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The map label for this gene is atpB [H]

Identifier: 29143943

GI number: 29143943

Start: 3754545

End: 3755360

Strand: Direct

Name: atpB [H]

Synonym: t3648

Alternate gene names: 29143943

Gene position: 3754545-3755360 (Clockwise)

Preceding gene: 29143942

Following gene: 29143944

Centisome position: 78.35

GC content: 51.72

Gene sequence:

>816_bases
ATGGCTTCAGAAAATATGACGCCGCAGGAATACATAGGACACCATCTGAATAACCTTCAGCTGGACCTGCGTACTTTCTC
GCTGGTGGATCCGCAGAACCCCCCAGCCACCTTCTGGACGCTCAATATTGACTCCATGTTCTTCTCGGTGGTGCTGGGTC
TGTTGTTTCTGGTGATGTTCCGTAGCGTTGCTAAAAAAGCGACCAGCGGCGTGCCAGGCAAGTTTCAGACCGCGATTGAG
CTGATAGTCGGCTTTGTGCATGGCAGCGTCAAAGACATGTACCATGGCAAAAGCAAGCTGATTGCGCCGCTGGCCCTGAC
GATTTTCGTCTGGGTATTCCTTATGAACCTGATGGACTTACTGCCTATCGACCTGCTGCCGTATATCGCTGAGCATTGGC
TGGGTCTGCCGGCAACGCGCGTGGTGCCGTCTGCTGACGTCAACATCACCCTGTCGATGGCGCTGGGCGTATTCATCCTT
ATTCTGTTCTACAGCATCAAAATGAAAGGCATCGGCGGCTTCGCAAAAGAGTTGACGCTGCAGCCGTTCAATCACTGGGC
GTTCATTCCTGTCAACTTAATCCTTGAAGGGGTAAGTCTGCTGTCCAAACCGGTTTCTCTCGGTCTGCGACTGTTCGGCA
ACATGTATGCCGGTGAGCTGATTTTCATTCTGATTGCTGGTCTGTTGCCGTGGTGGTCACAGTGGATTCTGAATGTGCCG
TGGGCCATTTTCCACATCCTGATTATTACGCTGCAAGCCTTCATTTTCATGGTTCTGACGATTGTCTATCTGTCGATGGC
GTCCGAAGAGCATTAA

Upstream 100 bases:

>100_bases
TAAAGGCGGTGTTTTTGCCGCTGATCGTTACGTGGGTTTTGGTGCTGGTGGTTCAGATACTGGCGCCGGCTGTAATTAAC
AACAAAGGGTAAAAGGCATC

Downstream 100 bases:

>100_bases
TTTACCAACACTACTACGTTTTAACTGAAACAAACTGGAGACTGTCATGGAAAACCTGAATATGGATCTGCTGTACATGG
CTGCCGCTGTGATGATGGGT

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6 [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MASENMTPQEYIGHHLNNLQLDLRTFSLVDPQNPPATFWTLNIDSMFFSVVLGLLFLVMFRSVAKKATSGVPGKFQTAIE
LIVGFVHGSVKDMYHGKSKLIAPLALTIFVWVFLMNLMDLLPIDLLPYIAEHWLGLPATRVVPSADVNITLSMALGVFIL
ILFYSIKMKGIGGFAKELTLQPFNHWAFIPVNLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWILNVP
WAIFHILIITLQAFIFMVLTIVYLSMASEEH

Sequences:

>Translated_271_residues
MASENMTPQEYIGHHLNNLQLDLRTFSLVDPQNPPATFWTLNIDSMFFSVVLGLLFLVMFRSVAKKATSGVPGKFQTAIE
LIVGFVHGSVKDMYHGKSKLIAPLALTIFVWVFLMNLMDLLPIDLLPYIAEHWLGLPATRVVPSADVNITLSMALGVFIL
ILFYSIKMKGIGGFAKELTLQPFNHWAFIPVNLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWILNVP
WAIFHILIITLQAFIFMVLTIVYLSMASEEH
>Mature_270_residues
ASENMTPQEYIGHHLNNLQLDLRTFSLVDPQNPPATFWTLNIDSMFFSVVLGLLFLVMFRSVAKKATSGVPGKFQTAIEL
IVGFVHGSVKDMYHGKSKLIAPLALTIFVWVFLMNLMDLLPIDLLPYIAEHWLGLPATRVVPSADVNITLSMALGVFILI
LFYSIKMKGIGGFAKELTLQPFNHWAFIPVNLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWILNVPW
AIFHILIITLQAFIFMVLTIVYLSMASEEH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane [H]

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family [H]

Homologues:

Organism=Escherichia coli, GI1790176, Length=271, Percent_Identity=96.309963099631, Blast_Score=503, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000568
- InterPro:   IPR023011 [H]

Pfam domain/function: PF00119 ATP-synt_A [H]

EC number: 3.6.3.14

Molecular weight: Translated: 30418; Mature: 30287

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASENMTPQEYIGHHLNNLQLDLRTFSLVDPQNPPATFWTLNIDSMFFSVVLGLLFLVMF
CCCCCCCHHHHHHHHHCCCEEEHHHEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHH
RSVAKKATSGVPGKFQTAIELIVGFVHGSVKDMYHGKSKLIAPLALTIFVWVFLMNLMDL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
LPIDLLPYIAEHWLGLPATRVVPSADVNITLSMALGVFILILFYSIKMKGIGGFAKELTL
HHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHC
QPFNHWAFIPVNLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWILNVP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
WAIFHILIITLQAFIFMVLTIVYLSMASEEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ASENMTPQEYIGHHLNNLQLDLRTFSLVDPQNPPATFWTLNIDSMFFSVVLGLLFLVMF
CCCCCCHHHHHHHHHCCCEEEHHHEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHH
RSVAKKATSGVPGKFQTAIELIVGFVHGSVKDMYHGKSKLIAPLALTIFVWVFLMNLMDL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
LPIDLLPYIAEHWLGLPATRVVPSADVNITLSMALGVFILILFYSIKMKGIGGFAKELTL
HHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHC
QPFNHWAFIPVNLILEGVSLLSKPVSLGLRLFGNMYAGELIFILIAGLLPWWSQWILNVP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
WAIFHILIITLQAFIFMVLTIVYLSMASEEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA