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The map label for this gene is serS [H]

Identifier: 29349720

GI number: 29349720

Start: 5682813

End: 5684087

Strand: Reverse

Name: serS [H]

Synonym: BT_4312

Alternate gene names: 29349720

Gene position: 5684087-5682813 (Counterclockwise)

Preceding gene: 29349721

Following gene: 29349719

Centisome position: 90.79

GC content: 46.67

Gene sequence:

>1275_bases
ATGCTTACCATTAAACAAATTACAGAAAATACAGAAGCGGTACTCCGCGGACTGGAAAAAAAGCATTTCAAGAATGCAAA
AGAGACGATTGACGAAGTCATCGCCCTCAACGACAAGAGACGTACTACGCAAAACCTATTAGATAAGAACCTGGCAGAGG
TTAATTCACTTTCCCGCACGATCGGTCAGCTGATGAAAGAAGGAAAGAAAGAAGAAGCCGAAGCTGCACGTGCACGTGTT
GCCGAACTGAAAGAAAGCAACAAAGCGCTGGACGCTACCATGACACAGGCTGCTACAGACATGCAGAATGTACTTTATAC
GATCCCCAACATTCCTTATGACAGCGTACCCGAAGGCGTAGGTGCCGAAGACAATGTCGTAGAAAAGATGGGAGGCATGG
AAACAGAACTTCCCAAAGATGCACTGCCTCACTGGGAACTGGCTAAAAAATACGATTTAATCGATTTCGACCTAGGTGTA
AAGATTACAGGTGCAGGCTTCCCCGTATACAAAGGAAAAGGTGCCCAACTGCAACGTGCCCTGATCAACTTCTTCCTGGA
CGAAGCACGCAAATCCGGATATACTGAAATCATGCCGCCGACAGTAGTCAATGCCGCTTCAGGTTATGGTACAGGCCAGC
TTCCCGACAAAGAAGGACAGATGTATCATTGCGAAGTAGATGATCTCTATCTGATCCCGACAGCCGAAGTACCTGTCACT
AACATCTACCGTGATGTTATCCTGGAAGAAAAACAGTTGCCGATTATGAACTGTGCATACACACAATGTTTCCGTCGCGA
AGCCGGTTCTTACGGTAAAGACGTACGCGGGCTGAACCGTCTGCACGAATTCTCCAAAGTAGAATTAGTGCGTATCGACA
AGCCGGAACATTCTAAAGAATCCCACCAGCAAATGCTTGACCACGTAGAAGGCCTGTTGCAGAAACTGGAACTTCCATAC
CGTATACTCCGCCTTTGTGGTGGTGATATGAGCTTTACTGCTGCGCTTTGTTTCGACTTCGAAGTATACTCCGAAGCACA
GAAACGCTGGCTGGAAGTAAGTTCCGTATCTAACTTCGACACTTACCAGGCCAACCGGCTGAAATGCCGCTACCGTAGTG
CAGAAAAGAAAACAGAACTCTGCCATACGTTAAATGGATCAGCACTGGCACTACCACGTATCGTCGCCGCTTTATTGGAA
AACAATCAAACCCCCGAAGGAATTAGAATTCCTAAAGCATTGGTTCCATACTGCGGTTTCGACATGATAGACTAA

Upstream 100 bases:

>100_bases
GCTTCTCCTTTCTTTTTTTATGCAGATTTTCATTGCTCGCTTATTCGTTTTTTCTTTATCTTTGTAGCCTTAATAAAGAA
AGTTCATAAAAAGTATAGAT

Downstream 100 bases:

>100_bases
GAAACTTTCTACTCCTGTAAGGATGAGATATCTCTGCCCCTTACAGGAGTTTCCTTTATTAACCTTTAACACATTTACCC
CCATGACAAAAAACACAAAA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MLTIKQITENTEAVLRGLEKKHFKNAKETIDEVIALNDKRRTTQNLLDKNLAEVNSLSRTIGQLMKEGKKEEAEAARARV
AELKESNKALDATMTQAATDMQNVLYTIPNIPYDSVPEGVGAEDNVVEKMGGMETELPKDALPHWELAKKYDLIDFDLGV
KITGAGFPVYKGKGAQLQRALINFFLDEARKSGYTEIMPPTVVNAASGYGTGQLPDKEGQMYHCEVDDLYLIPTAEVPVT
NIYRDVILEEKQLPIMNCAYTQCFRREAGSYGKDVRGLNRLHEFSKVELVRIDKPEHSKESHQQMLDHVEGLLQKLELPY
RILRLCGGDMSFTAALCFDFEVYSEAQKRWLEVSSVSNFDTYQANRLKCRYRSAEKKTELCHTLNGSALALPRIVAALLE
NNQTPEGIRIPKALVPYCGFDMID

Sequences:

>Translated_424_residues
MLTIKQITENTEAVLRGLEKKHFKNAKETIDEVIALNDKRRTTQNLLDKNLAEVNSLSRTIGQLMKEGKKEEAEAARARV
AELKESNKALDATMTQAATDMQNVLYTIPNIPYDSVPEGVGAEDNVVEKMGGMETELPKDALPHWELAKKYDLIDFDLGV
KITGAGFPVYKGKGAQLQRALINFFLDEARKSGYTEIMPPTVVNAASGYGTGQLPDKEGQMYHCEVDDLYLIPTAEVPVT
NIYRDVILEEKQLPIMNCAYTQCFRREAGSYGKDVRGLNRLHEFSKVELVRIDKPEHSKESHQQMLDHVEGLLQKLELPY
RILRLCGGDMSFTAALCFDFEVYSEAQKRWLEVSSVSNFDTYQANRLKCRYRSAEKKTELCHTLNGSALALPRIVAALLE
NNQTPEGIRIPKALVPYCGFDMID
>Mature_424_residues
MLTIKQITENTEAVLRGLEKKHFKNAKETIDEVIALNDKRRTTQNLLDKNLAEVNSLSRTIGQLMKEGKKEEAEAARARV
AELKESNKALDATMTQAATDMQNVLYTIPNIPYDSVPEGVGAEDNVVEKMGGMETELPKDALPHWELAKKYDLIDFDLGV
KITGAGFPVYKGKGAQLQRALINFFLDEARKSGYTEIMPPTVVNAASGYGTGQLPDKEGQMYHCEVDDLYLIPTAEVPVT
NIYRDVILEEKQLPIMNCAYTQCFRREAGSYGKDVRGLNRLHEFSKVELVRIDKPEHSKESHQQMLDHVEGLLQKLELPY
RILRLCGGDMSFTAALCFDFEVYSEAQKRWLEVSSVSNFDTYQANRLKCRYRSAEKKTELCHTLNGSALALPRIVAALLE
NNQTPEGIRIPKALVPYCGFDMID

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=445, Percent_Identity=29.2134831460674, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI8923421, Length=323, Percent_Identity=30.030959752322, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI225579074, Length=323, Percent_Identity=30.030959752322, Blast_Score=145, Evalue=8e-35,
Organism=Escherichia coli, GI1787120, Length=427, Percent_Identity=40.9836065573771, Blast_Score=296, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17539260, Length=445, Percent_Identity=28.9887640449438, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17542084, Length=365, Percent_Identity=26.8493150684932, Blast_Score=115, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6320226, Length=438, Percent_Identity=31.5068493150685, Blast_Score=186, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6321799, Length=425, Percent_Identity=27.7647058823529, Blast_Score=163, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24581334, Length=449, Percent_Identity=27.6169265033408, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI17737985, Length=278, Percent_Identity=30.5755395683453, Blast_Score=122, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47732; Mature: 47732

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTIKQITENTEAVLRGLEKKHFKNAKETIDEVIALNDKRRTTQNLLDKNLAEVNSLSRT
CCCHHHHHCHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
IGQLMKEGKKEEAEAARARVAELKESNKALDATMTQAATDMQNVLYTIPNIPYDSVPEGV
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GAEDNVVEKMGGMETELPKDALPHWELAKKYDLIDFDLGVKITGAGFPVYKGKGAQLQRA
CCCHHHHHHHCCCCCCCCHHCCCCHHHHHHCCCEEECCCEEEECCCCCCCCCCCHHHHHH
LINFFLDEARKSGYTEIMPPTVVNAASGYGTGQLPDKEGQMYHCEVDDLYLIPTAEVPVT
HHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCHH
NIYRDVILEEKQLPIMNCAYTQCFRREAGSYGKDVRGLNRLHEFSKVELVRIDKPEHSKE
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEECCCCCCHH
SHQQMLDHVEGLLQKLELPYRILRLCGGDMSFTAALCFDFEVYSEAQKRWLEVSSVSNFD
HHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TYQANRLKCRYRSAEKKTELCHTLNGSALALPRIVAALLENNQTPEGIRIPKALVPYCGF
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCC
DMID
CCCC
>Mature Secondary Structure
MLTIKQITENTEAVLRGLEKKHFKNAKETIDEVIALNDKRRTTQNLLDKNLAEVNSLSRT
CCCHHHHHCHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
IGQLMKEGKKEEAEAARARVAELKESNKALDATMTQAATDMQNVLYTIPNIPYDSVPEGV
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GAEDNVVEKMGGMETELPKDALPHWELAKKYDLIDFDLGVKITGAGFPVYKGKGAQLQRA
CCCHHHHHHHCCCCCCCCHHCCCCHHHHHHCCCEEECCCEEEECCCCCCCCCCCHHHHHH
LINFFLDEARKSGYTEIMPPTVVNAASGYGTGQLPDKEGQMYHCEVDDLYLIPTAEVPVT
HHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCHH
NIYRDVILEEKQLPIMNCAYTQCFRREAGSYGKDVRGLNRLHEFSKVELVRIDKPEHSKE
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEECCCCCCHH
SHQQMLDHVEGLLQKLELPYRILRLCGGDMSFTAALCFDFEVYSEAQKRWLEVSSVSNFD
HHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TYQANRLKCRYRSAEKKTELCHTLNGSALALPRIVAALLENNQTPEGIRIPKALVPYCGF
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCC
DMID
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA