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The map label for this gene is proY [H]

Identifier: 29142851

GI number: 29142851

Start: 2532873

End: 2534243

Strand: Reverse

Name: proY [H]

Synonym: t2463

Alternate gene names: 29142851

Gene position: 2534243-2532873 (Counterclockwise)

Preceding gene: 29142852

Following gene: 29142850

Centisome position: 52.89

GC content: 54.27

Gene sequence:

>1371_bases
ATGGAAAGCAATAATAAGCTAAAGCGTGGGCTGAGCACCCGGCACATTCGCTTTATGGCATTAGGTTCGGCAATCGGCAC
CGGCCTGTTTTACGGCTCGGCGGACGCCATCAAAATGGCGGGGCCGAGCGTGCTGTTGGCCTATATTATTGGCGGGGTCG
CGGCATATATCATTATGCGCGCATTGGGGGAAATGTCCGTTCACAACCCTGCCGCCAGCTCATTTTCGCGCTATGCGCAG
GAAAACCTCGGCCCGCTTGCGGGCTACATTACCGGCTGGACCTACTGTTTTGAGATCCTGATCGTCGCCATTGCTGACGT
GACCGCGTTCGGCATTTACATGGGGGTCTGGTTCCCCGCCGTGCCGCACTGGATTTGGGTGCTTAGCGTGGTGCTGATCA
TTTGCGCCATCAACCTGATGAGCGTCAAGATGTTCGGCGAGCTGGAGTTTTGGTTCTCCTTCTTCAAAGTCGCCACCATT
ATTATCATGATTGTCGCGGGTATCGGCATCATTGTGTGGGGAATTGGCAACGGCGGGCAGCCGACTGGCATTCATAACCT
GTGGAGCAACGGCGGCTTCTTCAGCAATGGCTGGCTGGGAATGATCATGTCGCTGCAAATGGTGATGTTCGCTTACGGCG
GGATTGAGATTATCGGTATCACCGCCGGGGAAGCGAAAGACCCGGAGAAATCCATTCCGCGCGCCATTAACTCAGTACCG
ATGCGTATCCTGGTATTTTATGTCGGCACGCTGTTCGTCATTATGTCTATCTATCCGTGGAATCAGGTCGGCACAAACGG
CAGCCCATTTGTGCTGACGTTCCAGCATATGGGGATTACCTTTGCCGCCAGCATTCTGAACTTTGTGGTATTGACCGCCT
CGCTTTCCGCTATCAACTCCGATGTGTTTGGCGTAGGCCGTATGCTGCATGGTATGGCGGAGCAGGGGAGCGCGCCGAAA
GTCTTTGCCAAAACGTCACGCCGTGGTATTCCGTGGGTCACTGTGCTGGTGATGACGATTGCGCTGCTGTTTGCGGTTTA
CCTGAACTACATCATGCCGGAAAACGTCTTCCTGGTGATTGCCTCGCTGGTGACGTTTGCGACGGTATGGGTATGGATTA
TGATCCTGCTGTCGCAAATCGCCTTCCGTCGTCGTTTACCGCCGGAAGAGGTAAAAGCGCTGAAGTTTAAGGTGCCGGGC
GGTGTCGTAACGACGATAGCGGGTCTGATTTTCCTGGTCTTCATTATTGCGCTTATCGGCTACCATCCGAATACCCGCAT
CTCACTGTATGTGGGCTTCGCCTGGATAGTTCTGCTGTTGATTGGCTGGATATTTAAACGCCGTCGCGACCGTCAATTGG
CGCAGGCGTAG

Upstream 100 bases:

>100_bases
CTGTTAGGGCGCGGCTGGTAAGAGAGCCTTACAGGCGCATCAGAAAAACCTCCGGCTATGCCGGAGGATATTTATTATTG
TGTTGATAGGTCAGAAATTG

Downstream 100 bases:

>100_bases
TCGTTTTTCTCTGCCTTATCCGGTCTGCAGGCAACGGCAGGCCGGATAAGCGGAGCCGTTTCTCCTCCTGGAGTCTCCTC
CCCTAATAAACCCCCGGATG

Product: proline-specific permease

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MESNNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMRALGEMSVHNPAASSFSRYAQ
ENLGPLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPAVPHWIWVLSVVLIICAINLMSVKMFGELEFWFSFFKVATI
IIMIVAGIGIIVWGIGNGGQPTGIHNLWSNGGFFSNGWLGMIMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVP
MRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITFAASILNFVVLTASLSAINSDVFGVGRMLHGMAEQGSAPK
VFAKTSRRGIPWVTVLVMTIALLFAVYLNYIMPENVFLVIASLVTFATVWVWIMILLSQIAFRRRLPPEEVKALKFKVPG
GVVTTIAGLIFLVFIIALIGYHPNTRISLYVGFAWIVLLLIGWIFKRRRDRQLAQA

Sequences:

>Translated_456_residues
MESNNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMRALGEMSVHNPAASSFSRYAQ
ENLGPLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPAVPHWIWVLSVVLIICAINLMSVKMFGELEFWFSFFKVATI
IIMIVAGIGIIVWGIGNGGQPTGIHNLWSNGGFFSNGWLGMIMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVP
MRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITFAASILNFVVLTASLSAINSDVFGVGRMLHGMAEQGSAPK
VFAKTSRRGIPWVTVLVMTIALLFAVYLNYIMPENVFLVIASLVTFATVWVWIMILLSQIAFRRRLPPEEVKALKFKVPG
GVVTTIAGLIFLVFIIALIGYHPNTRISLYVGFAWIVLLLIGWIFKRRRDRQLAQA
>Mature_456_residues
MESNNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMRALGEMSVHNPAASSFSRYAQ
ENLGPLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPAVPHWIWVLSVVLIICAINLMSVKMFGELEFWFSFFKVATI
IIMIVAGIGIIVWGIGNGGQPTGIHNLWSNGGFFSNGWLGMIMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVP
MRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITFAASILNFVVLTASLSAINSDVFGVGRMLHGMAEQGSAPK
VFAKTSRRGIPWVTVLVMTIALLFAVYLNYIMPENVFLVIASLVTFATVWVWIMILLSQIAFRRRLPPEEVKALKFKVPG
GVVTTIAGLIFLVFIIALIGYHPNTRISLYVGFAWIVLLLIGWIFKRRRDRQLAQA

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=351, Percent_Identity=24.7863247863248, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI181337167, Length=338, Percent_Identity=25.1479289940828, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI258645169, Length=429, Percent_Identity=21.9114219114219, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI258614005, Length=430, Percent_Identity=21.8604651162791, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI258614003, Length=430, Percent_Identity=21.8604651162791, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI4507047, Length=366, Percent_Identity=23.4972677595628, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786602, Length=455, Percent_Identity=95.1648351648352, Blast_Score=820, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=453, Percent_Identity=45.916114790287, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1786302, Length=450, Percent_Identity=43.3333333333333, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI48994972, Length=451, Percent_Identity=45.0110864745011, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1790653, Length=460, Percent_Identity=41.304347826087, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI87081915, Length=445, Percent_Identity=37.5280898876404, Blast_Score=312, Evalue=2e-86,
Organism=Escherichia coli, GI87081708, Length=457, Percent_Identity=35.6673960612691, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI1788480, Length=406, Percent_Identity=37.192118226601, Blast_Score=248, Evalue=7e-67,
Organism=Escherichia coli, GI1789017, Length=386, Percent_Identity=35.4922279792746, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI87081869, Length=176, Percent_Identity=27.8409090909091, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI87082023, Length=282, Percent_Identity=25.177304964539, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI2367353, Length=331, Percent_Identity=23.8670694864048, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=428, Percent_Identity=23.3644859813084, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531343, Length=372, Percent_Identity=24.7311827956989, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17533459, Length=401, Percent_Identity=23.6907730673317, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324061, Length=462, Percent_Identity=32.034632034632, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6320772, Length=466, Percent_Identity=32.1888412017167, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6324990, Length=444, Percent_Identity=32.8828828828829, Blast_Score=199, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6324924, Length=407, Percent_Identity=31.4496314496315, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6319824, Length=432, Percent_Identity=28.4722222222222, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324059, Length=406, Percent_Identity=32.2660098522167, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6322892, Length=474, Percent_Identity=29.535864978903, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6319542, Length=432, Percent_Identity=28.4722222222222, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324553, Length=388, Percent_Identity=32.2164948453608, Blast_Score=162, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6320251, Length=434, Percent_Identity=27.1889400921659, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6320717, Length=400, Percent_Identity=27.5, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6321629, Length=431, Percent_Identity=27.6102088167053, Blast_Score=157, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6321053, Length=468, Percent_Identity=25.6410256410256, Blast_Score=146, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6319543, Length=399, Percent_Identity=27.5689223057644, Blast_Score=145, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6319608, Length=454, Percent_Identity=25.1101321585903, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6322967, Length=398, Percent_Identity=26.3819095477387, Blast_Score=132, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6324981, Length=427, Percent_Identity=25.9953161592506, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320364, Length=508, Percent_Identity=24.4094488188976, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24666159, Length=413, Percent_Identity=22.0338983050847, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221512776, Length=413, Percent_Identity=22.0338983050847, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161077963, Length=331, Percent_Identity=25.3776435045317, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50108; Mature: 50108

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESNNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMR
CCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHH
ALGEMSVHNPAASSFSRYAQENLGPLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPA
HHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPHWIWVLSVVLIICAINLMSVKMFGELEFWFSFFKVATIIIMIVAGIGIIVWGIGNGGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCC
PTGIHNLWSNGGFFSNGWLGMIMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVP
CCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHH
MRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITFAASILNFVVLTASLSAINS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
DVFGVGRMLHGMAEQGSAPKVFAKTSRRGIPWVTVLVMTIALLFAVYLNYIMPENVFLVI
HHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ASLVTFATVWVWIMILLSQIAFRRRLPPEEVKALKFKVPGGVVTTIAGLIFLVFIIALIG
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHC
YHPNTRISLYVGFAWIVLLLIGWIFKRRRDRQLAQA
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MESNNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMR
CCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHH
ALGEMSVHNPAASSFSRYAQENLGPLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPA
HHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPHWIWVLSVVLIICAINLMSVKMFGELEFWFSFFKVATIIIMIVAGIGIIVWGIGNGGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCC
PTGIHNLWSNGGFFSNGWLGMIMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVP
CCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHH
MRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITFAASILNFVVLTASLSAINS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
DVFGVGRMLHGMAEQGSAPKVFAKTSRRGIPWVTVLVMTIALLFAVYLNYIMPENVFLVI
HHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ASLVTFATVWVWIMILLSQIAFRRRLPPEEVKALKFKVPGGVVTTIAGLIFLVFIIALIG
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHC
YHPNTRISLYVGFAWIVLLLIGWIFKRRRDRQLAQA
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]