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The map label for this gene is ipaH_4

Identifier: 30063279

GI number: 30063279

Start: 1887119

End: 1888870

Strand: Direct

Name: ipaH_4

Synonym: S1947

Alternate gene names: 30063279

Gene position: 1887119-1888870 (Clockwise)

Preceding gene: 30063278

Following gene: 30063282

Centisome position: 41.03

GC content: 47.03

Gene sequence:

>1752_bases
ATGCTCCCGACAAATAACAATCACAGATTAATTTCAAATTCGTTCTCCACTTATTCAATCGACACTAGCCGCGCATATGA
AAATTATCTAACCCATTGGACTGAATGGAAAAATAACCGCATACAAGAAGAACAACGAGACATCGCTTTTCAGCGACTAG
TATCATGTCTACAAAACCAAGAGACGAACCTGGACTTGTCTGAATTAGGCCTGACAACATTACCTGAAATCCCCCCGGGA
ATTAAATCAATTAATATAAGTAAAAATAATTTAAGCTTAATCCCCCCATTGCCTGCGTCCCTTACACAACTTAATGTCAG
CTATAACAGACTTATTGAACTGCCTGCTTTGCCTCAAGGACTTAAATTATTGAATGCGTCCCACAATCAACTAATCACAC
TACCCACACTCCCCATATCTTTGAAGGAGCTTCATGTCTCAAATAATCAATTATGTTCTCTTCCTGTTTTACCAGAACTA
CTGGAAACATTAGATGTATCATGTAATGGGCTGGCAGTTTTACCACCTTTACCATTTTCTTTACAAGAGATTAGCGCAAT
AGGGAATCTTCTTAGTGAACTCCCCCCTCTACCTCACAACATTCACTCCATATGGGCAATCGACAATATGTTAACCGATA
TTCCATACCTGCCGGAAAATTTAAGGAACGGTTATTTTGACATAAATCAGATAAGTCATATCCCGGAAAGCATTCTTAAT
CTGAGGAATGAATGTTCAATAGATATTAGTGATAACCCATTGTCATCCCATGCTCTGCAATCCCTGCAAAGATTAACATC
TTCGCCGGACTACCACGGCCCGCAGATTTACTTCTCCATGAGTGACGGACAACAGAATACACTCCATCGCCCCCTGGCTG
ATGCCGTGACAGCATGGTTCCCGGAAAACAAACAATCTGATGTATCACAGATATGGCATGCTTTTGAACATGAAGAGCAC
GCCAACACCTTTTCCGCGTTCCTTGACCGCCTTTCCGATACCGTCTCTGCACGCAATACCTCCGGATTCCGTGAACAGGT
CGCTGCATGGCTGGAAAAACTCAGTGCCTCTGCGGAGCTTCGACAGCAGTCTTTCGCTGTTGCTGCTGATGCCACTGAAA
GCTGTGAGGACCGTGTCGCGCTCACATGGAACAATCTCCGGAAAACCCTCCTGGTCCATCAGGCATCTGAAGGCCTTTTC
GATAATGATACCGGCGCTCTGCTCTCCCTGGGCAGGGAAATGTTCCGCCTCGAAATTCTGGAGGACATTGCCCGGGATAA
AGTCAGAACTCTCCATTTTGTGGATGAGATAGAAGTCTACCTGGCCTTCCAGACCATGCTCGCAGAGAAACTTCAGCTCT
CCACTGCCGTGAAGGAAATGCGTTTCTATGGCGTGTCGGGAGTGACAGCAAATGACCTCCGCACTGCCGAAGCCATGGTC
AGAAGCCGTGAAGAGAATGAATTTACGGACTGGTTCTCCCTCTGGGGACCATGGCATGCTGTACTGAAGCGTACGGAAGC
TGACCGCTGGGCGCTGGCAGAAGAGCAGAAATATGAGATGCTGGAGAATGAGTACCCTCAGAGGGTGGCTGACCGGCTGA
AAGCATCAGGTCTGAGCGGTGATGCGGATGCGGAGAGGGAAGCCGGTGCACAGGTGATGCGTGAGACTGAACAGCAGATT
TACCGTCAGCTGACTGACGAGGTACTGGCCCTGCGATTGCCTGAAAACGGCTCACAACTGCACCATTCATAA

Upstream 100 bases:

>100_bases
CCAGAAGTTCCTGTCTACTGCTGAAGGGAACCAATAACATTGCAAAGCAGATAAAAAAGAATCCAACACCTCTCAACATA
AAGAATACGCCCTGATATTT

Downstream 100 bases:

>100_bases
TCACATCGCATAAACCACAGACCGGACTGACTCCGGAAAAACAGAGGCCCGCCCCCGGGCCTCCCCGGATTCATCCGTTT
CTCTGTTCAGCCTGACCGCA

Product: invasion plasmid antigen

Products: NA

Alternate protein names: Invasion plasmid antigen ipaH9.8 [H]

Number of amino acids: Translated: 583; Mature: 583

Protein sequence:

>583_residues
MLPTNNNHRLISNSFSTYSIDTSRAYENYLTHWTEWKNNRIQEEQRDIAFQRLVSCLQNQETNLDLSELGLTTLPEIPPG
IKSINISKNNLSLIPPLPASLTQLNVSYNRLIELPALPQGLKLLNASHNQLITLPTLPISLKELHVSNNQLCSLPVLPEL
LETLDVSCNGLAVLPPLPFSLQEISAIGNLLSELPPLPHNIHSIWAIDNMLTDIPYLPENLRNGYFDINQISHIPESILN
LRNECSIDISDNPLSSHALQSLQRLTSSPDYHGPQIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEH
ANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLF
DNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMV
RSREENEFTDWFSLWGPWHAVLKRTEADRWALAEEQKYEMLENEYPQRVADRLKASGLSGDADAEREAGAQVMRETEQQI
YRQLTDEVLALRLPENGSQLHHS

Sequences:

>Translated_583_residues
MLPTNNNHRLISNSFSTYSIDTSRAYENYLTHWTEWKNNRIQEEQRDIAFQRLVSCLQNQETNLDLSELGLTTLPEIPPG
IKSINISKNNLSLIPPLPASLTQLNVSYNRLIELPALPQGLKLLNASHNQLITLPTLPISLKELHVSNNQLCSLPVLPEL
LETLDVSCNGLAVLPPLPFSLQEISAIGNLLSELPPLPHNIHSIWAIDNMLTDIPYLPENLRNGYFDINQISHIPESILN
LRNECSIDISDNPLSSHALQSLQRLTSSPDYHGPQIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEH
ANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLF
DNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMV
RSREENEFTDWFSLWGPWHAVLKRTEADRWALAEEQKYEMLENEYPQRVADRLKASGLSGDADAEREAGAQVMRETEQQI
YRQLTDEVLALRLPENGSQLHHS
>Mature_583_residues
MLPTNNNHRLISNSFSTYSIDTSRAYENYLTHWTEWKNNRIQEEQRDIAFQRLVSCLQNQETNLDLSELGLTTLPEIPPG
IKSINISKNNLSLIPPLPASLTQLNVSYNRLIELPALPQGLKLLNASHNQLITLPTLPISLKELHVSNNQLCSLPVLPEL
LETLDVSCNGLAVLPPLPFSLQEISAIGNLLSELPPLPHNIHSIWAIDNMLTDIPYLPENLRNGYFDINQISHIPESILN
LRNECSIDISDNPLSSHALQSLQRLTSSPDYHGPQIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEH
ANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLF
DNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMV
RSREENEFTDWFSLWGPWHAVLKRTEADRWALAEEQKYEMLENEYPQRVADRLKASGLSGDADAEREAGAQVMRETEQQI
YRQLTDEVLALRLPENGSQLHHS

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute inflammatory responses, thus facilit

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted. Host cytoplasm (By similarity). Host nucleus (By similarity). Note=Secreted via Mxi- Spa type III secretion system (TTSS), and delivered into the host cytoplasm. Transported into the host nucleus (By similarity) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 8 LRR (leucine-rich) repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 66007; Mature: 66007

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPTNNNHRLISNSFSTYSIDTSRAYENYLTHWTEWKNNRIQEEQRDIAFQRLVSCLQNQ
CCCCCCCCEEEECCCCEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
ETNLDLSELGLTTLPEIPPGIKSINISKNNLSLIPPLPASLTQLNVSYNRLIELPALPQG
CCCCCHHHCCCCCCCCCCCCCCEEEECCCCCEECCCCCCHHHHCCCCHHHEEECCCCCHH
LKLLNASHNQLITLPTLPISLKELHVSNNQLCSLPVLPELLETLDVSCNGLAVLPPLPFS
HHHHCCCCCCEEEECCCCCCHHHHCCCCCCEECCCHHHHHHHHHCCCCCCEEECCCCCCC
LQEISAIGNLLSELPPLPHNIHSIWAIDNMLTDIPYLPENLRNGYFDINQISHIPESILN
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHC
LRNECSIDISDNPLSSHALQSLQRLTSSPDYHGPQIYFSMSDGQQNTLHRPLADAVTAWF
CHHCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHC
PENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAEL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEIL
HHHHHHHCCCCHHHHCCCEEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
EDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
RSREENEFTDWFSLWGPWHAVLKRTEADRWALAEEQKYEMLENEYPQRVADRLKASGLSG
HHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCC
DADAEREAGAQVMRETEQQIYRQLTDEVLALRLPENGSQLHHS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC
>Mature Secondary Structure
MLPTNNNHRLISNSFSTYSIDTSRAYENYLTHWTEWKNNRIQEEQRDIAFQRLVSCLQNQ
CCCCCCCCEEEECCCCEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
ETNLDLSELGLTTLPEIPPGIKSINISKNNLSLIPPLPASLTQLNVSYNRLIELPALPQG
CCCCCHHHCCCCCCCCCCCCCCEEEECCCCCEECCCCCCHHHHCCCCHHHEEECCCCCHH
LKLLNASHNQLITLPTLPISLKELHVSNNQLCSLPVLPELLETLDVSCNGLAVLPPLPFS
HHHHCCCCCCEEEECCCCCCHHHHCCCCCCEECCCHHHHHHHHHCCCCCCEEECCCCCCC
LQEISAIGNLLSELPPLPHNIHSIWAIDNMLTDIPYLPENLRNGYFDINQISHIPESILN
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHC
LRNECSIDISDNPLSSHALQSLQRLTSSPDYHGPQIYFSMSDGQQNTLHRPLADAVTAWF
CHHCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHC
PENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAEL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEIL
HHHHHHHCCCCHHHHCCCEEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
EDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
RSREENEFTDWFSLWGPWHAVLKRTEADRWALAEEQKYEMLENEYPQRVADRLKASGLSG
HHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCC
DADAEREAGAQVMRETEQQIYRQLTDEVLALRLPENGSQLHHS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA