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The map label for this gene is trxC

Identifier: 30063983

GI number: 30063983

Start: 2709220

End: 2709639

Strand: Direct

Name: trxC

Synonym: S2817

Alternate gene names: 30063983

Gene position: 2709220-2709639 (Clockwise)

Preceding gene: 30063981

Following gene: 30063984

Centisome position: 58.9

GC content: 49.52

Gene sequence:

>420_bases
ATGAATACCGTTTGTACCCATTGTCAGGCCATCAATCGCATTCCCGACGATCGGATCGAAGATGCGGCAAAATGCGGACG
CTGCGGTCACGACTTGTTTGACGGAGAGGTGATTAATGCGACCGGTGAAACACTCGACAAATTGCTGAAGGATGATCTAC
CTGTGGTGATCGACTTCTGGGCACCGTGGTGCGGCCCCTGCCGTAATTTCGCACCAATTTTTGAAGATGTCGCGCAAGAG
CGTAGCGGTAAAGTGCGCTTTGTGAAAGTGAATACCGAAGCTGAACGTGAATTGAGCAGTCGCTTTGGAATTCGTAGTAT
ACCGACGATCATGATTTTCAAAAACGGTCAGGTTGTCGACATGCTTAATGGCGCAGTACCGAAAGCGCCGTTCGATAGCT
GGCTGAACGAATCTCTTTAA

Upstream 100 bases:

>100_bases
CAGATTGTTGTCTGGAACAATGTCCCCGATAATATGTAACATATTAGAAACATACCGGCGTCGTTGCCGATAAGTCTCCT
TACTCATCCCGAGGTTAGTT

Downstream 100 bases:

>100_bases
TCTTACCGGGGCGCATCTTGTGCCCCGTTTTCTCCTCTGCGACAATGGCGTTTTTTCGACGCTCTCTTATGACCGAAAAC
GCTGTTCTCCAGTTACGCGC

Product: thioredoxin 2

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase

Number of amino acids: Translated: 139; Mature: 139

Protein sequence:

>139_residues
MNTVCTHCQAINRIPDDRIEDAAKCGRCGHDLFDGEVINATGETLDKLLKDDLPVVIDFWAPWCGPCRNFAPIFEDVAQE
RSGKVRFVKVNTEAERELSSRFGIRSIPTIMIFKNGQVVDMLNGAVPKAPFDSWLNESL

Sequences:

>Translated_139_residues
MNTVCTHCQAINRIPDDRIEDAAKCGRCGHDLFDGEVINATGETLDKLLKDDLPVVIDFWAPWCGPCRNFAPIFEDVAQE
RSGKVRFVKVNTEAERELSSRFGIRSIPTIMIFKNGQVVDMLNGAVPKAPFDSWLNESL
>Mature_139_residues
MNTVCTHCQAINRIPDDRIEDAAKCGRCGHDLFDGEVINATGETLDKLLKDDLPVVIDFWAPWCGPCRNFAPIFEDVAQE
RSGKVRFVKVNTEAERELSSRFGIRSIPTIMIFKNGQVVDMLNGAVPKAPFDSWLNESL

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=32.6086956521739, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI4758304, Length=83, Percent_Identity=37.3493975903614, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI24308127, Length=68, Percent_Identity=45.5882352941176, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI5031973, Length=87, Percent_Identity=37.9310344827586, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI95113651, Length=77, Percent_Identity=38.961038961039, Blast_Score=64, Evalue=5e-11,
Organism=Escherichia coli, GI1788936, Length=139, Percent_Identity=100, Blast_Score=288, Evalue=9e-80,
Organism=Escherichia coli, GI87082331, Length=105, Percent_Identity=38.0952380952381, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI87081747, Length=105, Percent_Identity=30.4761904761905, Blast_Score=72, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=111, Percent_Identity=31.5315315315315, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17507705, Length=75, Percent_Identity=45.3333333333333, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25144092, Length=88, Percent_Identity=35.2272727272727, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17510299, Length=75, Percent_Identity=44, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=72, Percent_Identity=34.7222222222222, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=72, Percent_Identity=34.7222222222222, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=81, Percent_Identity=37.037037037037, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=42.2535211267606, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=99, Percent_Identity=29.2929292929293, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17544108, Length=102, Percent_Identity=29.4117647058824, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115532378, Length=99, Percent_Identity=29.2929292929293, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32566189, Length=104, Percent_Identity=28.8461538461538, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=104, Percent_Identity=28.8461538461538, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17507915, Length=85, Percent_Identity=34.1176470588235, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=104, Percent_Identity=28.8461538461538, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=89, Percent_Identity=33.7078651685393, Blast_Score=66, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=92, Percent_Identity=32.6086956521739, Blast_Score=63, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573567, Length=94, Percent_Identity=32.9787234042553, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24639826, Length=77, Percent_Identity=37.6623376623377, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI19921434, Length=100, Percent_Identity=39, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17647799, Length=104, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THIO2_ECO57 (P0AGG6)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   G85904
- PIR:   H91059
- RefSeq:   NP_289141.1
- RefSeq:   NP_311475.1
- ProteinModelPortal:   P0AGG6
- SMR:   P0AGG6
- MINT:   MINT-1227488
- EnsemblBacteria:   EBESCT00000025685
- EnsemblBacteria:   EBESCT00000056440
- GeneID:   914878
- GeneID:   957981
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z3867
- KEGG:   ecs:ECs3448
- GeneTree:   EBGT00050000008978
- HOGENOM:   HBG493509
- OMA:   MIFKQGH
- ProtClustDB:   PRK10996
- BioCyc:   ECOL83334:ECS3448-MONOMER
- GO:   GO:0005737
- GO:   GO:0006810
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10438
- PIRSF:   PIRSF000077
- PRINTS:   PR00421
- TIGRFAMs:   TIGR01068

Pfam domain/function: PF00085 Thioredoxin; SSF52833 Thiordxn-like_fd

EC number: =1.8.1.8

Molecular weight: Translated: 15555; Mature: 15555

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVCTHCQAINRIPDDRIEDAAKCGRCGHDLFDGEVINATGETLDKLLKDDLPVVIDFW
CCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHCCCCEEEECC
APWCGPCRNFAPIFEDVAQERSGKVRFVKVNTEAERELSSRFGIRSIPTIMIFKNGQVVD
CCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCCCEEEEECCCCEEE
MLNGAVPKAPFDSWLNESL
HHCCCCCCCCHHHHHCCCC
>Mature Secondary Structure
MNTVCTHCQAINRIPDDRIEDAAKCGRCGHDLFDGEVINATGETLDKLLKDDLPVVIDFW
CCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHCCCCEEEECC
APWCGPCRNFAPIFEDVAQERSGKVRFVKVNTEAERELSSRFGIRSIPTIMIFKNGQVVD
CCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCCCEEEEECCCCEEE
MLNGAVPKAPFDSWLNESL
HHCCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796