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The map label for this gene is ilvY [H]

Identifier: 29143712

GI number: 29143712

Start: 3492031

End: 3492918

Strand: Direct

Name: ilvY [H]

Synonym: t3390

Alternate gene names: 29143712

Gene position: 3492031-3492918 (Clockwise)

Preceding gene: 29143710

Following gene: 29143724

Centisome position: 72.87

GC content: 58.56

Gene sequence:

>888_bases
GTGGATTTACGCGATCTAAAAACCTTCCTGCATCTGGCGGAAAGCCGCCATTTTGGCCGCAGCGCGCGGGCGATGCATGT
CAGTCCTTCCACCCTTTCCCGACAGATTCAGCGGCTGGAAGAAGACCTCGGCCAGCCGCTGTTTGTGCGCGATAACCGTA
CGGTCACGCTGACCGAAGCGGGTGAAGAGCTGCGAGTGTTTGCCCAACAGACGCTTTTGCAATATCAGCAGTTGCGCCAT
ACCCTCGATCAGCAGGGGCCGTCCCTTTCCGGCGAACTCCATATCTTCTGTTCAGTGACTGCGGCGTACAGCCACCTGCC
GCCGATTCTCGACCGTTTTCGCGCCGAACACCCTTCTGTTGAAATCAAATTGACGACCGGAGACGCCGCCGATGCGATGG
AAAAGGTGGTAACGGGAGAAGCGGACCTGGCAATCGCCGGCAAACCAGAAACGCTGCCCGGCGCGGTGGCGTTTTCGATG
CTGGAAAATCTGGCGGTGGTGCTGATCGCCCCGGCGCTGCCCTGCCCGGTGCGTAATCAGGTGTCGGTTGATAAGCCCGA
CTGGTCAACGGTGCCGTTTATCATGGCCGATCAGGGACCGGTACGCCGCCGCATTGAGCTGTGGTTTCGCCGCCATAAAA
TCAGCAATCCGCAGATTTACGCCACCGTCGGCGGTCACGAAGCGATGGTCTCAATGGTGGCGCTGGGCTGCGGCGTGGCG
CTGCTGCCGGAAGTGGTGCTGGAAAACAGTCCGGAGCCGGTGCGCAACCGGGTGATGATTTTAGAACGCAGTGATGAAAA
AACGCCGTTTGAGCTTGGCGTCTGCGCGCAAAAAAAGCGGCTGCATGAGCCGCTAATTGATGCGTTCTGGAAGATTTTAC
CGAATTAG

Upstream 100 bases:

>100_bases
CGAATGAACCCACATTACAACAGGAAATTTATTGCGGAAATTGATATATTCACAACGTTATGTTGCGGTTTATGCAACGT
CAAAAACCGGAGGTCTGTCT

Downstream 100 bases:

>100_bases
TTTTACGGCCCTACCATTACCCGAACAGGCTTCCCAATACGGCTAAGCATATTCACCAGAGCATCAATGGTGAATTTGCT
GCATTTCTTGTTGACGACAT

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEAGEELRVFAQQTLLQYQQLRH
TLDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSM
LENLAVVLIAPALPCPVRNQVSVDKPDWSTVPFIMADQGPVRRRIELWFRRHKISNPQIYATVGGHEAMVSMVALGCGVA
LLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIDAFWKILPN

Sequences:

>Translated_295_residues
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEAGEELRVFAQQTLLQYQQLRH
TLDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSM
LENLAVVLIAPALPCPVRNQVSVDKPDWSTVPFIMADQGPVRRRIELWFRRHKISNPQIYATVGGHEAMVSMVALGCGVA
LLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIDAFWKILPN
>Mature_295_residues
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEAGEELRVFAQQTLLQYQQLRH
TLDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSM
LENLAVVLIAPALPCPVRNQVSVDKPDWSTVPFIMADQGPVRRRIELWFRRHKISNPQIYATVGGHEAMVSMVALGCGVA
LLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIDAFWKILPN

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=295, Percent_Identity=98.3050847457627, Blast_Score=597, Evalue=1e-172,
Organism=Escherichia coli, GI1790399, Length=261, Percent_Identity=29.8850574712644, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788297, Length=247, Percent_Identity=29.5546558704453, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI157672245, Length=243, Percent_Identity=27.5720164609054, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788887, Length=249, Percent_Identity=28.5140562248996, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787806, Length=256, Percent_Identity=24.609375, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787879, Length=247, Percent_Identity=26.7206477732794, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI145693105, Length=167, Percent_Identity=28.7425149700599, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI2367136, Length=257, Percent_Identity=25.2918287937743, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787601, Length=145, Percent_Identity=27.5862068965517, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788481, Length=249, Percent_Identity=24.4979919678715, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788296, Length=247, Percent_Identity=28.3400809716599, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790262, Length=253, Percent_Identity=25.6916996047431, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788748, Length=300, Percent_Identity=24.6666666666667, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1787530, Length=270, Percent_Identity=21.8518518518519, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788706, Length=143, Percent_Identity=32.1678321678322, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI48994962, Length=79, Percent_Identity=40.5063291139241, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789440, Length=168, Percent_Identity=26.1904761904762, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI145693193, Length=123, Percent_Identity=34.1463414634146, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1787589, Length=194, Percent_Identity=28.8659793814433, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1789173, Length=256, Percent_Identity=25.78125, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32931; Mature: 32931

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEA
CCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHCCCCEEEECCCEEEEECC
GEELRVFAQQTLLQYQQLRHTLDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHCCHHHHHHHHCCCCCE
EIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSMLENLAVVLIAPALPCPVRNQ
EEEEECCCHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCC
VSVDKPDWSTVPFIMADQGPVRRRIELWFRRHKISNPQIYATVGGHEAMVSMVALGCGVA
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCHH
LLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIDAFWKILPN
HHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEA
CCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHCCCCEEEECCCEEEEECC
GEELRVFAQQTLLQYQQLRHTLDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHCCHHHHHHHHCCCCCE
EIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSMLENLAVVLIAPALPCPVRNQ
EEEEECCCHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCC
VSVDKPDWSTVPFIMADQGPVRRRIELWFRRHKISNPQIYATVGGHEAMVSMVALGCGVA
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCHH
LLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIDAFWKILPN
HHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3003115; 1379743; 9278503; 3550695 [H]