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The map label for this gene is pgi [H]

Identifier: 29144389

GI number: 29144389

Start: 4269936

End: 4271585

Strand: Direct

Name: pgi [H]

Synonym: t4127

Alternate gene names: 29144389

Gene position: 4269936-4271585 (Clockwise)

Preceding gene: 29144382

Following gene: 29144390

Centisome position: 89.11

GC content: 53.15

Gene sequence:

>1650_bases
ATGAAAAACATCAATCCAACGCAGACTTCTGCCTGGCAGGCGCTCCAGAAACACTACGACGAAATGAAAGACGTTACGAT
CGCTGAGCTTTTCGCGAACGATAGCGACCGTTTCGCTAAATTTTCCGCGACGTTTGACGATCTGATGCTGGTGGACTTCT
CCAAAAACCGCATCACCGAAGAGACGCTGGCAAAATTACAGGATCTGGCGAAAGAGACCGATCTGGCCGGCGCGATTAAA
TCCATGTTCTCCGGCGAGAAGATCAACCGCACCGAAGACCGCGCCGTGCTGCACGTGGCGCTGCGTAACCGTAGCAATAC
GCCGATCATTGTGGACGGCAAAGATGTGATGCCGGAAGTGAACGCCGTGCTTGAGAAAATGAAAACTTTCTCGCAAGCGA
TTATCTCCGGTCAGTGGAAAGGCTACACCGGTAAGGCCATCACCGACGTGGTGAACATCGGTATCGGCGGTTCCGACCTC
GGCCCGTTCATGGTGACCGAAGCGCTGCGTCCGTATAAAAATCATCTGACTATGCACTTCGTCTCTAACGTTGATGGTAC
CCACATCGCTGAAGTGCTGAAAAAAGTGAACCCGGAAACGACTCTGTTCCTGGTGGCGTCGAAAACCTTCACCACGCAGG
AAACCATGACCAACGCCCACAGCGCGCGCGACTGGTTCCTGAAAAGTGCAGGCGATGAAAAACACGTGGCGAAACACTTT
GCTGCGCTCTCCACCAACGCCAAAGCGGTCGGCGAATTTGGTATCGACACGGCCAATATGTTCGAGTTCTGGGACTGGGT
CGGCGGTCGTTACTCGCTGTGGTCTGCCATCGGACTGTCCATTATTCTGTCCGTCGGTTTCGACAACTTTGTCGAGCTGC
TTTCCGGCGCGCACGCGATGGACAAGCATTTCTCCACCACTCCGGCGGAGAAAAACCTACCCATTCTGCTGGCGTTGATT
GGCATCTGGTACAACAATTTCTTCGGCGCGGAAACCGAAGCCATTCTGCCGTACGACCAGTATATGCACCGTTTCGCCGC
CTACTTCCAGCAGGGCAACATGGAATCCAACGGTAAATACGTTGACCGTAACGGCAACGCCGTGGATTACCAGACAGGCC
CAATTATCTGGGGCGAACCAGGCACCAACGGTCAGCACGCGTTTTATCAATTGATTCACCAGGGTACTAAAATGGTGCCG
TGTGACTTTATCGCCCCGGCTATCACCCATAACCCGCTATCCGATCATCATCAGAAGCTGCTGTCTAACTTCTTCGCGCA
GACCGAAGCGCTGGCGTTTGGTAAATCCCGCGAGGTGGTTGAGCAGGAATATCGCGATCAGGGTAAAGATCCGGCGCAGC
TTGAACACGTTGTGCCATTCAAAGTGTTTGAAGGCAACCGCCCGACCAACTCTATACTGCTGCGCGAAATTACGCCGTTC
AGCCTGGGCGCGCTGATTGCGTTGTATGAGCATAAAATCTTTACGCAGGGCGTCATCCTGAACATCTTTACTTTCGACCA
GTGGGGCGTTGAGTTGGGTAAACAGTTGGCTAACCGTATTCTGCCGGAGCTGGGCGATGATAAAGCTATTTCGTCCCATG
ATAGCTCTACTAACGGTCTGATTAACCGTTATAAAGCCTGGCGCGCCTGA

Upstream 100 bases:

>100_bases
GACAGTGCCTGGGGCAACGGCACTAAAACAATCACACTTTTCTGTGACTGGCGTTACAATCGATCCCAGTCACAATTCTC
AAATCAGAAGAGTATTGCTA

Downstream 100 bases:

>100_bases
TGGCGCTGCGCTTATCCGGTCTACGTAATGCATAGCGTCTGTAGGCCGGATAAGGCGTTTCGCCGCCATCCGGCAAAAAG
AGAATAAGATAATAAAAAGG

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MKNINPTQTSAWQALQKHYDEMKDVTIAELFANDSDRFAKFSATFDDLMLVDFSKNRITEETLAKLQDLAKETDLAGAIK
SMFSGEKINRTEDRAVLHVALRNRSNTPIIVDGKDVMPEVNAVLEKMKTFSQAIISGQWKGYTGKAITDVVNIGIGGSDL
GPFMVTEALRPYKNHLTMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKSAGDEKHVAKHF
AALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIILSVGFDNFVELLSGAHAMDKHFSTTPAEKNLPILLALI
GIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNAVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVP
CDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPAQLEHVVPFKVFEGNRPTNSILLREITPF
SLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELGDDKAISSHDSSTNGLINRYKAWRA

Sequences:

>Translated_549_residues
MKNINPTQTSAWQALQKHYDEMKDVTIAELFANDSDRFAKFSATFDDLMLVDFSKNRITEETLAKLQDLAKETDLAGAIK
SMFSGEKINRTEDRAVLHVALRNRSNTPIIVDGKDVMPEVNAVLEKMKTFSQAIISGQWKGYTGKAITDVVNIGIGGSDL
GPFMVTEALRPYKNHLTMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKSAGDEKHVAKHF
AALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIILSVGFDNFVELLSGAHAMDKHFSTTPAEKNLPILLALI
GIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNAVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVP
CDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPAQLEHVVPFKVFEGNRPTNSILLREITPF
SLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELGDDKAISSHDSSTNGLINRYKAWRA
>Mature_549_residues
MKNINPTQTSAWQALQKHYDEMKDVTIAELFANDSDRFAKFSATFDDLMLVDFSKNRITEETLAKLQDLAKETDLAGAIK
SMFSGEKINRTEDRAVLHVALRNRSNTPIIVDGKDVMPEVNAVLEKMKTFSQAIISGQWKGYTGKAITDVVNIGIGGSDL
GPFMVTEALRPYKNHLTMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKSAGDEKHVAKHF
AALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIILSVGFDNFVELLSGAHAMDKHFSTTPAEKNLPILLALI
GIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNAVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVP
CDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPAQLEHVVPFKVFEGNRPTNSILLREITPF
SLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELGDDKAISSHDSSTNGLINRYKAWRA

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=549, Percent_Identity=64.8451730418944, Blast_Score=739, Evalue=0.0,
Organism=Homo sapiens, GI296080693, Length=549, Percent_Identity=60.8378870673953, Blast_Score=679, Evalue=0.0,
Organism=Escherichia coli, GI1790457, Length=549, Percent_Identity=95.264116575592, Blast_Score=1100, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=546, Percent_Identity=63.5531135531135, Blast_Score=718, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996703, Length=541, Percent_Identity=63.9556377079482, Blast_Score=716, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319673, Length=549, Percent_Identity=58.8342440801457, Blast_Score=651, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651916, Length=549, Percent_Identity=64.1165755919854, Blast_Score=723, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651914, Length=549, Percent_Identity=64.1165755919854, Blast_Score=723, Evalue=0.0,
Organism=Drosophila melanogaster, GI17737445, Length=549, Percent_Identity=64.1165755919854, Blast_Score=723, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 61415; Mature: 61415

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNINPTQTSAWQALQKHYDEMKDVTIAELFANDSDRFAKFSATFDDLMLVDFSKNRITE
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHEEHHCCCCCEEEEECCCCCCCH
ETLAKLQDLAKETDLAGAIKSMFSGEKINRTEDRAVLHVALRNRSNTPIIVDGKDVMPEV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEEEECCCCCCCEEECCHHHHHHH
NAVLEKMKTFSQAIISGQWKGYTGKAITDVVNIGIGGSDLGPFMVTEALRPYKNHLTMHF
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCEEEEE
VSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKSAGDEKHVAKHF
ECCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
AALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIILSVGFDNFVELLSGAHAM
HHHCCCCHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHH
DKHFSTTPAEKNLPILLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKY
HHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCEE
VDRNGNAVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKL
ECCCCCEEEECCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHH
LSNFFAQTEALAFGKSREVVEQEYRDQGKDPAQLEHVVPFKVFEGNRPTNSILLREITPF
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHCCCEEEECCCCCCCCEEEECCCCH
SLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELGDDKAISSHDSSTNGL
HHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
INRYKAWRA
HHHHHHCCC
>Mature Secondary Structure
MKNINPTQTSAWQALQKHYDEMKDVTIAELFANDSDRFAKFSATFDDLMLVDFSKNRITE
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHEEHHCCCCCEEEEECCCCCCCH
ETLAKLQDLAKETDLAGAIKSMFSGEKINRTEDRAVLHVALRNRSNTPIIVDGKDVMPEV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEEEEECCCCCCCEEECCHHHHHHH
NAVLEKMKTFSQAIISGQWKGYTGKAITDVVNIGIGGSDLGPFMVTEALRPYKNHLTMHF
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCEEEEE
VSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKSAGDEKHVAKHF
ECCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
AALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIILSVGFDNFVELLSGAHAM
HHHCCCCHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHH
DKHFSTTPAEKNLPILLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKY
HHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCEE
VDRNGNAVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKL
ECCCCCEEEECCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHH
LSNFFAQTEALAFGKSREVVEQEYRDQGKDPAQLEHVVPFKVFEGNRPTNSILLREITPF
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHCCCEEEECCCCCCCCEEEECCCCH
SLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELGDDKAISSHDSSTNGL
HHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
INRYKAWRA
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA