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The map label for this gene is xerC

Identifier: 29143674

GI number: 29143674

Start: 3450462

End: 3451364

Strand: Reverse

Name: xerC

Synonym: t3348

Alternate gene names: 29143674

Gene position: 3451364-3450462 (Counterclockwise)

Preceding gene: 29143675

Following gene: 29143673

Centisome position: 72.02

GC content: 56.7

Gene sequence:

>903_bases
ATGACGGAGGTCGCGCTTTCTCTGGATGTCTCGCGGTTCCTGCGCTATTTAGGCGTGGAGCGCCAGCTTAGCCCCATTAC
CCTGCAGAACTACCAGCGTCAGCTTGATGCCATTATCGCTTTAGCCGGAGAAACCGGGCTGAAAAGCTGGCAACAATGTG
ACGCTGCGATTGTGCGCAGTTTTGCGGTGCGCAGTCGGCGTAAAGGGCTTGGCCCTGCCAGTCTGGCGCTACGTCTCTCG
GCATTGCGAAGCTTTTTTGACTGGTTAGTCAGTCAGGGCGAATTGAAAGCTAACCCGGCGAAGGGCGTCTCCGCACCGAA
AGCGCCGCGTCATCTGCCGAAAAATATTGATGTCGACGACGTTAACCGCCTGCTGGACATCGATCTTAACGATCCGCTCG
CCGTACGTGACCGGGCGATGCTGGAGGTCATGTACGGCGCGGGGCTGCGTTTATCCGAACTGGTTGGCCTGGATATAAAG
CACCTCGATCTCGATACCGGAGAAGTGTGGGTAATGGGTAAAGGCAGCAAAGAGCGACGCCTGCCGATTGGCCGTAACGC
GGTGACGTGGATTGAGCACTGGCTGGATCTGCGCGGCCTGTTCGCCAGCGATGAAGAGGCGTTATTCCTGTCGAAGCTCG
GCAAGCGTATCTCCGCGCGCAATGTCCAAAAACGGTTCGCCGAATGGGGCATAAAGCAGGGGCTAAACAGCCACGTGCAT
CCACATAAGCTGCGCCATTCGTTCGCGACCCATATGCTGGAATCGAGCGGCGATCTGCGCGGCGTGCAAGAGCTGCTGGG
TCATGCCAACCTTTCCACCACCCAAATTTATACTCATCTTGATTTTCAACATCTTGCTTCAGTGTACGACGCGGCGCATC
CGCGCGCTAAACGGGGGAAATAA

Upstream 100 bases:

>100_bases
GCCGTGACCCGCACCACTATCAGCCGGGGCAGGGGACGCAGCTTTTACAGGAGATCGCGCTGATGCTGCCGGAACTGCTG
GAACGCTGGATTAAACGCGT

Downstream 100 bases:

>100_bases
TGCGTTTTTACCGGCCTTTGGGGCGTATTGCCGCGCTCACCTTTGACCTGGATGATACCCTTTATGATAACCGTCCGGTG
ATTTTGCGTACTGAGCAGGA

Product: site-specific tyrosine recombinase XerC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTEVALSLDVSRFLRYLGVERQLSPITLQNYQRQLDAIIALAGETGLKSWQQCDAAIVRSFAVRSRRKGLGPASLALRLS
ALRSFFDWLVSQGELKANPAKGVSAPKAPRHLPKNIDVDDVNRLLDIDLNDPLAVRDRAMLEVMYGAGLRLSELVGLDIK
HLDLDTGEVWVMGKGSKERRLPIGRNAVTWIEHWLDLRGLFASDEEALFLSKLGKRISARNVQKRFAEWGIKQGLNSHVH
PHKLRHSFATHMLESSGDLRGVQELLGHANLSTTQIYTHLDFQHLASVYDAAHPRAKRGK

Sequences:

>Translated_300_residues
MTEVALSLDVSRFLRYLGVERQLSPITLQNYQRQLDAIIALAGETGLKSWQQCDAAIVRSFAVRSRRKGLGPASLALRLS
ALRSFFDWLVSQGELKANPAKGVSAPKAPRHLPKNIDVDDVNRLLDIDLNDPLAVRDRAMLEVMYGAGLRLSELVGLDIK
HLDLDTGEVWVMGKGSKERRLPIGRNAVTWIEHWLDLRGLFASDEEALFLSKLGKRISARNVQKRFAEWGIKQGLNSHVH
PHKLRHSFATHMLESSGDLRGVQELLGHANLSTTQIYTHLDFQHLASVYDAAHPRAKRGK
>Mature_299_residues
TEVALSLDVSRFLRYLGVERQLSPITLQNYQRQLDAIIALAGETGLKSWQQCDAAIVRSFAVRSRRKGLGPASLALRLSA
LRSFFDWLVSQGELKANPAKGVSAPKAPRHLPKNIDVDDVNRLLDIDLNDPLAVRDRAMLEVMYGAGLRLSELVGLDIKH
LDLDTGEVWVMGKGSKERRLPIGRNAVTWIEHWLDLRGLFASDEEALFLSKLGKRISARNVQKRFAEWGIKQGLNSHVHP
HKLRHSFATHMLESSGDLRGVQELLGHANLSTTQIYTHLDFQHLASVYDAAHPRAKRGK

Specific function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from xerD binding sites by a short central region, forming

COG id: COG4973

COG function: function code L; Site-specific recombinase XerC

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family. XerC subfamily

Homologues:

Organism=Escherichia coli, GI1790244, Length=295, Percent_Identity=90.1694915254237, Blast_Score=550, Evalue=1e-158,
Organism=Escherichia coli, GI1789261, Length=295, Percent_Identity=37.6271186440678, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1790768, Length=167, Percent_Identity=29.3413173652695, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1790767, Length=182, Percent_Identity=26.9230769230769, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XERC_SALTI (Q8Z3A8)

Other databases:

- EMBL:   AL627279
- EMBL:   AE014613
- RefSeq:   NP_457802.1
- RefSeq:   NP_807016.1
- ProteinModelPortal:   Q8Z3A8
- SMR:   Q8Z3A8
- GeneID:   1071532
- GeneID:   1249865
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t3348
- KEGG:   sty:STY3610
- HOGENOM:   HBG727654
- OMA:   TTEGIRD
- ProtClustDB:   PRK00236
- BioCyc:   SENT209261:T3348-MONOMER
- BioCyc:   SENT220341:STY3610-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01808
- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR010998
- InterPro:   IPR023109
- InterPro:   IPR004107
- InterPro:   IPR011931
- Gene3D:   G3DSA:1.10.150.130
- Gene3D:   G3DSA:1.10.443.10
- TIGRFAMs:   TIGR02224

Pfam domain/function: PF02899 Phage_integr_N; PF00589 Phage_integrase; SSF56349 DNA_brk_join_enz; SSF47823 L_intgrse_like_N

EC number: NA

Molecular weight: Translated: 33614; Mature: 33483

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: NA

Important sites: ACT_SITE 150-150 ACT_SITE 174-174 ACT_SITE 242-242 ACT_SITE 245-245 ACT_SITE 268-268 ACT_SITE 277-277

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEVALSLDVSRFLRYLGVERQLSPITLQNYQRQLDAIIALAGETGLKSWQQCDAAIVRS
CCCEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
FAVRSRRKGLGPASLALRLSALRSFFDWLVSQGELKANPAKGVSAPKAPRHLPKNIDVDD
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
VNRLLDIDLNDPLAVRDRAMLEVMYGAGLRLSELVGLDIKHLDLDTGEVWVMGKGSKERR
HHHEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCEEEECCCCCEEEEECCCCCCC
LPIGRNAVTWIEHWLDLRGLFASDEEALFLSKLGKRISARNVQKRFAEWGIKQGLNSHVH
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PHKLRHSFATHMLESSGDLRGVQELLGHANLSTTQIYTHLDFQHLASVYDAAHPRAKRGK
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHEECCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TEVALSLDVSRFLRYLGVERQLSPITLQNYQRQLDAIIALAGETGLKSWQQCDAAIVRS
CCEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
FAVRSRRKGLGPASLALRLSALRSFFDWLVSQGELKANPAKGVSAPKAPRHLPKNIDVDD
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
VNRLLDIDLNDPLAVRDRAMLEVMYGAGLRLSELVGLDIKHLDLDTGEVWVMGKGSKERR
HHHEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCEEEECCCCCEEEEECCCCCCC
LPIGRNAVTWIEHWLDLRGLFASDEEALFLSKLGKRISARNVQKRFAEWGIKQGLNSHVH
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PHKLRHSFATHMLESSGDLRGVQELLGHANLSTTQIYTHLDFQHLASVYDAAHPRAKRGK
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHEECCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504