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The map label for this gene is gabT [H]

Identifier: 29143055

GI number: 29143055

Start: 2780349

End: 2781632

Strand: Direct

Name: gabT [H]

Synonym: t2687

Alternate gene names: 29143055

Gene position: 2780349-2781632 (Clockwise)

Preceding gene: 29143054

Following gene: 29143056

Centisome position: 58.02

GC content: 57.79

Gene sequence:

>1284_bases
ATGAATACCAATAACACTTTAATGCAGCGCTGTCATAACGCCGTTCCTCGCGGCGTGGGCCAGATTCACCCGATTTTCGC
CGAGCGGGCGGAAAATTGTCGGGTCTGGGATGTCGAAGGCCGTGAGTATCTCGATTTCGCGGGCGGCATTGCCGTCCTGA
ACACCGGTCATTTACATCCGGGCATTGTTTCAGCGGTCGAAGCGCAGTTGAAGAAATTGTCGCATACCTGTTTTCAGGTG
CTGGCCTATGAACCGTACCTGGCGCTGTGCGAACGCATGAACCAGAAGGTACCGGGCGATTTCGCCAAAAAAACGTTGCT
GGTCACGACCGGTTCAGAAGCAGTTGAAAACGCGGTGAAAATCGCCCGCGCGGCGACAAAACGCAGCGGCGCTATCGCGT
TTAGCGGCGCTTACCACGGTCGTACCCACTACACGCTCTCTCTGACCGGGAAAGTACACCCGTACTCTGCGGGTATGGGA
TTGATGCCAGGCCATGTCTACCGCGCGCTTTATCCTTGCCCGCTACACAACATCAGCGACGACGACGCGATCGCCAGCAT
TGAACGCATCTTTAAAAATGATGCCGCGCCGGAAGATATCGCCGCCATTATTATTGAGCCGGTACAGGGCGAAGGCGGAT
TTTACGCCGCCTCTCCCGCGTTTATGCAGCGACTGCGCGCGCTATGCGACCAACACGGCATTATGTTGATTGCCGACGAA
GTGCAAAGCGGCGCGGGCCGGACCGGTACGCTGTTCGCCATGGAACAGATGGGCGTTGCGGCAGATATTACCACGTTTGC
GAAATCGATCGCCGGCGGCTTTCCGCTGGCAGGCGTTACCGGCCGGGCAGACGTGATGGACGCTATCGCGCCGGGCGGTC
TGGGCGGCACCTATGCCGGAAACCCGATTGCCTGCGTCGCCGCGCTGGCGGTACTGGACATTTTCGAGCAGGAAAATCTA
CTGCAAAAGGCGAATACGCTTGGCAAAACGCTGCGCGATGGCCTGATGGAGATAGCGGAAACGCACCGTGAGATTGGCGA
CGTGCGCGGACTGGGCGCCATGATCGCCATTGAGTTGTTCGAAAATGGCGACCCCGGCAAACCGAACGCGACTCTGACCG
CCGACATTGTGGCCCGCGCCCGCGAGAAAGGGTTAATTCTGCTCTCCTGCGGTCCTTACTACAACATCTTGCGCATCCTC
GTTCCACTCACTATTGAGGCCTCGCAGATTCGGCAAGGCCTGGAGATTATCGCCCAGTGCTTTGATGAGGCGAAACAAGC
GTAA

Upstream 100 bases:

>100_bases
TTAAGGCCTCCGGATTAGGCCGTGAAGGTTCCAAATACGGCATCGAAGATTATTTAGAAATCAAATATATGTGCATCGGC
CTTTAACAGGAGAGTCGCTA

Downstream 100 bases:

>100_bases
TGTCCAATAAGCAGCGTCGGATGGCGACGTAACTGTCTTATCCGGCCTACAAAAACCGTTTCGATTGTAGGCCGAATAAG
CCAGGCACCATCCGGTAAAC

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MNTNNTLMQRCHNAVPRGVGQIHPIFAERAENCRVWDVEGREYLDFAGGIAVLNTGHLHPGIVSAVEAQLKKLSHTCFQV
LAYEPYLALCERMNQKVPGDFAKKTLLVTTGSEAVENAVKIARAATKRSGAIAFSGAYHGRTHYTLSLTGKVHPYSAGMG
LMPGHVYRALYPCPLHNISDDDAIASIERIFKNDAAPEDIAAIIIEPVQGEGGFYAASPAFMQRLRALCDQHGIMLIADE
VQSGAGRTGTLFAMEQMGVAADITTFAKSIAGGFPLAGVTGRADVMDAIAPGGLGGTYAGNPIACVAALAVLDIFEQENL
LQKANTLGKTLRDGLMEIAETHREIGDVRGLGAMIAIELFENGDPGKPNATLTADIVARAREKGLILLSCGPYYNILRIL
VPLTIEASQIRQGLEIIAQCFDEAKQA

Sequences:

>Translated_427_residues
MNTNNTLMQRCHNAVPRGVGQIHPIFAERAENCRVWDVEGREYLDFAGGIAVLNTGHLHPGIVSAVEAQLKKLSHTCFQV
LAYEPYLALCERMNQKVPGDFAKKTLLVTTGSEAVENAVKIARAATKRSGAIAFSGAYHGRTHYTLSLTGKVHPYSAGMG
LMPGHVYRALYPCPLHNISDDDAIASIERIFKNDAAPEDIAAIIIEPVQGEGGFYAASPAFMQRLRALCDQHGIMLIADE
VQSGAGRTGTLFAMEQMGVAADITTFAKSIAGGFPLAGVTGRADVMDAIAPGGLGGTYAGNPIACVAALAVLDIFEQENL
LQKANTLGKTLRDGLMEIAETHREIGDVRGLGAMIAIELFENGDPGKPNATLTADIVARAREKGLILLSCGPYYNILRIL
VPLTIEASQIRQGLEIIAQCFDEAKQA
>Mature_427_residues
MNTNNTLMQRCHNAVPRGVGQIHPIFAERAENCRVWDVEGREYLDFAGGIAVLNTGHLHPGIVSAVEAQLKKLSHTCFQV
LAYEPYLALCERMNQKVPGDFAKKTLLVTTGSEAVENAVKIARAATKRSGAIAFSGAYHGRTHYTLSLTGKVHPYSAGMG
LMPGHVYRALYPCPLHNISDDDAIASIERIFKNDAAPEDIAAIIIEPVQGEGGFYAASPAFMQRLRALCDQHGIMLIADE
VQSGAGRTGTLFAMEQMGVAADITTFAKSIAGGFPLAGVTGRADVMDAIAPGGLGGTYAGNPIACVAALAVLDIFEQENL
LQKANTLGKTLRDGLMEIAETHREIGDVRGLGAMIAIELFENGDPGKPNATLTADIVARAREKGLILLSCGPYYNILRIL
VPLTIEASQIRQGLEIIAQCFDEAKQA

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=410, Percent_Identity=32.6829268292683, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI13994255, Length=421, Percent_Identity=29.4536817102138, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI37574042, Length=395, Percent_Identity=30.126582278481, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI284507298, Length=321, Percent_Identity=32.398753894081, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI226442709, Length=363, Percent_Identity=30.0275482093664, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI226442705, Length=395, Percent_Identity=29.3670886075949, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI24119277, Length=408, Percent_Identity=26.9607843137255, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI188536080, Length=398, Percent_Identity=26.1306532663317, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI38679950, Length=398, Percent_Identity=26.1306532663317, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI38679946, Length=398, Percent_Identity=26.1306532663317, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1789016, Length=426, Percent_Identity=88.7323943661972, Blast_Score=786, Evalue=0.0,
Organism=Escherichia coli, GI1787560, Length=421, Percent_Identity=52.7315914489311, Blast_Score=434, Evalue=1e-123,
Organism=Escherichia coli, GI1789759, Length=411, Percent_Identity=35.2798053527981, Blast_Score=241, Evalue=8e-65,
Organism=Escherichia coli, GI1788044, Length=401, Percent_Identity=33.9152119700748, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI145693181, Length=334, Percent_Identity=35.0299401197605, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1786349, Length=420, Percent_Identity=31.9047619047619, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1786991, Length=353, Percent_Identity=31.728045325779, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25144271, Length=431, Percent_Identity=30.1624129930394, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI32564660, Length=427, Percent_Identity=31.1475409836066, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI71992977, Length=423, Percent_Identity=29.3144208037825, Blast_Score=175, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI25144274, Length=231, Percent_Identity=34.1991341991342, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=404, Percent_Identity=25.7425742574257, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71981843, Length=118, Percent_Identity=34.7457627118644, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=422, Percent_Identity=30.8056872037915, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6324432, Length=407, Percent_Identity=30.2211302211302, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6324386, Length=435, Percent_Identity=20.6896551724138, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321456, Length=383, Percent_Identity=25.065274151436, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28574759, Length=415, Percent_Identity=32.7710843373494, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI161085790, Length=413, Percent_Identity=32.9297820823245, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI21357415, Length=405, Percent_Identity=30.6172839506173, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI21356575, Length=424, Percent_Identity=30.188679245283, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI281366494, Length=371, Percent_Identity=25.8760107816712, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24667139, Length=371, Percent_Identity=25.8760107816712, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24667143, Length=371, Percent_Identity=25.8760107816712, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 45642; Mature: 45642

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTNNTLMQRCHNAVPRGVGQIHPIFAERAENCRVWDVEGREYLDFAGGIAVLNTGHLHP
CCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEECCCCHHHHHCCCEEEEECCCCCC
GIVSAVEAQLKKLSHTCFQVLAYEPYLALCERMNQKVPGDFAKKTLLVTTGSEAVENAVK
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHCCEEEEECCHHHHHHHHH
IARAATKRSGAIAFSGAYHGRTHYTLSLTGKVHPYSAGMGLMPGHVYRALYPCPLHNISD
HHHHHHHCCCCEEEECCCCCCEEEEEEEECEECCCCCCCCCCCHHHHHHHCCCCCCCCCC
DDAIASIERIFKNDAAPEDIAAIIIEPVQGEGGFYAASPAFMQRLRALCDQHGIMLIADE
HHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEECCHHHHHHHHHHHCCCCEEEEEEC
VQSGAGRTGTLFAMEQMGVAADITTFAKSIAGGFPLAGVTGRADVMDAIAPGGLGGTYAG
HHCCCCCCCEEEEHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCC
NPIACVAALAVLDIFEQENLLQKANTLGKTLRDGLMEIAETHREIGDVRGLGAMIAIELF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEE
ENGDPGKPNATLTADIVARAREKGLILLSCGPYYNILRILVPLTIEASQIRQGLEIIAQC
CCCCCCCCCCEEHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
FDEAKQA
HHHHHCC
>Mature Secondary Structure
MNTNNTLMQRCHNAVPRGVGQIHPIFAERAENCRVWDVEGREYLDFAGGIAVLNTGHLHP
CCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEECCCCHHHHHCCCEEEEECCCCCC
GIVSAVEAQLKKLSHTCFQVLAYEPYLALCERMNQKVPGDFAKKTLLVTTGSEAVENAVK
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHCCEEEEECCHHHHHHHHH
IARAATKRSGAIAFSGAYHGRTHYTLSLTGKVHPYSAGMGLMPGHVYRALYPCPLHNISD
HHHHHHHCCCCEEEECCCCCCEEEEEEEECEECCCCCCCCCCCHHHHHHHCCCCCCCCCC
DDAIASIERIFKNDAAPEDIAAIIIEPVQGEGGFYAASPAFMQRLRALCDQHGIMLIADE
HHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEECCHHHHHHHHHHHCCCCEEEEEEC
VQSGAGRTGTLFAMEQMGVAADITTFAKSIAGGFPLAGVTGRADVMDAIAPGGLGGTYAG
HHCCCCCCCEEEEHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCC
NPIACVAALAVLDIFEQENLLQKANTLGKTLRDGLMEIAETHREIGDVRGLGAMIAIELF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEE
ENGDPGKPNATLTADIVARAREKGLILLSCGPYYNILRILVPLTIEASQIRQGLEIIAQC
CCCCCCCCCCEEHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
FDEAKQA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]