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The map label for this gene is ccmH

Identifier: 30063634

GI number: 30063634

Start: 2292816

End: 2293868

Strand: Reverse

Name: ccmH

Synonym: S2408

Alternate gene names: 30063634

Gene position: 2293868-2292816 (Counterclockwise)

Preceding gene: 30063635

Following gene: 30063632

Centisome position: 49.87

GC content: 54.51

Gene sequence:

>1053_bases
ATGAGGTTTTTATTGGGCGTGCTGATGCTGATGATCTCCGGCTCAGCGCTGGCGACCATCGACGTGTTGCAGTTTAAAGA
TGAAGCACAGGAACAACAGTTCCGTCAGCTCACTGAAGAACTGCGCTGCCCGAAATGCCAGAACAACAGCATTGCCGATT
CCAACTCGATGATTGCCACCGACCTGCGTCAGAAAGTGTATGAACTGATGCAGGAAGGTAAAAGTAAAAAAGAGATTGTC
GATTATATGGTGGCGCGTTACGGCAACTTCGTCACTTACGATCCGCCGTTAACGCCGCTGACCGTGCTGCTGTGGGTGCT
GCCAGTAGTGGCTATTGGCATTGGCGGTTGGGTCATATACGCCCGCTCGCGGCGTCGGGTACGCGTGGTGCCGGAAGCGT
TTCCTGAACAAAGCGTGCCGGAAGGTAAGCGTGCCGGATATGTTGTTTATCTGCCGGGTATTGTGGTGGCGTTAATTGTG
GCTGGCGTCAGCTACTACCAGACTGGCAATTATCAGCAGGTGAAAATCTGGCAGCAGGCCACGGCACAGGCTCCGGCGTT
GCTGGACAGGGCGCTGGACCCGAAAGCCGATCCGCTCAACGAAGAAGAGATGTCGCGCCTTGCGCTGGGGATGCGTACTC
AACTGCAAAAAAATCCGGGAGATATAGAAGGCTGGATTATGTTGGGCCGCGTTGGCATGGCGCTGGGTAACGCCAGTATC
GCCACCGATGCATACGCTACTGCGTATCGCCTCGATCCGAAGAACAGCGATGCCGCACTGGGATACGCTGAAGCGTTGAC
TCGTTCATCTGATCCCAACGACAACCGCCTCGGCGGTGAACTGCTACGTCAGCTGGTGAGAACGGACCATAGCAATATCC
GTGTGCTAAGCATGTATGCGTTTAATGCCTTTGAGCAGCAGCGATTTGGCGAAGCCGTTGCCGCGTGGGAGATGATGTTG
AAACTCTTACCTGCCAACGATACTCGCCGTGCGGTGATTGAACGTAGTATCGCGCAGGCGATGCAACATTTGTCGCCGCA
GGAGAGTAAATAA

Upstream 100 bases:

>100_bases
ACGGTATCATTCGCTATCGCCATGCGGGCGATCTCAATCCTCGCGTCTGGGAAGAAGAGATCAAGCCGCTGTGGGAGAAA
TACAGTAAGGAGGCCGCACA

Downstream 100 bases:

>100_bases
AAAGAGGCCCGATGGTGATGCCATCGGGCTAGACTGATGACAAAGTGCGCTTAGTTTATGCCGGATGCGGCGTGAACGCC
TTATCCGGCCTACAAAATTG

Product: subunit of heme lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MRFLLGVLMLMISGSALATIDVLQFKDEAQEQQFRQLTEELRCPKCQNNSIADSNSMIATDLRQKVYELMQEGKSKKEIV
DYMVARYGNFVTYDPPLTPLTVLLWVLPVVAIGIGGWVIYARSRRRVRVVPEAFPEQSVPEGKRAGYVVYLPGIVVALIV
AGVSYYQTGNYQQVKIWQQATAQAPALLDRALDPKADPLNEEEMSRLALGMRTQLQKNPGDIEGWIMLGRVGMALGNASI
ATDAYATAYRLDPKNSDAALGYAEALTRSSDPNDNRLGGELLRQLVRTDHSNIRVLSMYAFNAFEQQRFGEAVAAWEMML
KLLPANDTRRAVIERSIAQAMQHLSPQESK

Sequences:

>Translated_350_residues
MRFLLGVLMLMISGSALATIDVLQFKDEAQEQQFRQLTEELRCPKCQNNSIADSNSMIATDLRQKVYELMQEGKSKKEIV
DYMVARYGNFVTYDPPLTPLTVLLWVLPVVAIGIGGWVIYARSRRRVRVVPEAFPEQSVPEGKRAGYVVYLPGIVVALIV
AGVSYYQTGNYQQVKIWQQATAQAPALLDRALDPKADPLNEEEMSRLALGMRTQLQKNPGDIEGWIMLGRVGMALGNASI
ATDAYATAYRLDPKNSDAALGYAEALTRSSDPNDNRLGGELLRQLVRTDHSNIRVLSMYAFNAFEQQRFGEAVAAWEMML
KLLPANDTRRAVIERSIAQAMQHLSPQESK
>Mature_350_residues
MRFLLGVLMLMISGSALATIDVLQFKDEAQEQQFRQLTEELRCPKCQNNSIADSNSMIATDLRQKVYELMQEGKSKKEIV
DYMVARYGNFVTYDPPLTPLTVLLWVLPVVAIGIGGWVIYARSRRRVRVVPEAFPEQSVPEGKRAGYVVYLPGIVVALIV
AGVSYYQTGNYQQVKIWQQATAQAPALLDRALDPKADPLNEEEMSRLALGMRTQLQKNPGDIEGWIMLGRVGMALGNASI
ATDAYATAYRLDPKNSDAALGYAEALTRSSDPNDNRLGGELLRQLVRTDHSNIRVLSMYAFNAFEQQRFGEAVAAWEMML
KLLPANDTRRAVIERSIAQAMQHLSPQESK

Specific function: May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase

COG id: COG4235

COG function: function code O; Cytochrome c biogenesis factor

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats

Homologues:

Organism=Escherichia coli, GI1788522, Length=350, Percent_Identity=100, Blast_Score=719, Evalue=0.0,
Organism=Escherichia coli, GI1790512, Length=82, Percent_Identity=43.9024390243902, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMH_ECOLI (P0ABM9)

Other databases:

- EMBL:   U00008
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   H64988
- RefSeq:   AP_002790.1
- RefSeq:   NP_416698.1
- ProteinModelPortal:   P0ABM9
- DIP:   DIP-48146N
- IntAct:   P0ABM9
- MINT:   MINT-225097
- STRING:   P0ABM9
- EnsemblBacteria:   EBESCT00000004393
- EnsemblBacteria:   EBESCT00000004394
- EnsemblBacteria:   EBESCT00000004395
- EnsemblBacteria:   EBESCT00000017025
- GeneID:   946623
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW2182
- KEGG:   eco:b2194
- EchoBASE:   EB1983
- EcoGene:   EG12052
- eggNOG:   COG4235
- GeneTree:   EBGT00050000008887
- HOGENOM:   HBG417226
- OMA:   AYANAYH
- ProtClustDB:   CLSK880326
- BioCyc:   EcoCyc:EG12052-MONOMER
- Genevestigator:   P0ABM9
- InterPro:   IPR005616
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734
- Gene3D:   G3DSA:1.25.40.10

Pfam domain/function: PF03918 CcmH

EC number: NA

Molecular weight: Translated: 39090; Mature: 39090

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: PS50005 TPR; PS50293 TPR_REGION

Important sites: BINDING 43-43 BINDING 46-46

Signals:

None

Transmembrane regions:

HASH(0x13731fd0)-; HASH(0xf811694)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFLLGVLMLMISGSALATIDVLQFKDEAQEQQFRQLTEELRCPKCQNNSIADSNSMIAT
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
DLRQKVYELMQEGKSKKEIVDYMVARYGNFVTYDPPLTPLTVLLWVLPVVAIGIGGWVIY
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHCHHEEE
ARSRRRVRVVPEAFPEQSVPEGKRAGYVVYLPGIVVALIVAGVSYYQTGNYQQVKIWQQA
ECCCCCEEECCHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEHHHHHH
TAQAPALLDRALDPKADPLNEEEMSRLALGMRTQLQKNPGDIEGWIMLGRVGMALGNASI
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHH
ATDAYATAYRLDPKNSDAALGYAEALTRSSDPNDNRLGGELLRQLVRTDHSNIRVLSMYA
HHHHHHHEEEECCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEHH
FNAFEQQRFGEAVAAWEMMLKLLPANDTRRAVIERSIAQAMQHLSPQESK
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure
MRFLLGVLMLMISGSALATIDVLQFKDEAQEQQFRQLTEELRCPKCQNNSIADSNSMIAT
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
DLRQKVYELMQEGKSKKEIVDYMVARYGNFVTYDPPLTPLTVLLWVLPVVAIGIGGWVIY
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHCHHEEE
ARSRRRVRVVPEAFPEQSVPEGKRAGYVVYLPGIVVALIVAGVSYYQTGNYQQVKIWQQA
ECCCCCEEECCHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEEEHHHHHH
TAQAPALLDRALDPKADPLNEEEMSRLALGMRTQLQKNPGDIEGWIMLGRVGMALGNASI
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHH
ATDAYATAYRLDPKNSDAALGYAEALTRSSDPNDNRLGGELLRQLVRTDHSNIRVLSMYA
HHHHHHHEEEECCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEHH
FNAFEQQRFGEAVAAWEMMLKLLPANDTRRAVIERSIAQAMQHLSPQESK
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9278503; 7635817