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The map label for this gene is aroL

Identifier: 29142862

GI number: 29142862

Start: 2548222

End: 2548767

Strand: Reverse

Name: aroL

Synonym: t2476

Alternate gene names: 29142862

Gene position: 2548767-2548222 (Counterclockwise)

Preceding gene: 29142863

Following gene: 29142861

Centisome position: 53.19

GC content: 58.24

Gene sequence:

>546_bases
ATGATGCAACCTCTTTATCTTGTTGGCCCGCGGGGCTGTGGGAAAACCACCATCGGTATGGCGCTGGCGCAGGCAACCGG
TTTTCGGTTTGCAGATACCGACCGCTGGCTGCAATCGCACGTGCAGATGAGCGTCGCTGATATCGTTGAAAAAGAAGGCT
GGGGAGGGTTCCGCGCCCGGGAAACCGCGGCCCTGGAGGCGGTAAGCGCGCCTTCGACTGTCGTGGCGACGGGAGGCGGT
ATTATTCTCACGGAGTATAACCGACGTTATATGCACCGTGTTGGCGTAGTGATTTATCTGTGCGCGCCGGTATCCACGCT
GGTTAACCGGCTTGAGGCTGAACCTGAAGCGGATCTGCGCCCGACCCTCACCGGCAAGCCGTTGAGCGAAGAGGTTCGGG
AAGTGCTTGAGCAGCGTGACGCGTTGTATCGCGAAACGGCGCATTACATTATTGACGCGACGAAAGCGCCGGCCCAGGTC
GTTTCTGAAATTATTGCGGCGCTGCCGCCGTCGACGCAACGGTTACAGGGAGATGTCTATACTTAA

Upstream 100 bases:

>100_bases
TTATTATTTACATTTATGCGTTGTACTAGTTAGATGATATGATTATAACATTACTGATATCAAATCCTGCGTATGCGCAG
TTCCTGGGGGAACGCCTGCT

Downstream 100 bases:

>100_bases
CGCTCACCCAGAATAAAGGAAACGCTATGCCAACCAGACCACCTTATCCGCGGGAAGCTTATATCGTCACCATTGAAAAA
GGCACGCCGGGCCAGACGGT

Product: shikimate kinase II

Products: NA

Alternate protein names: SK 2

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MMQPLYLVGPRGCGKTTIGMALAQATGFRFADTDRWLQSHVQMSVADIVEKEGWGGFRARETAALEAVSAPSTVVATGGG
IILTEYNRRYMHRVGVVIYLCAPVSTLVNRLEAEPEADLRPTLTGKPLSEEVREVLEQRDALYRETAHYIIDATKAPAQV
VSEIIAALPPSTQRLQGDVYT

Sequences:

>Translated_181_residues
MMQPLYLVGPRGCGKTTIGMALAQATGFRFADTDRWLQSHVQMSVADIVEKEGWGGFRARETAALEAVSAPSTVVATGGG
IILTEYNRRYMHRVGVVIYLCAPVSTLVNRLEAEPEADLRPTLTGKPLSEEVREVLEQRDALYRETAHYIIDATKAPAQV
VSEIIAALPPSTQRLQGDVYT
>Mature_181_residues
MMQPLYLVGPRGCGKTTIGMALAQATGFRFADTDRWLQSHVQMSVADIVEKEGWGGFRARETAALEAVSAPSTVVATGGG
IILTEYNRRYMHRVGVVIYLCAPVSTLVNRLEAEPEADLRPTLTGKPLSEEVREVLEQRDALYRETAHYIIDATKAPAQV
VSEIIAALPPSTQRLQGDVYT

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family. AroL subfamily

Homologues:

Organism=Escherichia coli, GI1786587, Length=168, Percent_Identity=74.4047619047619, Blast_Score=270, Evalue=3e-74,
Organism=Escherichia coli, GI87082255, Length=170, Percent_Identity=32.9411764705882, Blast_Score=81, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320332, Length=166, Percent_Identity=28.9156626506024, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROL_SALA4 (B5EWS0)

Other databases:

- EMBL:   CP001138
- RefSeq:   YP_002145369.1
- ProteinModelPortal:   B5EWS0
- SMR:   B5EWS0
- GeneID:   6796365
- GenomeReviews:   CP001138_GR
- KEGG:   sea:SeAg_B0425
- HOGENOM:   HBG335815
- OMA:   VEKEGWE
- ProtClustDB:   PRK03731
- GO:   GO:0005737
- HAMAP:   MF_01269
- InterPro:   IPR000623
- InterPro:   IPR023000
- PRINTS:   PR01100

Pfam domain/function: PF01202 SKI

EC number: =2.7.1.71

Molecular weight: Translated: 19804; Mature: 19804

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS01128 SHIKIMATE_KINASE

Important sites: BINDING 34-34 BINDING 58-58 BINDING 79-79 BINDING 120-120 BINDING 139-139

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQPLYLVGPRGCGKTTIGMALAQATGFRFADTDRWLQSHVQMSVADIVEKEGWGGFRAR
CCCCEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
ETAALEAVSAPSTVVATGGGIILTEYNRRYMHRVGVVIYLCAPVSTLVNRLEAEPEADLR
HHHHHHHHCCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PTLTGKPLSEEVREVLEQRDALYRETAHYIIDATKAPAQVVSEIIAALPPSTQRLQGDVY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHCCCCCC
T
C
>Mature Secondary Structure
MMQPLYLVGPRGCGKTTIGMALAQATGFRFADTDRWLQSHVQMSVADIVEKEGWGGFRAR
CCCCEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
ETAALEAVSAPSTVVATGGGIILTEYNRRYMHRVGVVIYLCAPVSTLVNRLEAEPEADLR
HHHHHHHHCCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PTLTGKPLSEEVREVLEQRDALYRETAHYIIDATKAPAQVVSEIIAALPPSTQRLQGDVY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHCCCCCC
T
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA