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The map label for this gene is trkA [H]

Identifier: 29144360

GI number: 29144360

Start: 4233003

End: 4234379

Strand: Reverse

Name: trkA [H]

Synonym: t4095

Alternate gene names: 29144360

Gene position: 4234379-4233003 (Counterclockwise)

Preceding gene: 29144361

Following gene: 29144359

Centisome position: 88.36

GC content: 51.2

Gene sequence:

>1377_bases
ATGAAAATTATCATACTGGGCGCAGGGCAAGTTGGTGGAACACTGGCGGAAAACCTGGTCGGCGAAAACAACGACATCAC
GGTGGTTGATACCAACGGCGAACGATTACGCAGTTTGCAAGATAAGTTCGATCTACGCGTAGTTCAGGGGCATGGTTCGC
ATCCCCGCGTGTTGCGCGAAGCGGGCGCTGACGATGCGGATATGCTGGTCGCTGTCACCAGTTCAGATGAAACTAATATG
GTTGCCTGTCAGGTAGCCTATTCACTCTTCAACACCCCAAACCGTATCGCCCGCATTCGCTCCCCGGACTATGTTCGCGA
TGCGGATAAACTCTTTCATTCTGAAGCGGTTCCGATTGATCATCTGATCGCGCCGGAGCAGTTGGTTATCGATAATATTT
ATCGTCTGATCGAGTATCCGGGAGCATTACAGGTTGTAAACTTTGCCGAAGGGAAAGTCAGTCTGGCAGTAGTAAAAGCC
TACTATGGCGGTCCACTAATAGGTAACGCGCTCTCGACAATGCGAGAGCATATGCCGCATATCGATACCCGCGTTGCCGC
AATTTTCCGTCATGACAGACCAATCCGTCCTCAGGGCTCGACTATCGTGGAAGCAGGGGATGAAGTCTTCTTTATTGCGG
CTTCACAGCATATCCGTGCAGTAATGAGCGAATTACAGCGTCTGGAAAAACCCTACAAGCGCATCATGCTGGTGGGCGGC
GGCAATATCGGCGCCGGGCTGGCAAGGCGTCTGGAAAAAGACTATAGCGTTAAATTGATCGAACGCGATCAACAACGCGC
CGCAGAACTGGCTGAGAAGCTGCAAAACACGATCGTCTTTTTTGGCGACGCTTCCGATCAGGAATTGCTGGCGGAGGAGC
ATATTGATCAGGTCGATCTCTTTATCGCAGTCACTAACGATGACGAAGCCAATATCATGTCCGCGATGTTGGCTAAGCGG
ATGGGCGCCAAAAAAGTGATGGTGCTGATTCAGCGTCGAGCTTATGTCGATCTTGTGCAGGGTAGCGTTATAGATATTGC
GATTTCTCCGCAGCAGGCCACCATCTCTGCATTACTGAGCCATGTGCGTAAAGCAGATATCGTCGGCGTTTCCTCACTAC
GTCGCGGGGTTGCCGAAGCCATCGAAGCCGTCGCGCACGGCGATGAAAGCACTTCCCGCGTGGTTGGCCGCGTCATTGAC
GAAATAAAACTGCCGCCAGGCACCATTATTGGCGCGGTCGTTCGCGGTAATGATGTCATGATTGCTAATGACAATTTGCG
CATTGAACAAGGCGATCACGTCATTATGTTTTTGACCGATAAAAAGTTTATTACCGACGTCGAACGTCTGTTCCAGCCAA
GTCCTTTCTTCCTCTAA

Upstream 100 bases:

>100_bases
TGATCAGCCAGGACAGCAAAATCTGCCGGGCGGCGAAGAAGGTGATGGGTTCTTTTACGCTAAGCTAATCAAGAAGTGAT
GAGATAACGGGCCACGACTG

Downstream 100 bases:

>100_bases
TTTAAGGGGCGCTCATTCAGCGCCCTTTTTAATTCCCTTTATTTATCAAGGTTTAATTTATTTCGCTAAACAGAAGCCGT
AAATGGAAAATGCCTTAGCA

Product: potassium transporter peripheral membrane protein

Products: NA

Alternate protein names: K(+)-uptake protein trkA [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MKIIILGAGQVGGTLAENLVGENNDITVVDTNGERLRSLQDKFDLRVVQGHGSHPRVLREAGADDADMLVAVTSSDETNM
VACQVAYSLFNTPNRIARIRSPDYVRDADKLFHSEAVPIDHLIAPEQLVIDNIYRLIEYPGALQVVNFAEGKVSLAVVKA
YYGGPLIGNALSTMREHMPHIDTRVAAIFRHDRPIRPQGSTIVEAGDEVFFIAASQHIRAVMSELQRLEKPYKRIMLVGG
GNIGAGLARRLEKDYSVKLIERDQQRAAELAEKLQNTIVFFGDASDQELLAEEHIDQVDLFIAVTNDDEANIMSAMLAKR
MGAKKVMVLIQRRAYVDLVQGSVIDIAISPQQATISALLSHVRKADIVGVSSLRRGVAEAIEAVAHGDESTSRVVGRVID
EIKLPPGTIIGAVVRGNDVMIANDNLRIEQGDHVIMFLTDKKFITDVERLFQPSPFFL

Sequences:

>Translated_458_residues
MKIIILGAGQVGGTLAENLVGENNDITVVDTNGERLRSLQDKFDLRVVQGHGSHPRVLREAGADDADMLVAVTSSDETNM
VACQVAYSLFNTPNRIARIRSPDYVRDADKLFHSEAVPIDHLIAPEQLVIDNIYRLIEYPGALQVVNFAEGKVSLAVVKA
YYGGPLIGNALSTMREHMPHIDTRVAAIFRHDRPIRPQGSTIVEAGDEVFFIAASQHIRAVMSELQRLEKPYKRIMLVGG
GNIGAGLARRLEKDYSVKLIERDQQRAAELAEKLQNTIVFFGDASDQELLAEEHIDQVDLFIAVTNDDEANIMSAMLAKR
MGAKKVMVLIQRRAYVDLVQGSVIDIAISPQQATISALLSHVRKADIVGVSSLRRGVAEAIEAVAHGDESTSRVVGRVID
EIKLPPGTIIGAVVRGNDVMIANDNLRIEQGDHVIMFLTDKKFITDVERLFQPSPFFL
>Mature_458_residues
MKIIILGAGQVGGTLAENLVGENNDITVVDTNGERLRSLQDKFDLRVVQGHGSHPRVLREAGADDADMLVAVTSSDETNM
VACQVAYSLFNTPNRIARIRSPDYVRDADKLFHSEAVPIDHLIAPEQLVIDNIYRLIEYPGALQVVNFAEGKVSLAVVKA
YYGGPLIGNALSTMREHMPHIDTRVAAIFRHDRPIRPQGSTIVEAGDEVFFIAASQHIRAVMSELQRLEKPYKRIMLVGG
GNIGAGLARRLEKDYSVKLIERDQQRAAELAEKLQNTIVFFGDASDQELLAEEHIDQVDLFIAVTNDDEANIMSAMLAKR
MGAKKVMVLIQRRAYVDLVQGSVIDIAISPQQATISALLSHVRKADIVGVSSLRRGVAEAIEAVAHGDESTSRVVGRVID
EIKLPPGTIIGAVVRGNDVMIANDNLRIEQGDHVIMFLTDKKFITDVERLFQPSPFFL

Specific function: Part of the constitutive potassium transport systems trkG and trkH. May regulate the transport activity of trkG and trkH systems. Binds to NAD+ and NADH [H]

COG id: COG0569

COG function: function code P; K+ transport systems, NAD-binding component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripherally bound to the inner side of the inner membrane via the trkG and trkH proteins (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 RCK N-terminal domains [H]

Homologues:

Organism=Escherichia coli, GI1789685, Length=458, Percent_Identity=99.3449781659389, Blast_Score=920, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR006037
- InterPro:   IPR003148 [H]

Pfam domain/function: PF02080 TrkA_C; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 50370; Mature: 50370

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIILGAGQVGGTLAENLVGENNDITVVDTNGERLRSLQDKFDLRVVQGHGSHPRVLRE
CEEEEEECCCCCHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCEEEEECCCCCCHHHHH
AGADDADMLVAVTSSDETNMVACQVAYSLFNTPNRIARIRSPDYVRDADKLFHSEAVPID
CCCCCCCEEEEEECCCCCCEEHHHHHHHHHCCCHHHEECCCCCHHHHHHHHHHCCCCCHH
HLIAPEQLVIDNIYRLIEYPGALQVVNFAEGKVSLAVVKAYYGGPLIGNALSTMREHMPH
HHCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEEHHCCCHHHHHHHHHHHHCCC
IDTRVAAIFRHDRPIRPQGSTIVEAGDEVFFIAASQHIRAVMSELQRLEKPYKRIMLVGG
HHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHEEEEEEC
GNIGAGLARRLEKDYSVKLIERDQQRAAELAEKLQNTIVFFGDASDQELLAEEHIDQVDL
CCCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHCCCEEEE
FIAVTNDDEANIMSAMLAKRMGAKKVMVLIQRRAYVDLVQGSVIDIAISPQQATISALLS
EEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHH
HVRKADIVGVSSLRRGVAEAIEAVAHGDESTSRVVGRVIDEIKLPPGTIIGAVVRGNDVM
HHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCEEE
IANDNLRIEQGDHVIMFLTDKKFITDVERLFQPSPFFL
EECCCEEEECCCEEEEEEECCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKIIILGAGQVGGTLAENLVGENNDITVVDTNGERLRSLQDKFDLRVVQGHGSHPRVLRE
CEEEEEECCCCCHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCEEEEECCCCCCHHHHH
AGADDADMLVAVTSSDETNMVACQVAYSLFNTPNRIARIRSPDYVRDADKLFHSEAVPID
CCCCCCCEEEEEECCCCCCEEHHHHHHHHHCCCHHHEECCCCCHHHHHHHHHHCCCCCHH
HLIAPEQLVIDNIYRLIEYPGALQVVNFAEGKVSLAVVKAYYGGPLIGNALSTMREHMPH
HHCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEEHHCCCHHHHHHHHHHHHCCC
IDTRVAAIFRHDRPIRPQGSTIVEAGDEVFFIAASQHIRAVMSELQRLEKPYKRIMLVGG
HHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHEEEEEEC
GNIGAGLARRLEKDYSVKLIERDQQRAAELAEKLQNTIVFFGDASDQELLAEEHIDQVDL
CCCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHCCCEEEE
FIAVTNDDEANIMSAMLAKRMGAKKVMVLIQRRAYVDLVQGSVIDIAISPQQATISALLS
EEEEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHH
HVRKADIVGVSSLRRGVAEAIEAVAHGDESTSRVVGRVIDEIKLPPGTIIGAVVRGNDVM
HHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCEEE
IANDNLRIEQGDHVIMFLTDKKFITDVERLFQPSPFFL
EECCCEEEECCCEEEEEEECCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]