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The map label for this gene is menA [H]

Identifier: 29143833

GI number: 29143833

Start: 3632011

End: 3632940

Strand: Direct

Name: menA [H]

Synonym: t3528

Alternate gene names: 29143833

Gene position: 3632011-3632940 (Clockwise)

Preceding gene: 29143832

Following gene: 29143834

Centisome position: 75.79

GC content: 55.16

Gene sequence:

>930_bases
ATGACTGAACAACAACAAATTAGCCGCACCCAGGCCTGGCTGGAAAGCTTACGACCCAAAACCTTACCTCTCGCCTTCGC
GGCGATTATCGTCGGTACGGCCCTGGCATGGTGGCAAGGCTATTTCGATCCTCTGGTCGCACTGCTGGCCCTTATCACCG
CCGGGCTGTTGCAAATTTTATCCAACCTCGCCAACGATTACGGCGACGCTGTCAAAGGCAGTGATAAACCGGATCGCATC
GGACCGCTGCGGGGGATGCAAAAAGGCGTCATCACCCAGCAGGAGATGAAGCGGGCGTTAATCATTACCGTCGTGCTGAT
CTGTATCTCCGGACTGGCGCTGGTGGCGGTCGCGTGCCATACGTTAACCGATTTTGTCGGCTTCCTGATTTTGGGCGGGC
TGTCGATTATCGCCGCCATCACCTACACCGTGGGTAATCGGCCCTACGGTTATATCGGGCTGGGTGATATCTCTGTCCTG
GTATTCTTTGGCTGGCTAAGTGTCATGGGGAGCTGGTATCTCCAGGCGCATACGCTGATTCCGGCGCTGATTCTCCCGGC
CACCGCCTGCGGTTTACTGGCGACGGCGGTGCTGAATATTAATAACCTGCGCGATATTAATAGCGACAGAGAGAACGGCA
AAAACACCCTTGTGGTACGACTTGGCGATGTCAACGCGCGTCGTTATCACGCCTGCCTGTTGCTAGGCGCGCTGCTCTGT
CTGGCGCTGTTTAATCTGCTCTCGCTACACAGTCCGTGGGGATGGTTGTTTATTCTGGCCGCGCCCTTGCTCATTAAACA
AGCGCGCTACGTAATGCGCGAAAGGGAGCCTGCGGCAATGCGCCCGATGCTTGAACGTACCGTTAAAGGCGCGTTGTTAA
CCAACCTGTTATTTGTGATTGGGATACTCTTAAGTCAGTGGGCCGTTTAA

Upstream 100 bases:

>100_bases
CGCAGATGAAGATCTAAGCCGTTTTATCTTATAATCGCGTCCAATGCATTTTCATCACTGTTGATGGGGCTGAAAAGCCC
CATTTTTATTGGCGCTAAAT

Downstream 100 bases:

>100_bases
CTGACAAATATCAATTAACAATTGATGATTTTGCCAACAGTATACTTAGCGCGATATACTAAAAATTCTCGCAGCAACTG
AACGTTAAGCCTATGAAATA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MTEQQQISRTQAWLESLRPKTLPLAFAAIIVGTALAWWQGYFDPLVALLALITAGLLQILSNLANDYGDAVKGSDKPDRI
GPLRGMQKGVITQQEMKRALIITVVLICISGLALVAVACHTLTDFVGFLILGGLSIIAAITYTVGNRPYGYIGLGDISVL
VFFGWLSVMGSWYLQAHTLIPALILPATACGLLATAVLNINNLRDINSDRENGKNTLVVRLGDVNARRYHACLLLGALLC
LALFNLLSLHSPWGWLFILAAPLLIKQARYVMREREPAAMRPMLERTVKGALLTNLLFVIGILLSQWAV

Sequences:

>Translated_309_residues
MTEQQQISRTQAWLESLRPKTLPLAFAAIIVGTALAWWQGYFDPLVALLALITAGLLQILSNLANDYGDAVKGSDKPDRI
GPLRGMQKGVITQQEMKRALIITVVLICISGLALVAVACHTLTDFVGFLILGGLSIIAAITYTVGNRPYGYIGLGDISVL
VFFGWLSVMGSWYLQAHTLIPALILPATACGLLATAVLNINNLRDINSDRENGKNTLVVRLGDVNARRYHACLLLGALLC
LALFNLLSLHSPWGWLFILAAPLLIKQARYVMREREPAAMRPMLERTVKGALLTNLLFVIGILLSQWAV
>Mature_308_residues
TEQQQISRTQAWLESLRPKTLPLAFAAIIVGTALAWWQGYFDPLVALLALITAGLLQILSNLANDYGDAVKGSDKPDRIG
PLRGMQKGVITQQEMKRALIITVVLICISGLALVAVACHTLTDFVGFLILGGLSIIAAITYTVGNRPYGYIGLGDISVLV
FFGWLSVMGSWYLQAHTLIPALILPATACGLLATAVLNINNLRDINSDRENGKNTLVVRLGDVNARRYHACLLLGALLCL
ALFNLLSLHSPWGWLFILAAPLLIKQARYVMREREPAAMRPMLERTVKGALLTNLLFVIGILLSQWAV

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=305, Percent_Identity=29.8360655737705, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1790365, Length=308, Percent_Identity=94.4805194805195, Blast_Score=586, Evalue=1e-169,
Organism=Drosophila melanogaster, GI17737429, Length=295, Percent_Identity=27.1186440677966, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 33714; Mature: 33582

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQQQISRTQAWLESLRPKTLPLAFAAIIVGTALAWWQGYFDPLVALLALITAGLLQIL
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNLANDYGDAVKGSDKPDRIGPLRGMQKGVITQQEMKRALIITVVLICISGLALVAVACH
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLTDFVGFLILGGLSIIAAITYTVGNRPYGYIGLGDISVLVFFGWLSVMGSWYLQAHTLI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
PALILPATACGLLATAVLNINNLRDINSDRENGKNTLVVRLGDVNARRYHACLLLGALLC
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
LALFNLLSLHSPWGWLFILAAPLLIKQARYVMREREPAAMRPMLERTVKGALLTNLLFVI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
GILLSQWAV
HHHHHHCCC
>Mature Secondary Structure 
TEQQQISRTQAWLESLRPKTLPLAFAAIIVGTALAWWQGYFDPLVALLALITAGLLQIL
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNLANDYGDAVKGSDKPDRIGPLRGMQKGVITQQEMKRALIITVVLICISGLALVAVACH
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLTDFVGFLILGGLSIIAAITYTVGNRPYGYIGLGDISVLVFFGWLSVMGSWYLQAHTLI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
PALILPATACGLLATAVLNINNLRDINSDRENGKNTLVVRLGDVNARRYHACLLLGALLC
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
LALFNLLSLHSPWGWLFILAAPLLIKQARYVMREREPAAMRPMLERTVKGALLTNLLFVI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
GILLSQWAV
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]