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The map label for this gene is tdk

Identifier: 30062758

GI number: 30062758

Start: 1288459

End: 1289076

Strand: Direct

Name: tdk

Synonym: S1324

Alternate gene names: 30062758

Gene position: 1288459-1289076 (Clockwise)

Preceding gene: 30062756

Following gene: 30062761

Centisome position: 28.01

GC content: 42.39

Gene sequence:

>618_bases
ATGGCACAGCTATATTTCTACTATTCCGCAATGAATGCGGGTAAGTCTACAGCATTGTTGCAATCTTCATACAATTACCA
GGAACGCGGCATGCGCACTGTCGTATATACGGCAGAAATTGATGATCGCTTTGGTGCCGGGAAAGTCAGTTCGCGTATAG
GTTTGTCATCGCCTGCAAAATTATTTAACCAAAATTCATCATTATTTGATGAGATTCGTGCGGAACATGAACAGCAGGCA
ATTCATTGCGTACTGGTTGATGAATGCCAGTTTTTAACCAGACAACAAGTATATGAATTATCGGAGGTTGTCGATCAACT
CGATATACCCGTACTTTGTTATGGTTTACGTACCGATTTTCGAGGTGAATTATTTATTGGCAGCCAATACTTACTGGCAT
GGTCCGACAAACTGGTTGAATTAAAAACCATCTGTTTTTGTGGCCGTAAAGCAAGCATGGTGCTGCGTCTTGATCAAGCA
GGCAGACCTTATAACGAAGGTGAGCAGGTGGTAATTGGTGGTAATGAACGATACGTTTCTGTATGCCGTAAACACTATAA
AGAGGCGTTACAAGTCGGCTCATTAACGGCTATTCAGGAAAGGCATCGCCACGATTAA

Upstream 100 bases:

>100_bases
CGCATATACCCACTTCTGTGCATACTGTTGAGCTGAAAAACTGACGAATTATGATAAACTCCAGCCAACTTTATTTCATA
TCATTGAGGGCCTGTGGCTG

Downstream 100 bases:

>100_bases
TAAGAATTTCTTTACTGACAGGGTGAGCAGGGCACTTTTATCCTGTCAGTTCGTTTTACGCACTTCTTCCGGGCTATATA
CCCTTCTCAGCAGTTTTTTA

Product: thymidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MAQLYFYYSAMNAGKSTALLQSSYNYQERGMRTVVYTAEIDDRFGAGKVSSRIGLSSPAKLFNQNSSLFDEIRAEHEQQA
IHCVLVDECQFLTRQQVYELSEVVDQLDIPVLCYGLRTDFRGELFIGSQYLLAWSDKLVELKTICFCGRKASMVLRLDQA
GRPYNEGEQVVIGGNERYVSVCRKHYKEALQVGSLTAIQERHRHD

Sequences:

>Translated_205_residues
MAQLYFYYSAMNAGKSTALLQSSYNYQERGMRTVVYTAEIDDRFGAGKVSSRIGLSSPAKLFNQNSSLFDEIRAEHEQQA
IHCVLVDECQFLTRQQVYELSEVVDQLDIPVLCYGLRTDFRGELFIGSQYLLAWSDKLVELKTICFCGRKASMVLRLDQA
GRPYNEGEQVVIGGNERYVSVCRKHYKEALQVGSLTAIQERHRHD
>Mature_204_residues
AQLYFYYSAMNAGKSTALLQSSYNYQERGMRTVVYTAEIDDRFGAGKVSSRIGLSSPAKLFNQNSSLFDEIRAEHEQQAI
HCVLVDECQFLTRQQVYELSEVVDQLDIPVLCYGLRTDFRGELFIGSQYLLAWSDKLVELKTICFCGRKASMVLRLDQAG
RPYNEGEQVVIGGNERYVSVCRKHYKEALQVGSLTAIQERHRHD

Specific function: Phosphorylates both thymidine and deoxyuridine

COG id: COG1435

COG function: function code F; Thymidine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine kinase family

Homologues:

Organism=Escherichia coli, GI1787490, Length=205, Percent_Identity=99.5121951219512, Blast_Score=423, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KITH_ECO57 (P0A3L9)

Other databases:

- EMBL:   AB008676
- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   C85704
- PIR:   D90846
- RefSeq:   NP_287483.1
- RefSeq:   NP_309767.1
- ProteinModelPortal:   P0A3L9
- SMR:   P0A3L9
- EnsemblBacteria:   EBESCT00000027024
- EnsemblBacteria:   EBESCT00000058048
- GeneID:   913112
- GeneID:   960490
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z2015
- KEGG:   ecs:ECs1740
- GeneTree:   EBGT00050000011281
- HOGENOM:   HBG522108
- OMA:   FRYGAMN
- ProtClustDB:   PRK04296
- BioCyc:   ECOL83334:ECS1740-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00124
- InterPro:   IPR001267
- InterPro:   IPR020633
- InterPro:   IPR020634
- PANTHER:   PTHR11441
- PIRSF:   PIRSF035805

Pfam domain/function: PF00265 TK

EC number: =2.7.1.21

Molecular weight: Translated: 23399; Mature: 23268

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00603 TK_CELLULAR_TYPE

Important sites: ACT_SITE 88-88

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQLYFYYSAMNAGKSTALLQSSYNYQERGMRTVVYTAEIDDRFGAGKVSSRIGLSSPAK
CCEEEEEEEECCCCCHHHHHHCCCCHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHH
LFNQNSSLFDEIRAEHEQQAIHCVLVDECQFLTRQQVYELSEVVDQLDIPVLCYGLRTDF
HHCCCCHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
RGELFIGSQYLLAWSDKLVELKTICFCGRKASMVLRLDQAGRPYNEGEQVVIGGNERYVS
CCEEEECCEEEEEHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEECCCHHHHH
VCRKHYKEALQVGSLTAIQERHRHD
HHHHHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure 
AQLYFYYSAMNAGKSTALLQSSYNYQERGMRTVVYTAEIDDRFGAGKVSSRIGLSSPAK
CEEEEEEEECCCCCHHHHHHCCCCHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHH
LFNQNSSLFDEIRAEHEQQAIHCVLVDECQFLTRQQVYELSEVVDQLDIPVLCYGLRTDF
HHCCCCHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
RGELFIGSQYLLAWSDKLVELKTICFCGRKASMVLRLDQAGRPYNEGEQVVIGGNERYVS
CCEEEECCEEEEEHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEECCCHHHHH
VCRKHYKEALQVGSLTAIQERHRHD
HHHHHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10222209; 11206551; 11258796