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The map label for this gene is goaG

Identifier: 30062822

GI number: 30062822

Start: 1359562

End: 1360827

Strand: Direct

Name: goaG

Synonym: S1389

Alternate gene names: 30062822

Gene position: 1359562-1360827 (Clockwise)

Preceding gene: 30062821

Following gene: 30062824

Centisome position: 29.56

GC content: 57.19

Gene sequence:

>1266_bases
ATGAGCAACAATGAATTCCATCAGCGTCGTCTTTCTGCTACCCCACGCGGGGTTGGCGTGATGTGTAACTTCTTCGCCCA
GTCGGCAGAAAACGCTACGCTGAAGGACGTAGAGGGCAACGAATACATCGATTTCGCCGCAGGCATTGCGGTGCTGAATA
CCGGGCATCGCCACCCTGATCTGGTCGCGGCGGTGGAGCAGCAATTGCAACAGTTTACCCACACGGCGTATCAGATTGTG
CCGTACGAAAGCTACGTCACGCTGGCGGAGAAAATTAACACCCTTGCCCCAGTGAGCGGGCAGGCTAAAACCGCATTCTT
CACTACCGGCGCGGAAGCGGTGGAAAACGCGGTGAAAATTGCTCGCGCCCATACCGGACGACCTGGCGTGATTGCGTTTA
GCGGTGGCTTCCACGGTCGTACATATATGACCATGGCGCTGACCGGAAAAGTTGCGCCGTACAAAATCGGCTTCGGCCCG
TTCCCTGGTTCGGTGTATCACGTACCTTATCCGTCAGATTTACACGGCATTTCAACACAGGACTCCCTCGACGCCATCGA
ACGCTTGTTTAAATCAGACATCGAAGCGAAGCAGGTCGCGGCCATTATTTTCGAACCGGTGCAGGGCGAGTGCGGTTTCA
ACGTTGCGCCAAAAGAGCTGGTTGCCGCCATTCGCCGCCTGTGCGACGAGCACGGTATTGTGATGATTGCCGATGAAGTG
CAAAGCGGCTTTGCGCGTACCGGTAAACTGTTTGCCATGGATCATTACGCCGATAAGCCGGACTTAATGACGATGGCGAA
AAGCCTCGCGGGCGGGATGCCGCTTTCGGGCGTGGTCGGTAACGCGAATATTATGGACGCGCCCGCGCCGGGCGGGTTGG
GTGGCACCTACGCCGGGAACCCGCTGGCGGTGGCTGCCGCGCACGCGGTGCTCAATATTATCGACAAAGAATCACTCTGC
GAACGCGCGAATCAACTGGGCCAGCGTCTCAAAAACACGTTGATTGATGCCAAAGAAAGCGTTCCGGCCATTGCTGCGGT
ACGCGGCCTGGGGTCGATGATTGCGGCAGAGTTTAACGATCCGCAAACGGGCGAGCCGTCAGCGGCGATTGCACAGAAAA
TCCAGCAACGCGCGCTGGCGCAGGGGCTGCTCCTGCTGACCTGTGGCGCATACGGCAACGTGATTCGCTTCCTGTATCCG
CTGACCATCCCGGATGCGCAATTCGATGCGGCAATGAAAATTTTGCAGGATGCGCTGAGCGATTAA

Upstream 100 bases:

>100_bases
CGCGTGCCATTTACCGCGATGGGCGCGGCTTATTACAGCCTGCGCGATCGTCTGGGCGTTTAATTTCCGATTAACAGTGA
AGAGTCAAAAGGTGTGAAAC

Downstream 100 bases:

>100_bases
TAGCCCAACGCAATAATGTCTGATGCGCTGCGCTTATCAGGCCTGCAAACGACGTATTGATTATGTATGCCGAATAAAGC
ATTCACGCCGCATCCGGCAA

Product: 4-aminobutyrate transaminase

Products: NA

Alternate protein names: GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPDLVAAVEQQLQQFTHTAYQIV
PYESYVTLAEKINTLAPVSGQAKTAFFTTGAEAVENAVKIARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGP
FPGSVYHVPYPSDLHGISTQDSLDAIERLFKSDIEAKQVAAIIFEPVQGECGFNVAPKELVAAIRRLCDEHGIVMIADEV
QSGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGNPLAVAAAHAVLNIIDKESLC
ERANQLGQRLKNTLIDAKESVPAIAAVRGLGSMIAAEFNDPQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYP
LTIPDAQFDAAMKILQDALSD

Sequences:

>Translated_421_residues
MSNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPDLVAAVEQQLQQFTHTAYQIV
PYESYVTLAEKINTLAPVSGQAKTAFFTTGAEAVENAVKIARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGP
FPGSVYHVPYPSDLHGISTQDSLDAIERLFKSDIEAKQVAAIIFEPVQGECGFNVAPKELVAAIRRLCDEHGIVMIADEV
QSGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGNPLAVAAAHAVLNIIDKESLC
ERANQLGQRLKNTLIDAKESVPAIAAVRGLGSMIAAEFNDPQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYP
LTIPDAQFDAAMKILQDALSD
>Mature_420_residues
SNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPDLVAAVEQQLQQFTHTAYQIVP
YESYVTLAEKINTLAPVSGQAKTAFFTTGAEAVENAVKIARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGPF
PGSVYHVPYPSDLHGISTQDSLDAIERLFKSDIEAKQVAAIIFEPVQGECGFNVAPKELVAAIRRLCDEHGIVMIADEVQ
SGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGNPLAVAAAHAVLNIIDKESLCE
RANQLGQRLKNTLIDAKESVPAIAAVRGLGSMIAAEFNDPQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYPL
TIPDAQFDAAMKILQDALSD

Specific function: Involved in the breakdown of putrescine via transamination of gamma-aminobutyrate [H]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=400, Percent_Identity=32.5, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI284507298, Length=322, Percent_Identity=32.6086956521739, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI13994255, Length=417, Percent_Identity=29.9760191846523, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI37574042, Length=448, Percent_Identity=28.3482142857143, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI188536080, Length=445, Percent_Identity=28.0898876404494, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI38679950, Length=445, Percent_Identity=28.0898876404494, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI38679946, Length=445, Percent_Identity=28.0898876404494, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI24119277, Length=392, Percent_Identity=27.2959183673469, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI226442709, Length=389, Percent_Identity=29.305912596401, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI226442705, Length=448, Percent_Identity=27.9017857142857, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1787560, Length=421, Percent_Identity=99.2874109263658, Blast_Score=856, Evalue=0.0,
Organism=Escherichia coli, GI1789016, Length=421, Percent_Identity=54.6318289786223, Blast_Score=455, Evalue=1e-129,
Organism=Escherichia coli, GI1789759, Length=404, Percent_Identity=33.1683168316832, Blast_Score=214, Evalue=8e-57,
Organism=Escherichia coli, GI1788044, Length=390, Percent_Identity=34.3589743589744, Blast_Score=198, Evalue=6e-52,
Organism=Escherichia coli, GI145693181, Length=403, Percent_Identity=34.4913151364764, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1786349, Length=348, Percent_Identity=31.6091954022989, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1786991, Length=409, Percent_Identity=27.3838630806846, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI25144271, Length=407, Percent_Identity=32.9238329238329, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI32564660, Length=421, Percent_Identity=31.353919239905, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71992977, Length=424, Percent_Identity=29.4811320754717, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25144274, Length=295, Percent_Identity=32.5423728813559, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17541228, Length=426, Percent_Identity=25.3521126760563, Blast_Score=115, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6323470, Length=411, Percent_Identity=32.6034063260341, Blast_Score=189, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6324432, Length=406, Percent_Identity=31.0344827586207, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324386, Length=314, Percent_Identity=24.8407643312102, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321456, Length=372, Percent_Identity=26.3440860215054, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357415, Length=404, Percent_Identity=31.9306930693069, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI28574759, Length=419, Percent_Identity=29.5942720763723, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI161085790, Length=418, Percent_Identity=29.1866028708134, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI21356575, Length=430, Percent_Identity=28.1395348837209, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI281366494, Length=364, Percent_Identity=26.9230769230769, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24667139, Length=364, Percent_Identity=26.9230769230769, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24667143, Length=364, Percent_Identity=26.9230769230769, Blast_Score=108, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19 [H]

Molecular weight: Translated: 44778; Mature: 44646

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPD
CCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEECCCCCCEEHHHHHHHHCCCCCCCHH
LVAAVEQQLQQFTHTAYQIVPYESYVTLAEKINTLAPVSGQAKTAFFTTGAEAVENAVKI
HHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHH
ARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGPFPGSVYHVPYPSDLHGISTQ
HHHCCCCCCEEEECCCCCCCEEEEEEEECCCCCEEECCCCCCCCEEECCCCCCCCCCCCH
DSLDAIERLFKSDIEAKQVAAIIFEPVQGECGFNVAPKELVAAIRRLCDEHGIVMIADEV
HHHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEHHH
QSGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGN
HCCHHHCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCEECCCCEECCCCCCCCCCCCCCC
PLAVAAAHAVLNIIDKESLCERANQLGQRLKNTLIDAKESVPAIAAVRGLGSMIAAEFND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
PQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYPLTIPDAQFDAAMKILQDALS
CCCCCCHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
D
C
>Mature Secondary Structure 
SNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPD
CCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEECCCCCCEEHHHHHHHHCCCCCCCHH
LVAAVEQQLQQFTHTAYQIVPYESYVTLAEKINTLAPVSGQAKTAFFTTGAEAVENAVKI
HHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHH
ARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGPFPGSVYHVPYPSDLHGISTQ
HHHCCCCCCEEEECCCCCCCEEEEEEEECCCCCEEECCCCCCCCEEECCCCCCCCCCCCH
DSLDAIERLFKSDIEAKQVAAIIFEPVQGECGFNVAPKELVAAIRRLCDEHGIVMIADEV
HHHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEHHH
QSGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGN
HCCHHHCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCEECCCCEECCCCCCCCCCCCCCC
PLAVAAAHAVLNIIDKESLCERANQLGQRLKNTLIDAKESVPAIAAVRGLGSMIAAEFND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
PQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYPLTIPDAQFDAAMKILQDALS
CCCCCCHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]