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The map label for this gene is gabP

Identifier: 30064029

GI number: 30064029

Start: 2761448

End: 2762848

Strand: Direct

Name: gabP

Synonym: S2875

Alternate gene names: 30064029

Gene position: 2761448-2762848 (Clockwise)

Preceding gene: 30064028

Following gene: 30064030

Centisome position: 60.04

GC content: 51.25

Gene sequence:

>1401_bases
ATGGGGCAATCATCGCAACCACACGAGTTAGGCGGCGGGCTGAAATCACGCCACGTCACCATGTTGTCTATTGCCGGTGT
TATCGGCGCAAGTCTGTTTGTCGGTTCCAGCGTCGCCATCGCCGAAGCGGACCCGGCGGTATTACTGGCCTATCTGTTCG
CCGGATTACTGGTGGTTATGATTATGCGGATGCTGGCGGAAATGGCAGTTGCCACGCCCGATACCGGTTCGTTTTCCACC
TATGCCGATAAAGCCATTGGCCGCTGGGCGGGCTATACCATCGGCTGGTTGTACTGGTGGTTTTGGGTACTGGTTATCCC
ACTGGAAGCCAACATCGCCGCCATGATCCTGCACTCGTGGGTTCCAGGCATTCCCATCTGGTTATTTTCCCTCGTCATTA
CCCTCGCCTTAACTGGCAGTAATTTATTAAGCGTTAAAAACTACGGCGAATTTGAGTTCTGGCTGGCGCTGTGCAAAGTC
ATCGCTATCCTGGCCTTTATTTTCCTTGGTGCAGTCGCAATTAGCGGTTTTTACCCTTATGCCGAAGTGAGCGGGATCTC
AAGATTGTGGGATAGCGGCGGCTTTATGCCCAACGGTTTCGGTGCGGTATTAAGCGCGATGTTGATCACCATGTTCTCGT
TTATGGGCGCAGAAATTGTCACCATTGCCGCCGCGGAATCCGACATGCCGGAAAAACATATTGTCCGCGCCACCAACTCG
GTTATCTGGCGTATTTCTATCTTCTATTTGTGCTCTATTTTTGTCGTCGTGGCATTAATACCGTGGAATATGCCGGGGCT
GAAAGCCGTTGGATCTTATCGCTCGGTTCTGGAATTGCTCAATATTCCCCATGCGAAATTAATCATGGACTGTGTGATAT
TACTTTCCGTAACCAGTTGCCTGAACTCGGCCCTGTATACCGCCTCAAGGATGCTCTACTCCTTAAGCCGTCGCGGTGAT
GCTCCCGCGGTAATGGGTAAAATCAACCGCAGTAAAACCCCGTACGTGGCGGTGTTACTCTCCACCGGCGCAGCATTCTT
AACGGTGGTGGTGAACTATTACGCGCCTGCGAAGGTATTTAAATTTCTGATCGACAGCTCCGGCGCTATCGCCCTGCTGG
TTTATTTAGTCATCGCCGTTTCACAGTTGCGGATGCGCAAAATTCTGCGAGCAGAAGGAAGCGAAATTCGCTTGCGAATG
TGGCTTGATCCCTGGCTCACCTGGCTGGTCATCGGCTTTATTACCTTTGTGTTGGTAGTGATGCTATTCCGTCCGGCGCA
ACAGTTAGAAGTGATCTCCACCGGCTTATTAGCGATAGGGATTATCTGTACCGTGCCAATTATGGCTCGCTGGAAAAAGC
TGGTATTGTGGCAAAAAACACCCGTTCATAATACGCGCTGA

Upstream 100 bases:

>100_bases
CGCTCTCCGGCAAAAAGAATCAATAACAATTAAACGCGTGACCCGACGCGGGAAATGTCGGGGCGCTCTCCCAAGTGACA
CACTTTCGAGAGGATTCAGG

Downstream 100 bases:

>100_bases
TAATGATCAGGAGTCACACCATGACCATTACGTCTCTGGATGGCTATCGCTGGCTGAAGAACGATATTATTCGCGGTAAT
TTTCAACCGGATGAAAAATT

Product: gamma-aminobutyrate transporter

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MGQSSQPHELGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEADPAVLLAYLFAGLLVVMIMRMLAEMAVATPDTGSFST
YADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAMILHSWVPGIPIWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKV
IAILAFIFLGAVAISGFYPYAEVSGISRLWDSGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDMPEKHIVRATNS
VIWRISIFYLCSIFVVVALIPWNMPGLKAVGSYRSVLELLNIPHAKLIMDCVILLSVTSCLNSALYTASRMLYSLSRRGD
APAVMGKINRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVFKFLIDSSGAIALLVYLVIAVSQLRMRKILRAEGSEIRLRM
WLDPWLTWLVIGFITFVLVVMLFRPAQQLEVISTGLLAIGIICTVPIMARWKKLVLWQKTPVHNTR

Sequences:

>Translated_466_residues
MGQSSQPHELGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEADPAVLLAYLFAGLLVVMIMRMLAEMAVATPDTGSFST
YADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAMILHSWVPGIPIWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKV
IAILAFIFLGAVAISGFYPYAEVSGISRLWDSGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDMPEKHIVRATNS
VIWRISIFYLCSIFVVVALIPWNMPGLKAVGSYRSVLELLNIPHAKLIMDCVILLSVTSCLNSALYTASRMLYSLSRRGD
APAVMGKINRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVFKFLIDSSGAIALLVYLVIAVSQLRMRKILRAEGSEIRLRM
WLDPWLTWLVIGFITFVLVVMLFRPAQQLEVISTGLLAIGIICTVPIMARWKKLVLWQKTPVHNTR
>Mature_465_residues
GQSSQPHELGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEADPAVLLAYLFAGLLVVMIMRMLAEMAVATPDTGSFSTY
ADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAMILHSWVPGIPIWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVI
AILAFIFLGAVAISGFYPYAEVSGISRLWDSGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDMPEKHIVRATNSV
IWRISIFYLCSIFVVVALIPWNMPGLKAVGSYRSVLELLNIPHAKLIMDCVILLSVTSCLNSALYTASRMLYSLSRRGDA
PAVMGKINRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVFKFLIDSSGAIALLVYLVIAVSQLRMRKILRAEGSEIRLRMW
LDPWLTWLVIGFITFVLVVMLFRPAQQLEVISTGLLAIGIICTVPIMARWKKLVLWQKTPVHNTR

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789017, Length=466, Percent_Identity=99.3562231759657, Blast_Score=922, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=433, Percent_Identity=36.2586605080831, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1786789, Length=431, Percent_Identity=36.4269141531323, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI48994972, Length=464, Percent_Identity=32.7586206896552, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI87081708, Length=436, Percent_Identity=34.6330275229358, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI1788480, Length=392, Percent_Identity=33.9285714285714, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI87081915, Length=408, Percent_Identity=32.843137254902, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1790653, Length=447, Percent_Identity=29.7539149888143, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI1786602, Length=431, Percent_Identity=33.1786542923434, Blast_Score=223, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17532491, Length=364, Percent_Identity=22.2527472527473, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=443, Percent_Identity=30.2483069977427, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6324061, Length=435, Percent_Identity=29.8850574712644, Blast_Score=196, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6324059, Length=439, Percent_Identity=29.3849658314351, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324553, Length=389, Percent_Identity=31.8766066838046, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6324924, Length=464, Percent_Identity=28.448275862069, Blast_Score=174, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6324990, Length=421, Percent_Identity=30.6413301662708, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6322892, Length=410, Percent_Identity=30.4878048780488, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6320717, Length=413, Percent_Identity=28.8135593220339, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6319824, Length=408, Percent_Identity=28.1862745098039, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319543, Length=440, Percent_Identity=26.1363636363636, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6321053, Length=390, Percent_Identity=27.4358974358974, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6321629, Length=400, Percent_Identity=27.25, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6320251, Length=408, Percent_Identity=28.1862745098039, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319542, Length=404, Percent_Identity=27.4752475247525, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322967, Length=404, Percent_Identity=26.2376237623762, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6324981, Length=405, Percent_Identity=29.8765432098765, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6319608, Length=437, Percent_Identity=25.858123569794, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6320364, Length=501, Percent_Identity=22.7544910179641, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24667468, Length=408, Percent_Identity=22.7941176470588, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51121; Mature: 50990

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQSSQPHELGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEADPAVLLAYLFAGLLVVM
CCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHH
IMRMLAEMAVATPDTGSFSTYADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAMILHSW
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VPGIPIWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVIAILAFIFLGAVAISGFYPY
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
AEVSGISRLWDSGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDMPEKHIVRATNS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCHHHHHHHHHH
VIWRISIFYLCSIFVVVALIPWNMPGLKAVGSYRSVLELLNIPHAKLIMDCVILLSVTSC
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LNSALYTASRMLYSLSRRGDAPAVMGKINRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVF
HHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEEHHCCHHHHHHHHHHCCHHHHH
KFLIDSSGAIALLVYLVIAVSQLRMRKILRAEGSEIRLRMWLDPWLTWLVIGFITFVLVV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
MLFRPAQQLEVISTGLLAIGIICTVPIMARWKKLVLWQKTPVHNTR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
GQSSQPHELGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEADPAVLLAYLFAGLLVVM
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHH
IMRMLAEMAVATPDTGSFSTYADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAMILHSW
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VPGIPIWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVIAILAFIFLGAVAISGFYPY
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
AEVSGISRLWDSGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDMPEKHIVRATNS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCHHHHHHHHHH
VIWRISIFYLCSIFVVVALIPWNMPGLKAVGSYRSVLELLNIPHAKLIMDCVILLSVTSC
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LNSALYTASRMLYSLSRRGDAPAVMGKINRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVF
HHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEEHHCCHHHHHHHHHHCCHHHHH
KFLIDSSGAIALLVYLVIAVSQLRMRKILRAEGSEIRLRMWLDPWLTWLVIGFITFVLVV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
MLFRPAQQLEVISTGLLAIGIICTVPIMARWKKLVLWQKTPVHNTR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8297211; 9205837; 9278503 [H]