| Definition | Salmonella enterica subsp. enterica serovar Typhi str. Ty2 chromosome, complete genome. |
|---|---|
| Accession | NC_004631 |
| Length | 4,791,961 |
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The map label for this gene is kduD [H]
Identifier: 29143279
GI number: 29143279
Start: 3020422
End: 3021183
Strand: Reverse
Name: kduD [H]
Synonym: t2927
Alternate gene names: 29143279
Gene position: 3021183-3020422 (Counterclockwise)
Preceding gene: 29143280
Following gene: 29143278
Centisome position: 63.05
GC content: 51.84
Gene sequence:
>762_bases ATGATTTTGAATGCATTTTCTCTTGAAGGTAAAGTCGCGGTTGTGACGGGGTGCGATACCGGATTGGGACAGGGGATGGC GTTAGGGCTGGCGGAAGCGGGCTGTGACATTGTCGGTATTAACATTGTTGAACCGACGGAAACTATTGCGCGCGTCACCG CTCTGGGACGACGTTTTTTAAGCCTGACAGCCGATCTGCGTCAAATCGATGGTATTCCGGCGCTACTGGAACGGGCGGTG GCGGAATACGGTCATATTGATATTCTGGTGAATAACGCGGGTTTGATCCGTCGTGAAGATGCGATTGATTTCACGGAAAA AGACTGGGATGACGTCATGAACCTGAACATCAAGAGCGTGTTCTTTATGTCTCAGGCGGCGGCAAAATATTTTATTGCCC AGGGCAACGGCGGCAAAATTATTAATATCGCGTCTATGCTTTCCTTCCAGGGCGGCATTCGTGTTCCGTCTTATACCGCG TCGAAAAGCGGCGTAATGGGAATAACGCGTCTGATGGCGAACGAGTGGGCGAAACACAATATCAATGTAAACGCCATCGC GCCGGGCTATATGTCCACGAATAATACCCAGCAATTGCGCGCTGATGCACAACGTAGCGCCGAAATTCTCGACCGTATTC CGGCTGGACGTTGGGGGCTACCGGGCGATTTAATGGGGCCGGTAGTCTTCCTGGCATCCAGCGCCGCTGATTATATTAAC GGCTATACCATAGCGGTAGATGGCGGTTGGCTGGCGCGTTAA
Upstream 100 bases:
>100_bases GGTCTTCGATGACATGGATCACGTTGCGGTACAAGATCTGCGCTAGTCGCGACCGGTGATAACGCCTGTGTGACAGGCAT GACAAAAATAAGGATTAACA
Downstream 100 bases:
>100_bases TCCGCTACTGACAAATGCGTTTCTGGGAAAATCGACTCTTTGGCCGAAAAAACTGATAAAGCCCTGTCCTCGTACAGGGT TTTTTTATGATCTCATTAGC
Product: 2-deoxy-D-gluconate 3-dehydrogenase
Products: NA
Alternate protein names: 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase [H]
Number of amino acids: Translated: 253; Mature: 253
Protein sequence:
>253_residues MILNAFSLEGKVAVVTGCDTGLGQGMALGLAEAGCDIVGINIVEPTETIARVTALGRRFLSLTADLRQIDGIPALLERAV AEYGHIDILVNNAGLIRREDAIDFTEKDWDDVMNLNIKSVFFMSQAAAKYFIAQGNGGKIINIASMLSFQGGIRVPSYTA SKSGVMGITRLMANEWAKHNINVNAIAPGYMSTNNTQQLRADAQRSAEILDRIPAGRWGLPGDLMGPVVFLASSAADYIN GYTIAVDGGWLAR
Sequences:
>Translated_253_residues MILNAFSLEGKVAVVTGCDTGLGQGMALGLAEAGCDIVGINIVEPTETIARVTALGRRFLSLTADLRQIDGIPALLERAV AEYGHIDILVNNAGLIRREDAIDFTEKDWDDVMNLNIKSVFFMSQAAAKYFIAQGNGGKIINIASMLSFQGGIRVPSYTA SKSGVMGITRLMANEWAKHNINVNAIAPGYMSTNNTQQLRADAQRSAEILDRIPAGRWGLPGDLMGPVVFLASSAADYIN GYTIAVDGGWLAR >Mature_253_residues MILNAFSLEGKVAVVTGCDTGLGQGMALGLAEAGCDIVGINIVEPTETIARVTALGRRFLSLTADLRQIDGIPALLERAV AEYGHIDILVNNAGLIRREDAIDFTEKDWDDVMNLNIKSVFFMSQAAAKYFIAQGNGGKIINIASMLSFQGGIRVPSYTA SKSGVMGITRLMANEWAKHNINVNAIAPGYMSTNNTQQLRADAQRSAEILDRIPAGRWGLPGDLMGPVVFLASSAADYIN GYTIAVDGGWLAR
Specific function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI15277342, Length=255, Percent_Identity=31.3725490196078, Blast_Score=128, Evalue=5e-30, Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=32, Blast_Score=113, Evalue=1e-25, Organism=Homo sapiens, GI66933014, Length=249, Percent_Identity=30.9236947791165, Blast_Score=113, Evalue=2e-25, Organism=Homo sapiens, GI7705925, Length=254, Percent_Identity=28.740157480315, Blast_Score=111, Evalue=5e-25, Organism=Homo sapiens, GI19923817, Length=257, Percent_Identity=28.7937743190661, Blast_Score=105, Evalue=5e-23, Organism=Homo sapiens, GI10190704, Length=253, Percent_Identity=32.4110671936759, Blast_Score=100, Evalue=9e-22, Organism=Homo sapiens, GI40254992, Length=242, Percent_Identity=29.3388429752066, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI5031737, Length=244, Percent_Identity=26.6393442622951, Blast_Score=88, Evalue=6e-18, Organism=Homo sapiens, GI126723750, Length=253, Percent_Identity=28.4584980237154, Blast_Score=86, Evalue=2e-17, Organism=Homo sapiens, GI4504505, Length=254, Percent_Identity=25.9842519685039, Blast_Score=85, Evalue=8e-17, Organism=Homo sapiens, GI4503301, Length=250, Percent_Identity=29.6, Blast_Score=83, Evalue=3e-16, Organism=Homo sapiens, GI31542939, Length=199, Percent_Identity=30.6532663316583, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI40254986, Length=199, Percent_Identity=30.1507537688442, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI59889578, Length=191, Percent_Identity=27.7486910994764, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI33667109, Length=196, Percent_Identity=25.5102040816327, Blast_Score=71, Evalue=8e-13, Organism=Homo sapiens, GI209862901, Length=200, Percent_Identity=29.5, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI19923983, Length=200, Percent_Identity=29.5, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI224922801, Length=174, Percent_Identity=31.0344827586207, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=27.4509803921569, Blast_Score=69, Evalue=6e-12, Organism=Homo sapiens, GI109715829, Length=240, Percent_Identity=24.1666666666667, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI20149619, Length=211, Percent_Identity=29.8578199052133, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI126723191, Length=183, Percent_Identity=28.9617486338798, Blast_Score=66, Evalue=4e-11, Organism=Escherichia coli, GI1789208, Length=253, Percent_Identity=92.8853754940711, Blast_Score=490, Evalue=1e-140, Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=41.6342412451362, Blast_Score=195, Evalue=2e-51, Organism=Escherichia coli, GI1790717, Length=248, Percent_Identity=39.5161290322581, Blast_Score=172, Evalue=2e-44, Organism=Escherichia coli, GI1787335, Length=246, Percent_Identity=36.1788617886179, Blast_Score=144, Evalue=4e-36, Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=34.6938775510204, Blast_Score=133, Evalue=1e-32, Organism=Escherichia coli, GI87082100, Length=254, Percent_Identity=31.1023622047244, Blast_Score=117, Evalue=5e-28, Organism=Escherichia coli, GI1787905, Length=244, Percent_Identity=31.9672131147541, Blast_Score=102, Evalue=2e-23, Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=27.2, Blast_Score=87, Evalue=8e-19, Organism=Escherichia coli, GI1789378, Length=248, Percent_Identity=26.6129032258064, Blast_Score=83, Evalue=2e-17, Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=26.9387755102041, Blast_Score=75, Evalue=4e-15, Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=27.027027027027, Blast_Score=70, Evalue=2e-13, Organism=Escherichia coli, GI2367365, Length=176, Percent_Identity=28.4090909090909, Blast_Score=65, Evalue=3e-12, Organism=Escherichia coli, GI1787526, Length=192, Percent_Identity=26.0416666666667, Blast_Score=63, Evalue=2e-11, Organism=Caenorhabditis elegans, GI25147288, Length=245, Percent_Identity=32.6530612244898, Blast_Score=124, Evalue=7e-29, Organism=Caenorhabditis elegans, GI17555706, Length=245, Percent_Identity=31.0204081632653, Blast_Score=121, Evalue=4e-28, Organism=Caenorhabditis elegans, GI17561402, Length=260, Percent_Identity=32.3076923076923, Blast_Score=114, Evalue=7e-26, Organism=Caenorhabditis elegans, GI17560676, Length=249, Percent_Identity=29.3172690763052, Blast_Score=108, Evalue=3e-24, Organism=Caenorhabditis elegans, GI115534694, Length=247, Percent_Identity=26.7206477732794, Blast_Score=102, Evalue=3e-22, Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=29.0196078431373, Blast_Score=100, Evalue=7e-22, Organism=Caenorhabditis elegans, GI17562910, Length=261, Percent_Identity=29.8850574712644, Blast_Score=97, Evalue=6e-21, Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=28.7449392712551, Blast_Score=97, Evalue=7e-21, Organism=Caenorhabditis elegans, GI17544670, Length=269, Percent_Identity=29.368029739777, Blast_Score=97, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17559104, Length=257, Percent_Identity=29.1828793774319, Blast_Score=96, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17560220, Length=260, Percent_Identity=28.8461538461538, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17551412, Length=258, Percent_Identity=29.8449612403101, Blast_Score=94, Evalue=6e-20, Organism=Caenorhabditis elegans, GI17562906, Length=260, Percent_Identity=28.8461538461538, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17562908, Length=266, Percent_Identity=28.9473684210526, Blast_Score=93, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17568967, Length=192, Percent_Identity=28.6458333333333, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI17531453, Length=260, Percent_Identity=30, Blast_Score=91, Evalue=8e-19, Organism=Caenorhabditis elegans, GI17563726, Length=261, Percent_Identity=28.3524904214559, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=27.5862068965517, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17562990, Length=262, Percent_Identity=27.0992366412214, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17560150, Length=258, Percent_Identity=27.1317829457364, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=28.8973384030418, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17560332, Length=258, Percent_Identity=28.6821705426357, Blast_Score=85, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17562904, Length=261, Percent_Identity=26.4367816091954, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI72000259, Length=263, Percent_Identity=26.9961977186312, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17564282, Length=192, Percent_Identity=28.6458333333333, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17536025, Length=255, Percent_Identity=25.8823529411765, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17565030, Length=260, Percent_Identity=30.3846153846154, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI17538182, Length=256, Percent_Identity=29.6875, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17538486, Length=258, Percent_Identity=26.7441860465116, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17536651, Length=258, Percent_Identity=25.1937984496124, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17561272, Length=251, Percent_Identity=27.0916334661355, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI193203117, Length=195, Percent_Identity=28.2051282051282, Blast_Score=75, Evalue=4e-14, Organism=Caenorhabditis elegans, GI193203115, Length=193, Percent_Identity=28.4974093264249, Blast_Score=74, Evalue=5e-14, Organism=Caenorhabditis elegans, GI17555612, Length=221, Percent_Identity=28.9592760180996, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI32563809, Length=208, Percent_Identity=25.4807692307692, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17507613, Length=210, Percent_Identity=24.7619047619048, Blast_Score=71, Evalue=4e-13, Organism=Caenorhabditis elegans, GI71982365, Length=201, Percent_Identity=27.363184079602, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17508651, Length=160, Percent_Identity=30.625, Blast_Score=65, Evalue=4e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=200, Percent_Identity=32, Blast_Score=87, Evalue=3e-18, Organism=Saccharomyces cerevisiae, GI6324126, Length=251, Percent_Identity=25.8964143426295, Blast_Score=69, Evalue=8e-13, Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=31.5789473684211, Blast_Score=127, Evalue=8e-30, Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=29.718875502008, Blast_Score=111, Evalue=4e-25, Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=29.6442687747036, Blast_Score=105, Evalue=3e-23, Organism=Drosophila melanogaster, GI23397609, Length=250, Percent_Identity=29.2, Blast_Score=103, Evalue=7e-23, Organism=Drosophila melanogaster, GI28571526, Length=253, Percent_Identity=30.4347826086957, Blast_Score=103, Evalue=1e-22, Organism=Drosophila melanogaster, GI24644339, Length=254, Percent_Identity=27.5590551181102, Blast_Score=96, Evalue=3e-20, Organism=Drosophila melanogaster, GI24643142, Length=244, Percent_Identity=28.6885245901639, Blast_Score=93, Evalue=1e-19, Organism=Drosophila melanogaster, GI18859837, Length=258, Percent_Identity=31.0077519379845, Blast_Score=90, Evalue=2e-18, Organism=Drosophila melanogaster, GI21358495, Length=202, Percent_Identity=30.6930693069307, Blast_Score=83, Evalue=2e-16, Organism=Drosophila melanogaster, GI24644337, Length=206, Percent_Identity=27.1844660194175, Blast_Score=82, Evalue=2e-16, Organism=Drosophila melanogaster, GI21357673, Length=198, Percent_Identity=28.7878787878788, Blast_Score=78, Evalue=5e-15, Organism=Drosophila melanogaster, GI24649181, Length=198, Percent_Identity=29.2929292929293, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI17737361, Length=264, Percent_Identity=28.7878787878788, Blast_Score=75, Evalue=4e-14, Organism=Drosophila melanogaster, GI221331218, Length=220, Percent_Identity=27.7272727272727, Blast_Score=75, Evalue=5e-14, Organism=Drosophila melanogaster, GI24665243, Length=221, Percent_Identity=27.6018099547511, Blast_Score=75, Evalue=5e-14, Organism=Drosophila melanogaster, GI221331216, Length=222, Percent_Identity=27.9279279279279, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI24665247, Length=222, Percent_Identity=27.9279279279279, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI161076933, Length=253, Percent_Identity=26.4822134387352, Blast_Score=71, Evalue=6e-13, Organism=Drosophila melanogaster, GI24584748, Length=253, Percent_Identity=26.4822134387352, Blast_Score=71, Evalue=6e-13, Organism=Drosophila melanogaster, GI24640492, Length=214, Percent_Identity=25.2336448598131, Blast_Score=69, Evalue=2e-12, Organism=Drosophila melanogaster, GI24580925, Length=255, Percent_Identity=25.0980392156863, Blast_Score=67, Evalue=1e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011286 - InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.127 [H]
Molecular weight: Translated: 27050; Mature: 27050
Theoretical pI: Translated: 5.04; Mature: 5.04
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 3.6 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 3.6 %Met (Mature Protein) 4.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MILNAFSLEGKVAVVTGCDTGLGQGMALGLAEAGCDIVGINIVEPTETIARVTALGRRFL CEEEEEECCCCEEEEEECCCCCCCCCEEEHHHCCCCEEEEEEECHHHHHHHHHHHHHHHH SLTADLRQIDGIPALLERAVAEYGHIDILVNNAGLIRREDAIDFTEKDWDDVMNLNIKSV HHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCEEECCCCCCCCCCHHHHHCCCHHHH FFMSQAAAKYFIAQGNGGKIINIASMLSFQGGIRVPSYTASKSGVMGITRLMANEWAKHN HHHHHHHHEEEEEECCCCCEEEHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC INVNAIAPGYMSTNNTQQLRADAQRSAEILDRIPAGRWGLPGDLMGPVVFLASSAADYIN CCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC GYTIAVDGGWLAR CEEEEECCCEECC >Mature Secondary Structure MILNAFSLEGKVAVVTGCDTGLGQGMALGLAEAGCDIVGINIVEPTETIARVTALGRRFL CEEEEEECCCCEEEEEECCCCCCCCCEEEHHHCCCCEEEEEEECHHHHHHHHHHHHHHHH SLTADLRQIDGIPALLERAVAEYGHIDILVNNAGLIRREDAIDFTEKDWDDVMNLNIKSV HHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCEEECCCCCCCCCCHHHHHCCCHHHH FFMSQAAAKYFIAQGNGGKIINIASMLSFQGGIRVPSYTASKSGVMGITRLMANEWAKHN HHHHHHHHEEEEEECCCCCEEEHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC INVNAIAPGYMSTNNTQQLRADAQRSAEILDRIPAGRWGLPGDLMGPVVFLASSAADYIN CCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC GYTIAVDGGWLAR CEEEEECCCEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9278503; 2836407; 1766386 [H]