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The map label for this gene is yihU [H]

Identifier: 29143899

GI number: 29143899

Start: 3696330

End: 3697226

Strand: Direct

Name: yihU [H]

Synonym: t3598

Alternate gene names: 29143899

Gene position: 3696330-3697226 (Clockwise)

Preceding gene: 29143892

Following gene: 29143900

Centisome position: 77.14

GC content: 55.96

Gene sequence:

>897_bases
ATGGCAGTTATAGCATTTATCGGGTTGGGACAGATGGGCTCCCCTATGGCGAGCAATCTGCTAAAGCAGGGCCATCAACT
CAGCGTCTTCGATATTAATCCCGACGCCGTACAGCGTCTGGTAGACAAAGGCGCGCAACCTGCAAGCAGCCCGGCTCAGA
CAACCATCGGCGCTGAATTTGTTATCACCATGCTCCCGAACGGCGATCTGGTTCGTTCCGTTTTGTTTGGCGAGCAAGGC
GTTTGTGAAACTCTTTCCCGTGAAGCGCTGGTCATTGATATGTCCACTATTCATCCGTTGCAAACCGATAAGCTGATTGC
CGACATGCAGAGCAAAGGGTTCAGCATGATGGATGTGCCGGTAGGCCGGACATCCGACAACGCGATTACCGGCACATTGT
TGTTGCTGGCAGGCGGTACGACGGAGCAAGTAGAGCGCGCTACCCCTGTTCTGATGGCGATGGGTAATGAGCTGGTCAAC
ACCGGCGGCCCGGGAATGGGTATTCGCGTAAAACTGATCAACAACTACATGAGTATTGCGCTAAATGCGCTCTCCGCCGA
AGCCGCCGTGCTGTGTGAAGCGCTGGGGCTTTCCTTCGACGTGGCTTTAAAAGTGATGAGCGGCACTGCCGCAGGCAAAG
GGCATTTCACCACCACCTGGCCGAATAAAGTGATGAAAGGGGATCTGTCTCCCGCCTTCATGATCGATCTGGCGCACAAA
GATCTTGGCATCGCGTTGGATGTCGCCAATCAACTGCACGTACCGATGCCGCTCGGCGCCGCCTCCCGTGAAGTTTATAA
CCTGGCGCGGGCCGCAGGCCGCGGTCGGGAAGACTGGAGCGCCATCCTGGAACAGGTGCGCATCAGCGCCGGGCTGACTG
CCAACGTAAAAAAGTAA

Upstream 100 bases:

>100_bases
GCTGTCAATTTTTTGACCATAAATTACAAATACGATCACAAACAGACAGAAAAGGCTCATTAATGACAAAAAATGACACC
ACCGTGTTCAGGAGAACGAT

Downstream 100 bases:

>100_bases
CGACTGTATAAAGGAAAATTGAATGAACAACTACACCATCAAAGACATTACGCGAGCGTCCGGCGGGTTTGCCATGCTGG
CTGTCGATCAGCGCGAGGCG

Product: oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MAVIAFIGLGQMGSPMASNLLKQGHQLSVFDINPDAVQRLVDKGAQPASSPAQTTIGAEFVITMLPNGDLVRSVLFGEQG
VCETLSREALVIDMSTIHPLQTDKLIADMQSKGFSMMDVPVGRTSDNAITGTLLLLAGGTTEQVERATPVLMAMGNELVN
TGGPGMGIRVKLINNYMSIALNALSAEAAVLCEALGLSFDVALKVMSGTAAGKGHFTTTWPNKVMKGDLSPAFMIDLAHK
DLGIALDVANQLHVPMPLGAASREVYNLARAAGRGREDWSAILEQVRISAGLTANVKK

Sequences:

>Translated_298_residues
MAVIAFIGLGQMGSPMASNLLKQGHQLSVFDINPDAVQRLVDKGAQPASSPAQTTIGAEFVITMLPNGDLVRSVLFGEQG
VCETLSREALVIDMSTIHPLQTDKLIADMQSKGFSMMDVPVGRTSDNAITGTLLLLAGGTTEQVERATPVLMAMGNELVN
TGGPGMGIRVKLINNYMSIALNALSAEAAVLCEALGLSFDVALKVMSGTAAGKGHFTTTWPNKVMKGDLSPAFMIDLAHK
DLGIALDVANQLHVPMPLGAASREVYNLARAAGRGREDWSAILEQVRISAGLTANVKK
>Mature_297_residues
AVIAFIGLGQMGSPMASNLLKQGHQLSVFDINPDAVQRLVDKGAQPASSPAQTTIGAEFVITMLPNGDLVRSVLFGEQGV
CETLSREALVIDMSTIHPLQTDKLIADMQSKGFSMMDVPVGRTSDNAITGTLLLLAGGTTEQVERATPVLMAMGNELVNT
GGPGMGIRVKLINNYMSIALNALSAEAAVLCEALGLSFDVALKVMSGTAAGKGHFTTTWPNKVMKGDLSPAFMIDLAHKD
LGIALDVANQLHVPMPLGAASREVYNLARAAGRGREDWSAILEQVRISAGLTANVKK

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=293, Percent_Identity=33.1058020477816, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI40556376, Length=284, Percent_Identity=25.7042253521127, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1790315, Length=297, Percent_Identity=86.5319865319865, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI145693186, Length=280, Percent_Identity=37.1428571428571, Blast_Score=160, Evalue=8e-41,
Organism=Escherichia coli, GI1786719, Length=289, Percent_Identity=31.4878892733564, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1789092, Length=292, Percent_Identity=30.8219178082192, Blast_Score=112, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17557316, Length=301, Percent_Identity=28.2392026578073, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24655230, Length=292, Percent_Identity=32.8767123287671, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI19922568, Length=292, Percent_Identity=32.8767123287671, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI28574115, Length=289, Percent_Identity=23.8754325259516, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24655240, Length=64, Percent_Identity=51.5625, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: 1.1.-.- [C]

Molecular weight: Translated: 31355; Mature: 31224

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVIAFIGLGQMGSPMASNLLKQGHQLSVFDINPDAVQRLVDKGAQPASSPAQTTIGAEF
CEEEEEECCCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCCCCCCCHHHCCCEE
VITMLPNGDLVRSVLFGEQGVCETLSREALVIDMSTIHPLQTDKLIADMQSKGFSMMDVP
EEEECCCCHHHHHHHHCCCCHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEECC
VGRTSDNAITGTLLLLAGGTTEQVERATPVLMAMGNELVNTGGPGMGIRVKLINNYMSIA
CCCCCCCCEEEEEEEEECCCHHHHHHHCHHHHHHCCHHHHCCCCCCCEEEEEHHHHHHHH
LNALSAEAAVLCEALGLSFDVALKVMSGTAAGKGHFTTTWPNKVMKGDLSPAFMIDLAHK
HHHHHHHHHHHHHHHCCCHHHHEEEECCCCCCCCCEEECCCCHHHCCCCCCEEEEEECCC
DLGIALDVANQLHVPMPLGAASREVYNLARAAGRGREDWSAILEQVRISAGLTANVKK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEECCCC
>Mature Secondary Structure 
AVIAFIGLGQMGSPMASNLLKQGHQLSVFDINPDAVQRLVDKGAQPASSPAQTTIGAEF
EEEEEECCCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCCCCCCCHHHCCCEE
VITMLPNGDLVRSVLFGEQGVCETLSREALVIDMSTIHPLQTDKLIADMQSKGFSMMDVP
EEEECCCCHHHHHHHHCCCCHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEECC
VGRTSDNAITGTLLLLAGGTTEQVERATPVLMAMGNELVNTGGPGMGIRVKLINNYMSIA
CCCCCCCCEEEEEEEEECCCHHHHHHHCHHHHHHCCHHHHCCCCCCCEEEEEHHHHHHHH
LNALSAEAAVLCEALGLSFDVALKVMSGTAAGKGHFTTTWPNKVMKGDLSPAFMIDLAHK
HHHHHHHHHHHHHHHCCCHHHHEEEECCCCCCCCCEEECCCCHHHCCCCCCEEEEEECCC
DLGIALDVANQLHVPMPLGAASREVYNLARAAGRGREDWSAILEQVRISAGLTANVKK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]