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The map label for this gene is dxs

Identifier: 29349507

GI number: 29349507

Start: 5356034

End: 5357977

Strand: Reverse

Name: dxs

Synonym: BT_4099

Alternate gene names: 29349507

Gene position: 5357977-5356034 (Counterclockwise)

Preceding gene: 29349513

Following gene: 29349506

Centisome position: 85.59

GC content: 51.54

Gene sequence:

>1944_bases
ATGAAGAATGAACCGATATATAACTTGCTAAACTCAATCAACAGCCCCGATGATCTGCGCCGTCTGGAAGTAGACCAACT
GCCGGAAGTATGCGATGAATTAAGGCAAGACATTATTAAAGAACTCTCCTGCAATCCGGGGCACTTCGCTGCCAGCCTCG
GAACAGTGGAACTGACCGTAGCCCTGCACTACGTCTACAATACACCTTATGACCGTATTGTATGGGACGTGGGACATCAG
GCGTACGGCCACAAAATCCTCACAGGACGGCGTGAAGCATTCTCCACCAACCGGAAACTGGGAGGTATTCGCCCCTTCCC
TTCTCCCGAAGAGAGCGAATACGATACATTTACCTGCGGACACGCTTCCAATTCGATCTCCGCAGCCCTCGGCATGGCTG
TCGCCGCCGCCAAGAAGGGAGACGACCAACGTCATGTGATAGCCATCATCGGAGACGGTTCGATGAGCGGAGGACTGGCT
TTTGAAGGATTGAACAATTCTTCTACCACCCCGAACAACCTGCTTATTATCCTGAATGATAACGACATGGCTATCGACCG
CAGTGTCGGCGGTATGAAACAATACCTGTTCAACCTGACAACCTCGAACCGCTACAACCAACTGCGTTTCAAGGCTTCCC
GCCTGTTGTTCAAGCTCGGCATCCTGAACGATGAACGTCGCAAGGCACTGATCCGCTTCGGCAACAGTCTGAAGTCAATG
GCCGCCCAGCAACAGAATATATTCGAAGGAATGAACATCCGCTACTTCGGTCCTATCGATGGCCATGACATAAAGAACCT
TTCAAGGGTATTGCGTGACATTAAAGACCTCAAAGGTCCCAAAATACTGCATCTCCACACGATCAAAGGAAAAGGCTTCG
CCCCTGCCGAGAAACACGCCACCGAATGGCACGCTCCCGGCAAGTTCGATCCCGTCACCGGAGAGCGTTTCGTAGCCAAT
ACGGAAGGAATGCCTCCCCTGTTCCAAGACGTTTTCGGAAATACACTGGTGGAACTGGCGGAAGCCAATCCAAGGATCGT
AGGTGTGACTCCCGCCATGCCTTCCGGCTGTTCGATGAACATCCTCATGTCCAAAATGCCCAAGCGGGCTTTCGATGTGG
GTATTGCCGAAGGCCACGCCGTCACCTTCTCCGGAGGAATGGCAAAAGATGGCTTGCAGCCTTTCTGCAACATCTATTCA
TCGTTCATGCAACGGGCTTATGACAATATTATCCATGATGTGGCTATTCAGAATCTTCCCGTAGTTCTCTGTCTCGACCG
TGCCGGACTGGTAGGCGAAGACGGTCCGACACATCACGGTGCGTTCGACATGGCTTATCTGCGTCCGATACCTAATCTGA
CCATCGCCTCCCCTATGAATGAGCATGAGCTGCGACGACTGATGTACACGGCACAACTGCCGGATAAAGGTCCGTTCGTA
CTCCGCTATCCGCGTGGCCGTGGCGTATTGGTGGACTGGAAATGCCCGCTTGAAGAAATTCCTGTAGGCAAAGGACGGAA
ATTGAAGGACGGAAAAGATATAGCTGTCATCAGCATAGGACCTATCGGAAATAAAGCAAGGAGTGCCATCGCCCGTGCCG
AGTCCGAATCGGGAAGAAGCATCGCCCACTATGATCTGAGATTCCTCAAACCGCTGGACGAAGAACTGCTGCACGAAGTG
GGCCGCACATTCCGCCACATCGTCACCATAGAAGACGGAACGATTCAGGGAGGAATGGGAAGTGCCGTACTTGAATTCAT
GGCCGACCATGAATATACCCCGACAGTCAAACGCATCGGAATTCCGGATAAATTCGTGCAACACGGCACGGTAGCCGAGT
TATATCAGCTCTGCGGAATGGATGAAGACAGCCTGACAAAAGAATTGCTGAAGCAATGTGAACTTCTGCCCGACATGAGC
AAAATAAAAGAATTAACTAACTGA

Upstream 100 bases:

>100_bases
CCATTCCACCCTCGTACTTCGCTTTAACAATAAGAATTTAGGTAAAAAGAAAGGGCTTCCGCTTTCTTTTTCGTATTTTT
GCACCAAATTTTCTCGAATC

Downstream 100 bases:

>100_bases
AGATGAAGATAATTATCGCAGGTGCCGGAAACGTAGGCACCCACCTGGCTAAATTATTGTCCCGGGAAAAACAGGACATT
ATCCTGATGGACGATGACGA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 647; Mature: 647

Protein sequence:

>647_residues
MKNEPIYNLLNSINSPDDLRRLEVDQLPEVCDELRQDIIKELSCNPGHFAASLGTVELTVALHYVYNTPYDRIVWDVGHQ
AYGHKILTGRREAFSTNRKLGGIRPFPSPEESEYDTFTCGHASNSISAALGMAVAAAKKGDDQRHVIAIIGDGSMSGGLA
FEGLNNSSTTPNNLLIILNDNDMAIDRSVGGMKQYLFNLTTSNRYNQLRFKASRLLFKLGILNDERRKALIRFGNSLKSM
AAQQQNIFEGMNIRYFGPIDGHDIKNLSRVLRDIKDLKGPKILHLHTIKGKGFAPAEKHATEWHAPGKFDPVTGERFVAN
TEGMPPLFQDVFGNTLVELAEANPRIVGVTPAMPSGCSMNILMSKMPKRAFDVGIAEGHAVTFSGGMAKDGLQPFCNIYS
SFMQRAYDNIIHDVAIQNLPVVLCLDRAGLVGEDGPTHHGAFDMAYLRPIPNLTIASPMNEHELRRLMYTAQLPDKGPFV
LRYPRGRGVLVDWKCPLEEIPVGKGRKLKDGKDIAVISIGPIGNKARSAIARAESESGRSIAHYDLRFLKPLDEELLHEV
GRTFRHIVTIEDGTIQGGMGSAVLEFMADHEYTPTVKRIGIPDKFVQHGTVAELYQLCGMDEDSLTKELLKQCELLPDMS
KIKELTN

Sequences:

