Definition Shigella flexneri 2a str. 2457T, complete genome.
Accession NC_004741
Length 4,599,354

Click here to switch to the map view.

The map label for this gene is fhlA

Identifier: 30064085

GI number: 30064085

Start: 2817298

End: 2819376

Strand: Direct

Name: fhlA

Synonym: S2940

Alternate gene names: 30064085

Gene position: 2817298-2819376 (Clockwise)

Preceding gene: 30064084

Following gene: 30064089

Centisome position: 61.25

GC content: 52.53

Gene sequence:

>2079_bases
ATGTCATATACACCGATGAGTGATCTCGGACAGCAAGGGTTGTTCGACATCACTCGGACACTATTGCAGCAGCCCGATCT
GGCCTCGCTGTGTGAGGCTCTTTCGCAACTGGTAAAGCGTTCTGCGCTCGCCGACAACGCGGCTATTGTGTTGTGGCAAG
CGCAGACTCAACGTGCGTCTTATTACGCGTCGCGTGAAAAAGACACCCCCATTAAATATGAAGACGAAACTGTTCTGGCA
CACGGTCCGGTACGCAGCATTTTGTCGCGCCCTGATACGCTGCATTGCAGTTACGAAGAATTTTGTGAAACCTGGCCGCA
GCTGGCCGCAGGTGGGCTATACCCCAAATTTGGTCACTATTGCCTGATGCCACTGGCGGCGGGAGGGCATATTTTTGGTG
GCTGTGAATTTATTCGTTATGACGAGCGTCCCTGGAGCGAAAAAGAGTTCAATCGTCTGCAAACATTTACGCAGATCGTT
TCTGTCGTCACCGAACAAATCCAGAGCCGCGTCGTCAACAATGTCGACTATGAGTTGTTATGCCGGGAGCGCGATAACTT
CCGCATCCTGGTTGCCATTACCAACGCGGTGCTTTCCCGCCTGGATATGGACGAACTGGTCAGCGAAGTCGCCAAAGAAA
TCCATTACTATTTCGACATTGACGATATCAGCATTGTCTTACGCAGCCACCGTAAAAACAAACTCAACATCTACTCCACT
CACTATCTTGATAAACAACATCCCGCCCACGAACAGAGCGAAGTCGATGAAGCCGGAACCCTCACCGAACGCGTGTTCAA
AAGTAAAGAGATGCTGCTGATCAATCTCTACGAGCGGGACGATTTAGCCCCCTATGAACGCATGTTGTTCGACACCTGGG
GCAACCAGATTCAAACCTTGTGCCTGTTACCGCTGATGTCTGGCGACACCATGCTGGGCGTGCTGAAACTGGCGCAATGC
GAAGAGAAAGTGTTTACCACTACCAATCTGAATTTGCTGCGCCAGATTGCCGAACGTGTGGCAATCGCTGTCGATAACGC
CCTCGCCTATCAGGAAATCCATCGTCTGAAAGAACGGCTGGTTGATGAAAACCTCGCCCTGACCGAGCAGCTCAACAATG
TTGATAGTGAATTTGGCGAGATTATTGGCCGCAGCGAAGCCATGTACAGCGTGCTTAAACAAGTTGAAATGGTGGCGCAA
AGTGACAGTACCGTGCTGATCCTCGGTGAAACTGGCTCGGGTAAAGAGCTGATTGCCCGTGCGATCCATAATCTCAGTGG
GCGTAATAATCGCCGCATGGTCAAAATGAACTGCGCGGCGATGCCTGCCGGATTGCTGGAAAGCGATCTGTTTGGTCATG
AGCGTGGGGCTTTTACCGGTGCCAACGCCCAGCGCATTGGTCGTTTTGAACTGGCGGATAAAAGCTCTCTGTTCCTCGAC
GAAGTGGGCGATATGCCACTGGAGTTACAGCCGAAGTTGCTGCGTGTATTGCAGGAACAGGAGTTTGAACGTCTCGGCAG
CAACAAAATCATTCAGACGGACGTACGTTTAATTGCCGCGACTAACCGCGATCTGAAAAAAATGGTCGCCGACCGAGAGT
TCCGTAGCGATCTCTATTACCGCCTGAACGTATTCCCGATTCACCTGCCGCCACTACGCGAGCGTCCGGAAGATATTCCG
CTGCTGGCGAAAGCCTTTACCTTCAAAATTGCCCGTCGTCTGGGGCGCAATATCGACAGCATTCCTGCCGAGACGCTGCG
CACCTTGAGCAACATGGAGTGGCCGGGTAACGTACGCGAACTGGAAAACGTCATTGAGCGCGCAGTATTGCTAACACGCG
GCAACGTGCTGCAGCTGTCATTGCCAGATATTGCTTTACCGGAGCCTGAAACGCCGCCTGCCGCAACGGTTGTCGCCCAG
GAGGGCGAAGATGAATATCAGTTGATTGTGCGCGTGCTGAAAGAAACCAACAGCGTGGTTGCCGGGCCTAAAGGCGCTGC
GCAACGTCTGGGGCTGAAACGCACGACCCTGCTGTCACGGATGAAGCGGCTGGGAATTGATAAATCGGCATTGATTTAA

Upstream 100 bases:

>100_bases
GCCGAACCGCTTCCGCGTATATGCTAATAAAATTCTAAATCTCCTATAGTTAGTCAATGACCTTTTGCACCGCTTTGCGG
TGCTTTCCTGGAAGAACAAA

Downstream 100 bases:

>100_bases
CTGCAAATTGCCGGACAGATCTGCCTGTCCGGCATACTATTCACGAGGTTTTTTCGGACGATATTTTTCCGGCAGTTCTG
GCACCGGACGCTTGTCATCG

Product: formate hydrogen-lyase transcriptional activator for fdhF, hyc and hyp operons

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 692; Mature: 691

Protein sequence:

>692_residues
MSYTPMSDLGQQGLFDITRTLLQQPDLASLCEALSQLVKRSALADNAAIVLWQAQTQRASYYASREKDTPIKYEDETVLA
HGPVRSILSRPDTLHCSYEEFCETWPQLAAGGLYPKFGHYCLMPLAAGGHIFGGCEFIRYDERPWSEKEFNRLQTFTQIV
SVVTEQIQSRVVNNVDYELLCRERDNFRILVAITNAVLSRLDMDELVSEVAKEIHYYFDIDDISIVLRSHRKNKLNIYST
HYLDKQHPAHEQSEVDEAGTLTERVFKSKEMLLINLYERDDLAPYERMLFDTWGNQIQTLCLLPLMSGDTMLGVLKLAQC
EEKVFTTTNLNLLRQIAERVAIAVDNALAYQEIHRLKERLVDENLALTEQLNNVDSEFGEIIGRSEAMYSVLKQVEMVAQ
SDSTVLILGETGSGKELIARAIHNLSGRNNRRMVKMNCAAMPAGLLESDLFGHERGAFTGANAQRIGRFELADKSSLFLD
EVGDMPLELQPKLLRVLQEQEFERLGSNKIIQTDVRLIAATNRDLKKMVADREFRSDLYYRLNVFPIHLPPLRERPEDIP
LLAKAFTFKIARRLGRNIDSIPAETLRTLSNMEWPGNVRELENVIERAVLLTRGNVLQLSLPDIALPEPETPPAATVVAQ
EGEDEYQLIVRVLKETNSVVAGPKGAAQRLGLKRTTLLSRMKRLGIDKSALI

Sequences:

>Translated_692_residues
MSYTPMSDLGQQGLFDITRTLLQQPDLASLCEALSQLVKRSALADNAAIVLWQAQTQRASYYASREKDTPIKYEDETVLA
HGPVRSILSRPDTLHCSYEEFCETWPQLAAGGLYPKFGHYCLMPLAAGGHIFGGCEFIRYDERPWSEKEFNRLQTFTQIV
SVVTEQIQSRVVNNVDYELLCRERDNFRILVAITNAVLSRLDMDELVSEVAKEIHYYFDIDDISIVLRSHRKNKLNIYST
HYLDKQHPAHEQSEVDEAGTLTERVFKSKEMLLINLYERDDLAPYERMLFDTWGNQIQTLCLLPLMSGDTMLGVLKLAQC
EEKVFTTTNLNLLRQIAERVAIAVDNALAYQEIHRLKERLVDENLALTEQLNNVDSEFGEIIGRSEAMYSVLKQVEMVAQ
SDSTVLILGETGSGKELIARAIHNLSGRNNRRMVKMNCAAMPAGLLESDLFGHERGAFTGANAQRIGRFELADKSSLFLD
EVGDMPLELQPKLLRVLQEQEFERLGSNKIIQTDVRLIAATNRDLKKMVADREFRSDLYYRLNVFPIHLPPLRERPEDIP
LLAKAFTFKIARRLGRNIDSIPAETLRTLSNMEWPGNVRELENVIERAVLLTRGNVLQLSLPDIALPEPETPPAATVVAQ
EGEDEYQLIVRVLKETNSVVAGPKGAAQRLGLKRTTLLSRMKRLGIDKSALI
>Mature_691_residues
SYTPMSDLGQQGLFDITRTLLQQPDLASLCEALSQLVKRSALADNAAIVLWQAQTQRASYYASREKDTPIKYEDETVLAH
GPVRSILSRPDTLHCSYEEFCETWPQLAAGGLYPKFGHYCLMPLAAGGHIFGGCEFIRYDERPWSEKEFNRLQTFTQIVS
VVTEQIQSRVVNNVDYELLCRERDNFRILVAITNAVLSRLDMDELVSEVAKEIHYYFDIDDISIVLRSHRKNKLNIYSTH
YLDKQHPAHEQSEVDEAGTLTERVFKSKEMLLINLYERDDLAPYERMLFDTWGNQIQTLCLLPLMSGDTMLGVLKLAQCE
EKVFTTTNLNLLRQIAERVAIAVDNALAYQEIHRLKERLVDENLALTEQLNNVDSEFGEIIGRSEAMYSVLKQVEMVAQS
DSTVLILGETGSGKELIARAIHNLSGRNNRRMVKMNCAAMPAGLLESDLFGHERGAFTGANAQRIGRFELADKSSLFLDE
VGDMPLELQPKLLRVLQEQEFERLGSNKIIQTDVRLIAATNRDLKKMVADREFRSDLYYRLNVFPIHLPPLRERPEDIPL
LAKAFTFKIARRLGRNIDSIPAETLRTLSNMEWPGNVRELENVIERAVLLTRGNVLQLSLPDIALPEPETPPAATVVAQE
GEDEYQLIVRVLKETNSVVAGPKGAAQRLGLKRTTLLSRMKRLGIDKSALI

Specific function: Required for induction of expression of the formate dehydrogenase H and hydrogenase-3 structural genes [H]

COG id: COG3604

COG function: function code KT; Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1789087, Length=692, Percent_Identity=98.6994219653179, Blast_Score=1407, Evalue=0.0,
Organism=Escherichia coli, GI87082117, Length=566, Percent_Identity=50.530035335689, Blast_Score=516, Evalue=1e-147,
Organism=Escherichia coli, GI1790437, Length=313, Percent_Identity=46.3258785942492, Blast_Score=268, Evalue=1e-72,
Organism=Escherichia coli, GI1788550, Length=322, Percent_Identity=45.6521739130435, Blast_Score=266, Evalue=5e-72,
Organism=Escherichia coli, GI1788905, Length=307, Percent_Identity=46.2540716612378, Blast_Score=250, Evalue=2e-67,
Organism=Escherichia coli, GI87082152, Length=366, Percent_Identity=39.0710382513661, Blast_Score=242, Evalue=5e-65,
Organism=Escherichia coli, GI1790299, Length=365, Percent_Identity=40.8219178082192, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI1789233, Length=322, Percent_Identity=40.3726708074534, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87081872, Length=265, Percent_Identity=44.9056603773585, Blast_Score=211, Evalue=2e-55,
Organism=Escherichia coli, GI1786524, Length=332, Percent_Identity=37.6506024096386, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1787583, Length=333, Percent_Identity=36.036036036036, Blast_Score=188, Evalue=1e-48,
Organism=Escherichia coli, GI1789828, Length=254, Percent_Identity=36.2204724409449, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI87081858, Length=326, Percent_Identity=31.5950920245399, Blast_Score=135, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003018
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078 [H]

Pfam domain/function: PF01590 GAF; PF02954 HTH_8; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 78423; Mature: 78292

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYTPMSDLGQQGLFDITRTLLQQPDLASLCEALSQLVKRSALADNAAIVLWQAQTQRAS
CCCCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHH
YYASREKDTPIKYEDETVLAHGPVRSILSRPDTLHCSYEEFCETWPQLAAGGLYPKFGHY
HHHCCCCCCCCCCCCCEEEECCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHCCE
CLMPLAAGGHIFGGCEFIRYDERPWSEKEFNRLQTFTQIVSVVTEQIQSRVVNNVDYELL
EEHHCCCCCCEECCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
CRERDNFRILVAITNAVLSRLDMDELVSEVAKEIHYYFDIDDISIVLRSHRKNKLNIYST
EECCCCCEEEEEEHHHHHHHCCHHHHHHHHHHHHHEEECCHHHHHHHHHCCCCCEEEEEE
HYLDKQHPAHEQSEVDEAGTLTERVFKSKEMLLINLYERDDLAPYERMLFDTWGNQIQTL
ECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
CLLPLMSGDTMLGVLKLAQCEEKVFTTTNLNLLRQIAERVAIAVDNALAYQEIHRLKERL
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDENLALTEQLNNVDSEFGEIIGRSEAMYSVLKQVEMVAQSDSTVLILGETGSGKELIAR
HCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
AIHNLSGRNNRRMVKMNCAAMPAGLLESDLFGHERGAFTGANAQRIGRFELADKSSLFLD
HHHHCCCCCCCEEEEEECHHCCCHHHHHHHCCCCCCCCCCCCHHHCCCEEECCCCHHHHH
EVGDMPLELQPKLLRVLQEQEFERLGSNKIIQTDVRLIAATNRDLKKMVADREFRSDLYY
HHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHEEECCHHHHHHHHHHHHHHCCEE
RLNVFPIHLPPLRERPEDIPLLAKAFTFKIARRLGRNIDSIPAETLRTLSNMEWPGNVRE
EEEEEEEECCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHH
LENVIERAVLLTRGNVLQLSLPDIALPEPETPPAATVVAQEGEDEYQLIVRVLKETNSVV
HHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEE
AGPKGAAQRLGLKRTTLLSRMKRLGIDKSALI
CCCCHHHHHCCCHHHHHHHHHHHCCCCHHHCC
>Mature Secondary Structure 
SYTPMSDLGQQGLFDITRTLLQQPDLASLCEALSQLVKRSALADNAAIVLWQAQTQRAS
CCCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHH
YYASREKDTPIKYEDETVLAHGPVRSILSRPDTLHCSYEEFCETWPQLAAGGLYPKFGHY
HHHCCCCCCCCCCCCCEEEECCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHCCE
CLMPLAAGGHIFGGCEFIRYDERPWSEKEFNRLQTFTQIVSVVTEQIQSRVVNNVDYELL
EEHHCCCCCCEECCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
CRERDNFRILVAITNAVLSRLDMDELVSEVAKEIHYYFDIDDISIVLRSHRKNKLNIYST
EECCCCCEEEEEEHHHHHHHCCHHHHHHHHHHHHHEEECCHHHHHHHHHCCCCCEEEEEE
HYLDKQHPAHEQSEVDEAGTLTERVFKSKEMLLINLYERDDLAPYERMLFDTWGNQIQTL
ECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
CLLPLMSGDTMLGVLKLAQCEEKVFTTTNLNLLRQIAERVAIAVDNALAYQEIHRLKERL
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDENLALTEQLNNVDSEFGEIIGRSEAMYSVLKQVEMVAQSDSTVLILGETGSGKELIAR
HCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
AIHNLSGRNNRRMVKMNCAAMPAGLLESDLFGHERGAFTGANAQRIGRFELADKSSLFLD
HHHHCCCCCCCEEEEEECHHCCCHHHHHHHCCCCCCCCCCCCHHHCCCEEECCCCHHHHH
EVGDMPLELQPKLLRVLQEQEFERLGSNKIIQTDVRLIAATNRDLKKMVADREFRSDLYY
HHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHEEECCHHHHHHHHHHHHHHCCEE
RLNVFPIHLPPLRERPEDIPLLAKAFTFKIARRLGRNIDSIPAETLRTLSNMEWPGNVRE
EEEEEEEECCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHH
LENVIERAVLLTRGNVLQLSLPDIALPEPETPPAATVVAQEGEDEYQLIVRVLKETNSVV
HHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEE
AGPKGAAQRLGLKRTTLLSRMKRLGIDKSALI
CCCCHHHHHCCCHHHHHHHHHHHCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2280686; 2118503; 9278503 [H]