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The map label for this gene is melR [H]

Identifier: 29144466

GI number: 29144466

Start: 4370964

End: 4371896

Strand: Reverse

Name: melR [H]

Synonym: t4204

Alternate gene names: 29144466

Gene position: 4371896-4370964 (Counterclockwise)

Preceding gene: 29144469

Following gene: 29144465

Centisome position: 91.23

GC content: 52.09

Gene sequence:

>933_bases
ATGAGTACGCAAGCAATATCCCTCCTCCCGCCCGACCCGCACATGTGCAACGGCGATGAAAAGCAAACCCGTAGCCCGCT
GTCGCTCTATTCCGAATATCAACGACTGGACGTTGAGCTGAGGCCGCCGCACAGAATGGCCAGCAGTCACTGGCATGGGC
AAGTAGAAGTGAATGTTCCGTTTGACGGCGATGTGGAGTATTTAATCAACAATGAAGTCGTGCAGATAAAGCAGGGACAT
ATCACCCTGTTTTGGGCCTGTACGCCACACCAGCTTACCCGCCCCGGCAACTGCCGCCAGATGGCGATTTTCAGTTTGCC
GATGCACCTGTTTCTCTCCTGGCCGCTGGATCGCGATCTTATCAACCATGTCACGCACGGGATGGTGGTTAAATCACTGG
CGACCCAGCAGCTTAGCACCTTTGAAGTGTTGCGCTGGCAGCAGGAAACAAGCAGCCCGAATGAGCAAATTCGCCAGTTG
GCGATCGATGAAATCGGCTTGATGCTTAAACGCTTTAGCCTTTCCGGCTGGCAACCCATTTTGCTCAATAAAACATCACG
CACCCACAAGAATAGCGTCTCACGCCATGCGCAGTTTTACGTAAGCCAGATGCTGGGATTTATTGCCGATAACTACGATC
AGGCGCTAACCATTAACGACGTTGCGGAGCATGTCAAACTCAATGCTAACTACGCGATGGGAATATTCCAGCGGGTTATG
CAATTGACGATGAAGCAGTACATCACGGCGATGCGCATCAATCACGTACGTGCCTTATTGAGCGATACTGACAAAACGAT
CCTCGATGTCGCTCTGACTGCCGGGTTCCGATCCAGCAGCCGTTTTTACAGTACTTTTAGCAAATTTGTCGGTATGTCGC
CGCAACAATACCGCAAGCTAAGCCAGCAACGACGCCAGACGATGCCCGGCTAA

Upstream 100 bases:

>100_bases
CAGGCTACGCTCTACAATATCGACGGATTCTGTGTCCGGATTCCCGGTTTCCTCCCGGCTAAAGGGGCATAATTCTGATA
ATTCAGGAAATGGAGTGACG

Downstream 100 bases:

>100_bases
AGCCGGATACCACTATCAGCCAAAAAAATAATTCACCTGTCGATAAACGGCGGGTGAAATTGCTCGCTATCAATAATTAA
CCCATTGTTTATTAAACAAT

Product: DNA-binding transcriptional regulator MelR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MSTQAISLLPPDPHMCNGDEKQTRSPLSLYSEYQRLDVELRPPHRMASSHWHGQVEVNVPFDGDVEYLINNEVVQIKQGH
ITLFWACTPHQLTRPGNCRQMAIFSLPMHLFLSWPLDRDLINHVTHGMVVKSLATQQLSTFEVLRWQQETSSPNEQIRQL
AIDEIGLMLKRFSLSGWQPILLNKTSRTHKNSVSRHAQFYVSQMLGFIADNYDQALTINDVAEHVKLNANYAMGIFQRVM
QLTMKQYITAMRINHVRALLSDTDKTILDVALTAGFRSSSRFYSTFSKFVGMSPQQYRKLSQQRRQTMPG

Sequences:

>Translated_310_residues
MSTQAISLLPPDPHMCNGDEKQTRSPLSLYSEYQRLDVELRPPHRMASSHWHGQVEVNVPFDGDVEYLINNEVVQIKQGH
ITLFWACTPHQLTRPGNCRQMAIFSLPMHLFLSWPLDRDLINHVTHGMVVKSLATQQLSTFEVLRWQQETSSPNEQIRQL
AIDEIGLMLKRFSLSGWQPILLNKTSRTHKNSVSRHAQFYVSQMLGFIADNYDQALTINDVAEHVKLNANYAMGIFQRVM
QLTMKQYITAMRINHVRALLSDTDKTILDVALTAGFRSSSRFYSTFSKFVGMSPQQYRKLSQQRRQTMPG
>Mature_309_residues
STQAISLLPPDPHMCNGDEKQTRSPLSLYSEYQRLDVELRPPHRMASSHWHGQVEVNVPFDGDVEYLINNEVVQIKQGHI
TLFWACTPHQLTRPGNCRQMAIFSLPMHLFLSWPLDRDLINHVTHGMVVKSLATQQLSTFEVLRWQQETSSPNEQIRQLA
IDEIGLMLKRFSLSGWQPILLNKTSRTHKNSVSRHAQFYVSQMLGFIADNYDQALTINDVAEHVKLNANYAMGIFQRVMQ
LTMKQYITAMRINHVRALLSDTDKTILDVALTAGFRSSSRFYSTFSKFVGMSPQQYRKLSQQRRQTMPG

Specific function: Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790559, Length=299, Percent_Identity=88.2943143812709, Blast_Score=564, Evalue=1e-162,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008917
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR020449
- InterPro:   IPR018060
- InterPro:   IPR014710 [H]

Pfam domain/function: PF00165 HTH_AraC [H]

EC number: NA

Molecular weight: Translated: 35677; Mature: 35546

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQAISLLPPDPHMCNGDEKQTRSPLSLYSEYQRLDVELRPPHRMASSHWHGQVEVNVP
CCCCEEEECCCCCCCCCCCHHHCCCHHHHHHHHHHCCCEECCCHHHHCCCCCCEEEEECC
FDGDVEYLINNEVVQIKQGHITLFWACTPHQLTRPGNCRQMAIFSLPMHLFLSWPLDRDL
CCCCCCEEECCCEEEEECCCEEEEEEECCHHCCCCCCCCEEHHHHHHHHHHHCCCCCHHH
INHVTHGMVVKSLATQQLSTFEVLRWQQETSSPNEQIRQLAIDEIGLMLKRFSLSGWQPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEE
LLNKTSRTHKNSVSRHAQFYVSQMLGFIADNYDQALTINDVAEHVKLNANYAMGIFQRVM
EEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCCCHHHHHHHHHH
QLTMKQYITAMRINHVRALLSDTDKTILDVALTAGFRSSSRFYSTFSKFVGMSPQQYRKL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHH
SQQRRQTMPG
HHHHHHCCCC
>Mature Secondary Structure 
STQAISLLPPDPHMCNGDEKQTRSPLSLYSEYQRLDVELRPPHRMASSHWHGQVEVNVP
CCCEEEECCCCCCCCCCCHHHCCCHHHHHHHHHHCCCEECCCHHHHCCCCCCEEEEECC
FDGDVEYLINNEVVQIKQGHITLFWACTPHQLTRPGNCRQMAIFSLPMHLFLSWPLDRDL
CCCCCCEEECCCEEEEECCCEEEEEEECCHHCCCCCCCCEEHHHHHHHHHHHCCCCCHHH
INHVTHGMVVKSLATQQLSTFEVLRWQQETSSPNEQIRQLAIDEIGLMLKRFSLSGWQPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEE
LLNKTSRTHKNSVSRHAQFYVSQMLGFIADNYDQALTINDVAEHVKLNANYAMGIFQRVM
EEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCCCHHHHHHHHHH
QLTMKQYITAMRINHVRALLSDTDKTILDVALTAGFRSSSRFYSTFSKFVGMSPQQYRKL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHH
SQQRRQTMPG
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]