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The map label for this gene is dcuR [H]

Identifier: 29144472

GI number: 29144472

Start: 4378944

End: 4379663

Strand: Reverse

Name: dcuR [H]

Synonym: t4210

Alternate gene names: 29144472

Gene position: 4379663-4378944 (Counterclockwise)

Preceding gene: 29144473

Following gene: 29144471

Centisome position: 91.4

GC content: 49.03

Gene sequence:

>720_bases
ATGATCAATGTATTAATTGTCGATGACGATGCGATGGTCGCGGAGTTAAATCGCCGCTATGTCGCGCAAATCTCCGGTTT
TCATTGTTGTGGAACCGCTTCGACGCTGGAAAAAGCGAAAGAGTTTATCTTCAACAGTGAAAATCACATTGACCTAATCC
TGCTGGATATCTATATGCAGCAGGAAAACGGATTGGATCTGCTGCCTGTCCTGCACAGCGCAGGCTGCAAAAGCGACGTT
ATTGTCATTTCTTCTGCCGCTGACGCCGCCACCATTAAAGATTCGCTTCACTACGGCGTGGTGGATTATCTGATCAAGCC
TTTTCAGGCCACGCGCTTTGAAGAAGCGTTGACCGGCTGGCTACGTAAGAAAACGGCGATGGAAAAACGCCAGTATTACG
AACAGTCTGAGCTTGACCTGCTCATTCACGGTAATTCATCCAGCGAGCAGGAGCCTCGTCGGCTGCCAAAAAGGCTGACC
CAGCAAACGCTACGCACCTTATGCCAGTGGATTGATGCGCATCAGGAGCAGGAATTTTCTACCGACGAGTTAGCCAACGA
AGTGAATATCTCGCGCGTCTCCTGCCGTAAATATCTCATCTGGCTGGTGAATTGCCATATCTTGTTTACCAGTATTCATT
ACGGCGTGACCGGCAGGCCGGTTTACCGCTACCGCGTTCAGCCGGAACATTACTCTTTACTGAAACAATATTGTCAGTAA

Upstream 100 bases:

>100_bases
AGGTTGAAGCGCTTGGCGGCGTAATTTCCGTGGAGTCCGAGCCTGGGATCTTCACACAATTTTTTGTACAGTTACCCTGG
GATGGAAAAAGGACCAGCCT

Downstream 100 bases:

>100_bases
GGATACCGCATAAAGCCGACGCGAAGCGTTATATCTTGGTAACATTTATTATAACAATGCCAATAAAAACGCTATCACAT
TAATAACAAACCTGGGAAAT

Product: DNA-binding transcriptional activator DcuR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MINVLIVDDDAMVAELNRRYVAQISGFHCCGTASTLEKAKEFIFNSENHIDLILLDIYMQQENGLDLLPVLHSAGCKSDV
IVISSAADAATIKDSLHYGVVDYLIKPFQATRFEEALTGWLRKKTAMEKRQYYEQSELDLLIHGNSSSEQEPRRLPKRLT
QQTLRTLCQWIDAHQEQEFSTDELANEVNISRVSCRKYLIWLVNCHILFTSIHYGVTGRPVYRYRVQPEHYSLLKQYCQ

Sequences:

>Translated_239_residues
MINVLIVDDDAMVAELNRRYVAQISGFHCCGTASTLEKAKEFIFNSENHIDLILLDIYMQQENGLDLLPVLHSAGCKSDV
IVISSAADAATIKDSLHYGVVDYLIKPFQATRFEEALTGWLRKKTAMEKRQYYEQSELDLLIHGNSSSEQEPRRLPKRLT
QQTLRTLCQWIDAHQEQEFSTDELANEVNISRVSCRKYLIWLVNCHILFTSIHYGVTGRPVYRYRVQPEHYSLLKQYCQ
>Mature_239_residues
MINVLIVDDDAMVAELNRRYVAQISGFHCCGTASTLEKAKEFIFNSENHIDLILLDIYMQQENGLDLLPVLHSAGCKSDV
IVISSAADAATIKDSLHYGVVDYLIKPFQATRFEEALTGWLRKKTAMEKRQYYEQSELDLLIHGNSSSEQEPRRLPKRLT
QQTLRTLCQWIDAHQEQEFSTDELANEVNISRVSCRKYLIWLVNCHILFTSIHYGVTGRPVYRYRVQPEHYSLLKQYCQ

Specific function: Member of the two-component regulatory system dcuR/dcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-di

COG id: COG4565

COG function: function code KT; Response regulator of citrate/malate metabolism

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790566, Length=239, Percent_Identity=88.2845188284519, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI1786838, Length=220, Percent_Identity=30, Blast_Score=101, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR012287
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 27605; Mature: 27605

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINVLIVDDDAMVAELNRRYVAQISGFHCCGTASTLEKAKEFIFNSENHIDLILLDIYMQ
CEEEEEECCCHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHCCCCCCEEEEEEEEEEE
QENGLDLLPVLHSAGCKSDVIVISSAADAATIKDSLHYGVVDYLIKPFQATRFEEALTGW
CCCCCCHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LRKKTAMEKRQYYEQSELDLLIHGNSSSEQEPRRLPKRLTQQTLRTLCQWIDAHQEQEFS
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TDELANEVNISRVSCRKYLIWLVNCHILFTSIHYGVTGRPVYRYRVQPEHYSLLKQYCQ
HHHHHHHCCHHHHHHHHHHHHHHHHHHHEEHHHCCCCCCCEEEEEECCHHHHHHHHHCC
>Mature Secondary Structure
MINVLIVDDDAMVAELNRRYVAQISGFHCCGTASTLEKAKEFIFNSENHIDLILLDIYMQ
CEEEEEECCCHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHCCCCCCEEEEEEEEEEE
QENGLDLLPVLHSAGCKSDVIVISSAADAATIKDSLHYGVVDYLIKPFQATRFEEALTGW
CCCCCCHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LRKKTAMEKRQYYEQSELDLLIHGNSSSEQEPRRLPKRLTQQTLRTLCQWIDAHQEQEFS
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TDELANEVNISRVSCRKYLIWLVNCHILFTSIHYGVTGRPVYRYRVQPEHYSLLKQYCQ
HHHHHHHCCHHHHHHHHHHHHHHHHHHHEEHHHCCCCCCCEEEEEECCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]