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The map label for this gene is hypC [H]

Identifier: 29143117

GI number: 29143117

Start: 2839834

End: 2840106

Strand: Direct

Name: hypC [H]

Synonym: t2758

Alternate gene names: 29143117

Gene position: 2839834-2840106 (Clockwise)

Preceding gene: 29143116

Following gene: 29143118

Centisome position: 59.26

GC content: 55.31

Gene sequence:

>273_bases
ATGTGCATAGGCGTTCCGGGTCAAATCCGCGCCATTGACGGCAATCAGGCAAAAGTTGACGTCTGCGGCATTCAGCGCGA
CGTCGATCTCACATTAGTCGGCAGTTGTGATGAAAACGGTCAGCCGCGTCTGGGTCAGTGGGTGCTGGTTCATGTCGGAT
TCGCCATGAGCGTCATTAACGAAGCGGAAGCGCGCGACACGCTCGACGCGCTACAAAATATGTTTGATGTTGAGCCGGAC
GTCGGCGCACTGCTGTATGGTGAGGAGAGATAA

Upstream 100 bases:

>100_bases
CCAGCGCGCGTGAAGTGAACCCGGAGATTGAAATTATCCTGATTTCCGCCACCAGCGGCGAAGGCATGGATCAGTGGCTG
GCCTGGCTGGAGGCGCAGCG

Downstream 100 bases:

>100_bases
TGCGTTTTGTTGACGAGTACCGTGCGCCGGAACAGGTAATGCAGCTCATTGAACACCTGCGTGAACGCGCCGCCCTTCTT
CCTTACACTGCTGAACGACC

Product: hydrogenase assembly chaperone

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 90; Mature: 90

Protein sequence:

>90_residues
MCIGVPGQIRAIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRLGQWVLVHVGFAMSVINEAEARDTLDALQNMFDVEPD
VGALLYGEER

Sequences:

>Translated_90_residues
MCIGVPGQIRAIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRLGQWVLVHVGFAMSVINEAEARDTLDALQNMFDVEPD
VGALLYGEER
>Mature_90_residues
MCIGVPGQIRAIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRLGQWVLVHVGFAMSVINEAEARDTLDALQNMFDVEPD
VGALLYGEER

Specific function: Is required for the formation of all three hydrogenase isoenzymes. May bind to the precursor form of the large subunit of dehydrogenases to keep them in a conformation accessible for metal incorporation [H]

COG id: COG0298

COG function: function code O; Hydrogenase maturation factor

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hupF/hypC family [H]

Homologues:

Organism=Escherichia coli, GI1789083, Length=90, Percent_Identity=96.6666666666667, Blast_Score=180, Evalue=2e-47,
Organism=Escherichia coli, GI1789364, Length=81, Percent_Identity=59.2592592592593, Blast_Score=87, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019812
- InterPro:   IPR001109 [H]

Pfam domain/function: PF01455 HupF_HypC [H]

EC number: NA

Molecular weight: Translated: 9744; Mature: 9744

Theoretical pI: Translated: 3.96; Mature: 3.96

Prosite motif: PS01097 HUPF_HYPC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCIGVPGQIRAIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRLGQWVLVHVGFAMSVIN
CEECCCCEEEEECCCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHH
EAEARDTLDALQNMFDVEPDVGALLYGEER
HHHHHHHHHHHHHHHCCCCCCCEEEEECCC
>Mature Secondary Structure
MCIGVPGQIRAIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRLGQWVLVHVGFAMSVIN
CEECCCCEEEEECCCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHH
EAEARDTLDALQNMFDVEPDVGALLYGEER
HHHHHHHHHHHHHHHCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]