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The map label for this gene is srlD [H]

Identifier: 29143095

GI number: 29143095

Start: 2818970

End: 2819749

Strand: Direct

Name: srlD [H]

Synonym: t2736

Alternate gene names: 29143095

Gene position: 2818970-2819749 (Clockwise)

Preceding gene: 29143094

Following gene: 29143096

Centisome position: 58.83

GC content: 55.13

Gene sequence:

>780_bases
ATGAATCAAGTTGCCGTTGTCATTGGCGGAGGCCAGACCCTGGGGGCATTCCTTTGCCGTGGGCTTGCAGAAGAAGGATA
CCGCGTGGCGGTCGTTGATATTCAAAGCGATAAAGCCGCGAATGTCGCCCAGGAAATTAACGCCGATTTTGGCGAAGGTA
TGGCCTACGGTTTTGGCGCCGACGCCACCAGCGAGCAGAGCGTGCTGGCGCTGTCCCGCGGCGTAGACGAGATTTTCGGG
CGCGTCGATCTGCTGGTTTACAGCGCGGGTATCGCCAAAGCGGCGTTTATCAGCGATTTCCAGTTGGGCGATTTTGACCG
CTCGCTACAGGTGAATCTGGTGGGCTATTTCCTCTGCGCCCGTGAGTTTTCCCGCCTGATGATCCGCGACGGCATTCAGG
GGCGCATTATTCAGATTAACTCTAAATCCGGCAAAGTGGGCAGTAAACACAACTCCGGCTACAGCGCGGCGAAATTCGGC
GGCGTGGGGTTAACCCAGTCTCTGGCGCTGGACCTGGCGGAATACGGCATTACCGTACACTCGCTGATGCTCGGCAACCT
GTTGAAATCGCCGATGTTCCAGTCATTGCTGCCGCAATACGCCACTAAACTGTGCATTAAGCCCGACGAGGTGGAACAGT
ATTACATTGATAAAGTACCGCTCAAACGCGGGTGTGATTATCAGGATGTGCTGAACATGCTGCTATTTTATGCCAGCCCG
AAAGCGTCTTATTGCACCGGGCAGTCGATCAACGTAACCGGCGGTCAAGTGATGTTCTGA

Upstream 100 bases:

>100_bases
GCGAAGCGGAATTTCCCGGCACCGTACACGTTGCGGGGCCTGTACCGGACGATATCGCGCCGGGCTGTATTTTGACGTTT
GTCGCTTAAGGAGAAAAAAC

Downstream 100 bases:

>100_bases
CCGTGAATTGCCGGATGGCGCCGTAGGCCGGATAAGACGGTTACGCCGCCATCAGGCAAAACAACAGGAGCACATTATGG
TTTCCACTCTGATTACCGTC

Product: sorbitol-6-phosphate dehydrogenase

Products: NA

Alternate protein names: Glucitol-6-phosphate dehydrogenase; Ketosephosphate reductase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MNQVAVVIGGGQTLGAFLCRGLAEEGYRVAVVDIQSDKAANVAQEINADFGEGMAYGFGADATSEQSVLALSRGVDEIFG
RVDLLVYSAGIAKAAFISDFQLGDFDRSLQVNLVGYFLCAREFSRLMIRDGIQGRIIQINSKSGKVGSKHNSGYSAAKFG
GVGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYATKLCIKPDEVEQYYIDKVPLKRGCDYQDVLNMLLFYASP
KASYCTGQSINVTGGQVMF

Sequences:

>Translated_259_residues
MNQVAVVIGGGQTLGAFLCRGLAEEGYRVAVVDIQSDKAANVAQEINADFGEGMAYGFGADATSEQSVLALSRGVDEIFG
RVDLLVYSAGIAKAAFISDFQLGDFDRSLQVNLVGYFLCAREFSRLMIRDGIQGRIIQINSKSGKVGSKHNSGYSAAKFG
GVGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYATKLCIKPDEVEQYYIDKVPLKRGCDYQDVLNMLLFYASP
KASYCTGQSINVTGGQVMF
>Mature_259_residues
MNQVAVVIGGGQTLGAFLCRGLAEEGYRVAVVDIQSDKAANVAQEINADFGEGMAYGFGADATSEQSVLALSRGVDEIFG
RVDLLVYSAGIAKAAFISDFQLGDFDRSLQVNLVGYFLCAREFSRLMIRDGIQGRIIQINSKSGKVGSKHNSGYSAAKFG
GVGLTQSLALDLAEYGITVHSLMLGNLLKSPMFQSLLPQYATKLCIKPDEVEQYYIDKVPLKRGCDYQDVLNMLLFYASP
KASYCTGQSINVTGGQVMF

Specific function: Sorbitol metabolism. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=265, Percent_Identity=33.2075471698113, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI40254992, Length=256, Percent_Identity=27.734375, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4758504, Length=235, Percent_Identity=32.3404255319149, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI19923817, Length=270, Percent_Identity=26.6666666666667, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI83715985, Length=235, Percent_Identity=31.063829787234, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI59889578, Length=237, Percent_Identity=27.4261603375527, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4504505, Length=220, Percent_Identity=28.1818181818182, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI32483357, Length=256, Percent_Identity=25.78125, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=97.2972972972973, Blast_Score=510, Evalue=1e-146,
Organism=Escherichia coli, GI1787905, Length=255, Percent_Identity=30.9803921568627, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87082160, Length=260, Percent_Identity=29.6153846153846, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1787335, Length=256, Percent_Identity=28.515625, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788459, Length=264, Percent_Identity=28.4090909090909, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI2367175, Length=257, Percent_Identity=29.9610894941634, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=28.2945736434109, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=22.5296442687747, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1789208, Length=257, Percent_Identity=26.8482490272374, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25147288, Length=254, Percent_Identity=29.5275590551181, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17555706, Length=254, Percent_Identity=28.3464566929134, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17538182, Length=228, Percent_Identity=32.4561403508772, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17508895, Length=169, Percent_Identity=30.1775147928994, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17531453, Length=266, Percent_Identity=25.5639097744361, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=219, Percent_Identity=29.2237442922374, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=243, Percent_Identity=26.3374485596708, Blast_Score=64, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=243, Percent_Identity=26.3374485596708, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=211, Percent_Identity=31.7535545023697, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=28.2352941176471, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17737361, Length=233, Percent_Identity=30.9012875536481, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21355631, Length=170, Percent_Identity=30, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357041, Length=255, Percent_Identity=27.0588235294118, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI23397609, Length=266, Percent_Identity=25.9398496240602, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI18859837, Length=208, Percent_Identity=29.8076923076923, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.140 [H]

Molecular weight: Translated: 27922; Mature: 27922

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQVAVVIGGGQTLGAFLCRGLAEEGYRVAVVDIQSDKAANVAQEINADFGEGMAYGFGA
CCEEEEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCEECCCC
DATSEQSVLALSRGVDEIFGRVDLLVYSAGIAKAAFISDFQLGDFDRSLQVNLVGYFLCA
CCCCCHHHHHHHCCHHHHHHHHHHEEECCCHHHHHHHCCCCCCCCCCCEEHHHHHHHHHH
REFSRLMIRDGIQGRIIQINSKSGKVGSKHNSGYSAAKFGGVGLTQSLALDLAEYGITVH
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCHHHH
SLMLGNLLKSPMFQSLLPQYATKLCIKPDEVEQYYIDKVPLKRGCDYQDVLNMLLFYASP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHCCCCHHHHHHHHHHHCCC
KASYCTGQSINVTGGQVMF
CCCCCCCCEEECCCCEEEC
>Mature Secondary Structure
MNQVAVVIGGGQTLGAFLCRGLAEEGYRVAVVDIQSDKAANVAQEINADFGEGMAYGFGA
CCEEEEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCEECCCC
DATSEQSVLALSRGVDEIFGRVDLLVYSAGIAKAAFISDFQLGDFDRSLQVNLVGYFLCA
CCCCCHHHHHHHCCHHHHHHHHHHEEECCCHHHHHHHCCCCCCCCCCCEEHHHHHHHHHH
REFSRLMIRDGIQGRIIQINSKSGKVGSKHNSGYSAAKFGGVGLTQSLALDLAEYGITVH
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCHHHH
SLMLGNLLKSPMFQSLLPQYATKLCIKPDEVEQYYIDKVPLKRGCDYQDVLNMLLFYASP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHCCCCHHHHHHHHHHHCCC
KASYCTGQSINVTGGQVMF
CCCCCCCCEEECCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3553176; 9205837; 9278503; 6384188 [H]