>Translated_647_residues
MKNEPIYNLLNSINSPDDLRRLEVDQLPEVCDELRQDIIKELSCNPGHFAASLGTVELTVALHYVYNTPYDRIVWDVGHQ
AYGHKILTGRREAFSTNRKLGGIRPFPSPEESEYDTFTCGHASNSISAALGMAVAAAKKGDDQRHVIAIIGDGSMSGGLA
FEGLNNSSTTPNNLLIILNDNDMAIDRSVGGMKQYLFNLTTSNRYNQLRFKASRLLFKLGILNDERRKALIRFGNSLKSM
AAQQQNIFEGMNIRYFGPIDGHDIKNLSRVLRDIKDLKGPKILHLHTIKGKGFAPAEKHATEWHAPGKFDPVTGERFVAN
TEGMPPLFQDVFGNTLVELAEANPRIVGVTPAMPSGCSMNILMSKMPKRAFDVGIAEGHAVTFSGGMAKDGLQPFCNIYS
SFMQRAYDNIIHDVAIQNLPVVLCLDRAGLVGEDGPTHHGAFDMAYLRPIPNLTIASPMNEHELRRLMYTAQLPDKGPFV
LRYPRGRGVLVDWKCPLEEIPVGKGRKLKDGKDIAVISIGPIGNKARSAIARAESESGRSIAHYDLRFLKPLDEELLHEV
GRTFRHIVTIEDGTIQGGMGSAVLEFMADHEYTPTVKRIGIPDKFVQHGTVAELYQLCGMDEDSLTKELLKQCELLPDMS
KIKELTN
>Mature_647_residues
MKNEPIYNLLNSINSPDDLRRLEVDQLPEVCDELRQDIIKELSCNPGHFAASLGTVELTVALHYVYNTPYDRIVWDVGHQ
AYGHKILTGRREAFSTNRKLGGIRPFPSPEESEYDTFTCGHASNSISAALGMAVAAAKKGDDQRHVIAIIGDGSMSGGLA
FEGLNNSSTTPNNLLIILNDNDMAIDRSVGGMKQYLFNLTTSNRYNQLRFKASRLLFKLGILNDERRKALIRFGNSLKSM
AAQQQNIFEGMNIRYFGPIDGHDIKNLSRVLRDIKDLKGPKILHLHTIKGKGFAPAEKHATEWHAPGKFDPVTGERFVAN
TEGMPPLFQDVFGNTLVELAEANPRIVGVTPAMPSGCSMNILMSKMPKRAFDVGIAEGHAVTFSGGMAKDGLQPFCNIYS
SFMQRAYDNIIHDVAIQNLPVVLCLDRAGLVGEDGPTHHGAFDMAYLRPIPNLTIASPMNEHELRRLMYTAQLPDKGPFV
LRYPRGRGVLVDWKCPLEEIPVGKGRKLKDGKDIAVISIGPIGNKARSAIARAESESGRSIAHYDLRFLKPLDEELLHEV
GRTFRHIVTIEDGTIQGGMGSAVLEFMADHEYTPTVKRIGIPDKFVQHGTVAELYQLCGMDEDSLTKELLKQCELLPDMS
KIKELTN

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=683, Percent_Identity=22.2547584187408, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI4507521, Length=683, Percent_Identity=22.2547584187408, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI225637463, Length=371, Percent_Identity=26.4150943396226, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI225637461, Length=371, Percent_Identity=26.4150943396226, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI225637459, Length=371, Percent_Identity=26.4150943396226, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI133778974, Length=428, Percent_Identity=24.5327102803738, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1786622, Length=623, Percent_Identity=43.338683788122, Blast_Score=530, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17539652, Length=652, Percent_Identity=22.8527607361963, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24666278, Length=617, Percent_Identity=24.4732576985413, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI45551847, Length=401, Percent_Identity=26.1845386533666, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45550715, Length=401, Percent_Identity=26.1845386533666, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24645119, Length=401, Percent_Identity=26.1845386533666, Blast_Score=89, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_BACTN (Q8A0C2)

Other databases:

- EMBL:   AE015928
- RefSeq:   NP_813010.1
- ProteinModelPortal:   Q8A0C2
- SMR:   Q8A0C2
- GeneID:   1074692
- GenomeReviews:   AE015928_GR
- KEGG:   bth:BT_4099
- NMPDR:   fig|226186.1.peg.4097
- HOGENOM:   HBG571647
- OMA:   ILITIEE
- PhylomeDB:   Q8A0C2
- ProtClustDB:   PRK05444
- BioCyc:   BTHE226186:BT_4099-MONOMER
- BRENDA:   2.2.1.7
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 71646; Mature: 71646

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNEPIYNLLNSINSPDDLRRLEVDQLPEVCDELRQDIIKELSCNPGHFAASLGTVELTV
CCCCHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCEEEEEE
ALHYVYNTPYDRIVWDVGHQAYGHKILTGRREAFSTNRKLGGIRPFPSPEESEYDTFTCG
EEEEECCCCHHHHHHHCCCHHHCCHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEC
HASNSISAALGMAVAAAKKGDDQRHVIAIIGDGSMSGGLAFEGLNNSSTTPNNLLIILND
CCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCCEEEEECC
NDMAIDRSVGGMKQYLFNLTTSNRYNQLRFKASRLLFKLGILNDERRKALIRFGNSLKSM
CCEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AAQQQNIFEGMNIRYFGPIDGHDIKNLSRVLRDIKDLKGPKILHLHTIKGKGFAPAEKHA
HHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHCC
TEWHAPGKFDPVTGERFVANTEGMPPLFQDVFGNTLVELAEANPRIVGVTPAMPSGCSMN
CCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHH
ILMSKMPKRAFDVGIAEGHAVTFSGGMAKDGLQPFCNIYSSFMQRAYDNIIHDVAIQNLP
HHHHHCCHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VVLCLDRAGLVGEDGPTHHGAFDMAYLRPIPNLTIASPMNEHELRRLMYTAQLPDKGPFV
EEEEECCCCCCCCCCCCCCCCCCHHHHCCCCCCEEECCCCHHHHHHHHHHHCCCCCCCEE
LRYPRGRGVLVDWKCPLEEIPVGKGRKLKDGKDIAVISIGPIGNKARSAIARAESESGRS
EECCCCCCEEEECCCCHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCE
IAHYDLRFLKPLDEELLHEVGRTFRHIVTIEDGTIQGGMGSAVLEFMADHEYTPTVKRIG
EEEHHHHHHCCHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCHHCCC
IPDKFVQHGTVAELYQLCGMDEDSLTKELLKQCELLPDMSKIKELTN
CCHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHCC
>Mature Secondary Structure
MKNEPIYNLLNSINSPDDLRRLEVDQLPEVCDELRQDIIKELSCNPGHFAASLGTVELTV
CCCCHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCEEEEEE
ALHYVYNTPYDRIVWDVGHQAYGHKILTGRREAFSTNRKLGGIRPFPSPEESEYDTFTCG
EEEEECCCCHHHHHHHCCCHHHCCHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEC
HASNSISAALGMAVAAAKKGDDQRHVIAIIGDGSMSGGLAFEGLNNSSTTPNNLLIILND
CCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCCEEEEECC
NDMAIDRSVGGMKQYLFNLTTSNRYNQLRFKASRLLFKLGILNDERRKALIRFGNSLKSM
CCEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AAQQQNIFEGMNIRYFGPIDGHDIKNLSRVLRDIKDLKGPKILHLHTIKGKGFAPAEKHA
HHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHCC
TEWHAPGKFDPVTGERFVANTEGMPPLFQDVFGNTLVELAEANPRIVGVTPAMPSGCSMN
CCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHH
ILMSKMPKRAFDVGIAEGHAVTFSGGMAKDGLQPFCNIYSSFMQRAYDNIIHDVAIQNLP
HHHHHCCHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VVLCLDRAGLVGEDGPTHHGAFDMAYLRPIPNLTIASPMNEHELRRLMYTAQLPDKGPFV
EEEEECCCCCCCCCCCCCCCCCCHHHHCCCCCCEEECCCCHHHHHHHHHHHCCCCCCCEE
LRYPRGRGVLVDWKCPLEEIPVGKGRKLKDGKDIAVISIGPIGNKARSAIARAESESGRS
EECCCCCCEEEECCCCHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCE
IAHYDLRFLKPLDEELLHEVGRTFRHIVTIEDGTIQGGMGSAVLEFMADHEYTPTVKRIG
EEEHHHHHHCCHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCHHCCC
IPDKFVQHGTVAELYQLCGMDEDSLTKELLKQCELLPDMSKIKELTN
CCHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928