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The map label for this gene is glpK [H]

Identifier: 29144028

GI number: 29144028

Start: 3852049

End: 3853533

Strand: Direct

Name: glpK [H]

Synonym: t3737

Alternate gene names: 29144028

Gene position: 3852049-3853533 (Clockwise)

Preceding gene: 29144027

Following gene: 29144029

Centisome position: 80.39

GC content: 49.29

Gene sequence:

>1485_bases
ATGCCTGATTACCACGCAGCGCTTGTCATTGACATTGGTACAACTAACTGCAAAGTCAGCTGCTATTCCTGTCATGACGT
GTCAGTTCTGGAAGTCCGCAAGTTTCCGACGCCAACAATATCGTCGGACAAAGGCGAGGTAGATTTAGATATCGAAGCGC
TGTGGCAGGCACTGCGACTGGTAATGGCTGAACTGGTGGCTTCAGTACCGTTTCCGGTAAAAAATATCAGTATTGCGAGT
TTCGGTGAGTCTGGCGTCTTTGTGGATAAGGAGGGCGTCATTCTTACCCCGATGCTGGCCTGGTATGATCGACGTGGTGA
ATCTTATCTCTCGTCATTAAGCAAGGCAGAGGCTGAAGAACTGTATTCTATAACGGGATTGCCACCTCACAGTAATTACT
CAGCATTTAAAATGAGATGGTTGCTTGATAACTACTCCTTGCATGAAAGAAAAGATATCTGCTGGTTACATGCTCCAGAA
GTGTTGTTGTGGCGAATGACAGGTGCGAAAAAGACGGAAATATCCCTGGCCAGTAGAACGTTGTGTCTGGACATTGCTCG
CCGTACCTGGTCTCGTAATGCTGCCGGGATTCTCGGCATACCGTTCGGTGTACTGGCTCCGTTGATAAAGCCGGGTGAAG
TGGCTGGATGGGTGACGGCAACGCTCAGGCAGGAGTTGGGATTACCACATGAGGTAAAAGTTACCCTGGCCGGACACGAT
CATATGGTCGGTGCCCGCGCATTACAGATGCAACCGGGCGATGTGCTGAATTCTACCGGCACGACAGAGGGTATTTTACT
GCTGAATACACAGCCAACGCTTGATGTGCAGGCTCGCAGGGATAAGCTGGCAAATGGTTGTTACTCCGATGGTGAATTTT
TCACGCTTTTCGCTTCTCTGCCTGTCGGCGGTTATGCGCTTGAATGGGTGAAAAAAACCTTTCGTTTAACTGATAAGGAA
ATAAGCACAGGCCTGGAAAAAGTCATGGAGCAATACCTCAAACCTTCCTGGTCTGTCGAGCATGTGCCGGTATTTATTCC
TCATTTGCGGGGCTCGGGTTCGCCACATAAAAACCAGCACACTCGTGGCCTGCTTTTTGGTCTGACGGATTCACTTCCTC
CGGAGTCTCTGCTTGAGAGTGTCTTTATCGGCCTGGCGATGGAGTTTGCACACTGTCACGGGTGCTTTAATATCCCGGCA
GGCAGGACAGTAAAAGTCATTGGCCCTGCGGTGAAAAACCCATACTGGCTCCAGTTGAAGGCTGACATCCTCCAGTGTCC
AATTGAGGCCATTGCTTTTGATGAAACCGTCTCCCTTGGAGCATTGTTGATAGCCTGTCCGAATGTTGTCCCCCCGACTG
TTCCTGTGGCTGAGCGATATTTTCCTGACGCGGTTCGTTCTGCAAAGTTGAAAATATATCAGCAGCAATGGCTGTCATTT
TACCAATTTAAACTGCGGCAAGAAGGGGCGTTTATTGGTGAATAA

Upstream 100 bases:

>100_bases
CTGCTTGAAATTTTCAACGGAAATATTATTGCTATCGGGCTGATTCCTGTGCTTGCGCTGGTTATTTATGGTGTTTTTCG
CCTGACAAAAGGAACGGTCT

Downstream 100 bases:

>100_bases
CTGTGATAACTCAATAGTTCGATAATTTACTTATACTGCTCACATAAATATCTGGAGTTAATATGTCTTTAGTCAATGGT
AGGATCCTGCTCAATTGTAT

Product: carbohydrate kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MPDYHAALVIDIGTTNCKVSCYSCHDVSVLEVRKFPTPTISSDKGEVDLDIEALWQALRLVMAELVASVPFPVKNISIAS
FGESGVFVDKEGVILTPMLAWYDRRGESYLSSLSKAEAEELYSITGLPPHSNYSAFKMRWLLDNYSLHERKDICWLHAPE
VLLWRMTGAKKTEISLASRTLCLDIARRTWSRNAAGILGIPFGVLAPLIKPGEVAGWVTATLRQELGLPHEVKVTLAGHD
HMVGARALQMQPGDVLNSTGTTEGILLLNTQPTLDVQARRDKLANGCYSDGEFFTLFASLPVGGYALEWVKKTFRLTDKE
ISTGLEKVMEQYLKPSWSVEHVPVFIPHLRGSGSPHKNQHTRGLLFGLTDSLPPESLLESVFIGLAMEFAHCHGCFNIPA
GRTVKVIGPAVKNPYWLQLKADILQCPIEAIAFDETVSLGALLIACPNVVPPTVPVAERYFPDAVRSAKLKIYQQQWLSF
YQFKLRQEGAFIGE

Sequences:

>Translated_494_residues
MPDYHAALVIDIGTTNCKVSCYSCHDVSVLEVRKFPTPTISSDKGEVDLDIEALWQALRLVMAELVASVPFPVKNISIAS
FGESGVFVDKEGVILTPMLAWYDRRGESYLSSLSKAEAEELYSITGLPPHSNYSAFKMRWLLDNYSLHERKDICWLHAPE
VLLWRMTGAKKTEISLASRTLCLDIARRTWSRNAAGILGIPFGVLAPLIKPGEVAGWVTATLRQELGLPHEVKVTLAGHD
HMVGARALQMQPGDVLNSTGTTEGILLLNTQPTLDVQARRDKLANGCYSDGEFFTLFASLPVGGYALEWVKKTFRLTDKE
ISTGLEKVMEQYLKPSWSVEHVPVFIPHLRGSGSPHKNQHTRGLLFGLTDSLPPESLLESVFIGLAMEFAHCHGCFNIPA
GRTVKVIGPAVKNPYWLQLKADILQCPIEAIAFDETVSLGALLIACPNVVPPTVPVAERYFPDAVRSAKLKIYQQQWLSF
YQFKLRQEGAFIGE
>Mature_493_residues
PDYHAALVIDIGTTNCKVSCYSCHDVSVLEVRKFPTPTISSDKGEVDLDIEALWQALRLVMAELVASVPFPVKNISIASF
GESGVFVDKEGVILTPMLAWYDRRGESYLSSLSKAEAEELYSITGLPPHSNYSAFKMRWLLDNYSLHERKDICWLHAPEV
LLWRMTGAKKTEISLASRTLCLDIARRTWSRNAAGILGIPFGVLAPLIKPGEVAGWVTATLRQELGLPHEVKVTLAGHDH
MVGARALQMQPGDVLNSTGTTEGILLLNTQPTLDVQARRDKLANGCYSDGEFFTLFASLPVGGYALEWVKKTFRLTDKEI
STGLEKVMEQYLKPSWSVEHVPVFIPHLRGSGSPHKNQHTRGLLFGLTDSLPPESLLESVFIGLAMEFAHCHGCFNIPAG
RTVKVIGPAVKNPYWLQLKADILQCPIEAIAFDETVSLGALLIACPNVVPPTVPVAERYFPDAVRSAKLKIYQQQWLSFY
QFKLRQEGAFIGE

