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The map label for this gene is aroE [H]

Identifier: 29349623

GI number: 29349623

Start: 5552093

End: 5552839

Strand: Reverse

Name: aroE [H]

Synonym: BT_4215

Alternate gene names: 29349623

Gene position: 5552839-5552093 (Counterclockwise)

Preceding gene: 29349624

Following gene: 29349622

Centisome position: 88.7

GC content: 43.64

Gene sequence:

>747_bases
ATGGAAAAATACGGTTTAATCGGCTACCCCTTGCGACATTCGTTTTCAATCGGCTACTTTAACGAAAAGTTTAGGTCCGA
AGGCATCAATGCGGAATATGTGAATTTCGAGATTCCCAATATCAATGATTTTATGGAAGTTATTGAAGAGAATCCCAACT
TGTGCGGGCTCAATGTCACCATCCCCTACAAAGAGCAAGTGATTCCTTTTCTGAACGAACTCGATCGGGATACAGCTAAA
ATTGGCGCTGTAAACGTCATTAAGATTATCCGCCAACCGAAAGGAAAAGTAAAACTGGTCGGCTACAATTCCGACATCAT
CGGTTTTACACAATCTATTCAGCCGCTGCTACAACCTCAGCACAAAAAAGCACTGATCCTCGGCACCGGAGGTGCTTCCA
AAGCTGTTTATCACGGACTCAAGAATCTGGGTATCGAAAGCGTGTTTGTATCGCGGACACACAAGACCGACGATATGCTG
ACTTACGAAGAACTGACTCCGGAAATCATGGAGGAATACACCGTAATCGTCAACTGTACTCCGGTAGGAATGTACCCCAA
AGTAGATTTCTGCCCCAACATTCCTTACGAACTGCTCACTCCAAACCATTTGCTTTACGATTTGTTATATAATCCGAACG
TCACTCTTTTCATGAAAAAGGGAGAAGCACAAGGTGCTGTTACGAAAAACGGTTTGGAAATGCTACTTTTACAGGCATTT
GCCGCTTGGGAAATATGGCACCGATAA

Upstream 100 bases:

>100_bases
GCGAAGTTCATTTCCGACGGTTGACATTTGGTATCTGCACACTTTATACAGCGACAAAATAATGAAGAATGATGAATAAT
TAATTTAATCCTTTCGTGTC

Downstream 100 bases:

>100_bases
GATAAAGGTGCTGACAGCCGTTTTCTGATAGAGTTAAGAATATGGGCGTGATATTTTAATTGAGGGGATTTATTATGAAG
AAAAGAGCAGTCTACAGCAT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MEKYGLIGYPLRHSFSIGYFNEKFRSEGINAEYVNFEIPNINDFMEVIEENPNLCGLNVTIPYKEQVIPFLNELDRDTAK
IGAVNVIKIIRQPKGKVKLVGYNSDIIGFTQSIQPLLQPQHKKALILGTGGASKAVYHGLKNLGIESVFVSRTHKTDDML
TYEELTPEIMEEYTVIVNCTPVGMYPKVDFCPNIPYELLTPNHLLYDLLYNPNVTLFMKKGEAQGAVTKNGLEMLLLQAF
AAWEIWHR

Sequences:

>Translated_248_residues
MEKYGLIGYPLRHSFSIGYFNEKFRSEGINAEYVNFEIPNINDFMEVIEENPNLCGLNVTIPYKEQVIPFLNELDRDTAK
IGAVNVIKIIRQPKGKVKLVGYNSDIIGFTQSIQPLLQPQHKKALILGTGGASKAVYHGLKNLGIESVFVSRTHKTDDML
TYEELTPEIMEEYTVIVNCTPVGMYPKVDFCPNIPYELLTPNHLLYDLLYNPNVTLFMKKGEAQGAVTKNGLEMLLLQAF
AAWEIWHR
>Mature_248_residues
MEKYGLIGYPLRHSFSIGYFNEKFRSEGINAEYVNFEIPNINDFMEVIEENPNLCGLNVTIPYKEQVIPFLNELDRDTAK
IGAVNVIKIIRQPKGKVKLVGYNSDIIGFTQSIQPLLQPQHKKALILGTGGASKAVYHGLKNLGIESVFVSRTHKTDDML
TYEELTPEIMEEYTVIVNCTPVGMYPKVDFCPNIPYELLTPNHLLYDLLYNPNVTLFMKKGEAQGAVTKNGLEMLLLQAF
AAWEIWHR

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789675, Length=268, Percent_Identity=29.8507462686567, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1787983, Length=269, Percent_Identity=27.8810408921933, Blast_Score=88, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320332, Length=268, Percent_Identity=27.2388059701493, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 28160; Mature: 28160

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKYGLIGYPLRHSFSIGYFNEKFRSEGINAEYVNFEIPNINDFMEVIEENPNLCGLNVT
CCCCCCCCCCHHHEEEECCCHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCEEEEEEE
IPYKEQVIPFLNELDRDTAKIGAVNVIKIIRQPKGKVKLVGYNSDIIGFTQSIQPLLQPQ
CCCHHHHHHHHHHHCCHHHHHCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCC
HKKALILGTGGASKAVYHGLKNLGIESVFVSRTHKTDDMLTYEELTPEIMEEYTVIVNCT
CCCEEEEECCCCHHHHHHHHHHCCHHEEEEECCCCCCCCEEHHHCCHHHHHCEEEEEEEE
PVGMYPKVDFCPNIPYELLTPNHLLYDLLYNPNVTLFMKKGEAQGAVTKNGLEMLLLQAF
CCCCCCCCCCCCCCCHHHCCCCCEEEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHH
AAWEIWHR
HHHHHHCC
>Mature Secondary Structure
MEKYGLIGYPLRHSFSIGYFNEKFRSEGINAEYVNFEIPNINDFMEVIEENPNLCGLNVT
CCCCCCCCCCHHHEEEECCCHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCEEEEEEE
IPYKEQVIPFLNELDRDTAKIGAVNVIKIIRQPKGKVKLVGYNSDIIGFTQSIQPLLQPQ
CCCHHHHHHHHHHHCCHHHHHCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCC
HKKALILGTGGASKAVYHGLKNLGIESVFVSRTHKTDDMLTYEELTPEIMEEYTVIVNCT
CCCEEEEECCCCHHHHHHHHHHCCHHEEEEECCCCCCCCEEHHHCCHHHHHCEEEEEEEE
PVGMYPKVDFCPNIPYELLTPNHLLYDLLYNPNVTLFMKKGEAQGAVTKNGLEMLLLQAF
CCCCCCCCCCCCCCCHHHCCCCCEEEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHH
AAWEIWHR
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA