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The map label for this gene is fbp [H]

Identifier: 29144714

GI number: 29144714

Start: 4617493

End: 4618491

Strand: Reverse

Name: fbp [H]

Synonym: t4469

Alternate gene names: 29144714

Gene position: 4618491-4617493 (Counterclockwise)

Preceding gene: 29144716

Following gene: 29144713

Centisome position: 96.38

GC content: 53.05

Gene sequence:

>999_bases
ATGAAAACGTTAGGTGAATTTATTGTCGAAAAGCAGCACGAGTTCTCTCAGGCTACCGGTGAGCTCACTGCTTTGCTGTC
GGCAATAAAATTGGGCGCCAAGATCATCCACCGCGATATCAACAAGGCCGGTCTGGTCGATATCCTGGGTGCCAGCTGTG
CTGAGAACGTACAGGGCGAGGTTCAGCAGAAACTCGATCTGTTCGCGAACGAGAAACTGAAAGCTGCACTAAAAGCGCGC
GATATTGTAGCGGGCATCGCATCGGAAGAAGAGGACGAAATTGTCGTCTTTGAAGGCTGCGAACACGCGAAATATGTGGT
GCTGATGGACCCTCTGGATGGCTCTTCTAACATCGACGTTAACGTCTCTGTCGGTACGATTTTCTCGATTTATCGCCGCG
TGACGCCCGTCGGCACGCCGGTCACCGAAGAAGATTTCCTGCAACCCGGCAACAAACAGGTCGCTGCGGGATATGTCGTG
TATGGCTCGTCCACCATGCTGATTTACACCACCGGCTGCGGCGTACACGCTTTCACCTACGATCCGTCGTTGGGCGTGTT
CTGTCTGTGCCAAGAACGTATGCGTTTCCCGGAAAAGGGTAAAACCTACTCCATTAACGAAGGCAACTACATTAAGTTCC
CGAATGGCGTGAAGAAGTACATCAAATTCTGCCAGGAAGAGGATAGTTCAACAAGTCGCCCTTATACCTCACGTTACATT
GGCTCTCTGGTGGCCGATTTCCACCGCAACCTGCTGAAAGGCGGCATCTATCTCTACCCCAGCACCGCCAGCCATCCGCA
GGGGAAACTGCGTCTGCTGTATGAATGCAACCCGATGGCGTTCCTCGCGGAACAGGCCGGTGGCAAAGCAAGCGATGGTA
AAGAACGTATTCTGGATATCATTCCGGAAAGCCTGCACCAGCGCCGCTCGTTCTTCGTCGGCAACCGCCATATGGTTGAC
GATGTGGAACGCTTTATCCGCGAATACCCGGACGCGTAA

Upstream 100 bases:

>100_bases
ATCTGTACTTTGCTGGCGCGATTCACCTGAGCGCATCATCTGAAATGTTTGTTAAGATTGTTACGGTCGCTTTACTCCAA
TCAATTGCAGGGAAAGTGTT

Downstream 100 bases:

>100_bases
TCTTTACCACCATGCGGAATAACGCATGAAGCCGCCATTGGGCAATAAGATGTCCGATGGCGGCGTTGCCTTATCAGGCC
CGTGATTTTTTCGGTTCTTA

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKTLGEFIVEKQHEFSQATGELTALLSAIKLGAKIIHRDINKAGLVDILGASCAENVQGEVQQKLDLFANEKLKAALKAR
DIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVV
YGSSTMLIYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDSSTSRPYTSRYI
GSLVADFHRNLLKGGIYLYPSTASHPQGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPESLHQRRSFFVGNRHMVD
DVERFIREYPDA

Sequences:

>Translated_332_residues
MKTLGEFIVEKQHEFSQATGELTALLSAIKLGAKIIHRDINKAGLVDILGASCAENVQGEVQQKLDLFANEKLKAALKAR
DIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVV
YGSSTMLIYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDSSTSRPYTSRYI
GSLVADFHRNLLKGGIYLYPSTASHPQGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPESLHQRRSFFVGNRHMVD
DVERFIREYPDA
>Mature_332_residues
MKTLGEFIVEKQHEFSQATGELTALLSAIKLGAKIIHRDINKAGLVDILGASCAENVQGEVQQKLDLFANEKLKAALKAR
DIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVV
YGSSTMLIYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDSSTSRPYTSRYI
GSLVADFHRNLLKGGIYLYPSTASHPQGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPESLHQRRSFFVGNRHMVD
DVERFIREYPDA

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family [H]

Homologues:

Organism=Homo sapiens, GI189083692, Length=329, Percent_Identity=44.6808510638298, Blast_Score=268, Evalue=7e-72,
Organism=Homo sapiens, GI16579888, Length=329, Percent_Identity=44.6808510638298, Blast_Score=268, Evalue=7e-72,
Organism=Homo sapiens, GI22907028, Length=329, Percent_Identity=42.8571428571429, Blast_Score=245, Evalue=3e-65,
Organism=Escherichia coli, GI1790679, Length=332, Percent_Identity=96.9879518072289, Blast_Score=668, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17508131, Length=329, Percent_Identity=45.8966565349544, Blast_Score=297, Evalue=4e-81,
Organism=Saccharomyces cerevisiae, GI6323409, Length=320, Percent_Identity=43.125, Blast_Score=266, Evalue=5e-72,
Organism=Drosophila melanogaster, GI45550998, Length=325, Percent_Identity=46.7692307692308, Blast_Score=295, Evalue=3e-80,
Organism=Drosophila melanogaster, GI19921562, Length=325, Percent_Identity=46.7692307692308, Blast_Score=295, Evalue=3e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000146
- InterPro:   IPR020548 [H]

Pfam domain/function: PF00316 FBPase [H]

EC number: =3.1.3.11 [H]

Molecular weight: Translated: 36859; Mature: 36859

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00124 FBPASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLGEFIVEKQHEFSQATGELTALLSAIKLGAKIIHRDINKAGLVDILGASCAENVQGE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VQQKLDLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDV
HHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCEEE
NVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLIYTTGCGVHAFTY
EEEHHHHHHHHHHHCCCCCCCCHHHHHCCCCCEEEEEEEEECCCEEEEEEECCCEEEEEE
DPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDSSTSRPYTSRYI
CCCCCHHEEEHHHHCCCCCCCEEEECCCCEEECCHHHHHHHHHHHCCCCCCCCCHHHHHH
GSLVADFHRNLLKGGIYLYPSTASHPQGKLRLLYECNPMAFLAEQAGGKASDGKERILDI
HHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCCHHHHHHHH
IPESLHQRRSFFVGNRHMVDDVERFIREYPDA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKTLGEFIVEKQHEFSQATGELTALLSAIKLGAKIIHRDINKAGLVDILGASCAENVQGE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VQQKLDLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDV
HHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCEEE
NVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLIYTTGCGVHAFTY
EEEHHHHHHHHHHHCCCCCCCCHHHHHCCCCCEEEEEEEEECCCEEEEEEECCCEEEEEE
DPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDSSTSRPYTSRYI
CCCCCHHEEEHHHHCCCCCCCEEEECCCCEEECCHHHHHHHHHHHCCCCCCCCCHHHHHH
GSLVADFHRNLLKGGIYLYPSTASHPQGKLRLLYECNPMAFLAEQAGGKASDGKERILDI
HHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCCHHHHHHHH
IPESLHQRRSFFVGNRHMVDDVERFIREYPDA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA