGGGTGAATCATGCATGCGCGTCGATGCCATTGCTAAGGTCACCGGGCGGGCACG
ATATACTGACGATTATGTTATGGCGGGCATGTGTTACGCGAAATATGTACGTAGCCCTATCGCACATGGTTATGCCGTAA
GTATTAATGATGAACAAGCCAGAAGTTTACCGGGCGTACTGGCGATTTTTACTTGGGAAGATGTGCCTGATATTCCATTC
GCTACAGCTGGGCATGCCTGGACACTTGACGAAAACAAGCGCGATACCGCCGATCGCGCACTGCTAACTCGCCATGTTCG
TCATCATGGTGACGCCGTTGCCATCGTCGTGGCCCGCGATGAACTCACGGCAGAAAAAGCGGCGCAATTGGTCAGCATTG
AGTGGCAAGAATTACCCGTTATCACCACGCCAGAAGCGGCGCTGACAGAAGACGCTGCACCAATCCATAACGGCGGCAAT
TTACTGAAACAAAGCACGATGTCGACGGGCAATGTCCAACAAACAATCGATGCCGCCGACTACCAGGTACAGGGGCACTA
TCAGACTCCCGTTATTCAACATTGTCACATGGAAAGCGTAACATCGCTGGCGTGGATGGAGGATGACTCGCGAATTACCA
TCGTTTCCAGCACCCAGATCCCGCACATTGTTCGCCGCGTGGTTGGTCAGGCGCTGGATATTCCCTGGTCATGCGTACGA
GTCATCAAACCGTTTGTCGGTGGCGGTTTTGGTAATAAACAGGATGTACTGGAAGAGCCAATGGCGGCATTCCTGACCAG
CAAGCTTGGCGGCATTCCGGTGAAAGTTTCCCTTAGCCGTGAAGAGTGTTTCCTCGCAACCCGTACCCGCCACGCTTTTA
CTATTGACGGGCAAATGGGCGTGAACCGCGACGGAACCTTGAAAGGTTATAGTCTGGATGTTCTGTCTAACACCGGCGCT
TATGCATCTCACGGGCACTCCATCGCTTCTGCGGGGGGGAATAAAGTCGCTTACCTTTATCCTCGTTGTGCCTACGCTTA
CAGTTCAAAGACCTGCTATACCAACCTCCCCTCGGCTGGTGCGATGCGTGGTTATGGCGCGCCACAAGTCGTATTTGCCG
TTGAGTCTATGCTTGATGACGCCGCGACAGCGTTAGGTATTGATCCTGTTGAAATTCGTTTACGCAACGCCGCCCGCGAA
GGAGATGCTAATCCGCTCACGGGCAAACGTATTTGCAGCGCAGGGTTGCCGGAGTGTCTTGAAAAAGGCCGGAAAATCTT
TGAATGGGAAAAACGCCGTGCAGAATGCCAGAACCAGCAAGGCAATTTGCGCCGCGGCGTTGGCGTCGCCTGTTTTAGCT
ACACCTCTAACACCTGGCCTGTCGGCGTAGAAATAGCAGGCGCGCGCCTTCTGATGAATCAGGATGGAACCATCAACGTG
CAAAGCGGCGCGACGGAAATCGGTCAGGGTGCCGACACCGTCTTCTCGCAAATGGTGGCAGAAACCGTGGGGGTTCCGGT
CAGCGACGTTCGCGTTATTTCAACACAAGATACCGACGTTACGCCGTTCGATCCCGGCGCATTTGCCTCACGCCAGAGCT
ATGTTGCCGCGCCTGCGCTGCGCAGTGCGGCACTATTATTAAAAGAGAAAATCATCGCTCACGCCGCAGTCATGCTACAT
CAGTCAGCGATGAATTTGACCCTGATAAAAGGCCATATCGTGCTGGTTGAACGACCGGAAGAGCCGTTAATGTCGTTAAA
AGATTTGGCGATGGACGCTTTCTACCACCCTGAACGCGGCGGGCAGCTCTCTGCTGAAAGCTCCATCAAAACCACCACTA
ACCCACCGGCGTTTGGCTGTACCTTTGTTGATCTGACGGTCGATATTGCGCTGTGCAAAGTCACCATCAACCGCATCCTC
AACGTTCATGATTCAGGGCATATTCTTAATCCACTGCTGGCAGAAGGTCAGGTACACGGCGGAATGGGAATGGGCATTGG
CTGGGCGCTATTTGAAGAGATGATCATCGATGCTAAAAGCGGCGTGGTCCGTAACCCCAATCTGCTGGATTACAAAATGC
CGACCATGCCGGATCTGCCACAACTGGAAAGCGCGTTCGTCGAAATCAATGAGCCGCAATCCGCATACGGACATAAGTCA
CTGGGTGAGCCACCCATAATTCCTGTTGCCGCTGCTATTCGTAACGCGGTGAAGATGGCTACCGGTGTTGCAATCAATAC
ACTGCCGCTGACGCCAAAACGGTTATATGAAGAGTTCCATCTGGCAGGATTGATTTGA

Upstream 100 bases:

>100_bases
CTTCCTCCCCTAACGCTTATCGTCGTTTCTGGCGTAAATCTTGCCTGCTTAGACTAAATCTTTGCCATAAGAACCAAATG
TTCAAATCGAGGGGATTTCT

Downstream 100 bases:

>100_bases
GGATAACATCATGTTTGATTTTGCTTCTTACCATCGCGCAGCAACCCTTGCCGATGCCATCAACCTGCTGGCTGACAACC
CGCAGGCCAAACTGCTCGCC

Product: xanthine dehydrogenase subunit XdhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 765; Mature: 765

Protein sequence:

>765_residues
MEAREATATGESCMRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWEDVPDIPF
ATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSIEWQELPVITTPEAALTEDAAPIHNGGN
LLKQSTMSTGNVQQTIDAADYQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVR
VIKPFVGGGFGNKQDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMGVNRDGTLKGYSLDVLSNTGA
YASHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNAARE
GDANPLTGKRICSAGLPECLEKGRKIFEWEKRRAECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINV
QSGATEIGQGADTVFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIAHAAVMLH
QSAMNLTLIKGHIVLVERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRIL
NVHDSGHILNPLLAEGQVHGGMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKS
LGEPPIIPVAAAIRNAVKMATGVAINTLPLTPKRLYEEFHLAGLI

Sequences:

>Translated_765_residues
MEAREATATGESCMRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWEDVPDIPF
ATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSIEWQELPVITTPEAALTEDAAPIHNGGN
LLKQSTMSTGNVQQTIDAADYQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVR
VIKPFVGGGFGNKQDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMGVNRDGTLKGYSLDVLSNTGA
YASHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNAARE
GDANPLTGKRICSAGLPECLEKGRKIFEWEKRRAECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINV
QSGATEIGQGADTVFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIAHAAVMLH
QSAMNLTLIKGHIVLVERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRIL
NVHDSGHILNPLLAEGQVHGGMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKS
LGEPPIIPVAAAIRNAVKMATGVAINTLPLTPKRLYEEFHLAGLI
>Mature_765_residues
MEAREATATGESCMRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWEDVPDIPF
ATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSIEWQELPVITTPEAALTEDAAPIHNGGN
LLKQSTMSTGNVQQTIDAADYQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVR
VIKPFVGGGFGNKQDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMGVNRDGTLKGYSLDVLSNTGA
YASHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNAARE
GDANPLTGKRICSAGLPECLEKGRKIFEWEKRRAECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINV
QSGATEIGQGADTVFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIAHAAVMLH
QSAMNLTLIKGHIVLVERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRIL
NVHDSGHILNPLLAEGQVHGGMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKS
LGEPPIIPVAAAIRNAVKMATGVAINTLPLTPKRLYEEFHLAGLI

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71773480, Length=793, Percent_Identity=26.4817150063052, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI91823271, Length=780, Percent_Identity=24.6153846153846, Blast_Score=167, Evalue=3e-41,
Organism=Escherichia coli, GI1789230, Length=752, Percent_Identity=99.7340425531915, Blast_Score=1556, Evalue=0.0,
Organism=Escherichia coli, GI1789246, Length=798, Percent_Identity=29.6992481203008, Blast_Score=309, Evalue=4e-85,
Organism=Escherichia coli, GI1786478, Length=765, Percent_Identity=28.6274509803922, Blast_Score=220, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17540638, Length=779, Percent_Identity=26.5725288831836, Blast_Score=187, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17539860, Length=729, Percent_Identity=23.3196159122085, Blast_Score=156, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI32566215, Length=734, Percent_Identity=23.5694822888283, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17737937, Length=743, Percent_Identity=26.1103633916555, Blast_Score=191, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24647193, Length=769, Percent_Identity=24.1872561768531, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24647199, Length=749, Percent_Identity=23.3644859813084, Blast_Score=132, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24647201, Length=754, Percent_Identity=23.7400530503979, Blast_Score=127, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24647195, Length=713, Percent_Identity=21.3183730715288, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24647197, Length=709, Percent_Identity=21.4386459802539, Blast_Score=98, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 82629; Mature: 82629

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAREATATGESCMRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQA
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHH
RSLPGVLAIFTWEDVPDIPFATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARD
HCCCCEEEEEEECCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEECC
ELTAEKAAQLVSIEWQELPVITTPEAALTEDAAPIHNGGNLLKQSTMSTGNVQQTIDAAD
HHCHHHHHHEEEEEHHHCCEEECCCHHHCCCCCCCCCCCHHHHHHHCCCCCHHHHHCCCC
YQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVR
EEEECCCCCHHHHHHCHHHHHHEEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHH
VIKPFVGGGFGNKQDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMG
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCEEEEECCCCC
VNRDGTLKGYSLDVLSNTGAYASHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAG
CCCCCCCCCEEEEEECCCCCCCCCCCHHHCCCCCEEEEECCCEEEHCCCCCEECCCCCCC
AMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNAAREGDANPLTGKRICSAGLPECL
CCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHH
EKGRKIFEWEKRRAECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINV
HHCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEECEEEEECCCCEEEE
QSGATEIGQGADTVFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPAL
CCCCCHHCCCHHHHHHHHHHHHHCCCHHHEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
RSAALLLKEKIIAHAAVMLHQSAMNLTLIKGHIVLVERPEEPLMSLKDLAMDAFYHPERG
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCC
GQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRILNVHDSGHILNPLLAEGQVHG
CCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCC
GMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKS
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHEEEECCCHHHCCCCC
LGEPPIIPVAAAIRNAVKMATGVAINTLPLTPKRLYEEFHLAGLI
CCCCCCHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MEAREATATGESCMRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQA
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHH
RSLPGVLAIFTWEDVPDIPFATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARD
HCCCCEEEEEEECCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEECC
ELTAEKAAQLVSIEWQELPVITTPEAALTEDAAPIHNGGNLLKQSTMSTGNVQQTIDAAD
HHCHHHHHHEEEEEHHHCCEEECCCHHHCCCCCCCCCCCHHHHHHHCCCCCHHHHHCCCC
YQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVR
EEEECCCCCHHHHHHCHHHHHHEEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHH
VIKPFVGGGFGNKQDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMG
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEECCCEEEEECCCCC
VNRDGTLKGYSLDVLSNTGAYASHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAG
CCCCCCCCCEEEEEECCCCCCCCCCCHHHCCCCCEEEEECCCEEEHCCCCCEECCCCCCC
AMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNAAREGDANPLTGKRICSAGLPECL
CCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHH
EKGRKIFEWEKRRAECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINV
HHCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEECEEEEECCCCEEEE
QSGATEIGQGADTVFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPAL
CCCCCHHCCCHHHHHHHHHHHHHCCCHHHEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
RSAALLLKEKIIAHAAVMLHQSAMNLTLIKGHIVLVERPEEPLMSLKDLAMDAFYHPERG
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCC
GQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRILNVHDSGHILNPLLAEGQVHG
CCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCC
GMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKS
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHEEEECCCHHHCCCCC
LGEPPIIPVAAAIRNAVKMATGVAINTLPLTPKRLYEEFHLAGLI
CCCCCCHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]