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The map label for this gene is slyD [H]

Identifier: 29144315

GI number: 29144315

Start: 4207246

End: 4207836

Strand: Direct

Name: slyD [H]

Synonym: t4050

Alternate gene names: 29144315

Gene position: 4207246-4207836 (Clockwise)

Preceding gene: 29144314

Following gene: 29144317

Centisome position: 87.8

GC content: 55.84

Gene sequence:

>591_bases
ATGAAAGTAGCAAAAGACCTGGTGGTCAGCCTGGCCTATCAGGTACGTACAGAAGACGGTGTGTTGGTTGATGAGTCTCC
GGTGAGTGCGCCGCTGGATTACCTGCACGGTCACGGCTCCCTGATCTCTGGTCTGGAAACCGCGCTGGAAGGCCATGAAG
TTGGCGACAAATTTGATGTCGCTGTTGGCGCGAACGACGCTTACGGCCAGTATGACGAAAATCTGGTGCAGCGTGTGCCT
AAAGACGTCTTTATGGGCGTTGATGAACTGCAGGTAGGGATGCGTTTCCTGGCGGAAACCGACCAGGGCCCGGTACCGGT
AGAGATTACCGAAGTGGAAGACGATCACGTTGTGGTTGATGGTAACCACATGCTGGCGGGCCAGAATCTGAAATTTAACG
TCGAAGTTGTTGCGATTCGTGAAGCGACTGAAGAAGAACTGGCTCACGGTCATGTTCACGGCGCGCACGATCACCACCAC
GATCACGGTGAAGACGGCTGCTGTAGCGGTCATGGTCATGACCATGGTCACGAGCACGGCGGCGAAGGCTGCTGCGGCGG
TGGTGGTAAAGGCAGCTGCGGCTGCCATTAA

Upstream 100 bases:

>100_bases
GACTAGCGATATGCCGCAGGTTTTTTTAAGCTAAGGGGTACACGGCTGCAGAATTCCGCTACAATCTGCGCCACTATTCT
TCCCATGCTCAGGAGATATC

Downstream 100 bases:

>100_bases
TCCCCGTCGTCTTTCAAGCCACCGCGGTGTTGGCTACGCTTTCAAACCCCGGTCACATAGTTATCTATGTTCCCGGGGAA
TTTTCAAGCTTGCCGCTTTG

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Metallochaperone slyD [H]

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MKVAKDLVVSLAYQVRTEDGVLVDESPVSAPLDYLHGHGSLISGLETALEGHEVGDKFDVAVGANDAYGQYDENLVQRVP
KDVFMGVDELQVGMRFLAETDQGPVPVEITEVEDDHVVVDGNHMLAGQNLKFNVEVVAIREATEEELAHGHVHGAHDHHH
DHGEDGCCSGHGHDHGHEHGGEGCCGGGGKGSCGCH

Sequences:

>Translated_196_residues
MKVAKDLVVSLAYQVRTEDGVLVDESPVSAPLDYLHGHGSLISGLETALEGHEVGDKFDVAVGANDAYGQYDENLVQRVP
KDVFMGVDELQVGMRFLAETDQGPVPVEITEVEDDHVVVDGNHMLAGQNLKFNVEVVAIREATEEELAHGHVHGAHDHHH
DHGEDGCCSGHGHDHGHEHGGEGCCGGGGKGSCGCH
>Mature_196_residues
MKVAKDLVVSLAYQVRTEDGVLVDESPVSAPLDYLHGHGSLISGLETALEGHEVGDKFDVAVGANDAYGQYDENLVQRVP
KDVFMGVDELQVGMRFLAETDQGPVPVEITEVEDDHVVVDGNHMLAGQNLKFNVEVVAIREATEEELAHGHVHGAHDHHH
DHGEDGCCSGHGHDHGHEHGGEGCCGGGGKGSCGCH

Specific function: Also involved in hydrogenase metallocenter assembly, probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain, but not PPIase activity [H]

COG id: COG1047

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 2

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI1789748, Length=148, Percent_Identity=99.3243243243243, Blast_Score=293, Evalue=7e-81,
Organism=Escherichia coli, GI1786211, Length=135, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20848; Mature: 20848

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAKDLVVSLAYQVRTEDGVLVDESPVSAPLDYLHGHGSLISGLETALEGHEVGDKFDV
CCHHHHHHHHHHHHEECCCCEEEECCCCCCCHHHHCCCCHHHHHHHHHHCCCCCCCEEEE
AVGANDAYGQYDENLVQRVPKDVFMGVDELQVGMRFLAETDQGPVPVEITEVEDDHVVVD
EECCCCCCCHHHHHHHHHCCHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEC
GNHMLAGQNLKFNVEVVAIREATEEELAHGHVHGAHDHHHDHGEDGCCSGHGHDHGHEHG
CCEEEECCCEEEEEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GEGCCGGGGKGSCGCH
CCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKVAKDLVVSLAYQVRTEDGVLVDESPVSAPLDYLHGHGSLISGLETALEGHEVGDKFDV
CCHHHHHHHHHHHHEECCCCEEEECCCCCCCHHHHCCCCHHHHHHHHHHCCCCCCCEEEE
AVGANDAYGQYDENLVQRVPKDVFMGVDELQVGMRFLAETDQGPVPVEITEVEDDHVVVD
EECCCCCCCHHHHHHHHHCCHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEC
GNHMLAGQNLKFNVEVVAIREATEEELAHGHVHGAHDHHHDHGEDGCCSGHGHDHGHEHG
CCEEEECCCEEEEEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GEGCCGGGGKGSCGCH
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]