Click here to switch to the map view.

The map label for this gene is ubiB [H]

Identifier: 29143651

GI number: 29143651

Start: 3424863

End: 3426503

Strand: Reverse

Name: ubiB [H]

Synonym: t3325

Alternate gene names: 29143651

Gene position: 3426503-3424863 (Counterclockwise)

Preceding gene: 29143652

Following gene: 29143650

Centisome position: 71.51

GC content: 50.58

Gene sequence:

>1641_bases
ATGACGCCAGGTGAAGTACGGCGCCTATATTTCATCATCCGCACGTTTCTAAGCTACGGCCTTGATGAACTCATCCCCCG
AATGCGTCTTACACTGCCACTCCGATTATGGCGCTATTCGCTGTTCTGGATGCCAAACCGGCATAAAGATAAATTGCTGG
GTGAACGATTAAGACTGGCGTTGCAAGAGCTGGGACCGGTCTGGATCAAATTTGGTCAGATGCTCTCCACGCGCCGTGAC
CTGTTCCCGCCGCAAATCGCCGATCAGCTCGCTTTGCTCCAGGATAAAGTCGCGCCATTCGATGGTCGGCTGGCGAAAGC
CCAGATTGAAGAGGCGATGGGGGGGCTACCTGTCGAAGCCTGGTTTGACGACTTTGATATCCAGCCTTTAGCGTCGGCGT
CAATCGCCCAGGTACATACCGCGCGATTGAAATCAAACGGTAAAGAAGTGGTTATTAAGGTCATTCGCCCGGATATTTTG
CCGGTAATTCAGGCAGACCTGAAACTGATTTATCGCCTTGCTCGCTGGGTACCACGCCTGTTGCCGGATGGGCGTCGTCT
GCGCCCGACGGAAGTGGTGCGTGAGTATGAGAAAACGCTGATCGATGAGCTGAATCTGCTGCGGGAATCGGCCAACGCGA
TTCAGTTACGTCGCAATTTTGAAAATAGTCCCATGCTGTATATCCCGGAGGTGTACTCCGATTACTGTAGCCAGAACATG
ATGGTGATGGAGCGGATATATGGCATTCCGGTTTCGGATGTGGCGGCGCTGGAAAAGAACGGCACCAACATGAAACTGCT
GGCGGAACGCGGAGTTAAAGTTTTCTTCACCCAGGTTTTCCGCGACAGCTTTTTCCATGCGGACATGCATCCGGGAAATA
TTTTTGTCAGTCATGAACACCCTGAAAATCCGCAATATATCGGCATTGACTGCGGTATCGTCGGGTCGCTAAACAAAGAA
GATAAGCGTTATCTGGCTGAAAACTTTATCGCGTTTTTTAATCGCGATTACCGAAAGGTGGCGGAGCTGCATGTCGATTC
AGGTTGGGTTCCGCCAGATACCAACGTTGAAGATTTTGAGTTTGCCATCCGCACCGTCTGTGAACCTATTTTTGAAAAGC
CGCTCGCGGAAATCTCGTTTGGTCATGTGTTGTTAAACCTTTTCAATACAGCGCGTCGATTTAACATGGAAGTCCAGCCG
CAACTGGTGTTGTTGCAGAAAACATTATTGTATGTTGAAGGGGTTGGGCGGCAACTTTATCCTCAGCTTGATTTGTGGAA
AACGGCGAAGCCGTTTCTTGAGTCCTGGATCAAAGATCAGGTGGGTATTCCGGCTCTCACGCGGGCTCTTAAAGAAAAAG
CGCCGTTCTGGGTCGAAAAAATGCCAGAAATACCTGAACTGGTGTACGACAGTTTGCGCCAGGGCAAATATTTACAGCAC
AGTGTTGATAAGATTGCGCGCGAGTTACAGGTAAACCATGTGCGCCAAAGTCAGTCTCGTTATTTATTGGGAATTGGCGC
AACGCTGTTACTGAGCGGGTCATTCTTACTCGTCAACCGCCCTGAATGGGGATTGATGCCTGGCTGGCTCATGGTCGGCG
GCGTAGTGGTCTGGCTGGTTGGCTGGCGTAAAACTCGTTGA

Upstream 100 bases:

>100_bases
CGCCTGGCCCGCTGGAAGTCGCATGGTTTGCCGAAGAAACCGCGGCTGTTGAGCGCGCCGTAGATTCTCTGACCACACGG
CTGGAAAAACTGGGGGCCAA

Downstream 100 bases:

>100_bases
GATTTTTTATCGCTCAACGCCGGTTGTGTCACGCAGGTACATATTATCACTCGAGGCAATACTCAGGCCGCAAGTCAATG
TCGTCCCGGTCGTATGTAAA

Product: ubiquinone biosynthesis protein UbiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MTPGEVRRLYFIIRTFLSYGLDELIPRMRLTLPLRLWRYSLFWMPNRHKDKLLGERLRLALQELGPVWIKFGQMLSTRRD
LFPPQIADQLALLQDKVAPFDGRLAKAQIEEAMGGLPVEAWFDDFDIQPLASASIAQVHTARLKSNGKEVVIKVIRPDIL
PVIQADLKLIYRLARWVPRLLPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFENSPMLYIPEVYSDYCSQNM
MVMERIYGIPVSDVAALEKNGTNMKLLAERGVKVFFTQVFRDSFFHADMHPGNIFVSHEHPENPQYIGIDCGIVGSLNKE
DKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEDFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQP
QLVLLQKTLLYVEGVGRQLYPQLDLWKTAKPFLESWIKDQVGIPALTRALKEKAPFWVEKMPEIPELVYDSLRQGKYLQH
SVDKIARELQVNHVRQSQSRYLLGIGATLLLSGSFLLVNRPEWGLMPGWLMVGGVVVWLVGWRKTR

Sequences:

>Translated_546_residues
MTPGEVRRLYFIIRTFLSYGLDELIPRMRLTLPLRLWRYSLFWMPNRHKDKLLGERLRLALQELGPVWIKFGQMLSTRRD
LFPPQIADQLALLQDKVAPFDGRLAKAQIEEAMGGLPVEAWFDDFDIQPLASASIAQVHTARLKSNGKEVVIKVIRPDIL
PVIQADLKLIYRLARWVPRLLPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFENSPMLYIPEVYSDYCSQNM
MVMERIYGIPVSDVAALEKNGTNMKLLAERGVKVFFTQVFRDSFFHADMHPGNIFVSHEHPENPQYIGIDCGIVGSLNKE
DKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEDFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQP
QLVLLQKTLLYVEGVGRQLYPQLDLWKTAKPFLESWIKDQVGIPALTRALKEKAPFWVEKMPEIPELVYDSLRQGKYLQH
SVDKIARELQVNHVRQSQSRYLLGIGATLLLSGSFLLVNRPEWGLMPGWLMVGGVVVWLVGWRKTR
>Mature_545_residues
TPGEVRRLYFIIRTFLSYGLDELIPRMRLTLPLRLWRYSLFWMPNRHKDKLLGERLRLALQELGPVWIKFGQMLSTRRDL
FPPQIADQLALLQDKVAPFDGRLAKAQIEEAMGGLPVEAWFDDFDIQPLASASIAQVHTARLKSNGKEVVIKVIRPDILP
VIQADLKLIYRLARWVPRLLPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFENSPMLYIPEVYSDYCSQNMM
VMERIYGIPVSDVAALEKNGTNMKLLAERGVKVFFTQVFRDSFFHADMHPGNIFVSHEHPENPQYIGIDCGIVGSLNKED
KRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEDFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQ
LVLLQKTLLYVEGVGRQLYPQLDLWKTAKPFLESWIKDQVGIPALTRALKEKAPFWVEKMPEIPELVYDSLRQGKYLQHS
VDKIARELQVNHVRQSQSRYLLGIGATLLLSGSFLLVNRPEWGLMPGWLMVGGVVVWLVGWRKTR

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=272, Percent_Identity=29.7794117647059, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI32261307, Length=320, Percent_Identity=25, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI40254938, Length=255, Percent_Identity=27.843137254902, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI217035081, Length=200, Percent_Identity=29.5, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI34147522, Length=213, Percent_Identity=28.169014084507, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI27363457, Length=212, Percent_Identity=28.3018867924528, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI2367309, Length=546, Percent_Identity=94.3223443223443, Blast_Score=1067, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17559152, Length=280, Percent_Identity=27.1428571428571, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI32565180, Length=304, Percent_Identity=24.6710526315789, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325148, Length=441, Percent_Identity=24.0362811791383, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6323282, Length=297, Percent_Identity=24.2424242424242, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321319, Length=201, Percent_Identity=27.363184079602, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24662575, Length=232, Percent_Identity=32.7586206896552, Blast_Score=122, Evalue=9e-28,
Organism=Drosophila melanogaster, GI22024280, Length=253, Percent_Identity=30.8300395256917, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 63240; Mature: 63108

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPGEVRRLYFIIRTFLSYGLDELIPRMRLTLPLRLWRYSLFWMPNRHKDKLLGERLRLA
CCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHH
LQELGPVWIKFGQMLSTRRDLFPPQIADQLALLQDKVAPFDGRLAKAQIEEAMGGLPVEA
HHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHH
WFDDFDIQPLASASIAQVHTARLKSNGKEVVIKVIRPDILPVIQADLKLIYRLARWVPRL
HCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHH
LPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFENSPMLYIPEVYSDYCSQNM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHCCCH
MVMERIYGIPVSDVAALEKNGTNMKLLAERGVKVFFTQVFRDSFFHADMHPGNIFVSHEH
HHHHHHHCCCHHHHHHHHCCCCCEEEHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCC
PENPQYIGIDCGIVGSLNKEDKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEDFE
CCCCCEEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
FAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGVGRQLY
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHC
PQLDLWKTAKPFLESWIKDQVGIPALTRALKEKAPFWVEKMPEIPELVYDSLRQGKYLQH
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHCCHHHHH
SVDKIARELQVNHVRQSQSRYLLGIGATLLLSGSFLLVNRPEWGLMPGWLMVGGVVVWLV
HHHHHHHHHHHHHHHHHCCCEEEEECHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHH
GWRKTR
HHCCCC
>Mature Secondary Structure 
TPGEVRRLYFIIRTFLSYGLDELIPRMRLTLPLRLWRYSLFWMPNRHKDKLLGERLRLA
CCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHH
LQELGPVWIKFGQMLSTRRDLFPPQIADQLALLQDKVAPFDGRLAKAQIEEAMGGLPVEA
HHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHH
WFDDFDIQPLASASIAQVHTARLKSNGKEVVIKVIRPDILPVIQADLKLIYRLARWVPRL
HCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHH
LPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFENSPMLYIPEVYSDYCSQNM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHCCCH
MVMERIYGIPVSDVAALEKNGTNMKLLAERGVKVFFTQVFRDSFFHADMHPGNIFVSHEH
HHHHHHHCCCHHHHHHHHCCCCCEEEHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCC
PENPQYIGIDCGIVGSLNKEDKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEDFE
CCCCCEEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
FAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGVGRQLY
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHC
PQLDLWKTAKPFLESWIKDQVGIPALTRALKEKAPFWVEKMPEIPELVYDSLRQGKYLQH
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHCCHHHHH
SVDKIARELQVNHVRQSQSRYLLGIGATLLLSGSFLLVNRPEWGLMPGWLMVGGVVVWLV
HHHHHHHHHHHHHHHHHCCCEEEEECHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHH
GWRKTR
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA