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The map label for this gene is fucO [H]

Identifier: 29143235

GI number: 29143235

Start: 2965937

End: 2967085

Strand: Reverse

Name: fucO [H]

Synonym: t2881

Alternate gene names: 29143235

Gene position: 2967085-2965937 (Counterclockwise)

Preceding gene: 29143236

Following gene: 29143229

Centisome position: 61.92

GC content: 56.22

Gene sequence:

>1149_bases
ATGGCGAACAGAATGATTCTGAATGAAACGGCATGGTTTGGCCGGGGAGCGGTGGACGCATTAACCGATGAGGTGACGCG
CCGCGGTTATCATAAGGCGCTGATTGTTACCGATAAAACGCTGGTGCAATGCGGTGTGGTCGATAAGGTTACAAGCAGAA
TGGATGCCGCAGGGCTGGCGTGGGAGATCTATGCGGGCGTGATCCCTAATCCTACGATTTCCGTTGTCCAGGAAGGGCTT
AAGGTCTTTACCCAAAGTGGCGCGGACTATCTCATCGCCATTGGCGGCGGTTCTCCGCAGGATACCTGCAAAGCGGTCGG
TATTATCAGTAACAATCCGGAATTTGCCGATGTGCGCAGTCTGGAAGGGCTATCGCCGACCCGTAAACCCAGCGTGCCGA
TTATGGCGATCCCGACAACGGCGGGAACCGCGGCGGAAGTCACTATCAATTATGTGATTACCGATGAAGAGAAACGGCGC
AAATTCGTTTGTGTCGATCCGCATGATATTCCGCAGGCGGCATTTATCGATGCCGATATGATGGACGGTATGCCGCCCGC
GCTGAAAGCGGCAACGGGCGTGGATGCGCTAACCCATGCTATTGAAGGCTATATTACCCGGGCCGCATGGGCGCTGACGG
ATGCATTACATATCAAAGCCATTGAGATTATTGCTGGCGCGCTGCGCGGCGCCGTAGCCGGAGAAAAAGAGGCCGGTGAG
GCGATGGCGCTGGGGCAATACGTTGCCGGGATGGGGTTTTCCAATGTGGGGCTGGGACTGGTGCATGGGATGGCGCATCC
GTTGGGCGCGTTTTACAACACGCCGCACGGCGTCGCGAATGCTATTTTGCTCCCGCATGTGATGCGTTTCAATGCCGGGT
CTACCAACGAGAAATTCCGTGATATCGCCCGGGCGATGGGGGTGAAGGTAGAAGGATTGAGCCTTGAAGAGGCGCGTAAT
GCCGCAGTGGAAGCCGTATTTACGCTAAATCGCGATGTGGGAATTCCGCTGCATTTGCGTGATGTCGGCGTTCGAAAAGA
GGATATCCCGGCGCTGGCGCAGGCGGCGTTCGATGATGTCTGTACGGGCGGCAATCCGCGTGAAGCGAGTCTGGCGGACA
TTGTCGAACTGTATCATACCGCCTGGTAA

Upstream 100 bases:

>100_bases
GATCCGGTACCGGTACTGGATGACGAGGCGATCGCTATCGTACTGGAGAAATTTAAAACTTACGGATTACGTATTGAAGA
GTGATGTCAGGAGACAGGCG

Downstream 100 bases:

>100_bases
TTTTGCCGGATGGCGCTGCGCTTATCCGCTCTACATTTCGTGCAGTTCTGTAGGCCGGATAAGGCGTTCACGCCGCCATC
CGGCAACAAAACTACCGTAC

Product: L-1,2-propanediol oxidoreductase

Products: NA

Alternate protein names: Propanediol oxidoreductase [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MANRMILNETAWFGRGAVDALTDEVTRRGYHKALIVTDKTLVQCGVVDKVTSRMDAAGLAWEIYAGVIPNPTISVVQEGL
KVFTQSGADYLIAIGGGSPQDTCKAVGIISNNPEFADVRSLEGLSPTRKPSVPIMAIPTTAGTAAEVTINYVITDEEKRR
KFVCVDPHDIPQAAFIDADMMDGMPPALKAATGVDALTHAIEGYITRAAWALTDALHIKAIEIIAGALRGAVAGEKEAGE
AMALGQYVAGMGFSNVGLGLVHGMAHPLGAFYNTPHGVANAILLPHVMRFNAGSTNEKFRDIARAMGVKVEGLSLEEARN
AAVEAVFTLNRDVGIPLHLRDVGVRKEDIPALAQAAFDDVCTGGNPREASLADIVELYHTAW

Sequences:

>Translated_382_residues
MANRMILNETAWFGRGAVDALTDEVTRRGYHKALIVTDKTLVQCGVVDKVTSRMDAAGLAWEIYAGVIPNPTISVVQEGL
KVFTQSGADYLIAIGGGSPQDTCKAVGIISNNPEFADVRSLEGLSPTRKPSVPIMAIPTTAGTAAEVTINYVITDEEKRR
KFVCVDPHDIPQAAFIDADMMDGMPPALKAATGVDALTHAIEGYITRAAWALTDALHIKAIEIIAGALRGAVAGEKEAGE
AMALGQYVAGMGFSNVGLGLVHGMAHPLGAFYNTPHGVANAILLPHVMRFNAGSTNEKFRDIARAMGVKVEGLSLEEARN
AAVEAVFTLNRDVGIPLHLRDVGVRKEDIPALAQAAFDDVCTGGNPREASLADIVELYHTAW
>Mature_381_residues
ANRMILNETAWFGRGAVDALTDEVTRRGYHKALIVTDKTLVQCGVVDKVTSRMDAAGLAWEIYAGVIPNPTISVVQEGLK
VFTQSGADYLIAIGGGSPQDTCKAVGIISNNPEFADVRSLEGLSPTRKPSVPIMAIPTTAGTAAEVTINYVITDEEKRRK
FVCVDPHDIPQAAFIDADMMDGMPPALKAATGVDALTHAIEGYITRAAWALTDALHIKAIEIIAGALRGAVAGEKEAGEA
MALGQYVAGMGFSNVGLGLVHGMAHPLGAFYNTPHGVANAILLPHVMRFNAGSTNEKFRDIARAMGVKVEGLSLEEARNA
AVEAVFTLNRDVGIPLHLRDVGVRKEDIPALAQAAFDDVCTGGNPREASLADIVELYHTAW

Specific function: Fucose metabolism; fourth step. [C]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=406, Percent_Identity=28.0788177339901, Blast_Score=115, Evalue=7e-26,
Organism=Escherichia coli, GI1789163, Length=382, Percent_Identity=90.8376963350785, Blast_Score=713, Evalue=0.0,
Organism=Escherichia coli, GI48994951, Length=369, Percent_Identity=43.6314363143631, Blast_Score=292, Evalue=2e-80,
Organism=Escherichia coli, GI87082107, Length=372, Percent_Identity=39.5161290322581, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1787493, Length=402, Percent_Identity=32.3383084577114, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1789386, Length=356, Percent_Identity=25.561797752809, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17537053, Length=418, Percent_Identity=24.4019138755981, Blast_Score=118, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6321181, Length=376, Percent_Identity=38.031914893617, Blast_Score=262, Evalue=8e-71,
Organism=Drosophila melanogaster, GI24657991, Length=412, Percent_Identity=25.4854368932039, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211
- InterPro:   IPR013460 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.77 [H]

Molecular weight: Translated: 40525; Mature: 40394

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANRMILNETAWFGRGAVDALTDEVTRRGYHKALIVTDKTLVQCGVVDKVTSRMDAAGLA
CCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHCCHHHHHHHHHHCCCE
WEIYAGVIPNPTISVVQEGLKVFTQSGADYLIAIGGGSPQDTCKAVGIISNNPEFADVRS
EEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHEEEEECCCCCCHHHHH
LEGLSPTRKPSVPIMAIPTTAGTAAEVTINYVITDEEKRRKFVCVDPHDIPQAAFIDADM
CCCCCCCCCCCCCEEEECCCCCCEEEEEEEEEEECHHHCCCEEEECCCCCCCHHEECCHH
MDGMPPALKAATGVDALTHAIEGYITRAAWALTDALHIKAIEIIAGALRGAVAGEKEAGE
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
AMALGQYVAGMGFSNVGLGLVHGMAHPLGAFYNTPHGVANAILLPHVMRFNAGSTNEKFR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHH
DIARAMGVKVEGLSLEEARNAAVEAVFTLNRDVGIPLHLRDVGVRKEDIPALAQAAFDDV
HHHHHHCCEEECCCHHHHHHHHEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHH
CTGGNPREASLADIVELYHTAW
HCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
ANRMILNETAWFGRGAVDALTDEVTRRGYHKALIVTDKTLVQCGVVDKVTSRMDAAGLA
CCCEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHCCHHHHHHHHHHCCCE
WEIYAGVIPNPTISVVQEGLKVFTQSGADYLIAIGGGSPQDTCKAVGIISNNPEFADVRS
EEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHEEEEECCCCCCHHHHH
LEGLSPTRKPSVPIMAIPTTAGTAAEVTINYVITDEEKRRKFVCVDPHDIPQAAFIDADM
CCCCCCCCCCCCCEEEECCCCCCEEEEEEEEEEECHHHCCCEEEECCCCCCCHHEECCHH
MDGMPPALKAATGVDALTHAIEGYITRAAWALTDALHIKAIEIIAGALRGAVAGEKEAGE
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
AMALGQYVAGMGFSNVGLGLVHGMAHPLGAFYNTPHGVANAILLPHVMRFNAGSTNEKFR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHH
DIARAMGVKVEGLSLEEARNAAVEAVFTLNRDVGIPLHLRDVGVRKEDIPALAQAAFDDV
HHHHHHCCEEECCCHHHHHHHHEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHH
CTGGNPREASLADIVELYHTAW
HCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]