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The map label for this gene is ptpA [H]

Identifier: 29349601

GI number: 29349601

Start: 5527974

End: 5530184

Strand: Reverse

Name: ptpA [H]

Synonym: BT_4193

Alternate gene names: 29349601

Gene position: 5530184-5527974 (Counterclockwise)

Preceding gene: 29349605

Following gene: 29349600

Centisome position: 88.34

GC content: 46.49

Gene sequence:

>2211_bases
ATGAGAAAAGTAAGTTTAGCCCTGCTCCTCTGCCTTCTCTGCCTCGCCGGAATGGCACAAGGACAAAAGGCACTTGATTT
AAAAGATATTACCTCCGGACGCTTCCGCCCGGAAAATATTCAGGGAGTCATCCCCACACCAGATGGAGAGCACTACACAC
AAATGAACGCCGATGGTACGCAAATCATCAAATACTCATTCCGCACAGGAGAAAAGGTAGAGGTGATCTTTGACGTGAAC
CAGGCACGCGAATGTGACTTCAAGAATTTCGACAGCTATCAGTTCTCACCCGATGGTGACAAATTACTGATCGCTACCAA
AACGACCCCGATATACCGGCATTCATACACAGCTGTGCATTATATATACCCTTTGAAACGAAATGATAAGGGAGTTACGA
CAAACAACATTATTGAACGGCTGTCCGACGGCGGACCTCAACAGGTCCCCGTCTTTTCTCCAGACGGAACGATGATCGCT
TTCGTGCGTGACAATAATATATTTCTCGTAAAGCTGCTCTACGGTAACAGCGAAAGCCAGGTGACCGAAGATGGCAAGCA
AAATATGGTTCTCAACGGTATCCCCGACTGGGTATATGAGGAAGAGTTCGGTTTCAACCGCGCCCTGGAGTTCAGTGCCG
ATAATACCATGATTGCTTTCATCCGCTTCGACGAGTCGGAAGTTCCTTCCTATTCTTTTCCGATGTTCGCGGGAGAAGCA
CCGCAGATTACTCCTTTGAAAGATTATCCGGGAGAATACACCTACAAGTATCCGAAAGCCGGATACCCGAACTCGAAAGT
AGAAGTACGTACGTACGACATCAAATCGCACGTGACCCGCACCATGAAGCTTCCGATAGATGCAGACGGATATATCCCCC
GCATCCGCTTCACGAAAGATGCCAGCAAACTTGCCGTTATGACATTGAACCGCCATCAGGATCGTTTCGACCTTTATTTT
GCCGATCCGCGCTCAACGCTCTGCAAGTTAGTGTTGCGTGATGAGTCACCTTATTATATTAAGGAGAACGTGTTCGATAA
TATCAAGTTCTATCCGGAAACTTTCAGTTTGCTTAGCGAACGTGACGGTTTCAGCCATCTTTACTGGTACAGCATGGGGG
GAAACCTTATCAAGAAAGTAACCAATGGCAAATATGAAGTGAAGGATTTTCTGGGTTATGACGCAACAGACGGCTCTTTC
TATTATACCAGCAATGAGGAAAGCCCCTTGCGTAAAGCAGTCTACAAGATTGATAAGAAAGGCAAAAAGACAAAGTTGTC
TCAACGTGAAGGAACCAATACGCCGTTATTCAGCAAATCGATGAAGTATTATATGAACAAATTCTCGAATCTGGATACTC
CTATGCTAGTTACGCTGAATGACAACACAGGCAAAACCTTAAAAACGCTTATCACCAACGACCAGTTGAAACAAACGTTA
GCCGGCTATGCTATCCCGCAAAAAGAGTTCTTTACCTTCCAGACTACGGACGGGGTAACTTTGAATGGATGGATGATGAA
GCCTGTCAACTTCTCCGCATCCAAGAAATATCCGGTGCTGATGTACCAGTATAGCGGTCCGGGGTCACAACAAGTTCTGG
ATACTTGGGGAATCAGCTGGGAGACTTACATGGCCAGCCTCGGCTATATCGTTGTATGTGTAGACGGTCGTGGTACAGGA
GGCCGCGGAGAAGCGTTCGAGAAGTGCACTTATCTCAAAATCGGCGTGAAAGAAGCCAAAGACCAGGTCGAAACAGCTCT
CTATTTAGGCAAACAGCCGTATGTGGATAAAGACCGTATCGGTATCTGGGGATGGAGCTATGGCGGATACATGACATTGA
TGAGTATGAGCGAAGGAACTCCGGTATTCAAAGCCGGTGTAGCTGTTGCCGCACCTACGGACTGGCGTTTCTACGACACT
ATATATACAGAACGTTTCATGCGCACCCCGAAAGAAAACGCAGAAGGATACAAAGAATCATCCGCTTTCACACGGGCTGA
CAAACTGCACGGCAATCTGTTGCTGGTACATGGTATGGCAGACGATAATGTTCACTTCCAGAACTGTGCAGAATATGCCG
AGCATCTGGTGCAGTTGGGTAAACAATTTGATATGCAAGTATATACCAATCGTAATCATGGCATATACGGCGGCAACACC
CGTCAGCATCTATATACACGATTGACCAACTTCTTCCTGAACAATTTGTAA

Upstream 100 bases:

>100_bases
CAAAAACAGGATGTACTTTGAGGTATTTAAGTTTATTGTTATTTTTGCAGGGTATGAACTTAACCCCCTTAAACAAGTAA
AATATAAAACGATTTATAAA

Downstream 100 bases:

>100_bases
TGGCTGACAGAGTGCGCAAGCCTGAATGGCTGAAAATAAATATCGGTGCCAACGACCGTTACACCGAAACTAAAAGAATT
GTCGACTCCCACTGCCTGCA

Product: dipeptidyl peptidase IV

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 736; Mature: 736

Protein sequence:

>736_residues
MRKVSLALLLCLLCLAGMAQGQKALDLKDITSGRFRPENIQGVIPTPDGEHYTQMNADGTQIIKYSFRTGEKVEVIFDVN
QARECDFKNFDSYQFSPDGDKLLIATKTTPIYRHSYTAVHYIYPLKRNDKGVTTNNIIERLSDGGPQQVPVFSPDGTMIA
FVRDNNIFLVKLLYGNSESQVTEDGKQNMVLNGIPDWVYEEEFGFNRALEFSADNTMIAFIRFDESEVPSYSFPMFAGEA
PQITPLKDYPGEYTYKYPKAGYPNSKVEVRTYDIKSHVTRTMKLPIDADGYIPRIRFTKDASKLAVMTLNRHQDRFDLYF
ADPRSTLCKLVLRDESPYYIKENVFDNIKFYPETFSLLSERDGFSHLYWYSMGGNLIKKVTNGKYEVKDFLGYDATDGSF
YYTSNEESPLRKAVYKIDKKGKKTKLSQREGTNTPLFSKSMKYYMNKFSNLDTPMLVTLNDNTGKTLKTLITNDQLKQTL
AGYAIPQKEFFTFQTTDGVTLNGWMMKPVNFSASKKYPVLMYQYSGPGSQQVLDTWGISWETYMASLGYIVVCVDGRGTG
GRGEAFEKCTYLKIGVKEAKDQVETALYLGKQPYVDKDRIGIWGWSYGGYMTLMSMSEGTPVFKAGVAVAAPTDWRFYDT
IYTERFMRTPKENAEGYKESSAFTRADKLHGNLLLVHGMADDNVHFQNCAEYAEHLVQLGKQFDMQVYTNRNHGIYGGNT
RQHLYTRLTNFFLNNL

Sequences:

