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The map label for this gene is pnuC [H]

Identifier: 29143707

GI number: 29143707

Start: 3487624

End: 3488355

Strand: Reverse

Name: pnuC [H]

Synonym: t3385

Alternate gene names: 29143707

Gene position: 3488355-3487624 (Counterclockwise)

Preceding gene: 29143708

Following gene: 29143706

Centisome position: 72.8

GC content: 50.55

Gene sequence:

>732_bases
ATGATGGACTTTTTCAGCATTAACAATGTAATGGTCAACATTCCTCTCGGCGAGGGTGGGTATGCGCTATCGTGGATTGA
GGCTATCGGTACCGTCTTTGGCTTATTGTGCATCTGGTGCGCCAGCCGGGAAAAAATCATTAATTACCTGTTTGGCTTGA
TTAACGTCACTCTGTTTGCCGCCATCTTTTTTCAGATTCAACTGTATGCCAGCTTGCTACTTCAGGTGTTTTTCTTTGCG
GCGAATATTTACGGCTGGTACGCATGGAGCCGGCAGAATGACGCCCGGGAAGCCGCTCTGAAAGTACGCTGGCTTTCTTG
TCAACAAACATGGAGGTTGGGGGGCATATGTATTATTAGCATTCTGCTGATGACGTGGTTTATCGATCCGGTCTTCGCTA
TGTTGACCCGCGTTATGCTCGCTCTGCTGCAAACGGTAGGTATGCAGGTGGCGATGCCTGAACTCCAGCCGGACGCGTTC
CCGTTCTGGGATTCCACCATGCTGGTGTTGTCGATTGCGGCGATGGTGCTGATGACCCGCAAGTACGTGGAAAACTGGCT
GCTGTGGGTGATTATTGATGTAATTAGCGTCGTGATCTATGCAGTACAGGGCGTTTATGCGATGTCGCTTGAGTATGTTC
TGCTGACGGTGATCGCGCTAATGGGTTCTTACAGTTGGATCAAGAGCGCACAGCGTAATGGCTATACGTCGCTTGCCGCC
AGAGCCTGCTGA

Upstream 100 bases:

>100_bases
ACCATTATGTTCAGCAGGAAACCTTGTGCCAGCAAGGTGAAGAGCGCCAGATTTCTCTGGCGCTTCAGGCCATTTATTTC
GATAGTTTGCAAGGAGAGCA

Downstream 100 bases:

>100_bases
TTGACCTTTTCCAGGCTGCCTGAAAAAGCAGCCTGGTCTTCTCTGGGCCTCGCTTTCTGCTACAATCCCTCCCCCGTTCG
AAGATTGAGCACTATTCCCA

Product: membrane transport protein

Products: nicotinamide nucleotide [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MMDFFSINNVMVNIPLGEGGYALSWIEAIGTVFGLLCIWCASREKIINYLFGLINVTLFAAIFFQIQLYASLLLQVFFFA
ANIYGWYAWSRQNDAREAALKVRWLSCQQTWRLGGICIISILLMTWFIDPVFAMLTRVMLALLQTVGMQVAMPELQPDAF
PFWDSTMLVLSIAAMVLMTRKYVENWLLWVIIDVISVVIYAVQGVYAMSLEYVLLTVIALMGSYSWIKSAQRNGYTSLAA
RAC

Sequences:

>Translated_243_residues
MMDFFSINNVMVNIPLGEGGYALSWIEAIGTVFGLLCIWCASREKIINYLFGLINVTLFAAIFFQIQLYASLLLQVFFFA
ANIYGWYAWSRQNDAREAALKVRWLSCQQTWRLGGICIISILLMTWFIDPVFAMLTRVMLALLQTVGMQVAMPELQPDAF
PFWDSTMLVLSIAAMVLMTRKYVENWLLWVIIDVISVVIYAVQGVYAMSLEYVLLTVIALMGSYSWIKSAQRNGYTSLAA
RAC
>Mature_243_residues
MMDFFSINNVMVNIPLGEGGYALSWIEAIGTVFGLLCIWCASREKIINYLFGLINVTLFAAIFFQIQLYASLLLQVFFFA
ANIYGWYAWSRQNDAREAALKVRWLSCQQTWRLGGICIISILLMTWFIDPVFAMLTRVMLALLQTVGMQVAMPELQPDAF
PFWDSTMLVLSIAAMVLMTRKYVENWLLWVIIDVISVVIYAVQGVYAMSLEYVLLTVIALMGSYSWIKSAQRNGYTSLAA
RAC

Specific function: Required for nicotinamide riboside transport across the inner membrane [H]

COG id: COG3201

COG function: function code H; Nicotinamide mononucleotide transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family [H]

Homologues:

Organism=Escherichia coli, GI1786965, Length=238, Percent_Identity=70.1680672268908, Blast_Score=322, Evalue=2e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006419 [H]

Pfam domain/function: PF04973 NMN_transporter [H]

EC number: NA

Molecular weight: Translated: 27606; Mature: 27606

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDFFSINNVMVNIPLGEGGYALSWIEAIGTVFGLLCIWCASREKIINYLFGLINVTLFA
CCCEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AIFFQIQLYASLLLQVFFFAANIYGWYAWSRQNDAREAALKVRWLSCQQTWRLGGICIIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILLMTWFIDPVFAMLTRVMLALLQTVGMQVAMPELQPDAFPFWDSTMLVLSIAAMVLMTR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KYVENWLLWVIIDVISVVIYAVQGVYAMSLEYVLLTVIALMGSYSWIKSAQRNGYTSLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHH
RAC
CCC
>Mature Secondary Structure
MMDFFSINNVMVNIPLGEGGYALSWIEAIGTVFGLLCIWCASREKIINYLFGLINVTLFA
CCCEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AIFFQIQLYASLLLQVFFFAANIYGWYAWSRQNDAREAALKVRWLSCQQTWRLGGICIIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILLMTWFIDPVFAMLTRVMLALLQTVGMQVAMPELQPDAFPFWDSTMLVLSIAAMVLMTR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KYVENWLLWVIIDVISVVIYAVQGVYAMSLEYVLLTVIALMGSYSWIKSAQRNGYTSLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHH
RAC
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: nicotinamide nucleotide [Periplasm] [C]

Specific reaction: nicotinamide nucleotide [Periplasm] = nicotinamide nucleotide [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 2841129; 2198247 [H]