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The map label for this gene is hilD [H]

Identifier: 29143136

GI number: 29143136

Start: 2855707

End: 2856636

Strand: Direct

Name: hilD [H]

Synonym: t2777

Alternate gene names: 29143136

Gene position: 2855707-2856636 (Clockwise)

Preceding gene: 29143126

Following gene: 29143137

Centisome position: 59.59

GC content: 40.32

Gene sequence:

>930_bases
ATGGAAAATGTAACCTTTGTAAGTAATAGTCATCAGCGTCCTGCCGCAGATAACTTACAGAAATTAAAATCACTTTTGAC
AAATACCCAGCAGCAAATTAAAAGTCAGACTCAGCAGGTTACCATCAAAAATCTTTATGTAAGCAGTTTCACTTTAGTTT
GCTTTCGGAGCGGTAAACTGACGATTAGCAATAATCACGATACGATTTACTGTGACGAACCTGGGATGTTGGTGCTCAAA
AAAGAGCAGGTAGTTAACGTGACGCTTGAAGAGGTCAATGGCCACATGGATTTCGATATACTCGAGATACCGACGCAACG
ACTTGGCGCTCTCTATGCACTTATCCCAAACGAGCAGCAAACCAAAATGGCGGTACCCACAGAGAAAGCGCAGAAAATCT
TCTATACACCTGACTTTCCTGCCAGAAGAGAGGTATTTGAACATCTGAAAACGGCGTTCTCCTGTACGAAGGATACAAGC
AAAGGTTGCAGTAATTGTAACAACAAAAGTTGTATTGAAAATGAAGAGTTAATTCCTTATTTTCTGCTGTTCCTGCTTAC
TGCTTTTCTCCGACTCCCTGAGAGTTATGAGATCATCCTTAGCTCGGCTCAGATAACGTTAAAGAAGCGCGTTTACAACA
TTATATCTTCGTCACCCAGTAGACAGTGGAAGCTTACGGATGTTGCCGATCATATATTTATGAGTACGTCAACGCTCAAA
CGGAAACTTGCAGAAGAAGGTACCAGCTTTAGCGATATCTACTTATCGGCAAGAATGAATCAGGCAGCAAAACTTTTACG
CATAGGCAACCATAATGTTAATGCTGTAGCATTAAAATGTGGTTATGACAGCACGTCCTACTTCATTCAATGTTTCAAAA
AATATTTTAAAACTACGCCATCGACATTCATAAAAATGGCGAACCATTAA

Upstream 100 bases:

>100_bases
GACCATTGCCAACACACGCTAATAAAGAGCATTTACAACTCAGATTTTTTCAGTAGGATACCAGTAAGGAACATTAAAAT
AACATCAACAAAGGGATAAT

Downstream 100 bases:

>100_bases
CATTTTTGTATCAGTCACTCAAGTAAAGATTTTTATTAAAATTTTAATAATTTAAAATTCAGACCGTGCATTAACACGCT
ATATCAGGATGGGAGGCTAT

Product: AraC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MENVTFVSNSHQRPAADNLQKLKSLLTNTQQQIKSQTQQVTIKNLYVSSFTLVCFRSGKLTISNNHDTIYCDEPGMLVLK
KEQVVNVTLEEVNGHMDFDILEIPTQRLGALYALIPNEQQTKMAVPTEKAQKIFYTPDFPARREVFEHLKTAFSCTKDTS
KGCSNCNNKSCIENEELIPYFLLFLLTAFLRLPESYEIILSSAQITLKKRVYNIISSSPSRQWKLTDVADHIFMSTSTLK
RKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPSTFIKMANH

Sequences:

>Translated_309_residues
MENVTFVSNSHQRPAADNLQKLKSLLTNTQQQIKSQTQQVTIKNLYVSSFTLVCFRSGKLTISNNHDTIYCDEPGMLVLK
KEQVVNVTLEEVNGHMDFDILEIPTQRLGALYALIPNEQQTKMAVPTEKAQKIFYTPDFPARREVFEHLKTAFSCTKDTS
KGCSNCNNKSCIENEELIPYFLLFLLTAFLRLPESYEIILSSAQITLKKRVYNIISSSPSRQWKLTDVADHIFMSTSTLK
RKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPSTFIKMANH
>Mature_309_residues
MENVTFVSNSHQRPAADNLQKLKSLLTNTQQQIKSQTQQVTIKNLYVSSFTLVCFRSGKLTISNNHDTIYCDEPGMLVLK
KEQVVNVTLEEVNGHMDFDILEIPTQRLGALYALIPNEQQTKMAVPTEKAQKIFYTPDFPARREVFEHLKTAFSCTKDTS
KGCSNCNNKSCIENEELIPYFLLFLLTAFLRLPESYEIILSSAQITLKKRVYNIISSSPSRQWKLTDVADHIFMSTSTLK
RKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPSTFIKMANH

Specific function: Induces The Expression Of Gade And Yhiuv. Could Also Regulate The Expression Of Other Genes Involved In Acid Resistance. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787776, Length=120, Percent_Identity=39.1666666666667, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1786776, Length=119, Percent_Identity=42.0168067226891, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1789933, Length=137, Percent_Identity=35.7664233576642, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789932, Length=98, Percent_Identity=40.8163265306122, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790557, Length=124, Percent_Identity=36.2903225806452, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786778, Length=129, Percent_Identity=35.6589147286822, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786758, Length=103, Percent_Identity=33.9805825242718, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR020449
- InterPro:   IPR018060 [H]

Pfam domain/function: PF00165 HTH_AraC [H]

EC number: NA

Molecular weight: Translated: 35190; Mature: 35190

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENVTFVSNSHQRPAADNLQKLKSLLTNTQQQIKSQTQQVTIKNLYVSSFTLVCFRSGKL
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCEE
TISNNHDTIYCDEPGMLVLKKEQVVNVTLEEVNGHMDFDILEIPTQRLGALYALIPNEQQ
EEECCCCEEEECCCCEEEEECCHHEEEEHHHCCCCCCEEHEECCHHHHCEEEEECCCCCC
TKMAVPTEKAQKIFYTPDFPARREVFEHLKTAFSCTKDTSKGCSNCNNKSCIENEELIPY
CEEECCCHHCCEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCHHHH
FLLFLLTAFLRLPESYEIILSSAQITLKKRVYNIISSSPSRQWKLTDVADHIFMSTSTLK
HHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHH
RKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTP
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCC
STFIKMANH
HHHHEECCC
>Mature Secondary Structure
MENVTFVSNSHQRPAADNLQKLKSLLTNTQQQIKSQTQQVTIKNLYVSSFTLVCFRSGKL
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCEE
TISNNHDTIYCDEPGMLVLKKEQVVNVTLEEVNGHMDFDILEIPTQRLGALYALIPNEQQ
EEECCCCEEEECCCCEEEEECCHHEEEEHHHCCCCCCEEHEECCHHHHCEEEEECCCCCC
TKMAVPTEKAQKIFYTPDFPARREVFEHLKTAFSCTKDTSKGCSNCNNKSCIENEELIPY
CEEECCCHHCCEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCHHHH
FLLFLLTAFLRLPESYEIILSSAQITLKKRVYNIISSSPSRQWKLTDVADHIFMSTSTLK
HHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHH
RKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTP
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCC
STFIKMANH
HHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10320584; 11677609; 7476203 [H]