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI42794763, Length=387, Percent_Identity=24.8062015503876, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI189409120, Length=385, Percent_Identity=25.1948051948052, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI4504007, Length=385, Percent_Identity=25.1948051948052, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI41393575, Length=378, Percent_Identity=24.0740740740741, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1789168, Length=455, Percent_Identity=23.956043956044, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789987, Length=492, Percent_Identity=23.9837398373984, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790361, Length=461, Percent_Identity=21.9088937093275, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1786249, Length=499, Percent_Identity=20.6412825651303, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17535599, Length=440, Percent_Identity=22.7272727272727, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17864214, Length=394, Percent_Identity=25.6345177664975, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24654573, Length=394, Percent_Identity=25.8883248730964, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24655555, Length=466, Percent_Identity=21.6738197424893, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24655560, Length=466, Percent_Identity=21.6738197424893, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24655570, Length=466, Percent_Identity=21.6738197424893, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24655574, Length=466, Percent_Identity=21.6738197424893, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24655565, Length=466, Percent_Identity=21.6738197424893, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 54705; Mature: 54574

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDYHAALVIDIGTTNCKVSCYSCHDVSVLEVRKFPTPTISSDKGEVDLDIEALWQALRL
CCCCEEEEEEEECCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCEEEEHHHHHHHHHH
VMAELVASVPFPVKNISIASFGESGVFVDKEGVILTPMLAWYDRRGESYLSSLSKAEAEE
HHHHHHHHCCCCCCCCEEEECCCCCEEECCCCEEEEHHHHHHHCCCHHHHHHHHHHHHHH
LYSITGLPPHSNYSAFKMRWLLDNYSLHERKDICWLHAPEVLLWRMTGAKKTEISLASRT
HHEECCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCCHHHHHHH
LCLDIARRTWSRNAAGILGIPFGVLAPLIKPGEVAGWVTATLRQELGLPHEVKVTLAGHD
HHHHHHHHHHCCCCCCEEECCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCC
HMVGARALQMQPGDVLNSTGTTEGILLLNTQPTLDVQARRDKLANGCYSDGEFFTLFASL
CCCCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEEEC
PVGGYALEWVKKTFRLTDKEISTGLEKVMEQYLKPSWSVEHVPVFIPHLRGSGSPHKNQH
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCC
TRGLLFGLTDSLPPESLLESVFIGLAMEFAHCHGCFNIPAGRTVKVIGPAVKNPYWLQLK
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEECCCCCCCEEEEEE
ADILQCPIEAIAFDETVSLGALLIACPNVVPPTVPVAERYFPDAVRSAKLKIYQQQWLSF
HHHHHCCHHHHCCCCHHHHCCCEEECCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHH
YQFKLRQEGAFIGE
HHHHHHHCCCCCCC
>Mature Secondary Structure 
PDYHAALVIDIGTTNCKVSCYSCHDVSVLEVRKFPTPTISSDKGEVDLDIEALWQALRL
CCCEEEEEEEECCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCCEEEEHHHHHHHHHH
VMAELVASVPFPVKNISIASFGESGVFVDKEGVILTPMLAWYDRRGESYLSSLSKAEAEE
HHHHHHHHCCCCCCCCEEEECCCCCEEECCCCEEEEHHHHHHHCCCHHHHHHHHHHHHHH
LYSITGLPPHSNYSAFKMRWLLDNYSLHERKDICWLHAPEVLLWRMTGAKKTEISLASRT
HHEECCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCCHHHHHHH
LCLDIARRTWSRNAAGILGIPFGVLAPLIKPGEVAGWVTATLRQELGLPHEVKVTLAGHD
HHHHHHHHHHCCCCCCEEECCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCC
HMVGARALQMQPGDVLNSTGTTEGILLLNTQPTLDVQARRDKLANGCYSDGEFFTLFASL
CCCCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEEEC
PVGGYALEWVKKTFRLTDKEISTGLEKVMEQYLKPSWSVEHVPVFIPHLRGSGSPHKNQH
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCC
TRGLLFGLTDSLPPESLLESVFIGLAMEFAHCHGCFNIPAGRTVKVIGPAVKNPYWLQLK
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEECCCCCCCEEEEEE
ADILQCPIEAIAFDETVSLGALLIACPNVVPPTVPVAERYFPDAVRSAKLKIYQQQWLSF
HHHHHCCHHHHCCCCHHHHCCCEEECCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHH
YQFKLRQEGAFIGE
HHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA