Click here to switch to the map view.

The map label for this gene is sirC [H]

Identifier: 29144481

GI number: 29144481

Start: 4390003

End: 4390878

Strand: Reverse

Name: sirC [H]

Synonym: t4221

Alternate gene names: 29144481

Gene position: 4390878-4390003 (Counterclockwise)

Preceding gene: 29144482

Following gene: 29144480

Centisome position: 91.63

GC content: 35.5

Gene sequence:

>876_bases
ATGCTAAAGGTGTTTAATCCCTCACCTGTCCAGGTGGGGAGCATTGAATGTTTACAATCAGCGCAAAACTGGCAGAGGAA
ATCCTTATCACTTCAGGGATTAAATTTACTGCAGTCCGTACTCATCAAGCTCACCACGGGTAAAATTTCAATTACGACAT
CGTCCGGGGAGTATATTACGGCATCAGGGCCAATGTTAATATTTTTAGCTAAAGATCAAACCATTCATATCACTATGGAA
GAGACTCATGAACAGTTAAATTATAATTTAATTGAATTAGATTCAGCGTCAATAAAAAATGCTTATAATTTTTTTCTGTA
TGAACATGCAGACTTTTCGGCCCCATTAACAAAACCGACGACAAAACATCTGTTAGCGCCAATAGAAACAGGCGTAGCAA
GAGTATTCAACCTCTTACACTCTTCAAATAAAAGCCAGAAATTATCCCAAGATAAAAAGGAATATTTAATAAGATTTCTG
CTTTCAGAGTTCATCTATGAACCTGAAGCATTTGCTCTCTTCAGAGAACTATCGCAAAATACATTAGCCGAAAACATCTA
TAATATTATTATAAGCGACATAAGTCGAAAATGGGCGCTCAAGGATATTTCTGACTCACTCTATATGAGTTGTTCCACAT
TAAAAAGGAAATTGAAACAAGAGCACACCTCATTCAGTGAAGTTTACCTTAATGCGCGAATGAATAAAGCGACAAAACTT
CTACGCAATAGTGAATATAATATTACTCGAGTGGCTTATATGTGTGGTTATGATAGTGCTTCTTATTTTACATGCGTTTT
TAAAAAACATTTCAAAACTACACCATCGGAATTTTTAGCGTTTTTATCCTCCTCTCGTCATCAATATGTTAATTGA

Upstream 100 bases:

>100_bases
AAGTTCGCAAATAATTATATAGCTATATATTAGTTTTCTTTTGAAATATTTTTCAGAATAATTTTTGATTTACACGCACA
TTTAATAAAAGGAAATTATC

Downstream 100 bases:

>100_bases
GATATCTGACAATGCAGTATAAGAACAAAGCAAAACATATTAATATAAGAGATGGAATTCTGTTGCTCGCTAAAAAATTC
GATCTAACATTGAGCGAGAA

Product: AraC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MLKVFNPSPVQVGSIECLQSAQNWQRKSLSLQGLNLLQSVLIKLTTGKISITTSSGEYITASGPMLIFLAKDQTIHITME
ETHEQLNYNLIELDSASIKNAYNFFLYEHADFSAPLTKPTTKHLLAPIETGVARVFNLLHSSNKSQKLSQDKKEYLIRFL
LSEFIYEPEAFALFRELSQNTLAENIYNIIISDISRKWALKDISDSLYMSCSTLKRKLKQEHTSFSEVYLNARMNKATKL
LRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSEFLAFLSSSRHQYVN

Sequences:

>Translated_291_residues
MLKVFNPSPVQVGSIECLQSAQNWQRKSLSLQGLNLLQSVLIKLTTGKISITTSSGEYITASGPMLIFLAKDQTIHITME
ETHEQLNYNLIELDSASIKNAYNFFLYEHADFSAPLTKPTTKHLLAPIETGVARVFNLLHSSNKSQKLSQDKKEYLIRFL
LSEFIYEPEAFALFRELSQNTLAENIYNIIISDISRKWALKDISDSLYMSCSTLKRKLKQEHTSFSEVYLNARMNKATKL
LRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSEFLAFLSSSRHQYVN
>Mature_291_residues
MLKVFNPSPVQVGSIECLQSAQNWQRKSLSLQGLNLLQSVLIKLTTGKISITTSSGEYITASGPMLIFLAKDQTIHITME
ETHEQLNYNLIELDSASIKNAYNFFLYEHADFSAPLTKPTTKHLLAPIETGVARVFNLLHSSNKSQKLSQDKKEYLIRFL
LSEFIYEPEAFALFRELSQNTLAENIYNIIISDISRKWALKDISDSLYMSCSTLKRKLKQEHTSFSEVYLNARMNKATKL
LRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSEFLAFLSSSRHQYVN

Specific function: Positive regulator of the expression of the invasion- associated type III secretion system encoded within SPI-1 (pathogenicity island 1) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789933, Length=247, Percent_Identity=29.9595141700405, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786776, Length=190, Percent_Identity=33.1578947368421, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787776, Length=95, Percent_Identity=45.2631578947368, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790557, Length=166, Percent_Identity=33.1325301204819, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786778, Length=199, Percent_Identity=34.1708542713568, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789932, Length=118, Percent_Identity=35.5932203389831, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786758, Length=101, Percent_Identity=32.6732673267327, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR020449
- InterPro:   IPR018060 [H]

Pfam domain/function: PF00165 HTH_AraC [H]

EC number: NA

Molecular weight: Translated: 33326; Mature: 33326

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKVFNPSPVQVGSIECLQSAQNWQRKSLSLQGLNLLQSVLIKLTTGKISITTSSGEYIT
CCEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEECCEEEEEECCCCEEE
ASGPMLIFLAKDQTIHITMEETHEQLNYNLIELDSASIKNAYNFFLYEHADFSAPLTKPT
ECCCEEEEEECCCEEEEEEHHHHHHHCCCEEEECCHHHHHHHEEEEEECCCCCCCCCCCC
TKHLLAPIETGVARVFNLLHSSNKSQKLSQDKKEYLIRFLLSEFIYEPEAFALFRELSQN
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
TLAENIYNIIISDISRKWALKDISDSLYMSCSTLKRKLKQEHTSFSEVYLNARMNKATKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSEFLAFLSSSRHQYVN
HHCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLKVFNPSPVQVGSIECLQSAQNWQRKSLSLQGLNLLQSVLIKLTTGKISITTSSGEYIT
CCEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEECCEEEEEECCCCEEE
ASGPMLIFLAKDQTIHITMEETHEQLNYNLIELDSASIKNAYNFFLYEHADFSAPLTKPT
ECCCEEEEEECCCEEEEEEHHHHHHHCCCEEEECCHHHHHHHEEEEEECCCCCCCCCCCC
TKHLLAPIETGVARVFNLLHSSNKSQKLSQDKKEYLIRFLLSEFIYEPEAFALFRELSQN
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
TLAENIYNIIISDISRKWALKDISDSLYMSCSTLKRKLKQEHTSFSEVYLNARMNKATKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSEFLAFLSSSRHQYVN
HHCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]