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The map label for this gene is gntU [H]

Identifier: 29144248

GI number: 29144248

Start: 4119060

End: 4120400

Strand: Direct

Name: gntU [H]

Synonym: t3979

Alternate gene names: 29144248

Gene position: 4119060-4120400 (Clockwise)

Preceding gene: 29144247

Following gene: 29144249

Centisome position: 85.96

GC content: 57.64

Gene sequence:

>1341_bases
GTGAGTACATTAACACTGGTTTTAACCGCCGTCGGTTCCGTCTTACTGCTGCTGTTTCTCGTGATGAAGGCGCGTATGCA
CGCCTTCGTCGCGTTAATGGTCGTCTCAATGGGCGCGGGGCTTTTTTCAGGGATGCCGCTTGATAAAATCGCCGCGACCA
TGGAAAAAGGGATGGGCGGCACGCTGGGCTTCCTGGCGATTGTGGTCGCGCTGGGGGCGATGTTCGGTAAAATTCTGCAT
GAAACCGGCGCGGTCGATCAGATAGCCGTGAAAATGCTTAAATCCTTTGGCCATAACCGCGCGCACTATGCGATTGGCCT
TGCCGGGCTGATTTGCGCGCTCCCGCTATTCTTTGAAGTGGCGATTGTGCTGCTGATAAGTGTGGCGTTCTCTATGGCGC
GTCATACCGGCACAAACCTGGTGAAGCTGGTCATTCCGCTGTTTGCGGGCGTGGCGGCAGCCGCGGCGTTTTTGTTGCCT
GGGCCTGCGCCGATGCTGCTGGCTTCCCAGATGCATGCTGATTTCGGCTGGATGATCCTGATTGGGCTGTGCGCCGCCAT
TCCTGGCATGATTATCGCCGGGCCGCTGTGGGGGAATTTTATCAGCCGTTACGTTGAGCTGCGTATTCCTGACGACATTA
CCGAGCCGCATCTGGGCGAAGGCAAAATGCCTTCTTTCGGCTTCAGCCTGTCGCTGATCCTGCTGCCGTTGGTGCTGGTA
GGACTGAAAACGATCGCCGCGCGCTTTGTGCCGGAAGGTTCCACCGCTTATGAATGGTTTGAGTTTATCGGCCACCCCTT
CACTGCGATTCTGGTCGCTTGTCTGGTAGCGATTTACGGCCTGGCGATGCGCCAGGGGATGCCGAAAGACAAAGTGATGG
AAATCTGCGGCCACGCGCTACAACCGGCGGGCATTATTCTGCTGGTGATTGGCGCAGGCGGGGTGTTCAAACAGGTACTG
GTTGACTCCGGCGTCGGCCCGGCGCTGGGCGAAGCGTTAACCGGTATGGGACTGCCGATTGCCATTACCTGCTTTGTGCT
GGCGGCGGCGGTGCGCATCATTCAGGGTTCCGCGACCGTGGCGTGTTTAACCGCGGTCGGTCTGGTGATGCCGGTCATTG
AGCAACTGAATTTCTCCGGCGCGCAGATGGCGGCGCTCTCTATCTGTATCGCCGGCGGTTCAATTGTGGTTTCTCATGTT
AACGACGCTGGCTTCTGGCTGTTCGGTAAATTTACCGGCGCGACCGAAGCGCAGACGCTGAAGACCTGGACGATGATGGA
AACTATCCTCGGCACGGTCGGCGCGATTGTCGGGATGATTGCTTTCCAACTGCTGAGCTGA

Upstream 100 bases:

>100_bases
CGGGTGCCGACGAACGCGATGTTCTGGTGGTGGATATCGACCAGCCGCTGGAAGGCGTTGTGGCGAGCACCATTGAGGTC
ATCAATAAAGGCAGTACGCT

Downstream 100 bases:

>100_bases
GTCTTGTTGCCCGGTGGCGCTGTGCTTACCGGGCCTGGAAACGGGCACATATCGATACCGTAAGCCGGGTAAGGCGTAAT
CGCTACCCGGTTTTTTTATT

Product: low affinity gluconate transporter

Products: Proton [Cytoplasm]; gluconate [Cytoplasm] [C]

Alternate protein names: Gluconate permease; Gnt-I system [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MSTLTLVLTAVGSVLLLLFLVMKARMHAFVALMVVSMGAGLFSGMPLDKIAATMEKGMGGTLGFLAIVVALGAMFGKILH
ETGAVDQIAVKMLKSFGHNRAHYAIGLAGLICALPLFFEVAIVLLISVAFSMARHTGTNLVKLVIPLFAGVAAAAAFLLP
GPAPMLLASQMHADFGWMILIGLCAAIPGMIIAGPLWGNFISRYVELRIPDDITEPHLGEGKMPSFGFSLSLILLPLVLV
GLKTIAARFVPEGSTAYEWFEFIGHPFTAILVACLVAIYGLAMRQGMPKDKVMEICGHALQPAGIILLVIGAGGVFKQVL
VDSGVGPALGEALTGMGLPIAITCFVLAAAVRIIQGSATVACLTAVGLVMPVIEQLNFSGAQMAALSICIAGGSIVVSHV
NDAGFWLFGKFTGATEAQTLKTWTMMETILGTVGAIVGMIAFQLLS

Sequences:

>Translated_446_residues
MSTLTLVLTAVGSVLLLLFLVMKARMHAFVALMVVSMGAGLFSGMPLDKIAATMEKGMGGTLGFLAIVVALGAMFGKILH
ETGAVDQIAVKMLKSFGHNRAHYAIGLAGLICALPLFFEVAIVLLISVAFSMARHTGTNLVKLVIPLFAGVAAAAAFLLP
GPAPMLLASQMHADFGWMILIGLCAAIPGMIIAGPLWGNFISRYVELRIPDDITEPHLGEGKMPSFGFSLSLILLPLVLV
GLKTIAARFVPEGSTAYEWFEFIGHPFTAILVACLVAIYGLAMRQGMPKDKVMEICGHALQPAGIILLVIGAGGVFKQVL
VDSGVGPALGEALTGMGLPIAITCFVLAAAVRIIQGSATVACLTAVGLVMPVIEQLNFSGAQMAALSICIAGGSIVVSHV
NDAGFWLFGKFTGATEAQTLKTWTMMETILGTVGAIVGMIAFQLLS
>Mature_445_residues
STLTLVLTAVGSVLLLLFLVMKARMHAFVALMVVSMGAGLFSGMPLDKIAATMEKGMGGTLGFLAIVVALGAMFGKILHE
TGAVDQIAVKMLKSFGHNRAHYAIGLAGLICALPLFFEVAIVLLISVAFSMARHTGTNLVKLVIPLFAGVAAAAAFLLPG
PAPMLLASQMHADFGWMILIGLCAAIPGMIIAGPLWGNFISRYVELRIPDDITEPHLGEGKMPSFGFSLSLILLPLVLVG
LKTIAARFVPEGSTAYEWFEFIGHPFTAILVACLVAIYGLAMRQGMPKDKVMEICGHALQPAGIILLVIGAGGVFKQVLV
DSGVGPALGEALTGMGLPIAITCFVLAAAVRIIQGSATVACLTAVGLVMPVIEQLNFSGAQMAALSICIAGGSIVVSHVN
DAGFWLFGKFTGATEAQTLKTWTMMETILGTVGAIVGMIAFQLLS

Specific function: Part of the gluconate utilization system Gnt-I; low- affinity intake of gluconate [H]

COG id: COG2610

COG function: function code GE; H+/gluconate symporter and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gntP permease family [H]

Homologues:

Organism=Escherichia coli, GI48994939, Length=446, Percent_Identity=97.5336322869955, Blast_Score=805, Evalue=0.0,
Organism=Escherichia coli, GI1790716, Length=430, Percent_Identity=36.7441860465116, Blast_Score=287, Evalue=1e-78,
Organism=Escherichia coli, GI48994935, Length=434, Percent_Identity=35.7142857142857, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI2367370, Length=429, Percent_Identity=34.032634032634, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1789097, Length=450, Percent_Identity=33.7777777777778, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1788707, Length=440, Percent_Identity=34.7727272727273, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI1790776, Length=431, Percent_Identity=31.554524361949, Blast_Score=206, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003474 [H]

Pfam domain/function: PF02447 GntP_permease [H]

EC number: NA

Molecular weight: Translated: 46497; Mature: 46366

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STLTLVLTAVGSVLLLLFLVMKARMHAFVALMVVSMGAGLFSGMPLDKIAATMEKGMGG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHCCCC
TLGFLAIVVALGAMFGKILHETGAVDQIAVKMLKSFGHNRAHYAIGLAGLICALPLFFEV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
AIVLLISVAFSMARHTGTNLVKLVIPLFAGVAAAAAFLLPGPAPMLLASQMHADFGWMIL
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHH
IGLCAAIPGMIIAGPLWGNFISRYVELRIPDDITEPHLGEGKMPSFGFSLSLILLPLVLV
HHHHHHCCHHHEECHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
GLKTIAARFVPEGSTAYEWFEFIGHPFTAILVACLVAIYGLAMRQGMPKDKVMEICGHAL
HHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
QPAGIILLVIGAGGVFKQVLVDSGVGPALGEALTGMGLPIAITCFVLAAAVRIIQGSATV
CCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHH
ACLTAVGLVMPVIEQLNFSGAQMAALSICIAGGSIVVSHVNDAGFWLFGKFTGATEAQTL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCHHHHH
KTWTMMETILGTVGAIVGMIAFQLLS
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; gluconate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + gluconate [Periplasm] = Proton [Cytoplasm] + gluconate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]