>Translated_736_residues
MRKVSLALLLCLLCLAGMAQGQKALDLKDITSGRFRPENIQGVIPTPDGEHYTQMNADGTQIIKYSFRTGEKVEVIFDVN
QARECDFKNFDSYQFSPDGDKLLIATKTTPIYRHSYTAVHYIYPLKRNDKGVTTNNIIERLSDGGPQQVPVFSPDGTMIA
FVRDNNIFLVKLLYGNSESQVTEDGKQNMVLNGIPDWVYEEEFGFNRALEFSADNTMIAFIRFDESEVPSYSFPMFAGEA
PQITPLKDYPGEYTYKYPKAGYPNSKVEVRTYDIKSHVTRTMKLPIDADGYIPRIRFTKDASKLAVMTLNRHQDRFDLYF
ADPRSTLCKLVLRDESPYYIKENVFDNIKFYPETFSLLSERDGFSHLYWYSMGGNLIKKVTNGKYEVKDFLGYDATDGSF
YYTSNEESPLRKAVYKIDKKGKKTKLSQREGTNTPLFSKSMKYYMNKFSNLDTPMLVTLNDNTGKTLKTLITNDQLKQTL
AGYAIPQKEFFTFQTTDGVTLNGWMMKPVNFSASKKYPVLMYQYSGPGSQQVLDTWGISWETYMASLGYIVVCVDGRGTG
GRGEAFEKCTYLKIGVKEAKDQVETALYLGKQPYVDKDRIGIWGWSYGGYMTLMSMSEGTPVFKAGVAVAAPTDWRFYDT
IYTERFMRTPKENAEGYKESSAFTRADKLHGNLLLVHGMADDNVHFQNCAEYAEHLVQLGKQFDMQVYTNRNHGIYGGNT
RQHLYTRLTNFFLNNL
>Mature_736_residues
MRKVSLALLLCLLCLAGMAQGQKALDLKDITSGRFRPENIQGVIPTPDGEHYTQMNADGTQIIKYSFRTGEKVEVIFDVN
QARECDFKNFDSYQFSPDGDKLLIATKTTPIYRHSYTAVHYIYPLKRNDKGVTTNNIIERLSDGGPQQVPVFSPDGTMIA
FVRDNNIFLVKLLYGNSESQVTEDGKQNMVLNGIPDWVYEEEFGFNRALEFSADNTMIAFIRFDESEVPSYSFPMFAGEA
PQITPLKDYPGEYTYKYPKAGYPNSKVEVRTYDIKSHVTRTMKLPIDADGYIPRIRFTKDASKLAVMTLNRHQDRFDLYF
ADPRSTLCKLVLRDESPYYIKENVFDNIKFYPETFSLLSERDGFSHLYWYSMGGNLIKKVTNGKYEVKDFLGYDATDGSF
YYTSNEESPLRKAVYKIDKKGKKTKLSQREGTNTPLFSKSMKYYMNKFSNLDTPMLVTLNDNTGKTLKTLITNDQLKQTL
AGYAIPQKEFFTFQTTDGVTLNGWMMKPVNFSASKKYPVLMYQYSGPGSQQVLDTWGISWETYMASLGYIVVCVDGRGTG
GRGEAFEKCTYLKIGVKEAKDQVETALYLGKQPYVDKDRIGIWGWSYGGYMTLMSMSEGTPVFKAGVAVAAPTDWRFYDT
IYTERFMRTPKENAEGYKESSAFTRADKLHGNLLLVHGMADDNVHFQNCAEYAEHLVQLGKQFDMQVYTNRNHGIYGGNT
RQHLYTRLTNFFLNNL

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI16933540, Length=772, Percent_Identity=31.6062176165803, Blast_Score=335, Evalue=8e-92,
Organism=Homo sapiens, GI18765694, Length=691, Percent_Identity=32.7062228654124, Blast_Score=309, Evalue=5e-84,
Organism=Homo sapiens, GI86792778, Length=668, Percent_Identity=27.6946107784431, Blast_Score=263, Evalue=6e-70,
Organism=Homo sapiens, GI86792863, Length=668, Percent_Identity=27.6946107784431, Blast_Score=263, Evalue=6e-70,
Organism=Homo sapiens, GI86792774, Length=668, Percent_Identity=27.6946107784431, Blast_Score=263, Evalue=6e-70,
Organism=Homo sapiens, GI295842359, Length=677, Percent_Identity=26.8833087149188, Blast_Score=242, Evalue=8e-64,
Organism=Homo sapiens, GI52426756, Length=677, Percent_Identity=26.8833087149188, Blast_Score=242, Evalue=8e-64,
Organism=Homo sapiens, GI295842403, Length=677, Percent_Identity=26.8833087149188, Blast_Score=242, Evalue=8e-64,
Organism=Homo sapiens, GI85787627, Length=677, Percent_Identity=27.178729689808, Blast_Score=242, Evalue=1e-63,
Organism=Homo sapiens, GI295849272, Length=677, Percent_Identity=26.8833087149188, Blast_Score=242, Evalue=1e-63,
Organism=Homo sapiens, GI18450280, Length=712, Percent_Identity=29.0730337078652, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI37577089, Length=712, Percent_Identity=29.0730337078652, Blast_Score=230, Evalue=5e-60,
Organism=Homo sapiens, GI194394146, Length=559, Percent_Identity=27.906976744186, Blast_Score=191, Evalue=3e-48,
Organism=Homo sapiens, GI37577091, Length=711, Percent_Identity=26.1603375527426, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI18450278, Length=496, Percent_Identity=24.7983870967742, Blast_Score=85, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17508017, Length=251, Percent_Identity=36.6533864541833, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17508019, Length=251, Percent_Identity=36.6533864541833, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17550672, Length=684, Percent_Identity=24.1228070175439, Blast_Score=163, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17564634, Length=612, Percent_Identity=23.6928104575163, Blast_Score=149, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17564632, Length=612, Percent_Identity=23.6928104575163, Blast_Score=148, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17552908, Length=258, Percent_Identity=27.1317829457364, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321817, Length=692, Percent_Identity=31.6473988439306, Blast_Score=293, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6324793, Length=678, Percent_Identity=27.2861356932153, Blast_Score=228, Evalue=2e-60,
Organism=Drosophila melanogaster, GI17933704, Length=768, Percent_Identity=29.1666666666667, Blast_Score=275, Evalue=8e-74,
Organism=Drosophila melanogaster, GI221331178, Length=768, Percent_Identity=29.1666666666667, Blast_Score=274, Evalue=2e-73,
Organism=Drosophila melanogaster, GI161083744, Length=768, Percent_Identity=29.1666666666667, Blast_Score=273, Evalue=3e-73,
Organism=Drosophila melanogaster, GI24582032, Length=672, Percent_Identity=30.5059523809524, Blast_Score=259, Evalue=5e-69,
Organism=Drosophila melanogaster, GI45550825, Length=705, Percent_Identity=26.0992907801418, Blast_Score=198, Evalue=1e-50,
Organism=Drosophila melanogaster, GI45553511, Length=705, Percent_Identity=26.0992907801418, Blast_Score=198, Evalue=1e-50,
Organism=Drosophila melanogaster, GI45551969, Length=705, Percent_Identity=26.0992907801418, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24582257, Length=273, Percent_Identity=36.2637362637363, Blast_Score=185, Evalue=1e-46,
Organism=Drosophila melanogaster, GI45551475, Length=694, Percent_Identity=23.6311239193084, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI221372263, Length=694, Percent_Identity=23.6311239193084, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI221372266, Length=694, Percent_Identity=23.6311239193084, Blast_Score=164, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 84034; Mature: 84034

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKVSLALLLCLLCLAGMAQGQKALDLKDITSGRFRPENIQGVIPTPDGEHYTQMNADGT
CCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCEEECCCCCCCEEEECCCCC
QIIKYSFRTGEKVEVIFDVNQARECDFKNFDSYQFSPDGDKLLIATKTTPIYRHSYTAVH
EEEEEEECCCCEEEEEEECCCCCCCCCCCCCCEEECCCCCEEEEEECCCCEEECCCEEEE
YIYPLKRNDKGVTTNNIIERLSDGGPQQVPVFSPDGTMIAFVRDNNIFLVKLLYGNSESQ
EEEEEECCCCCCCHHHHHHHHHCCCCCCCEEECCCCCEEEEEECCCEEEEEEEECCCCCC
VTEDGKQNMVLNGIPDWVYEEEFGFNRALEFSADNTMIAFIRFDESEVPSYSFPMFAGEA
CCCCCCCCEEEECCCCHHCCCCCCCCEEEEECCCCEEEEEEEECCCCCCCCCCCEECCCC
PQITPLKDYPGEYTYKYPKAGYPNSKVEVRTYDIKSHVTRTMKLPIDADGYIPRIRFTKD
CCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEEHHHHCEEEEECCCCCCCCCCEEEEECC
ASKLAVMTLNRHQDRFDLYFADPRSTLCKLVLRDESPYYIKENVFDNIKFYPETFSLLSE
CCEEEEEEECCCCCEEEEEEECCHHHHEEEEEECCCCEEEECCCCCCCEECHHHHHHHHC
RDGFSHLYWYSMGGNLIKKVTNGKYEVKDFLGYDATDGSFYYTSNEESPLRKAVYKIDKK
CCCCCEEEEEECCCHHHHHHCCCCEEEHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHCC
GKKTKLSQREGTNTPLFSKSMKYYMNKFSNLDTPMLVTLNDNTGKTLKTLITNDQLKQTL
CCCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHCCHHHHHHH
AGYAIPQKEFFTFQTTDGVTLNGWMMKPVNFSASKKYPVLMYQYSGPGSQQVLDTWGISW
HHCCCCCHHEEEEECCCCEEECCEEECCCCCCCCCCCCEEEEEECCCCCCHHHHHCCCCH
ETYMASLGYIVVCVDGRGTGGRGEAFEKCTYLKIGVKEAKDQVETALYLGKQPYVDKDRI
HHHHHCCCEEEEEEECCCCCCCCCHHHCEEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCE
GIWGWSYGGYMTLMSMSEGTPVFKAGVAVAAPTDWRFYDTIYTERFMRTPKENAEGYKES
EEEEECCCCEEEEEECCCCCCEEECCEEEECCCCCCHHHHHHHHHHHCCCCHHCCCCHHH
SAFTRADKLHGNLLLVHGMADDNVHFQNCAEYAEHLVQLGKQFDMQVYTNRNHGIYGGNT
HHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCH
RQHLYTRLTNFFLNNL
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKVSLALLLCLLCLAGMAQGQKALDLKDITSGRFRPENIQGVIPTPDGEHYTQMNADGT
CCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCEEECCCCCCCEEEECCCCC
QIIKYSFRTGEKVEVIFDVNQARECDFKNFDSYQFSPDGDKLLIATKTTPIYRHSYTAVH
EEEEEEECCCCEEEEEEECCCCCCCCCCCCCCEEECCCCCEEEEEECCCCEEECCCEEEE
YIYPLKRNDKGVTTNNIIERLSDGGPQQVPVFSPDGTMIAFVRDNNIFLVKLLYGNSESQ
EEEEEECCCCCCCHHHHHHHHHCCCCCCCEEECCCCCEEEEEECCCEEEEEEEECCCCCC
VTEDGKQNMVLNGIPDWVYEEEFGFNRALEFSADNTMIAFIRFDESEVPSYSFPMFAGEA
CCCCCCCCEEEECCCCHHCCCCCCCCEEEEECCCCEEEEEEEECCCCCCCCCCCEECCCC
PQITPLKDYPGEYTYKYPKAGYPNSKVEVRTYDIKSHVTRTMKLPIDADGYIPRIRFTKD
CCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEEHHHHCEEEEECCCCCCCCCCEEEEECC
ASKLAVMTLNRHQDRFDLYFADPRSTLCKLVLRDESPYYIKENVFDNIKFYPETFSLLSE
CCEEEEEEECCCCCEEEEEEECCHHHHEEEEEECCCCEEEECCCCCCCEECHHHHHHHHC
RDGFSHLYWYSMGGNLIKKVTNGKYEVKDFLGYDATDGSFYYTSNEESPLRKAVYKIDKK
CCCCCEEEEEECCCHHHHHHCCCCEEEHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHCC
GKKTKLSQREGTNTPLFSKSMKYYMNKFSNLDTPMLVTLNDNTGKTLKTLITNDQLKQTL
CCCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHCCHHHHHHH
AGYAIPQKEFFTFQTTDGVTLNGWMMKPVNFSASKKYPVLMYQYSGPGSQQVLDTWGISW
HHCCCCCHHEEEEECCCCEEECCEEECCCCCCCCCCCCEEEEEECCCCCCHHHHHCCCCH
ETYMASLGYIVVCVDGRGTGGRGEAFEKCTYLKIGVKEAKDQVETALYLGKQPYVDKDRI
HHHHHCCCEEEEEEECCCCCCCCCHHHCEEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCE
GIWGWSYGGYMTLMSMSEGTPVFKAGVAVAAPTDWRFYDTIYTERFMRTPKENAEGYKES
EEEEECCCCEEEEEECCCCCCEEECCEEEECCCCCCHHHHHHHHHHHCCCCHHCCCCHHH
SAFTRADKLHGNLLLVHGMADDNVHFQNCAEYAEHLVQLGKQFDMQVYTNRNHGIYGGNT
HHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCH
RQHLYTRLTNFFLNNL
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA