| Definition | Shigella flexneri 2a str. 2457T, complete genome. |
|---|---|
| Accession | NC_004741 |
| Length | 4,599,354 |
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The map label for this gene is kduD
Identifier: 30064183
GI number: 30064183
Start: 2937539
End: 2938300
Strand: Reverse
Name: kduD
Synonym: S3050
Alternate gene names: 30064183
Gene position: 2938300-2937539 (Counterclockwise)
Preceding gene: 30064184
Following gene: 30064182
Centisome position: 63.89
GC content: 51.97
Gene sequence:
>762_bases ATGATTTTAAGTGCATTTTCTCTCCAAGGTAAAGTTGCGGTCGTCACTGGTTGTGATACTGGGCTGGGCCAGGGGATGGC GTTGGGGCTGGCGCAAGCGGGCTGTGACATTGTTGGCATTAACATCGTTGAACCGACTGAAACCATCGAGCAGGTCACGG CGCTGGGGCGTCGTTTTTTAAGCCTGACCGCCGATCTGCGAAAGATTGATGGCATTCCTGGACTGCTGGATCGCGCGGTA GCTGAATTTGGTCATATTGATATCCTGGTGAATAACGCCGGATTGATTCGCCGCGAAGACGCTCTCGAGTTCAGCGAAAA AGACTGGGACGATGTCATGAACCTGAATATCAAGAGCGTATTCTTCATGTCTCAGGCAGCGGCGAAACACTTTATCGCGC AAGGCAATGGCGGCAAGATTATCAATATCGCGTCAATGCTCTCCTTCCAGGGCGGGATCCGTGTGCCTTCTTATACCGCA TCAAAAAGCGGCGTGATGGGTGTGACGCGATTGATGGCAAACGAATGGGCTAAACACAACATTAATGTTAATGCGATAGC TCCGGGTTACATGGCGACCAACAATACCCAACAACTGCGGGCAGATGAACAACGTAGCGCGGAAATTCTCGATCGCATTC CAGCTGGCCGTTGGGGACTGCCGAGTGACCTGATGGGGCCGGTAGTGTTTCTTGCCTCCAGCGCTTCAGATTATGTAAAT GGTTATACCATTGCTGTGGATGGCGGTTGGCTGGCGCGTTAA
Upstream 100 bases:
>100_bases TCTGGGGCATGGTCGGTGAAAACCAGGTCTTTAATGATATGGACCATGTGGGCGTTAAAGATTTGCGCTAGTTGTGGGCA TAAACGAATAAGGTGTTGTT
Downstream 100 bases:
>100_bases TTCATTCCTCTTACTTTTATGACCCTGCCGCATGGCAGGGTTTTTTATATCTCTAGATCATCATAATCCATATCATGGTT ATGAAATAATCCATATCAAT
Product: 2-deoxy-D-gluconate 3-dehydrogenase
Products: NA
Alternate protein names: 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase [H]
Number of amino acids: Translated: 253; Mature: 253
Protein sequence:
>253_residues MILSAFSLQGKVAVVTGCDTGLGQGMALGLAQAGCDIVGINIVEPTETIEQVTALGRRFLSLTADLRKIDGIPGLLDRAV AEFGHIDILVNNAGLIRREDALEFSEKDWDDVMNLNIKSVFFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTA SKSGVMGVTRLMANEWAKHNINVNAIAPGYMATNNTQQLRADEQRSAEILDRIPAGRWGLPSDLMGPVVFLASSASDYVN GYTIAVDGGWLAR
Sequences:
>Translated_253_residues MILSAFSLQGKVAVVTGCDTGLGQGMALGLAQAGCDIVGINIVEPTETIEQVTALGRRFLSLTADLRKIDGIPGLLDRAV AEFGHIDILVNNAGLIRREDALEFSEKDWDDVMNLNIKSVFFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTA SKSGVMGVTRLMANEWAKHNINVNAIAPGYMATNNTQQLRADEQRSAEILDRIPAGRWGLPSDLMGPVVFLASSASDYVN GYTIAVDGGWLAR >Mature_253_residues MILSAFSLQGKVAVVTGCDTGLGQGMALGLAQAGCDIVGINIVEPTETIEQVTALGRRFLSLTADLRKIDGIPGLLDRAV AEFGHIDILVNNAGLIRREDALEFSEKDWDDVMNLNIKSVFFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTA SKSGVMGVTRLMANEWAKHNINVNAIAPGYMATNNTQQLRADEQRSAEILDRIPAGRWGLPSDLMGPVVFLASSASDYVN GYTIAVDGGWLAR
Specific function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI15277342, Length=254, Percent_Identity=32.2834645669291, Blast_Score=133, Evalue=1e-31, Organism=Homo sapiens, GI66933014, Length=249, Percent_Identity=31.7269076305221, Blast_Score=114, Evalue=8e-26, Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=30.8, Blast_Score=110, Evalue=1e-24, Organism=Homo sapiens, GI7705925, Length=254, Percent_Identity=29.1338582677165, Blast_Score=109, Evalue=2e-24, Organism=Homo sapiens, GI19923817, Length=257, Percent_Identity=28.0155642023346, Blast_Score=106, Evalue=2e-23, Organism=Homo sapiens, GI10190704, Length=251, Percent_Identity=31.4741035856574, Blast_Score=104, Evalue=7e-23, Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=30.8943089430894, Blast_Score=100, Evalue=9e-22, Organism=Homo sapiens, GI4504505, Length=261, Percent_Identity=26.8199233716475, Blast_Score=91, Evalue=7e-19, Organism=Homo sapiens, GI126723750, Length=253, Percent_Identity=29.2490118577075, Blast_Score=90, Evalue=2e-18, Organism=Homo sapiens, GI5031737, Length=245, Percent_Identity=28.1632653061224, Blast_Score=89, Evalue=4e-18, Organism=Homo sapiens, GI4503301, Length=253, Percent_Identity=29.6442687747036, Blast_Score=87, Evalue=1e-17, Organism=Homo sapiens, GI31542939, Length=205, Percent_Identity=28.780487804878, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI59889578, Length=191, Percent_Identity=27.7486910994764, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI40254986, Length=199, Percent_Identity=29.1457286432161, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI4758504, Length=264, Percent_Identity=28.030303030303, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI33667109, Length=196, Percent_Identity=26.0204081632653, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI209862901, Length=210, Percent_Identity=28.0952380952381, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI19923983, Length=210, Percent_Identity=28.0952380952381, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI109715829, Length=242, Percent_Identity=25.6198347107438, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI224922801, Length=172, Percent_Identity=29.6511627906977, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI126723191, Length=183, Percent_Identity=29.5081967213115, Blast_Score=65, Evalue=5e-11, Organism=Escherichia coli, GI1789208, Length=253, Percent_Identity=98.8142292490119, Blast_Score=512, Evalue=1e-146, Organism=Escherichia coli, GI87082160, Length=254, Percent_Identity=43.7007874015748, Blast_Score=200, Evalue=8e-53, Organism=Escherichia coli, GI1790717, Length=248, Percent_Identity=41.5322580645161, Blast_Score=179, Evalue=2e-46, Organism=Escherichia coli, GI1787335, Length=246, Percent_Identity=34.9593495934959, Blast_Score=144, Evalue=7e-36, Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=34.6938775510204, Blast_Score=133, Evalue=9e-33, Organism=Escherichia coli, GI87082100, Length=253, Percent_Identity=32.4110671936759, Blast_Score=120, Evalue=9e-29, Organism=Escherichia coli, GI1787905, Length=244, Percent_Identity=31.9672131147541, Blast_Score=105, Evalue=2e-24, Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=27.6, Blast_Score=87, Evalue=8e-19, Organism=Escherichia coli, GI1789378, Length=248, Percent_Identity=26.6129032258064, Blast_Score=83, Evalue=2e-17, Organism=Escherichia coli, GI2367175, Length=252, Percent_Identity=28.1746031746032, Blast_Score=75, Evalue=4e-15, Organism=Escherichia coli, GI1789057, Length=188, Percent_Identity=27.1276595744681, Blast_Score=68, Evalue=6e-13, Organism=Escherichia coli, GI2367365, Length=176, Percent_Identity=29.5454545454545, Blast_Score=67, Evalue=1e-12, Organism=Escherichia coli, GI1787526, Length=192, Percent_Identity=26.5625, Blast_Score=64, Evalue=8e-12, Organism=Caenorhabditis elegans, GI25147288, Length=245, Percent_Identity=33.469387755102, Blast_Score=128, Evalue=3e-30, Organism=Caenorhabditis elegans, GI17555706, Length=246, Percent_Identity=31.7073170731707, Blast_Score=122, Evalue=1e-28, Organism=Caenorhabditis elegans, GI17561402, Length=253, Percent_Identity=33.9920948616601, Blast_Score=119, Evalue=1e-27, Organism=Caenorhabditis elegans, GI17560676, Length=251, Percent_Identity=29.8804780876494, Blast_Score=114, Evalue=4e-26, Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=30.9803921568627, Blast_Score=112, Evalue=2e-25, Organism=Caenorhabditis elegans, GI17559104, Length=257, Percent_Identity=31.5175097276265, Blast_Score=109, Evalue=1e-24, Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=30.7692307692308, Blast_Score=108, Evalue=3e-24, Organism=Caenorhabditis elegans, GI17562910, Length=257, Percent_Identity=29.9610894941634, Blast_Score=104, Evalue=5e-23, Organism=Caenorhabditis elegans, GI115534694, Length=247, Percent_Identity=27.1255060728745, Blast_Score=103, Evalue=9e-23, Organism=Caenorhabditis elegans, GI17560150, Length=262, Percent_Identity=29.0076335877863, Blast_Score=100, Evalue=6e-22, Organism=Caenorhabditis elegans, GI17562906, Length=265, Percent_Identity=30.188679245283, Blast_Score=100, Evalue=8e-22, Organism=Caenorhabditis elegans, GI17560220, Length=260, Percent_Identity=29.6153846153846, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17562908, Length=266, Percent_Identity=29.6992481203008, Blast_Score=98, Evalue=5e-21, Organism=Caenorhabditis elegans, GI17531453, Length=260, Percent_Identity=30.7692307692308, Blast_Score=97, Evalue=7e-21, Organism=Caenorhabditis elegans, GI17544670, Length=266, Percent_Identity=29.6992481203008, Blast_Score=97, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17551412, Length=258, Percent_Identity=29.4573643410853, Blast_Score=96, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17562990, Length=262, Percent_Identity=28.6259541984733, Blast_Score=94, Evalue=5e-20, Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=27.9693486590038, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=29.6577946768061, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI17560332, Length=258, Percent_Identity=30.2325581395349, Blast_Score=90, Evalue=9e-19, Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=28.030303030303, Blast_Score=90, Evalue=9e-19, Organism=Caenorhabditis elegans, GI17568967, Length=192, Percent_Identity=28.6458333333333, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17562904, Length=258, Percent_Identity=28.6821705426357, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17536025, Length=255, Percent_Identity=27.4509803921569, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17565030, Length=258, Percent_Identity=31.0077519379845, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI72000259, Length=258, Percent_Identity=27.5193798449612, Blast_Score=84, Evalue=6e-17, Organism=Caenorhabditis elegans, GI17538486, Length=260, Percent_Identity=29.2307692307692, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17536651, Length=258, Percent_Identity=25.968992248062, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17561272, Length=253, Percent_Identity=29.2490118577075, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI193203117, Length=195, Percent_Identity=29.2307692307692, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI193203115, Length=193, Percent_Identity=29.5336787564767, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17564282, Length=200, Percent_Identity=28, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17538182, Length=254, Percent_Identity=29.1338582677165, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17555612, Length=222, Percent_Identity=28.8288288288288, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI71982365, Length=190, Percent_Identity=26.8421052631579, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17507613, Length=217, Percent_Identity=24.4239631336406, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI32563809, Length=217, Percent_Identity=24.4239631336406, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17508651, Length=160, Percent_Identity=30.625, Blast_Score=66, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=198, Percent_Identity=30.3030303030303, Blast_Score=88, Evalue=2e-18, Organism=Saccharomyces cerevisiae, GI6324126, Length=250, Percent_Identity=25.6, Blast_Score=73, Evalue=5e-14, Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=33.1983805668016, Blast_Score=133, Evalue=1e-31, Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=30.8300395256917, Blast_Score=113, Evalue=1e-25, Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=29.3172690763052, Blast_Score=110, Evalue=8e-25, Organism=Drosophila melanogaster, GI28571526, Length=253, Percent_Identity=30.8300395256917, Blast_Score=109, Evalue=2e-24, Organism=Drosophila melanogaster, GI23397609, Length=250, Percent_Identity=28.8, Blast_Score=107, Evalue=9e-24, Organism=Drosophila melanogaster, GI24643142, Length=244, Percent_Identity=28.6885245901639, Blast_Score=98, Evalue=5e-21, Organism=Drosophila melanogaster, GI24644339, Length=254, Percent_Identity=26.3779527559055, Blast_Score=93, Evalue=2e-19, Organism=Drosophila melanogaster, GI18859837, Length=257, Percent_Identity=31.9066147859922, Blast_Score=92, Evalue=5e-19, Organism=Drosophila melanogaster, GI24644337, Length=206, Percent_Identity=27.1844660194175, Blast_Score=82, Evalue=4e-16, Organism=Drosophila melanogaster, GI21358495, Length=201, Percent_Identity=28.8557213930348, Blast_Score=80, Evalue=1e-15, Organism=Drosophila melanogaster, GI24649181, Length=198, Percent_Identity=29.7979797979798, Blast_Score=79, Evalue=2e-15, Organism=Drosophila melanogaster, GI21357673, Length=192, Percent_Identity=28.6458333333333, Blast_Score=77, Evalue=2e-14, Organism=Drosophila melanogaster, GI17737361, Length=257, Percent_Identity=28.0155642023346, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI24665243, Length=223, Percent_Identity=27.3542600896861, Blast_Score=73, Evalue=1e-13, Organism=Drosophila melanogaster, GI221331218, Length=220, Percent_Identity=27.7272727272727, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI24665247, Length=226, Percent_Identity=27.4336283185841, Blast_Score=72, Evalue=3e-13, Organism=Drosophila melanogaster, GI221331216, Length=223, Percent_Identity=27.8026905829596, Blast_Score=72, Evalue=3e-13, Organism=Drosophila melanogaster, GI24640492, Length=214, Percent_Identity=26.6355140186916, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI24580925, Length=201, Percent_Identity=27.363184079602, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI24648944, Length=201, Percent_Identity=29.3532338308458, Blast_Score=69, Evalue=2e-12, Organism=Drosophila melanogaster, GI24584748, Length=196, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=7e-12, Organism=Drosophila melanogaster, GI161076933, Length=196, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=8e-12, Organism=Drosophila melanogaster, GI281364892, Length=171, Percent_Identity=28.0701754385965, Blast_Score=67, Evalue=1e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011286 - InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.127 [H]
Molecular weight: Translated: 27041; Mature: 27041
Theoretical pI: Translated: 5.30; Mature: 5.30
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 3.6 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 3.6 %Met (Mature Protein) 4.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MILSAFSLQGKVAVVTGCDTGLGQGMALGLAQAGCDIVGINIVEPTETIEQVTALGRRFL CEEECEECCCCEEEEEECCCCCCCCHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHH SLTADLRKIDGIPGLLDRAVAEFGHIDILVNNAGLIRREDALEFSEKDWDDVMNLNIKSV HHHHHHHHHCCCCHHHHHHHHHCCCEEEEECCCCCEEECCHHCCCCCCHHHHHCCCHHHH FFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTASKSGVMGVTRLMANEWAKHN HHHHHHHHHHHEEECCCCCEEEHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC INVNAIAPGYMATNNTQQLRADEQRSAEILDRIPAGRWGLPSDLMGPVVFLASSASDYVN CCEEEECCCEEECCCCHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHC GYTIAVDGGWLAR CEEEEECCCEECC >Mature Secondary Structure MILSAFSLQGKVAVVTGCDTGLGQGMALGLAQAGCDIVGINIVEPTETIEQVTALGRRFL CEEECEECCCCEEEEEECCCCCCCCHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHH SLTADLRKIDGIPGLLDRAVAEFGHIDILVNNAGLIRREDALEFSEKDWDDVMNLNIKSV HHHHHHHHHCCCCHHHHHHHHHCCCEEEEECCCCCEEECCHHCCCCCCHHHHHCCCHHHH FFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTASKSGVMGVTRLMANEWAKHN HHHHHHHHHHHEEECCCCCEEEHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC INVNAIAPGYMATNNTQQLRADEQRSAEILDRIPAGRWGLPSDLMGPVVFLASSASDYVN CCEEEECCCEEECCCCHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHC GYTIAVDGGWLAR CEEEEECCCEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9278503; 2836407; 1766386 [H]