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The map label for this gene is aceB [H]

Identifier: 29144373

GI number: 29144373

Start: 4249387

End: 4250988

Strand: Direct

Name: aceB [H]

Synonym: t4111

Alternate gene names: 29144373

Gene position: 4249387-4250988 (Clockwise)

Preceding gene: 29144372

Following gene: 29144374

Centisome position: 88.68

GC content: 51.81

Gene sequence:

>1602_bases
ATGAATCCACAGGCAACCACAACTGATGAATTAACCTTTACCAGGCCGCAAGGCGAGCTGGAAAAGCAAGTCCTGACCGC
TGAGGCAGTCGAGTTTTTGACGGAGTTAGTCACCCGTTTTACGCCAAAACGCAATAAACTCCTGGCTGCACGTATCCAGC
AACAGCAGGATATTGATAACGGTAAGTTGCCTGATTTTATTTCGGAAACCACTTCCATTAGAGAAAGTAATTGGCAGATT
CGTGGTATTCCGGCGGATTTACAGGATCGCCGAGTAGAAATTACCGGGCCGGTTGAACGTAAAATGGTGATTAATGCCCT
GAACGCAAATGTGAAAGTGTTTATGGCGGATTTTGAAGACTCGCTGGCGCCGGACTGGAATAAAGTTATTGATGGTCAAA
TCAACCTGCGTGATGCGGTGAACGGCACCATTAGCTATACCAACGAAGCCGGAAAAATCTATCAGCTCAAGCCCGATCCG
GCCGTATTGATTTGTCGTGTACGCGGTCTACATCTGCCAGAAAAACATGTTACCTGGCGGGGGGAAGCCATTCCCGGCAG
CCTGTTTGATTTTGCTCTGTACTTTTTCCACAACTACAAAGCGCTGCTCGCTAAAGGTAGCGGCCCGTATTTTTACCTGC
CGAAAACGCAAGCCTGGCAGGAGGCAGCCTGGTGGAGTGAAGTTTTCAGCTACGCCGAAGACCGCTTCAATCTACCGCGC
GGTACGATCAAAGCGACCCTGTTGATTGAAACGCTGCCTGCTGTTTTCCAGATGGATGAGATTCTTCATGCGTTGCGTGA
TCATATCGTCGGTCTCAACTGTGGTCGCTGGGATTATATTTTCAGCTATATCAAAACGTTGAAAAATCACCCGGATCGCG
TCCTGCCGGACAGGCAGGTGGTAACGATGGACAAACCGTTTCTGAGTGCCTACTCGCGCCTGCTGATCAAAACCTGTCAC
AAGCGCGGCGCGTTCGCGATGGGCGGTATGGCGGCGTTTATCCCGAGCAAAGACGTTGAACGCAATAATCAGGTCCTTGC
CAAAGTGAAAGCGGATAAAGCGCTGGAAGCGAACAACGGCCACGACGGCACGTGGATTGCGCATCCCGGGTTGGCGGATA
CGGCAATGGCCGTCTTTAACGAGGTACTGGGCGAGTACAAAAATCAGCTGTTCATTACCCGTGATGAAGATGCGCCGATT
ACCGCTGAGCAGTTACTGGAGCCATGTGAAGGCGAACGCACAGAAGCGGGAATGCGCGCCAATATTCGCGTGGCAGTGCA
GTACATTGAAGCGTGGATCCCCGGCAATGGCTGTGTACCGATTTACGGTCTGATGGAGGATGCCGCGACGGCGGAAATCT
CACGAACCTCTATCTGGCAGTGGATTCACCATGAGAAAACACTGAGCAATGGAAAACCCGTAACGAAAGCGCTTTTCCGC
GAAATGTTGGCGGAAGAGATGCGGGTAATCCAGGACGAACTGGGCGAGCACCGCTACAGCAGCGGGCGCTTCGACGATGC
CGCACGTCTGATGGAGCAAATCACCACATCAGATGACTTAATCGACTTCCTCACCCTGCCGGGCTATCGCTTACTGGCTT
AA

Upstream 100 bases:

>100_bases
AAATTTAATTGAGTAGTCTTAGTTGTGTTGAACGAAAAGCGCACAGTGATCCTTCGTTCGCATTGGGGATGTATCTGGAT
CAACAACGAGGAGCTGCATG

Downstream 100 bases:

>100_bases
TTCACCACATAACAATATGGAGCATCTGCACATGAAAACCCGTACTCAACAAATCGAAGAATTACAGAAAGAGTGGACAC
AACCGCGCTGGGAAGGCATC

Product: malate synthase

Products: NA

Alternate protein names: MSA [H]

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MNPQATTTDELTFTRPQGELEKQVLTAEAVEFLTELVTRFTPKRNKLLAARIQQQQDIDNGKLPDFISETTSIRESNWQI
RGIPADLQDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPDWNKVIDGQINLRDAVNGTISYTNEAGKIYQLKPDP
AVLICRVRGLHLPEKHVTWRGEAIPGSLFDFALYFFHNYKALLAKGSGPYFYLPKTQAWQEAAWWSEVFSYAEDRFNLPR
GTIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNHPDRVLPDRQVVTMDKPFLSAYSRLLIKTCH
KRGAFAMGGMAAFIPSKDVERNNQVLAKVKADKALEANNGHDGTWIAHPGLADTAMAVFNEVLGEYKNQLFITRDEDAPI
TAEQLLEPCEGERTEAGMRANIRVAVQYIEAWIPGNGCVPIYGLMEDAATAEISRTSIWQWIHHEKTLSNGKPVTKALFR
EMLAEEMRVIQDELGEHRYSSGRFDDAARLMEQITTSDDLIDFLTLPGYRLLA

Sequences:

>Translated_533_residues
MNPQATTTDELTFTRPQGELEKQVLTAEAVEFLTELVTRFTPKRNKLLAARIQQQQDIDNGKLPDFISETTSIRESNWQI
RGIPADLQDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPDWNKVIDGQINLRDAVNGTISYTNEAGKIYQLKPDP
AVLICRVRGLHLPEKHVTWRGEAIPGSLFDFALYFFHNYKALLAKGSGPYFYLPKTQAWQEAAWWSEVFSYAEDRFNLPR
GTIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNHPDRVLPDRQVVTMDKPFLSAYSRLLIKTCH
KRGAFAMGGMAAFIPSKDVERNNQVLAKVKADKALEANNGHDGTWIAHPGLADTAMAVFNEVLGEYKNQLFITRDEDAPI
TAEQLLEPCEGERTEAGMRANIRVAVQYIEAWIPGNGCVPIYGLMEDAATAEISRTSIWQWIHHEKTLSNGKPVTKALFR
EMLAEEMRVIQDELGEHRYSSGRFDDAARLMEQITTSDDLIDFLTLPGYRLLA
>Mature_533_residues
MNPQATTTDELTFTRPQGELEKQVLTAEAVEFLTELVTRFTPKRNKLLAARIQQQQDIDNGKLPDFISETTSIRESNWQI
RGIPADLQDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPDWNKVIDGQINLRDAVNGTISYTNEAGKIYQLKPDP
AVLICRVRGLHLPEKHVTWRGEAIPGSLFDFALYFFHNYKALLAKGSGPYFYLPKTQAWQEAAWWSEVFSYAEDRFNLPR
GTIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNHPDRVLPDRQVVTMDKPFLSAYSRLLIKTCH
KRGAFAMGGMAAFIPSKDVERNNQVLAKVKADKALEANNGHDGTWIAHPGLADTAMAVFNEVLGEYKNQLFITRDEDAPI
TAEQLLEPCEGERTEAGMRANIRVAVQYIEAWIPGNGCVPIYGLMEDAATAEISRTSIWQWIHHEKTLSNGKPVTKALFR
EMLAEEMRVIQDELGEHRYSSGRFDDAARLMEQITTSDDLIDFLTLPGYRLLA

Specific function: Glyoxylate bypass; second step. [C]

COG id: COG2225

COG function: function code C; Malate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790444, Length=533, Percent_Identity=90.8067542213884, Blast_Score=1021, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17561814, Length=528, Percent_Identity=51.3257575757576, Blast_Score=511, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI71982926, Length=422, Percent_Identity=54.0284360189574, Blast_Score=426, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6322222, Length=528, Percent_Identity=46.2121212121212, Blast_Score=432, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6324212, Length=488, Percent_Identity=47.3360655737705, Blast_Score=431, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011076
- InterPro:   IPR006252
- InterPro:   IPR001465
- InterPro:   IPR019830 [H]

Pfam domain/function: PF01274 Malate_synthase [H]

EC number: =2.3.3.9 [H]

Molecular weight: Translated: 60390; Mature: 60390

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00510 MALATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPQATTTDELTFTRPQGELEKQVLTAEAVEFLTELVTRFTPKRNKLLAARIQQQQDIDN
CCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
GKLPDFISETTSIRESNWQIRGIPADLQDRRVEITGPVERKMVINALNANVKVFMADFED
CCCCHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCHHHHHHHHHHCCCEEEEEECCCC
SLAPDWNKVIDGQINLRDAVNGTISYTNEAGKIYQLKPDPAVLICRVRGLHLPEKHVTWR
CCCCCHHHHCCCCEEEHHHCCCEEEEECCCCEEEEECCCCEEEEEEECCCCCCCHHCCCC
GEAIPGSLFDFALYFFHNYKALLAKGSGPYFYLPKTQAWQEAAWWSEVFSYAEDRFNLPR
CCCCCCHHHHHHHHHHHCCHHEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC
GTIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNHPDRVLPDRQV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEE
VTMDKPFLSAYSRLLIKTCHKRGAFAMGGMAAFIPSKDVERNNQVLAKVKADKALEANNG
EEECCHHHHHHHHHHHHHHHHCCCEECCCEEEECCCCCCCCCCCEEEEEHHCCCEECCCC
HDGTWIAHPGLADTAMAVFNEVLGEYKNQLFITRDEDAPITAEQLLEPCEGERTEAGMRA
CCCCEEECCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHCCCCCCCCCCCCCC
NIRVAVQYIEAWIPGNGCVPIYGLMEDAATAEISRTSIWQWIHHEKTLSNGKPVTKALFR
HHHHHEEHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EMLAEEMRVIQDELGEHRYSSGRFDDAARLMEQITTSDDLIDFLTLPGYRLLA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHCC
>Mature Secondary Structure
MNPQATTTDELTFTRPQGELEKQVLTAEAVEFLTELVTRFTPKRNKLLAARIQQQQDIDN
CCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
GKLPDFISETTSIRESNWQIRGIPADLQDRRVEITGPVERKMVINALNANVKVFMADFED
CCCCHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCHHHHHHHHHHCCCEEEEEECCCC
SLAPDWNKVIDGQINLRDAVNGTISYTNEAGKIYQLKPDPAVLICRVRGLHLPEKHVTWR
CCCCCHHHHCCCCEEEHHHCCCEEEEECCCCEEEEECCCCEEEEEEECCCCCCCHHCCCC
GEAIPGSLFDFALYFFHNYKALLAKGSGPYFYLPKTQAWQEAAWWSEVFSYAEDRFNLPR
CCCCCCHHHHHHHHHHHCCHHEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC
GTIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNHPDRVLPDRQV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEE
VTMDKPFLSAYSRLLIKTCHKRGAFAMGGMAAFIPSKDVERNNQVLAKVKADKALEANNG
EEECCHHHHHHHHHHHHHHHHCCCEECCCEEEECCCCCCCCCCCEEEEEHHCCCEECCCC
HDGTWIAHPGLADTAMAVFNEVLGEYKNQLFITRDEDAPITAEQLLEPCEGERTEAGMRA
CCCCEEECCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHCCCCCCCCCCCCCC
NIRVAVQYIEAWIPGNGCVPIYGLMEDAATAEISRTSIWQWIHHEKTLSNGKPVTKALFR
HHHHHEEHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EMLAEEMRVIQDELGEHRYSSGRFDDAARLMEQITTSDDLIDFLTLPGYRLLA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3050899; 3060852; 8265357; 9278503 [H]