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The map label for this gene is dxs

Identifier: 30061914

GI number: 30061914

Start: 366822

End: 368684

Strand: Reverse

Name: dxs

Synonym: S0365

Alternate gene names: 30061914

Gene position: 368684-366822 (Counterclockwise)

Preceding gene: 30061915

Following gene: 161486536

Centisome position: 8.02

GC content: 53.89

Gene sequence:

>1863_bases
ATGAGTTTTGATATTGCCAAATACCCGACCCTGGCACTGGTCGACTCCACCCAGGAGTTACGACTGTTGCCGAAAGAGAG
TTTACCGAAACTCTGCGACGAACTGCGCCGCTATTTACTCGACAGCGTGAGCCGTTCCAGCGGGCACTTCGCCTCCGGGC
TGGGCACGGTCGAACTGACCGTGGCGCTGCACTATGTCTACAACACCCCATTTGACCAATTGATTTGGGATGTGGGACAT
CAGGCTTATCCGCATAAAATTTTGACCGGACGCCGCGACAAAATCGGCACCATCCGTCAGAAAGGCGGTCTGCACCCGTT
CCCGTGGCGCGGCGAAAGCGAATATGACGTATTAAGCGTCGGGCATTCATCAACCTCCATCAGTGCCGGAATTGGTATTG
CGGTTGCTGCCGAGAAAGAAGGCAAAAATCGCCGCACCGTCTGTGTGATTGGCGACGGCGCGATTACCGCTGGCATGGCG
TTTGAAGCGATGAATCACGCGGGCGATATTCGTCCTGATATGCTGGTGGTCCTCAACGACAATGAAATGTCGATTTCCGA
AAATGTTGGCGCGCTTAACAACCATCTGGCTCAGCTGCTTTCCGGTAAGCTTTACTCTTCACTGCGCGAAGGCGGGAAAA
AAGTTTTCTCTGGCGTGCCGCCCATTAAAGAGCTGCTCAAACGTACCGAAGAACATATTAAAGGCATGGTGGTGCCTGGC
ACGTTGTTTGAAGAGCTGGGATTTAACTACATCGGCCCGGTGGACGGTCACGATGTGCTGGGGCTTATCACCACGCTAAA
GAACATGCGCGACCTGAAAGGCCCGCAGTTCCTGCATATCATGACCAAAAAAGGTCGTGGTTATGAACCGGCAGAAAAAG
ACCCGATCACTTTCCACGCCGTGCCTAAATTTGATCCCTCCAGCGGTTGTTTGCCGAAAAGTAGCGGCGGTTTGCCGAGC
TATTCAAAAATCTTTGGCGACTGGTTGTGCGAAACGGCAGCGAAAGACAACAAGCTGATGGCGATTACTCCGGCGATGCG
TGAAGGTTCCGGCATGGTCGAGTTTTCACGTAAATTCCCGGATCGTTACTTCGACGTGGCTATTGCCGAGCAACACGCAG
TGACCTTTGCCGCCGGTCTGGCGATTGGTGGATACAAACCCATTGTCGCGATCTACTCCACCTTCCTGCAACGCGCCTAT
GATCAGGTGCTGCATGACGTGGCAATTCAAAAGCTACCGGTCCTGTTCGCCATTGACCGCGCGGGCATTGTTGGTGCTGA
CGGTCAAACTCACCAGGGCGCTTTTGATCTCTCTTACCTGCGCTGCATACCAGAAATGGTCATTATGACCCCGAGCGATG
AAAACGAATGTCGCCAGATGCTCTATACCGGCTATCACTATAACGATGGCCCGTCCGCGGTGCGCTACCCGCGCGGCAAC
GCGGTTGGCGTGGAACTGACGCCGCTGGAAAAACTACCAATTGGCAAAGGCATTGTGAAGCGTCGTGGCGAGAAACTGGT
GATCCTTAACTTTGGTACGCTGATGCCAGAAACGGCCAAAGTCGCCGAATCGCTGAACGCTACGCTGGTCGATATGCGTT
TTGTGAAACCACTTGATGAAGCGTTAATTCTGGAAATGGCCGCCAGCCATGAAGCGCTGGTCACCGTAGAAGAAAACGCC
ATTATGGGCGGCGCAGGTAGCGGAGTGAACGAAGTGCTGATGGCCCATCGTAAACCAGTACCCGTGCTGAACATTGGCCT
GCCGGACTTCTTTATTCCGCAAGGAACTCAGGAAGAAATGCGCGCCGAACTCGGCCTCGATGCCGCCGGTATGGAAGCCA
AAATCAAGGCCTGGCTGGCATAA

Upstream 100 bases:

>100_bases
ACAACTGGCTGAACAGTCACTCGATACCTCGGCACTGGAAGCGCTAGCGGACTACATCATCCAGCGTAATAAATAAACAA
TAAGTATTAATAGGCCCCTG

Downstream 100 bases:

>100_bases
TCCCTACTCCACTCCTGCTATGCTTAAGAAATTATTCATGGCAGGAGTGGCAGCATGCAATACAACCCCTTAGGAAAAAC
CGACCTTCGCGTTTCCCGAC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 620; Mature: 619

Protein sequence:

>620_residues
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGH
QAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMA
FEAMNHAGDIRPDMLVVLNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
TLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPS
YSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAY
DQVLHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGN
AVGVELTPLEKLPIGKGIVKRRGEKLVILNFGTLMPETAKVAESLNATLVDMRFVKPLDEALILEMAASHEALVTVEENA
IMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEMRAELGLDAAGMEAKIKAWLA

Sequences:

>Translated_620_residues
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGH
QAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMA
FEAMNHAGDIRPDMLVVLNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
TLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPS
YSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAY
DQVLHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGN
AVGVELTPLEKLPIGKGIVKRRGEKLVILNFGTLMPETAKVAESLNATLVDMRFVKPLDEALILEMAASHEALVTVEENA
IMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEMRAELGLDAAGMEAKIKAWLA
>Mature_619_residues
SFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGHQ
AYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAF
EAMNHAGDIRPDMLVVLNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGT
LFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPSY
SKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAYD
QVLHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGNA
VGVELTPLEKLPIGKGIVKRRGEKLVILNFGTLMPETAKVAESLNATLVDMRFVKPLDEALILEMAASHEALVTVEENAI
MGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEMRAELGLDAAGMEAKIKAWLA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=496, Percent_Identity=22.7822580645161, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI4507521, Length=496, Percent_Identity=22.7822580645161, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI225637463, Length=546, Percent_Identity=23.0769230769231, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI225637461, Length=546, Percent_Identity=23.0769230769231, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI225637459, Length=546, Percent_Identity=23.0769230769231, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI133778974, Length=497, Percent_Identity=23.943661971831, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1786622, Length=620, Percent_Identity=99.5161290322581, Blast_Score=1272, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=508, Percent_Identity=25.3937007874016, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24645119, Length=531, Percent_Identity=24.2937853107345, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45551847, Length=632, Percent_Identity=23.8924050632911, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45550715, Length=632, Percent_Identity=23.8924050632911, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24666278, Length=487, Percent_Identity=24.0246406570842, Blast_Score=84, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67662; Mature: 67531

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELT
CCCCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
VALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSV
EEEEEHHCCCHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEE
GHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVVLND
CCCCCEECCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
CCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEE
VPKFDPSSGCLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCHHHHHCC
DRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAYDQVLHDVAIQKLPVLFAIDR
CHHHEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
AGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGN
CCEECCCCCCCCCCHHHHHHHHCCHHEEECCCCHHHHHHHHHCCCCCCCCCCCEECCCCC
AVGVELTPLEKLPIGKGIVKRRGEKLVILNFGTLMPETAKVAESLNATLVDMRFVKPLDE
EEEEEECCHHHCCCCCHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCEEEHHHHHHHHHH
ALILEMAASHEALVTVEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEM
HHHHHHHCCCCEEEEEECCEEECCCCCCHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHH
RAELGLDAAGMEAKIKAWLA
HHHHCCCCCCCCHHHHEECC
>Mature Secondary Structure 
SFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELT
CCCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
VALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSV
EEEEEHHCCCHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEE
GHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVVLND
CCCCCEECCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
CCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEE
VPKFDPSSGCLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCHHHHHCC
DRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAYDQVLHDVAIQKLPVLFAIDR
CHHHEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
AGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGN
CCEECCCCCCCCCCHHHHHHHHCCHHEEECCCCHHHHHHHHHCCCCCCCCCCCEECCCCC
AVGVELTPLEKLPIGKGIVKRRGEKLVILNFGTLMPETAKVAESLNATLVDMRFVKPLDE
EEEEEECCHHHCCCCCHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCEEEHHHHHHHHHH
ALILEMAASHEALVTVEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEM
HHHHHHHCCCCEEEEEECCEEECCCCCCHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHH
RAELGLDAAGMEAKIKAWLA
HHHHCCCCCCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA