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The map label for this gene is panF [H]

Identifier: 29143630

GI number: 29143630

Start: 3391363

End: 3392814

Strand: Direct

Name: panF [H]

Synonym: t3297

Alternate gene names: 29143630

Gene position: 3391363-3392814 (Clockwise)

Preceding gene: 29143629

Following gene: 29143631

Centisome position: 70.77

GC content: 54.89

Gene sequence:

>1452_bases
ATGCAGCTTGAGGTCATTCTACCGCTGGTAGCCTATCTGGTCGTGGTCTTCGGGGTCTCGATTTACGCTATGCGCAAGCG
TACCGCCGGCACCTTTTTAAACGAGTATTTTCTTGGCAGTCGTTCGATGGGCGGGATCGTGCTCGCGATGACGCTGACCG
CCACCTATATTAGCGCCAGTTCATTTATCGGCGGTCCCGGCGCGGCTTATAAATATGGTCTGGGCTGGGTCTTGCTGGCG
ATGATCCAGCTTCCCGCCGTCTGGCTTTCACTGGGTATTCTGGGTAAAAAATTCGCTATCCTGGCGCGTCGCTATAATGC
CGTCACGCTTAACGATATGCTATTCGCTCGTTACCAAAGCCGCCTGCTGGTGTGGTTAGCAAGCCTGAGTTTATTGGTCG
CGTTTATTGGCGCAATGACCGTACAATTTATCGGCGGCGCGCGACTACTGGAAACCGCGGCGGGAATTCCCTACGAAACC
GGCCTGCTAATATTTGGCGTCAGTATCGCACTCTATACGGCGTTTGGCGGCTTTCGCGCCAGCGTACTTAACGATACGCT
ACAGGGCCTGGTGATGCTGGTCGGCACGATAGTGCTGCTGGTGGGCGTGGTGCATGCGGCGGGCGGTTTACATCAGGCCG
TTGACACGCTGCACGCTCTCGACCCCAAACTGGTAACGCCGCAGGGCGCCGATGACATACTTTCTCCCGCTTTTATGACC
TCTTTTTGGGTACTGGTCTGTTTTGGCGTGATTGGCCTGCCGCATACGGCAGTGCGCTGCATTTCTTATAAAGACAGTAA
AGCGGTACACCGGGGCATTATTATCGGTACGATTGTCGTGGCGATTTTAATGTTCGGGATGCACCTTGCCGGCGCGCTGG
GTCGCGCGGTGCTTCCGGATCTGACGGTGCCGGATCTGGTGATCCCAACGCTAATGGTGAAAGTTTTGCCGCCGTTTGCC
GCCGGGATCTTCCTTGCTGCGCCAATGGCGGCGATCATGTCAACAATTAACGCCCAACTGCTGCAAAGTTCCGCGACGAT
CATTAAAGATCTCTATCTCAACCTGCGTCCCGATCAGATGCAAAATGAGATCCGGCTGAAGCGTATGTCGGCAGCGATTA
CATTACTGTTAGGCGCGCTGTTGCTGCTGGCCGCGTGGAAACCGCCAGAGATGATCATTTGGCTCAACCTGCTGGCGTTT
GGCGGCCTGGAAGCGGTGTTCTTATGGCCGCTGGTACTGGGCCTTTACTGGGAGCGGGCAAACGCGGCAGGCGCGTTAAG
CGCCATGATCGTGGGCGGCGTGCTATATGCCCTGCTTGCCACATTTAATATTCAGTACCTGGGCTTTCATCCGATTGTGC
CCGCGTTACTGTTAAGTTTATTGGCTTTTCTGATCGGAAACCGATTCGGCTCTTCCGCTTCGCAAGCCACCGTATTGTCT
ACTGATAAATAA

Upstream 100 bases:

>100_bases
TGGTTCGAGATGGCCTGCTTATTGACGCCGCTGGTCTTTATTTTGCTGTGCTGGGCGATGGTGAAATTCATTTATCGCGA
TATTCCGCTGGAGGATGACG

Downstream 100 bases:

>100_bases
AGAGTTTTGCCATGCCATGGATCCAATTGAAACTGAATACCACCGGCGCGAATGCTGAAGAGCTAAGTGATGCGCTGATG
GAAGCGGGCGCCGTTTCCAT

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MQLEVILPLVAYLVVVFGVSIYAMRKRTAGTFLNEYFLGSRSMGGIVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFIGAMTVQFIGGARLLETAAGIPYET
GLLIFGVSIALYTAFGGFRASVLNDTLQGLVMLVGTIVLLVGVVHAAGGLHQAVDTLHALDPKLVTPQGADDILSPAFMT
SFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVLPDLTVPDLVIPTLMVKVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNLRPDQMQNEIRLKRMSAAITLLLGALLLLAAWKPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAAGALSAMIVGGVLYALLATFNIQYLGFHPIVPALLLSLLAFLIGNRFGSSASQATVLS
TDK

Sequences:

>Translated_483_residues
MQLEVILPLVAYLVVVFGVSIYAMRKRTAGTFLNEYFLGSRSMGGIVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFIGAMTVQFIGGARLLETAAGIPYET
GLLIFGVSIALYTAFGGFRASVLNDTLQGLVMLVGTIVLLVGVVHAAGGLHQAVDTLHALDPKLVTPQGADDILSPAFMT
SFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVLPDLTVPDLVIPTLMVKVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNLRPDQMQNEIRLKRMSAAITLLLGALLLLAAWKPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAAGALSAMIVGGVLYALLATFNIQYLGFHPIVPALLLSLLAFLIGNRFGSSASQATVLS
TDK
>Mature_483_residues
MQLEVILPLVAYLVVVFGVSIYAMRKRTAGTFLNEYFLGSRSMGGIVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFIGAMTVQFIGGARLLETAAGIPYET
GLLIFGVSIALYTAFGGFRASVLNDTLQGLVMLVGTIVLLVGVVHAAGGLHQAVDTLHALDPKLVTPQGADDILSPAFMT
SFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVLPDLTVPDLVIPTLMVKVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNLRPDQMQNEIRLKRMSAAITLLLGALLLLAAWKPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAAGALSAMIVGGVLYALLATFNIQYLGFHPIVPALLLSLLAFLIGNRFGSSASQATVLS
TDK

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=473, Percent_Identity=26.8498942917548, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI14140236, Length=478, Percent_Identity=24.0585774058577, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4507033, Length=410, Percent_Identity=26.3414634146341, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI4507031, Length=479, Percent_Identity=25.2609603340292, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI110835708, Length=491, Percent_Identity=23.2179226069246, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI4507035, Length=361, Percent_Identity=24.3767313019391, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI157671931, Length=386, Percent_Identity=20.7253886010363, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI109659836, Length=494, Percent_Identity=24.0890688259109, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87082237, Length=483, Percent_Identity=93.5817805383023, Blast_Score=878, Evalue=0.0,
Organism=Escherichia coli, GI1787251, Length=482, Percent_Identity=26.3485477178423, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1790113, Length=479, Percent_Identity=23.7995824634656, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790503, Length=492, Percent_Identity=22.3577235772358, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51621; Mature: 51621

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure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CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]