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The map label for this gene is cycA [H]

Identifier: 29144694

GI number: 29144694

Start: 4593294

End: 4594697

Strand: Direct

Name: cycA [H]

Synonym: t4449

Alternate gene names: 29144694

Gene position: 4593294-4594697 (Clockwise)

Preceding gene: 161486767

Following gene: 29144695

Centisome position: 95.85

GC content: 53.77

Gene sequence:

>1404_bases
ATGGTAGATCAGGTAAAAGTCGCAGCCGACGAACAGGCTCCGGCTGAACAGTCGCTACGGCGCAATCTTACAAACCGTCA
TATACAGCTTATCGCTATTGGCGGCGCTATTGGTACCGGTCTGTTTATGGGATCGGGTAAAACGATCAGTCTCGCCGGAC
CGTCGATCATTTTTGTGTATATGATCATCGGTTTTATGCTTTTTTTCGTGATGCGCGCCATGGGGGAATTGCTGCTCTCG
AATCTGGAATATAAATCGTTTAGCGATTTTGCTTCCGACCTGCTTGGCCCCTGGGCGGGATATTTCACCGGCTGGACGTA
CTGGTTTTGCTGGGTAGTGACCGGTATGGCTGACGTGGTGGCGATTACCGCCTACGCGCAGTTCTGGTTTCCCGGCCTTT
CCGATTGGGTCGCCTCGCTGGCGGTAGTGGTCCTGCTGCTAAGCCTCAACCTCGCCACCGTTAAAATGTTTGGTGAAATG
GAATTTTGGTTTGCTATGGTCAAAATCGTCGCCATCGTGGCGTTGATTGTGGTTGGGTTGGTGATGATTGCGATGCACTT
TAAATCGCCGACCGGCGTTGAAGCGTCTTTCGCGCATCTGTGGAATGACGGCGGCTGGTTCCCGAAAGGTATTAGCGGGT
TCTTTGCCGGTTTCCAGATTGCGGTGTTCGCCTTCGTGGGCATTGAGCTGGTCGGTACTACCGCCGCAGAAACTAAAGAT
CCGGAAAAATCGCTGCCGCGCGCGATCAACTCAATACCGATCCGTATCATCATGTTCTACGTCTTTGCGCTGATTGTCAT
TATGTCGGTAACGCCGTGGAGTTCAGTCGTACCGGATAAGAGCCCGTTTGTTGAGCTGTTTGTACTGGTGGGTCTGCCTG
CCGCCGCGAGCGTGATCAACTTTGTTGTGCTGACCTCGGCGGCGTCTTCCGCCAACAGCGGCGTCTTCTCGACCAGCCGT
ATGCTGTTTGGCCTGGCGCAAGAAGGCGTGGCGCCAAAAGCGTTCGCTAAGCTATCGAAACGCGCGGTACCGGCGAAAGG
CCTGACCTTCTCCTGTATCTGCCTGCTGGGCGGCGTGGTTATGCTGATGGTCAACCCGAGCGTGATTGGCGCATTCACCA
TGATCACTACGGTTTCGGCCATCCTGTTTATGTTTGTCTGGACCATCATTCTGTGTTCATACCTGGTGTACCGCAAAAAG
CGTCCCCACCTGCATGAAAAATCCATCTATAAGATGCCGCTCGGTAAGCTGATGTGCTGGGTCTGCATGGCGTTCTTTGC
GTTCGTGCTGGTATTGCTGACGCTGGAAGATGATACGCGCCAGGCGCTGATCGTGACGCCGCTGTGGTTTATCGCGTTGG
GTCTGGGCTGGCTGTTCCTGCGTAAGAACAAACTGGCTAAATGA

Upstream 100 bases:

>100_bases
ATTCTTACCTAATATCGATGAGTCCTGATAACAGGATCGTCGTATCATAGACCAAAGGCCGTAGAGCCCGCACAACACAG
ACAGGTACAGGAAGAAAAAC

Downstream 100 bases:

>100_bases
CGGATTTATCCCTCTCGCTTAGGCGAGGGGGTATGCGCATAACGTACCCGCCGGGGCGCTTTCTTCATTTTTACGCCCCA
TTTTGTCGCTTCCCGCTCCT

Product: D-alanine/D-serine/glycine permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MVDQVKVAADEQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPGLSDWVASLAVVVLLLSLNLATVKMFGEM
EFWFAMVKIVAIVALIVVGLVMIAMHFKSPTGVEASFAHLWNDGGWFPKGISGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVPDKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLMVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKK
RPHLHEKSIYKMPLGKLMCWVCMAFFAFVLVLLTLEDDTRQALIVTPLWFIALGLGWLFLRKNKLAK

Sequences:

>Translated_467_residues
MVDQVKVAADEQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPGLSDWVASLAVVVLLLSLNLATVKMFGEM
EFWFAMVKIVAIVALIVVGLVMIAMHFKSPTGVEASFAHLWNDGGWFPKGISGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVPDKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLMVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKK
RPHLHEKSIYKMPLGKLMCWVCMAFFAFVLVLLTLEDDTRQALIVTPLWFIALGLGWLFLRKNKLAK
>Mature_467_residues
MVDQVKVAADEQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPGLSDWVASLAVVVLLLSLNLATVKMFGEM
EFWFAMVKIVAIVALIVVGLVMIAMHFKSPTGVEASFAHLWNDGGWFPKGISGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVPDKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLMVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKK
RPHLHEKSIYKMPLGKLMCWVCMAFFAFVLVLLTLEDDTRQALIVTPLWFIALGLGWLFLRKNKLAK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=358, Percent_Identity=22.3463687150838, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI114326544, Length=367, Percent_Identity=22.6158038147139, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI114326550, Length=367, Percent_Identity=22.6158038147139, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI115648063, Length=463, Percent_Identity=25.2699784017279, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI115648022, Length=463, Percent_Identity=25.2699784017279, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI258645169, Length=363, Percent_Identity=22.5895316804408, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI181337167, Length=346, Percent_Identity=21.3872832369942, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790653, Length=467, Percent_Identity=95.2890792291221, Blast_Score=904, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=458, Percent_Identity=41.2663755458515, Blast_Score=352, Evalue=4e-98,
Organism=Escherichia coli, GI1786789, Length=466, Percent_Identity=37.3390557939914, Blast_Score=338, Evalue=3e-94,
Organism=Escherichia coli, GI1786602, Length=454, Percent_Identity=40.7488986784141, Blast_Score=335, Evalue=3e-93,
Organism=Escherichia coli, GI48994972, Length=445, Percent_Identity=39.5505617977528, Blast_Score=318, Evalue=4e-88,
Organism=Escherichia coli, GI87081915, Length=452, Percent_Identity=36.7256637168142, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI87081708, Length=474, Percent_Identity=33.3333333333333, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI1788480, Length=459, Percent_Identity=34.640522875817, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1789017, Length=447, Percent_Identity=30.8724832214765, Blast_Score=229, Evalue=4e-61,
Organism=Escherichia coli, GI87082023, Length=351, Percent_Identity=22.5071225071225, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI2367353, Length=333, Percent_Identity=24.024024024024, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=362, Percent_Identity=24.8618784530387, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17531343, Length=442, Percent_Identity=21.9457013574661, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6324061, Length=422, Percent_Identity=32.2274881516588, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6324924, Length=428, Percent_Identity=30.8411214953271, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6320772, Length=447, Percent_Identity=29.082774049217, Blast_Score=182, Evalue=8e-47,
Organism=Saccharomyces cerevisiae, GI6324990, Length=419, Percent_Identity=31.0262529832936, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6322892, Length=401, Percent_Identity=29.1770573566085, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6324059, Length=456, Percent_Identity=28.5087719298246, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6324553, Length=410, Percent_Identity=29.5121951219512, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320717, Length=414, Percent_Identity=26.0869565217391, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6321629, Length=421, Percent_Identity=27.3159144893112, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6319543, Length=446, Percent_Identity=27.1300448430493, Blast_Score=146, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6319824, Length=399, Percent_Identity=26.3157894736842, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319542, Length=404, Percent_Identity=25.7425742574257, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319608, Length=419, Percent_Identity=26.7303102625298, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320251, Length=403, Percent_Identity=27.5434243176179, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6321053, Length=411, Percent_Identity=27.007299270073, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6322967, Length=419, Percent_Identity=29.1169451073986, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324981, Length=420, Percent_Identity=27.8571428571429, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320364, Length=471, Percent_Identity=24.203821656051, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221512776, Length=399, Percent_Identity=21.0526315789474, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24666159, Length=399, Percent_Identity=21.0526315789474, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI45550968, Length=424, Percent_Identity=25.9433962264151, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921172, Length=424, Percent_Identity=25.9433962264151, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51185; Mature: 51185

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDQVKVAADEQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVY
CCCCEEECCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHH
MIIGFMLFFVMRAMGELLLSNLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITAYAQFWFPGLSDWVASLAVVVLLLSLNLATVKMFGEMEFWFAMVKIVAIVALIVVGL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMIAMHFKSPTGVEASFAHLWNDGGWFPKGISGFFAGFQIAVFAFVGIELVGTTAAETKD
HHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVPDKSPFVELFVLVGLPAAASVIN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHCCCHHHHHHH
FVVLTSAASSANSGVFSTSRMLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVV
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MLMVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKKRPHLHEKSIYKMPLGKLMCW
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHH
VCMAFFAFVLVLLTLEDDTRQALIVTPLWFIALGLGWLFLRKNKLAK
HHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVDQVKVAADEQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVY
CCCCEEECCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHH
MIIGFMLFFVMRAMGELLLSNLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITAYAQFWFPGLSDWVASLAVVVLLLSLNLATVKMFGEMEFWFAMVKIVAIVALIVVGL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMIAMHFKSPTGVEASFAHLWNDGGWFPKGISGFFAGFQIAVFAFVGIELVGTTAAETKD
HHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVPDKSPFVELFVLVGLPAAASVIN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHCCCHHHHHHH
FVVLTSAASSANSGVFSTSRMLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVV
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MLMVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKKRPHLHEKSIYKMPLGKLMCW
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHH
VCMAFFAFVLVLLTLEDDTRQALIVTPLWFIALGLGWLFLRKNKLAK
HHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]